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2. DTC drain: consumer ad spend fell sharply in 2012 as the number of mass-market blockbusters continued to dwindle and marketers shifted their focus away from TV and toward digital channels. Meanwhile, as Matthew Arnold finds, the debate over the pros and cons of DTC is still raging, even as evidence of its merits accumulates

3. Sanofi proves its pluck

4. From AIC to Z: sites like Novo Nordisk's Cornerstones4Care are bringing full-spectrum segmentation to the task of bolstering adherence and being there for the patient, reports Matthew Arnold

5. The APP avant-garde: medical devices marrying apps and consumer electronics are setting off a wave that will revolutionize chronic-disease management--and could upturn biopharma business models, Matthew Arnold reports

6. DTC: beyond the block-buster: the mass-market, TV-and-print DTC formula is going the way of the vanishing primary care blockbusters it was designed to boost as new media and 'niche products fill the breach Matthew Arnold reports

7. Tailor made marketing: aided by the digital revolution, patient marketing programs are getting increasingly personal, with greater levels of customization aimed at differentiating products and keeping patients on therapy Matthew Arnold reports

8. Screen play: the suddenly hot market for high-risk HPV tests, where Roche diagnostics is launching against two entrenched brands, offers a window into a future of personalized medicine and the convergence of drugs, diagnostics and devices. Matthew Arnold reports

9. Cliff notes: drug revenues barely kept pace last year, as other indicators like numbers of protected brands and reps have decreased, amid the overall trend of industry consolidation. With more products set to take the plunge over the patent cliff, analysts say margins are due to be tight for the foreseeable future. Marc Iskowitz and Matthew Arnold report

10. Code red for DTC? DTC spending continues to slide, and with many of the blockbuster, mass-market drugs that have sustained it over the past decade set to lose patent protection, the print-and-TV-advertising formula seems sure to go with it. Matthew Arnold reports

11. Class apps: mobile apps are the future of patient education and disease management, promising better tracking, improved adherence and richer patient-doctor dialogue, reports Matthew Arnold

12. Pharma's got a brand new bag: pharmas aren't merely downsizing reps, they're rethinking the detail and installing specialized sales forces, breaking them up into regions and making outcomes king, Matthew Arnold reports

13. Thinking past the pill: Pfizer is investing heavily in adherence, putting patient support programs on equal footing with some of its drugs, Matthew Arnold reports

14. Out of the box: the formerly sleepy business of marketing devices and diagnostics is getting much savvier amid technological innovations, empowered patients and an evermore complicated healthcare system, reports

15. Flat is the new up: after a sharp downturn, consumer ad outlays have stabilized. Advertisers are spending again, but with budgets under pressure, they're seeking deals, and amid thinning pipelines, they're supporting mature blockbusters later in their lifecycles. Matthew Arnold reports on the trends

16. A bountiful alpine pipeline

17. A new Dawn: the healthcare reform legislation inching toward the president's desk will mean big changes for the pharmaceutical industry, whatever its final form. Matthew Arnold takes a look at what's ahead

18. Course correction

21. Poll reversal: it's an Alice in Wonderland election for the industry, which finds itself favoring the Democratic candidate after eight years of alignment with the party of business. Would pharma fare better under Obama? Matthew Arnold looks at the candidates and their positions

22. Lesson plans: CME support is likely to slump amid regulatory uncertainty and a multi-pronged assault on alleged industry influence

23. Steady migration: slowly but surely, consumer advertising and promotion is getting smarter and more targeted as marketers broaden their media plans to cope with a dearth of blockbusters to birth. Matthew Arnold reports on the trends and figures for DTC

24. Merck sets science in motion

26. Biotech blurring: big pharma has long looked to biotechs to help fatten pipelines, but one company has experienced the benefits of keeping things in-house. Matthew Arnold looks at how Wyeth came up with another way to conduct business

27. Top 20 pharma companies: while the US saw a rebound in prescription drug growth in 2006, few companies are sitting pretty. Matthew Arnold charts the trends, events, stories and numbers of the biggest players

28. DTC the first 10 years: so much has happened since Claritin's 'Blue Skies' spots ushered in a new era of consumer drug advertising that it's difficult to believe the DTC adventure is only a decade old. Matthew Arnold charts the key milestones, players and campaigns, and looks ahead to the future of DTC

29. House of hearings: with the Democrats set to take control of Congress, the new guard of committee leadership presents a mixed-to-bleak picture for pharma industry interests

30. Interactive forces: Merck has taken the hi-tech route to improving efficiency in the field, while other firms experiment with promising new approaches to targeting and detailing physicians

31. Publicis Healthcare Communications Group: the medical advertising behemoth completes a reorganization and rolls on with major-league brands

32. The science of DTC: Pharma once again has a spring in its step about consumer campaigns. Only this time, beaches and bold efficacy claims have been replaced by lab coats and risk information, as Merck and others amass data on how viewers absorb TV ads

33. Flexible forces

34. The hard sell: when the new Medicare Prescription Drug Benefit takes effect in January, government will replace the individual consumer as pharma's biggest customer. Onlookers hope that both industry and consumers will come out on top. But first there is the small matter of persuading 30 million Americans to enroll

35. New channels in TV

36. Changing channels

37. In the face of crisis: the COX-2 crisis has rocked the industry, with intense scrutiny from the media and the numerous stakeholders. Matthew Arnold compares the crisis PR efforts of Merck and Pfizer and looks at how other pharmas can learn from this episode to better shape their future communications strategies

38. Uncertain term: while the industry's initial response to the re-election of President George W. Bush has been positive, there are still unresolved issues, such as drug importation from Canada, that cloud pharma's security in 2005

39. The hidden prescribers: while pharmaceutical companies continue to target fewer high-prescribing physicians with less time than ever, an increasingly important segment of healthcare professionals is going largely neglected. Matthew Arnold looks at how companies can harness the growing clout of physician assistants and nurse practitioners

40. The agency conundrum: the challenges facing medical advertising agencies continue to mount, but business and morale remain intact. Matthew Arnold looks at the trends of the past year and how firms are squaring up to the future

41. Directing compliance: patient non-compliance in the statin category alone costs pharma companies billions in lost revenues. Matthew Arnold looks at how Pfizer and others are pushing the boundaries of relationship marketing to keep patients on board and on track

42. PR: the DTC you don't see: there was a time when communications professionals languished on the fringe of the pharma and biotech marketing mix, called on only to deliver bad news and defuse crises. But now, with the increasing primacy of the consumer, proliferation of constituencies and a wave of restructurings, PR is emerging from the shadows as a strategic force

43. Advanstar's advance: Advanstar's acquisition of Thomson's Medical Economics unit, priced at an eye-popping $135 million, showcases the growing value of those big-name, multi-specialty titles not in the hands of associations. Matthew Arnold looks at this major deal and what it means for the medical publishing industry

44. Agency Review 2003: Masters of Medical Advertising

45. Direct delivers 5 factors driving direct marketing

46. Damned if it works; Damned if it doesn't. (DTC Diagnosis)

47. Measuring online ROI. (The Internet Puzzle)

48. For pay it ward: after a tumultuous few years of healthcare policymaking, a big victory for Obamacare. It's now all systems go for the law, with sweeping change for the American healthcare system and tens of millions more insured. Expect this more insured. Expect this status quo to be anything but boring. Matthew Arnold reports

49. A movable feast: marketing now means digital, digital means mobile and search is no longer the starting point for online promotion. Matthew Arnold charts the trends

50. Embracing the new terrain

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