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Carbon nanotubes as novel nanomaterials, which are widely used in biomedical field. Through the respiratory tract, digestive tract, and circulation, carbon nanotubes can come into contact with vascular endothelial cells and damage the endothelial cells. In this paper, the factors effecting the damage of carbon nanotubes to endothelial cells was reviewed, and the effects of carbon nanotubes on endothelial cell inflammation, monocyte adhesion, lipid accumulation, endothelial permeability, angiogenesis, and pro-coagulant ability were reviewed. Meanwhile, this paper reviewed that carbon nanotubes promote the formation of atherosclerotic plaques and the impairment of blood-brain barrier function by damaging endothelial cells in animal experiments, so as to provide a reference for decision-making on the application of carbon nanotubes in biomedical field [ABSTRACT FROM AUTHOR]

Ischemic stroke is a cerebrovascular disease with high incidence and disability rate. After ischemic stroke, different parts of the nervous system injury may lead to different degrees of diaphragmatic dysfunction, which not only affects the respiratory function and physical stability of patients, but also restricts the overall rehabilitation process of patients. According to the characteristics of diaphragmatic dysfunction at different stages after ischemic stroke, selecting appropriate rehabilitation treatment techniques will effectively improve diaphragmatic function, enhance lung function reserve and physical stability, and provide a basis for motor function rehabilitation. According to the clinical characteristics of ischemic stroke in different periods, this paper reviewed the research progress and comprehensive application of diaphragmatic rehabilitation treatment techniques in different periods, in order to provide reference for the formulation of clinical treatment strategies. [ABSTRACT FROM AUTHOR]

In recent years, with the continuous advancement of wound healing research, it has become a consensus that wet wound treatment can effectively promote healing. The wound microenvironment plays a crucial role in all stages of wound healing and is a key factor for successful wound management. The “moisture balance” theory provides a novel perspective on managing wound moisture. However, further research is required to determine the optimal moisture level required for wound healing. This paper reviewed the benefits of wet wound healing and its impact on effective wound management. It is recommended to assess and monitor the moisture levels of wounds in order to regulate their moisture management and achieve optimal healing outcomes. [ABSTRACT FROM AUTHOR]

The adherence of rehabilitation exercise of rotator cuff repair patients is very important for the recovery of shoulder joint function, but the situation is not ideal. By searching the literature of domestic and foreign databases, this paper reviewed the status quo of rehabilitation exercise compliance of patients with rotator cuff repair, analyzed the influence of physiological and psychological factors, rehabilitation exercise load, social support and medical support on rehabilitation exercise adherence of patients with rotator cuff repair, and explained relevant nursing intervention modes, aiming at providing reference for improving rehabilitation exercise adherence of patients with rotator cuff repair. [ABSTRACT FROM AUTHOR]

Oxidative stress is closely linked to the decline inof female fertility caused by various factors. Antioxidants, which can counteract oxidative stress. have been increasingly used as adjunctive therapy for women with reduced fertility. However, there are limited clinical studies on whether antioxidants can enhance fertility in women with low reproductive capacity and improve pregnancy outcomes, with inconsistent results and generally low-quality evidence. This paper reviewed the impact of oxidative stress on female fertility and discusses the progress of research on the application of antioxidants in common conditions that lead to reduced female fertility and are closely associated with oxidative stress, such as polycystic ovary syndrome, endometriosis, and unexplained infertility, aiming to provide a reference for clinical treatment. [ABSTRACT FROM AUTHOR]

Digestive tract malignant tumor refers to the general term of malignant tumor occurring in digestive tract, including esophageal cancer, gastric cancer, colorectal cancer, liver cancer and pancreatic cancer. Narrative nursing is a kind of nursing measure developed from narrative medicine with the characteristics of holistic nursing concept and humanistic care. This paper reviwed the application research progress of narrative nursing in clinical nursing of patients with digestive tract malignant tumor, and put forward relevant suggestions, so as to provide basis for follow-up nurses to implement narrative nursing intervention for patients with digestive tract malignant tumor and provided reference for further improvement of narrative nursing intervention. [ABSTRACT FROM AUTHOR]

Vitamin D is an indispensable fat-soluble vitamin in the human body, mainly in the form of vitamin D2 and vitamin D3,which can be synthesized by the skin and ingested in the diet. Vitamin D deficiency is currently a global public health problem, with approximately one billion people worldwide suffering from vitamin D deficiency, and pregnant women are at high risk. Gestational diabetes mellitus（GDM） refers to normal glucose metabolism before pregnancy, and abnormal glucose tolerance of different degrees occurs for the first time during pregnancy, which is one of the complications of pregnancy. Continuous studies have proved that vitamin D deficiency during pregnancy is closely related to GDM,which can affect glucose balance through various mechanisms, leading to an increased risk of GDM. In addition, GDM increases the incidence of maternal and infant complications such as hyperamniotic fluid, pregnancy-induced hypertension, premature rupture of membranes, premature delivery, macrosomia, low body weight, and teratoma, which threatens maternal and infant health. In recent years, the research on the correlation between vitamin D and GDM has been increasing, and its correlation has been paid more and more attention by more and more scholars. This paper reviewed the research progress on the correlation between vitamin D and GDM. [ABSTRACT FROM AUTHOR]

Asthma is one of the most common chronic diseases in childhood, and its pathogenesis is not yet clear. In recent years, the imbalance of intestinal flora has attracted more and more attention to the occurrence and development of childhood asthma. Traditional Chinese medicine believes that the lung and the large intestine are interrelated, and the occurrence of childhood asthma is closely related to the dysfunction of the lung and the large intestine, while Western medicine believes that the occurrence of childhood asthma is related to various factors. Among them, pulmonary immune imbalance caused by intestinal flora disorder is one of the important causes of its occurrence. This paper discussed the occurrence of childhood asthma by focusing on pulmonary and intestinal pathophysiology, so as to provide new targets or therapeutic ideas for the prevention and treatment of childhood asthma. [ABSTRACT FROM AUTHOR]

Alzheimer′s disease (AD) is a neurodegenerative disease with a hidden onset and complex pathology. The clinical diagnosis of AD has probably developed to the middle or late stage. The relative protein biomarkers in the cerebrospinal fluid can pass through the blood-brain barrier and participate the peripheral circulation in the very early stage of AD. Peripheral blood biomarker detection has the characteristics of convenient collection and minimal trauma, and is expected to become the most promising early screening and follow-up method. However, the traditional immunoassay methods cannot meet the demand for the accurate quantitative analysis of ultra-trace protein biomarkers in peripheral blood. In recent years, the newly developed immunoassay techniques in recent years have been widely applied in the analysis of ultra trace protein biomarkers. The paper reviews the recent research progress and analysis methods of early peripheral blood biomarkers of AD. [ABSTRACT FROM AUTHOR]

Heat shock protein 70(HSP70) is a protein that can inhibit cell protein denaturation or expansion under stress or high temperature. It plays a key role in the expression of inflammatory factors, inhibition of apoptosis, and inhibition of protein aggregation. HSP70 is a protein that can inhibit cell protein denaturation or expansion under stress or high temperature. It plays a key role in the expression of inflammatory factors, inhibition of apoptosis, and inhibition of protein aggregation. This paper expounds the close relationship between heat shock protein 70 and the pathogenesis of lung diseases such as lung cancer, pneumonia, pulmonary tuberculosis and asthma, and provides a new idea for the rapid diagnosis of lung diseases. [ABSTRACT FROM AUTHOR]

A patent foramen ovale(PFO) is a cardiac anatomical abnormality that usually fails to close normally at birth, resulting in the blood flow channel between the left ventricle and the right ventricle still existing. In recent years, a growing number of studies have shown that there is a correlation between PFO and migraine, especially in migraine patients with aura. With the continuous development of interventional techniques in cardiology, interventional closure has become an effective method for the treatment of PFO. Studies have shown that the closure of PFO by using a closure device can reduce the risks associated with patent foramen ovale, such as stroke. More encouragingly, some studies have found that PFO closure may help reduce the frequency and severity of migraine attacks. Anxiety and depression are common mental complications in migraine patients. Percutaneous PFO closure has shown favorable results in alleviating migraine symptoms and improving psychological status and quality of life. This review will also discuss the safety and efficacy of PFO closure, as well as the mechanisms associated with migraine, in order to further explore the clinical advances in this field. Finally, this paper emphasize the necessity of screening and managing the mental health status of patients, and expects that future research can provide more clear guidance for PFO closure in the treatment of migraine. [ABSTRACT FROM AUTHOR]

The patient-reported outcome measurement information system can help doctors make decisions, promote nursing-patient communication and improve patient compliance, which has been widely used in lung cancer clinical practice in Western countries and has become the most valuable tool for evaluating outcome indicators in lung cancer patients. This paper reviewed the current status of the application of patient-reported outcome measurement information system for lung cancer patients both domestically and internationally, aiming to provide reference for clinical nursing research and improve the quality of life of lung cancer patients. The patient-reported outcome measurement information system still has great development potential in the field of lung cancer in China, and it was expected that more practical explorations to promote its true implementation and development in China. [ABSTRACT FROM AUTHOR]

Pericardial effusion is a potentially life-threatening complication after hematopoietic stem cell transplantation (HSCT) in children. The incidence of pericardial effusion in children was 4.4% to 37.8%.The occurrence of pericardial effusion is related to many risk factors such as transplant-related thrombomicroangiopathy, pretreatment drugs, graft-versus-host disease, graft type, immunosuppressant, infection and so on. The treatment of pericardial effusion lacks a unified protocol, mainly focus onsupportive treatment, etiologic treatment and pericardial puncture. his paper reviewed the risk factors and treatment of pericardial effusion after HSCT in recent years, and provided suggestions for improving the early identification, diagnosis and treatment of pericardial effusion after HSCT in children. [ABSTRACT FROM AUTHOR]

Alzheimer's disease (AD) is a persistent neurological disorder, its main pathological changes are age spots and neurofibrillary tangles, there is no treatment to prevent its progression currently. Autophagy is an intracellular degradation pathway that maintains cellular homeostasis by removing large insoluble proteins. With the deepening of related studies, it is found that the dysfunction of autophagy is related to the pathological process of AD. Hydrogen sulfide (H2S) can regulate autophagy and play a protective role in AD, but the specific mechanism is not fully understood. This paper reviewed the role of H2S in regulating autophagy in the pathological process of AD in recent years, providing new ideas for the prevention and treatment of AD. [ABSTRACT FROM AUTHOR]

Vascular endothelial injury is the initiating factor in atherosclerosis Currently, western medical treatment is ineffective and has many adverse effects. It has been found that flavonoids, the active ingredients of Chinese medicine, can regulate endothelial cell function by reducing inflammation, inhibiting oxidative stress, improving apoptosis and autophagy. They have the advantages of multiple pathways, links and targets in the prevention and treatment of atherosclerosis, and have great potential for development. This paper reviewed the recent studies on the mechanism of flavonoids in improving endothelial injury, and provided reference and theoretical basis to promote the discovery of new drug candidates for vascular endothelial injury and the wide application of flavonoids. [ABSTRACT FROM AUTHOR]

At present, cardiovascular and cerebrovascular diseases are currently one of the chronic diseases with the heaviest disease burden in China. With the gradual aging of China's population, the traditional chronic disease management mode of "disease-centered" can no longer meet the health service needs of current residents. The chronic disease management model based on the concept of "active health" is a new type of "health-centered" chronic disease health management model. This mode has established a closer, more convenient and affordable communication mode between residents and family doctor teams.It saves the time, manpower and economic cost of family doctor team service, and is conducive to improving the quality and efficiency of chronic disease management and residents' health literacy. Taking cardiovascular and cerebrovascular diseases as an example, this paper discusseed the chronic disease management mode and research content based on the concept of "active health" aiming to explore the form and standard of "active health" chronic disease management mode, and provide reference for the promotion of this mode [ABSTRACT FROM AUTHOR]

Acute pulmonary embolism (APE) is one of the common acute and critical cardiovascular diseases. Currently, the methods used to diagnose APE rely on imaging and laboratory tests. The commonly used imaging detection methods are complex, consuming time, inconvenient handling for acute and severe patients and high examination cost. Therefore, exploring a simple, economical and effective evaluation method for acute non-high-risk pulmonary embolism patients has important clinical significance. Immune/inflammatory response plays an important role in the pathogenesis of vascular disease. Representative indicators in blood include neutrophil/lymphocyte ratio, monocyte-related indicators, platelet/lymphocyte ratio, systemic immune/inflammatory index, etc. This paper focused on the value of novel inflammatory markers in predicting the diagnosis and prognosis of APE patients. [ABSTRACT FROM AUTHOR]

Parkinson′s disease (PD) is a neurodegenerative disease commonly in the elderly, which is mainly characterized by resting tremor, bradykinesia, and muscle tonus. Caenorhabditis elegans has its unique advantages in the study of neurological diseases and is a widely used model organism. The paper briefly summarized the characteristics of the Caenorhabditis elegans model and focuses on the application of Caenorhabditis elegans in the study of PD, which provided reference and options for the study of PD mechanism and the development of new drugs. [ABSTRACT FROM AUTHOR]

Refeeding syndrome (RFS) is a series of life-threatening clinical symptoms caused by abnormal metabolism in the early stage of re-intake of nutrition in the patients with chronic malnutrition. Due to the lack of specificity it is difficult to identify, and has higher mortality in ICU patients. At present, there are few studies on the management and prognosis of RFS by domestic scholars, moreover the specific management measures are still controversial. In addition, there are also differences in the methods and conclusions of RFS prognostic studies. Thus this paper systematically reviews the diagnostic criteria, occurrence status, management status and disease prognosis of RFS, aiming at offering the experience to medical staffs on RFS management and providing reference for follow-up related research. [ABSTRACT FROM AUTHOR]

Anterior cruciate ligament (ACL) injury of knee joint is a common sports injury, which can lead to instability of knee joint, reduce the movement ability of the patients, and affect the quality of life of the patients. This paper reviews the anatomy, injury risk factors, imaging findings and treatment of the anterior cruciate ligament of the knee aiming to provide further understanding for clinical prevention and treatment of anterior cruciate ligament injury. [ABSTRACT FROM AUTHOR]

Preeclampsia is a pregnancy-specific complication, and hypertension is the main feature of preeclampsia.At present, preeclampsia is still an important cause of maternal and fetal morbidity and mortality, and its pathogenesis is still unclear.The immune intolerance of pregant women to allogeneic embryos is one of the important mechanisms of preeclampsia.miR-155 has important value in the regulation of immune function and can accurately regulate the expression of interleukin-17A.Suppressor of cytokine signaling 1（SOCS1） has been reported to be the only direct target of miR-155 in CD4+T cells and has the biological function of regulating T cell differentiation.This paper preliminarily expounded that miR-155 in placental-derived exosomes affects the differentiation of Treg cells and Th17 cells and the production of IL-17 by inhibiting SOCS1 and regulating JAK/STAT pathway, which provided theoretical guidance for the prevention, diagnosis and treatment of preeclampsia. [ABSTRACT FROM AUTHOR]

At present, the nursing intervention methods of anticipatory grief (AG) in caregivers of patients with chronic diseases mainly include narrative intervention, psychosocial intervention, cognitive behavioral therapy, mindfulness intervene, family dignity intervention, and expressive writing. This paper reviews the relevant research at home and abroad, in order to provide reference for the development of AG nursing intervention programs for caregivers of patients with chronic diseases in China. [ABSTRACT FROM AUTHOR]

Duhuo Jisheng Decoction affects the synthesis and apoptosis of bone and cartilage by inhibiting the expression of ASFla and HIRA, reducing the levels of cytochrome C and nitric oxide, and regulating some inflammatory factors. The application examples of Duhuo Jisheng Decoction in different bone trauma and reconstruction have confirmed that it has a good effect in the application of common orthopedic diseases such as lumbocrural pain, arthritis, and scapulohumeral periarthritis. Based on the pharmacological analysis of Duhuo Jisheng Decoction, this paper reviews the clinical application of Duhuo Jisheng Decoction in the treatment of orthopedic diseases. [ABSTRACT FROM AUTHOR]

Asthma is one of the most common respiratory diseases in the world. According to the latest statistics, the incidence of asthma is increasing year by year, but the effective control rate is only 45%. Its recurrent nature seriously affects people′s physical and mental health. Currently, the asthma guidelines recommend the control of medication is still to inhaled glucocorticosteroids and beta agonists is given priority to, although it is true that recent years the emergence of the biological preparation makes severe asthma control, due to economic factors in patients with difficult to sustain, lead to drug is difficult to popularize, asthma clinical control effect is still poor, and even can be life threatening. Therefore, it is necessary to develop new drugs for asthma. In recent years, Suzi-Jiangqi decoction has significant curative effect in the treatment of asthma with few side effects. This paper reviewed the mechanism of action of the active ingredients of Suzi-Jiangqi decoction in the treatment of asthma, in order to provide new ideas for the treatment of asthma. [ABSTRACT FROM AUTHOR]

Breast cancer is one of the most common malignant tumors in Chinese women. In recent years, with the introduction of precision therapy, immunotherapy has become a new treatment option. However, many patients still do not benefit from it, suggesting the need to find new targets and treatments. T-lymphocyte immunoglobulin and immunoreceptor tyrosine-based inhibitory template (TIGIT) is a novel immune molecule that has been found to be aberrantly expressed in a variety of solid tumors. This paper outlined the progress of TIGIT research in the immune response to breast cancer. [ABSTRACT FROM AUTHOR]

Allergic rhinitis (AR), as a recurrent allergic inflammatory disease, has an increasing inci- dence year by year in China, which seriously affects the work and life of patients. However, the pathogenesis of AR is still unclear, and the studies have found that intestinal flora and fecal metabolites can not only interact with each other, but both can participate in the occurrence and development of AR by affecting mucosal barrier function, regulating immunity, and so on, which may provide new possibilities for the treatment of AR. This paper reviewed the articles on the relationship between intestinal flora and related fecal metabolites and AR in recent years, in order to provide ideas for the treatment and pathogenesis of AR. [ABSTRACT FROM AUTHOR]

Anti-platelet therapy is the basic strategy for the prevention and treatment of ischemic stroke. Aspirin plays an anti-platelet aggregation role by inhibiting TXA2 pathway, while thiopyridine drugs such as clopidogrel and ticagrelor play an anti-platelet aggregation role by inhibiting ADP pathway. Both of these pathways play a role in the upstream pathway of platelet aggregation, while platelet glycoprotein (GP) IIb/II a receptor is the final pathway of platelet aggregation and thrombosis, and the antagonists can quickly exert their anti-platelet aggregation effects by directly binding to GP II b/ II a receptors.. Tirofiban is the main GP IIb/Il a receptor antagonist used in clinic in China at present, and its application in cardiovascular field and coronary intervention therapy has also been recommended by authoritative guidelines for coronary atherosclerotic heart disease at home and abroad. However, the application of tirofiban in cerebrovascular diseases is still in the exploratory stage, lacking the support of large-scale clinical trial data, and it belongs to off-label drug use. This paper reviewed the application status and research progress of tirofiban in acute ischemic stroke based on the relevant literature at home and abroad in recent five years. [ABSTRACT FROM AUTHOR]

Interleukin (IL)-37 is a member of the IL-1 family, which can control excessive inflammation and immunity during the progression of inflammation, thus protecting or mitigating tissue damage. Macrophages are the key cellular components in the innate immune system. Under the action of local microenvironment, macrophages can be activated into pro-inflammatory M1 type and anti-inflammatory M2 type to participate in the inflammatory process. With the deepening of research in recent years. the role of IL-37 in combating excessive inflammation in a variety of inflammatory diseases by inhibiting M1 macrophage polarization or promoting M2 macrophage polarization has been mentioned more and more. This paper mainly reviewed the anti-inflammatory mechanism and macrophage polarization of IL-37, and focused on the role of IL-37 in various inflammatory diseases by regulating macrophage polarization, and its therapeutic value in inflammatory diseases. [ABSTRACT FROM AUTHOR]

Mitochondria is one of the important organelles in eukaryotic cells, participating in various physiological activities. Ferroptosis is a new iron-dependent programmed cell death, which is characterized by iron overload, antioxidant system imbalance and lipid peroxidation. Mitochondria are involved in various forms of cell death. It is of great significance to understand the role of mitochondria in ferroptosis for cell biology and clinical disease treatment. In this paper, the role of mitochondrial tricarboxylic acid cycle. oxidative phospho- rylation. mitochondrial mitophagy, mitochondrial DNA and other aspects in the occurrence of ferroptosis was discussed. which provided theoretical basis for the prevention and treatment of ferroptosis-related diseases based on mitochondria. [ABSTRACT FROM AUTHOR]

Spastic hemiplegia, also known as upper motor neuron paralysis and central hemiplegia, is one of the common symptoms and important complications of stroke sequelae, and it is a major problem in the rehabilitation treatment of stroke patients in the later stage, which seriously affects the patients’ daily life and social participation.it brings serious burden to the family and society, so exploring effective treatment methods has been paid more and more attention. In recent years, clinical observation and related studies have found that acupuncture combined with exercise therapy is significant in the treatment of this disease. This paper summarizes the relevant literature on acupuncture combined with exercise in the treatment of spastic hemiplegia after stroke, and reviews the clinical research situation of different acupuncture methods combined with exercise treatment for stroke spastic hemiplegia. [ABSTRACT FROM AUTHOR]

The OPRL1 gene encodes the nociceptin opioid peptide (NOP) receptor, while the NOP and its endogenous ligand nociceptin/orphanin FQ(N/OFQ), as an important member of the endocannabinoid system, can regulate a variety of biological functions and neurological behaviors, which are closely related to pain and psychiatric disorders such as depressive disorders, psychoactive substance-induced disorders, and stress-related disorders. This paper reviews the research progress on the relationship of OPRL1 gene with pain and psychosomatic disorders. [ABSTRACT FROM AUTHOR]

Based on the three-dimensional quality evaluation model of structure-process result, this paper reviewed the evaluation indexes of nursing staff empathy fatigue management quality. The structural indicators mainly include working environment, knowledge and technology system and policy support. The process indicators include empathy fatigue assessment, empathy fatigue intervention and monitoring. The results indexes included quality of life, mental health, job satisfaction and turnover rate, so as to provide reference for the construction of evaluation index system of nursing staff empathy fatigue management quality, and then improve the ability of nursing staff empathy. [ABSTRACT FROM AUTHOR]

With the development of medical level and the increase of child survival rate, chronic diseases show an increasing trend year by year. Due to the immature stage of children′s mental development and cognitive ability, it not only brings great challenges to pediatric treatment and nursing work, but also causes short-term or long-term effects on children′s psychological and social status if there is no timely intervention. This review summarized the definition and principles of therapeutic play, and summarized the classification of therapeutic play, including distracting games, medical program preparation games, rehabilitation or sports training games, health education games and emotional expression games. This paper discussed the application of therapeutic play in cognitive, emotional and interpersonal fields at home and abroad, in order to provide a reference basis for the application of therapeutic play in the practice of chronic diseases in pediatrics. [ABSTRACT FROM AUTHOR]

Thyroid cancer(THCA) is a common malignant tumor of the head and neck, and the incidence rate has increased year by year in recent years.The risk factors of THCA are not clear, and relevant studies have shown that this may be related to demographic factors, environmental factors, genetic and epigenetic factors, among which epigenetic factors are the research hotspots in the pathogenesis of THCA in recent years.In this paper, RNA methylation factors in epigenetics were reviewed, in order to further reveal the pathogenesis of THCA,understand its prognosis and hereditability, and provide a basis for the accurate and scientific prevention and control of THCA. [ABSTRACT FROM AUTHOR]

Messenger RNA(mRNA)delivery technology refers to the synthesis of mRNA by in vitro transcription and delivery to cells, and the expression of corresponding proteins to exert important biological functions.In recent years, mRNA delivery technology has become a research frontier and hotspot in vaccine and gene therapy.mRNA is generally packaged with nanoparticles or non-nanoparticles for delivery.Despite many advances, the lack of effective and non-toxic delivery methods remains a major factor limiting the application of mRNA.The use of viral systems(such as lentiviruses and adeno-associated viruses)has been widely recognized as an effective way to deliver nucleic acids, but an unwanted immune response is a fundamental barrier to its development.As a result, more and more non-viral vectors(including lipids, polymers, nano-based carriers or functional carriers)have attracted attention as safe and effective delivery vehicles.This paper reviewed the progress, challenges and future directions of various mRNA delivery materials in recent years. [ABSTRACT FROM AUTHOR]

Adequate bone tissue is a prerequisite for oral implant administration. The common causes of bone defect are periodontal disease, trauma, cyst or tumor removal and related systemic diseases. With the development of oral implant surgery, advances in bone augmentation techniques have become a significant topic in the field of oral implantology. In this paper, the application progress of this topic is reviewed. [ABSTRACT FROM AUTHOR]

Non-alcoholic fatty liver disease (NAFLD) has become the most common liver disease worldwide. To date, the US Food and Drug Administration has not approved any treatment for NAFLD. According to the latest diagnosis and treatment guidelines, the primary goal of treatment for NAFLD patients is to lose weight, and dietary intervention is the main means of treatment. The patients can not take into account the nutrition and treatment of daily diet adjustment, unscientific diet and fat reduction can aggravate the progress of fatty liver. The emergence of food for special medical purpose (FSMP) and its successful application in diabetes and other chronic diseases show that it plays an auxiliary role in the treatment of diseases. The development of a FSMP for NAFLD will bring more benefits to the patients. This paper reviewed the development status of FSMP and analyzed the research status of FSMP related to NAFLD,explored the advantages of FSMP compared to conventional dietary interventions, in order to provide theoretical reference for the development and application of NAFLD FSMP in the future. [ABSTRACT FROM AUTHOR]

Sodium glucose cotransporter-2 inhibitors (SGLT-2i) has the functions of glucose lowering, diuretic, blood pressure lowering, oxidative stress reducing, myocardial metabolism improving and weight reducing. The pathogenesis of heart failure with preserved ejection fraction (HFpEF) is not entirely clear, and the overall curative effect is not good. Recently, many clinical studies have shown that SGLT-2i could significantly reduce the hospitalization rates and risk of cardiovascular mortality of patient with HFpEF, improve the heart failure symptoms, and have significant benefits in patients with heart failure. This paper reviews the possible benefit mechanisms and related research progress of SGLT-2i in the treatment of HFpEF. [ABSTRACT FROM AUTHOR]

Fecal microbiota transplantation (FMT) has a unique therapeutic effect on a variety of diseases, and its common therapeutic approaches mainly include oral administration, nasointestinal tube, colonoscopy, enema and etc. Among them, because of its convenience in taking, the injury of taking oral administration multiple times is relatively small. But oral fecal bacteria will affect the FMT effect if it disintegrates in the stomach or small intestine. Colon targeted drug delivery system (CTDDS) enables drugs to act on the colon more accurately, which can improve the therapeutic effect and reduce the adverse reactions. In addition to the traditional pH-sensitive, time-delayed, enzyme-triggered, pressure-dependent and so on, CTDDS has developed into magnetic-driven, ligand (acceptor) -mediated, nano-drug and so on with the deepening of research. In recent years, some studies have combined them and used CTDDS to carry out FMT, which has achieved certain effects. This paper systematically introduces the application of CTDDS in FMT. [ABSTRACT FROM AUTHOR]

Glioma-amplified sequence 41（GAS41） is a transcription factor isolated from glioblastoma, which plays an important role in gene transcription, histone acetylation and human tumor regulation. The abnormal increase of GAS41 will affect the transcription process and thus regulate the proliferation and metastasis of tumor cells. This paper expounds the research progress of GAS41 from three aspects of its structure, biological function and role in cancer. [ABSTRACT FROM AUTHOR]

Sleep is an important physiological process to maintain the normal survival of the body and maintain a good state of life. However, sleep deprivation can lead to fatigue and a series of adverse consequences. This paper reviews the relevant literature on fatigue caused by sleep deprivation at home and abroad in recent years, and analyzes the impact of sleep deprivation on fatigue in terms of clinical trials and detection methods, and further summarizes the existing treatment methods to further understand the impact of sleep deprivation on fatigue. [ABSTRACT FROM AUTHOR]

Breast cancer is a malignant tumor with the highest morbidity and mortality in women. Chemotherapy is one of the most important parts in the comprehensive treatment of breast cancer. During chemotherapy, breast cancer patients will suffer from sleep disorder due to various factors, which will reduce their cognitive function, immune function and quality of life. This paper expounds the present situation of sleep disorder in breast cancer patients during chemotherapy at home and abroad, the harm of sleep disorder to this kind of patients, the influencing factors of sleep disorder and the research status and progress of intervention measures, in order to improve the cognition of clinical medical staff on sleep disorder in breast cancer patients undergoing chemotherapy and provide new ideas for sleep intervention in breast cancer patients undergoing chemotherapy in the future. [ABSTRACT FROM AUTHOR]

The diversity of the gut microbiota and the role of derived metabolites in maintaining intestinal functional homeostasis and inflammatory bowel disease are increasingly recognized. Inflammatory bowel disease（IBD) as an immune-mediated disease has a complex pathogenesis and seriously affects the quality of life, which is a challenging health problem.The occurrence and development of IBD is accompanied by the changes of intestinal flora and the participation of metabolites. Short-chain fatty acids（SCFAs) can further delay the clinical progression of IBD through their anti-inflammatory effects and preventing the excessive immune responses, so they are considered as bioactive molecules with potential therapeutic effects in intestinal inflammatory diseases. In this paper, the key role of the gut microflora metabolite SCFAs in the development of IBD is emphasized, which is expected to be a new tool for early prevention and treatment of IBD in the future [ABSTRACT FROM AUTHOR]

This paper summarizes and analyzes the development and connotation of the Kano model and its application in nursing service demand. Understanding the changes in the nursing service needs of different patients based on the Kano model and pointing out the advantages and disadvantages of this model in the nursing service needs and development direction, and provide a new research direction in order to improve the patient satisfaction, improve the quality of nursing services and professional quality. [ABSTRACT FROM AUTHOR]

Acquired hemophilia A（AHA) is a rare bleeding disorder caused by the circulating autoantibodies directedly against coagulation factor Ⅷ, resulting in decreased activity of coagulation factor Ⅷ.In recent years, awareness of the disease has gradually increased due to the increased reporting of the disease and data reported from several large registry studies in China and abroad, but due to the relative rarity of the disease itself, there is still a lack of awareness and delay in diagnosis and treatment.Its treatment consists of three main aspects: control of bleeding in the acute phase, eradication of inhibitors, and treatment of the primary disease or removal of the causative agent. Immunosuppressive treatment（IST) to eradicate inhibitors is the therapeutic foundation. However, recent studies have shown that IST-related mortality exceeds even that caused directly by bleeding, so the IST of AHA is still very challenging and requires continuous experience and exploration of optimal treatment protocols. In this paper, we will focus on the basic clinical features, characteristics of coagulation factor Ⅷ inhibitors in acquired hemophilia A, the current major immunosuppressive treatment options, and the latest treatment options. [ABSTRACT FROM AUTHOR]

Nuclear enriched abundant transcript 1 (NEAT1) is a long chain non-coding RNA (In- CRNA), which is up-regulated in many types of tumors, LncRNA NEATI is not only involved in the regulation of tumor cell proliferation, migration and invasion, but also related to tumor staging, metastasis, recurrence and poor prognosis. Peripheral blood IncRNA NEAT1 also shows the unique value in the diagnosis of tumors. This paper reviews the research progress of peripheral blood lncRNA NEAT1 as a malignant tumor diagnostic marker in recent years. [ABSTRACT FROM AUTHOR]

As we age, skin aging becomes an inevitable process. In this paper, the modeling method of skin aging research is discussed by summarizing the previous research on the construction of skin aging model. It is divided into animal model and cell model according to different experimental subjects, hoping to provide ideas for establishing skin aging model effectively. [ABSTRACT FROM AUTHOR]

The problem of short stature in children has received increasing attention in recent years, and the factors affecting growth and development in children are complex. The gut microbiota is closely related to the human neuroendocrine system, immune metabolism, growth and development. Previous studies have shown that gut microbiota and their metabolites can regulate host growth. In this paper, the mechanism and prospects of the effects of gut microbiota and their main metabolites, short-chain fatty acids, on growth hormone/insulin-like growth factor-1 axis, thyroid gland and sex hormones were reviewed from the endocrine point of view, in order to provide new ideas for improving short stature in children in the future. [ABSTRACT FROM AUTHOR]

The condition of patients with nervous system diseases changes quickly, the disability rate and mortality rate are high. Early identification and treatment are the key to reduce the mortality rate of patients. At present, the early warning score system combined with the Glasgow coma score and related physiological indicators has been widely used in stroke, brain tumor, craniocerebral injury and other diseases, which makes the prediction efficiency of the improved early warning scoring system for such diseases significantly improved. However, the application of the improved early warning score based on informatization in the specialized wards of nervous system diseases needs further study. This paper reviewed the development, application status in nervous system diseases at home and abroad and significance to clinical nursing work of early warning scoring, so as to provide the basis for the construction of early warning scoring tools and intervention process with the characteristics of nervous system specialty [ABSTRACT FROM AUTHOR]

Hip fracture in the elderly is a low-energy fragility fracture, and its incidence rate is increasing as China gradually enters the aging society. However, the traditional dialectical thinking of fracture in traditionalChinesemedicine (TCM) is dividied into three-stage treatment, which summarizes fracture healing as "blood stasis, neogenesis, and osteosynthesis", with special attention to early promoting blood circulation and removing blood stasis. However, the elderly patients with hip fracture have the dialecticalcharacteristics of deficiency of liver, spleen and kidney, and under the concept of enhanced recovery aftersurgery (ERAS), it is necessary to promote early ambulation of patients. Therefore, this paper discusses the dialectic of hip fracture in the elderly under the concept of ERAS, and proposes that it should be discussed from the movingtheory, with the muscles and bones as the pivot, and the dialectic should be based on tonifying the liver, spleen and kidney, relaxing the tendons and activating the collaterals, in order topromote action by tonifying, promote communication by moving, and promote healing by moving. [ABSTRACT FROM AUTHOR]