结肠靶向给药系统在粪菌移植中的应用.

Fecal microbiota transplantation (FMT) has a unique therapeutic effect on a variety of diseases, and its common therapeutic approaches mainly include oral administration, nasointestinal tube, colonoscopy, enema and etc. Among them, because of its convenience in taking, the injury of taking oral administration multiple times is relatively small. But oral fecal bacteria will affect the FMT effect if it disintegrates in the stomach or small intestine. Colon targeted drug delivery system (CTDDS) enables drugs to act on the colon more accurately, which can improve the therapeutic effect and reduce the adverse reactions. In addition to the traditional pH-sensitive, time-delayed, enzyme-triggered, pressure-dependent and so on, CTDDS has developed into magnetic-driven, ligand (acceptor) -mediated, nano-drug and so on with the deepening of research. In recent years, some studies have combined them and used CTDDS to carry out FMT, which has achieved certain effects. This paper systematically introduces the application of CTDDS in FMT. [ABSTRACT FROM AUTHOR]