短链脂肪酸在炎症性肠病中的作用研究进展.

The diversity of the gut microbiota and the role of derived metabolites in maintaining intestinal functional homeostasis and inflammatory bowel disease are increasingly recognized. Inflammatory bowel disease（IBD) as an immune-mediated disease has a complex pathogenesis and seriously affects the quality of life, which is a challenging health problem.The occurrence and development of IBD is accompanied by the changes of intestinal flora and the participation of metabolites. Short-chain fatty acids（SCFAs) can further delay the clinical progression of IBD through their anti-inflammatory effects and preventing the excessive immune responses, so they are considered as bioactive molecules with potential therapeutic effects in intestinal inflammatory diseases. In this paper, the key role of the gut microflora metabolite SCFAs in the development of IBD is emphasized, which is expected to be a new tool for early prevention and treatment of IBD in the future [ABSTRACT FROM AUTHOR]