胎盘源外泌体中 miR-155对 Th17/Treg免疫细胞的影响 在子痫前期发病中的作用研究进展.

Preeclampsia is a pregnancy-specific complication, and hypertension is the main feature of preeclampsia.At present, preeclampsia is still an important cause of maternal and fetal morbidity and mortality, and its pathogenesis is still unclear.The immune intolerance of pregant women to allogeneic embryos is one of the important mechanisms of preeclampsia.miR-155 has important value in the regulation of immune function and can accurately regulate the expression of interleukin-17A.Suppressor of cytokine signaling 1（SOCS1） has been reported to be the only direct target of miR-155 in CD4+T cells and has the biological function of regulating T cell differentiation.This paper preliminarily expounded that miR-155 in placental-derived exosomes affects the differentiation of Treg cells and Th17 cells and the production of IL-17 by inhibiting SOCS1 and regulating JAK/STAT pathway, which provided theoretical guidance for the prevention, diagnosis and treatment of preeclampsia. [ABSTRACT FROM AUTHOR]