阿尔茨海默病外周血早期生物标志物及其分析方法研究进展.

Alzheimer′s disease (AD) is a neurodegenerative disease with a hidden onset and complex pathology. The clinical diagnosis of AD has probably developed to the middle or late stage. The relative protein biomarkers in the cerebrospinal fluid can pass through the blood-brain barrier and participate the peripheral circulation in the very early stage of AD. Peripheral blood biomarker detection has the characteristics of convenient collection and minimal trauma, and is expected to become the most promising early screening and follow-up method. However, the traditional immunoassay methods cannot meet the demand for the accurate quantitative analysis of ultra-trace protein biomarkers in peripheral blood. In recent years, the newly developed immunoassay techniques in recent years have been widely applied in the analysis of ultra trace protein biomarkers. The paper reviews the recent research progress and analysis methods of early peripheral blood biomarkers of AD. [ABSTRACT FROM AUTHOR]