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Liver cancer is a significant public health issue in Mongolia, with the highest age-standardized disability-adjusted life-years (DALYs) for liver cancer in the world. The primary causes of liver cancer in Mongolia are alcohol consumption, hepatitis B, and hepatitis C. Over the past 30 years, there has been a steady increase in the incidence and number of deaths caused by liver cancer in Mongolia. Alcohol use is a primary cause of liver cancer mortality, particularly affecting men, while viral hepatitis remains a major public health concern in the country. Tailored approaches are needed to address the unique challenges faced by specific target populations in Mongolia. This analysis provides crucial evidence to support policy guidance, inform evidence-based decisions, and guide public health prevention measures in Mongolia. [Extracted from the article]

A recent study conducted by researchers at Jiangsu Agri-Animal Husbandry Vocational College in China analyzed the codon usage patterns of Duck Hepatitis Virus 1 (DHV-1) genomes to better understand its evolution and host adaptation strategies. The study identified three distinct DHV-1 phylogroups with different genetic diversity patterns. The analysis also revealed a preference for A/U-ended codons and a biased pattern of dinucleotide usage in the DHV-1 genome. The findings contribute to our understanding of DHV-1 evolution and host adaptation, which could have implications for the development of control measures and vaccines. [Extracted from the article]

A recent study conducted by researchers from the Agency for Science Technology and Research (ASTAR) in Singapore provides new insights into the immune-pathological biomarkers and underlying mechanisms of functional cure (FC) in patients with chronic hepatitis B (CHB). The study utilized single-cell transcriptomics, flow cytometry-based immune phenotyping, and immunofluorescence to analyze intrahepatic tissue and peripheral blood mononuclear cells (PBMCs) from CHB patients and those who achieved FC. The findings revealed specific cell identities and molecular signatures associated with FC, including an altered adaptive immune response and an activated innate response. The study suggests that these discoveries may have broader implications for the resolution of chronic viral hepatitis. [Extracted from the article]

A recent study conducted by researchers at Capital Medical University in Beijing aimed to understand the changes in fibrosis and its relationship with post-treatment viral hepatitis in patients with chronic hepatitis B and C. The study analyzed 158 liver samples from patients with chronic hepatitis B and C using qFibrosis, an artificial intelligence-based tool. The results showed that after successful antiviral treatment, there was heterogeneity in the regression of fibrosis in both patient groups. This study suggests that qFibrosis has the potential to provide new insights into fibrosis regression in patients with chronic hepatitis B and C. [Extracted from the article]

A study conducted by researchers at Lahore University of Management Sciences in Pakistan has identified a potential covalent inhibitor for drug-resistant genotype 3 variants of Hepatitis C viral NS3/4A serine protease. The researchers investigated mutagenic variations in the binding pocket of the virus and evaluated ligands for inhibition. They found that a compound called cpd-217 showed significant covalent docking scores with all NS3/4A G3 variants. Further in vitro and in vivo studies are needed to validate the potential of cpd-217 as an inhibitor. This study provides a theoretical foundation for drug design and development targeting Hepatitis C genotype 3 NS3/4A. [Extracted from the article]

A study conducted by researchers at the University of New Mexico explores the expansion of hepatitis C virus (HCV) treatment in the state prison system. The study highlights the use of the ECHO model, a virtual mentorship program, and the NM Peer Education Program to increase HCV knowledge among incarcerated individuals. The research found that implementing simplified treatment algorithms, utilizing the ECHO model for patients with advanced disease, and providing peer education can effectively expand HCV treatment in prisons. The study emphasizes the importance of addressing HCV in carceral settings to achieve global elimination of the virus. [Extracted from the article]

A new study conducted at Hospital Prof. Doutor Fernando Fonseca in Portugal has found that hepatitis delta virus (HDV) infection, the most severe form of viral hepatitis, is prevalent in the country. The study analyzed a large cohort of HBsAg-positive patients and found that 6.5% of them were positive for anti-HDV antibodies. Further analysis revealed that HDV-5 genotype was the most common, particularly among patients from African countries. This study provides important insights into the epidemiology of HDV in Portugal, highlighting the influence of immigration on seroprevalence and genotype distribution. [Extracted from the article]

A recent study conducted in Taiwan explored the impact of ZNF208 gene polymorphisms on the clinicopathological features of hepatocellular carcinoma (HCC) patients. The study found that while there was no substantial association between ZNF208 single nucleotide polymorphisms (SNPs) and increased HCC risk, certain clinical features such as distant metastasis and vascular invasion showed significant associations with these SNPs, suggesting their influence on disease aggressiveness. The study highlights the complexity of genetic influences on HCC and suggests that ZNF208 polymorphisms may affect tumor progression and patient outcomes. [Extracted from the article]

A recent study conducted by researchers at Shanghai Jiao Tong University in China has developed a new method for detecting hepatitis viruses. The current methods for detection have limitations such as low sensitivity and high error rates. The researchers have designed a method using gold nanoparticles and complementary DNA strands to detect viral DNA fragments through a colorimetric assay and fluorescence detection. This innovative method offers a more convenient and reliable way to detect hepatitis viruses with high specificity for the target sequence. [Extracted from the article]

Asian Americans make up only 6% of the U.S. population but account for over 60% of Americans with hepatitis B (HBV). HBV is a virus that infects the liver and can lead to liver failure or cancer. The majority of Asian Americans acquire the disease through mother-to-child transmission during birth. Stigma against HBV still exists in both China and the U.S., despite laws in China that previously allowed discrimination against people with HBV being outlawed in 2010. A study conducted by researcher Hee-Soon Juon at Thomas Jefferson University found that stigma against HBV negatively affects the physical and mental health of those with the condition. The study also revealed that greater knowledge of the disease did not necessarily reduce feelings of judgment. Perceived racial discrimination was also linked to stigma and depression. The research aims to develop interventions to combat stigma and improve the treatment journey for those with HBV. [Extracted from the article]

Researchers from Hamad Medical Corporation in Doha, Qatar have published a clinical practice guideline on viral hepatitis in pregnancy. The guideline provides recommendations on screening, management, and prevention of hepatitis B virus (HBV) and hepatitis C virus (HCV) infections in pregnant women. The recommendations are based on a comprehensive literature search and are classified by strength and evidence quality. The guideline also includes ungraded good practice points to provide guidance in the absence of sufficient evidence. This research has been peer-reviewed and is available in the journal Obstetrics & Gynecology. [Extracted from the article]

A study conducted by researchers from the University of Kiel in Germany has developed bioselective membranes to remove trace levels of Hepatitis A virus (HAV) from contaminated water. The membranes were created using chitosan hydrophilic surface modification and immobilization of HAV-specific epitope-imprinted polymers (eIPs). The study found that these membranes were able to remove 99.99% of viruses from water samples, demonstrating their potential for use in drinking water purification. The research was supported by the German Research Foundation (DFG). [Extracted from the article]

A recent study conducted at the Veterans Affairs Palo Alto Healthcare Systems in California aimed to evaluate the outcomes of a universal hepatitis delta virus (HDV) testing approach among veterans with chronic hepatitis B (CHB). The study found that implementing reflex testing of all CHB patients with anti-HDV antibodies, followed by automated HDV RNA testing for positive patients, could improve the HDV testing cascade and lead to timely diagnosis of HDV. The research suggests that there is limited data on universal HDV testing programs in the United States, and further studies are needed to determine the most effective testing approach. [Extracted from the article]

A new study conducted in the Tyva Republic of the Russian Federation examined the effectiveness of single-dose vaccination against hepatitis A in children. The study found that the vaccination program resulted in high seroprotection rates, with 99.4% of children in the Year 9 cohort and 75.4% in the Year 11 cohort having anti-HAV antibodies. The vaccination program also led to zero rates of hepatitis A incidence in the Tyva Republic since 2016. However, the study suggests the need to expand the vaccination program to include children aged 12 months and older for maximum effectiveness. [Extracted from the article]

A recent study conducted by the U.S. Centers for Disease Control and Prevention (CDC) has highlighted the prevalence of injection drug use (IDU) among cases of acute hepatitis C. The study utilized a method called multiple imputation by chained equations (MICE) to estimate the missing IDU data in national surveillance systems. The results showed that the estimated IDU prevalence among acute hepatitis C cases increased from 63.5% to 85.1% when using MICE imputation, particularly the random forest (RF) method. The researchers concluded that including imputed IDU data could enhance future surveillance and prevention efforts for IDU-related infections. [Extracted from the article]

A study conducted at the University of Valencia in Spain aimed to develop a screening strategy for viral hepatitis elimination in Spain. The study found that the prevalence of hepatitis B (HBV) was 0.44%, with higher rates in men and migrants compared to women and Spanish nationals. The prevalence of hepatitis C (HCV) was 0.35%, again higher in men and migrants compared to women and Spanish nationals. The study highlights the need for targeted interventions for individuals aged 45-64 and migrants, and emphasizes the importance of designing specific screening programs in collaboration with social workers and cultural mediators to improve access to care. [Extracted from the article]

A recent study conducted by the Shenzhen Institute for Drug Control in China explores the potential of Phyllanthus urinaria L. (P. urinaria) in the treatment of liver diseases such as viral hepatitis, liver fibrosis/cirrhosis, and hepatocellular carcinoma (HCC). The study highlights the various metabolites found in P. urinaria, including flavonoids, lignans, tannins, phenolic acids, and terpenoids. The research suggests that P. urinaria exhibits anti-viral, anti-fibrosis/cirrhosis, and anti-HCC activities through mechanisms such as reducing surface antigen secretion, interfering with DNA polymerase synthesis, reducing hepatic stellate cells activity, and preventing tumor proliferation. This review provides valuable insights into the potential future application of natural products in the treatment of liver diseases. [Extracted from the article]

A study conducted at Afyonkarahisar Health Sciences University aimed to determine the financial burden caused by inappropriate serological test requests for viral hepatitis and to investigate physicians' reasons for making unnecessary test requests. The study found that there were 2183 inappropriate test requests, costing $3309.00, with male physicians being more likely to make these requests. The main reasons for requesting tests were identified as protecting against malpractice and fears of misdiagnosis or overlooking a diagnosis. The study concludes that identifying unnecessary test requests is the first step in preventing them, and appropriate measures include highlighting these issues, providing necessary information, and offering in-service training. [Extracted from the article]

A recent report from the Metropolitan Autonomous University Iztapalapa in Mexico discusses the significance of occult hepatitis B virus infection (OBI) in the development of hepatic diseases and its implications for the World Health Organization's (WHO) Viral Hepatitis Elimination Plan. The research highlights the prevalence of OBI and its association with liver diseases such as cirrhosis and hepatocellular carcinoma (HCC). Specific gene mutations in the hepatitis B virus (HBV) have been linked to HCC and other liver diseases. The study emphasizes the importance of health initiatives and research on OBI in Latin American countries to achieve the WHO's goal of eradicating viral hepatitis by 2030. [Extracted from the article]

A study conducted by the National Center for HIV examined testing trends and co-testing patterns for HIV, hepatitis C, and sexually transmitted infections (STIs) in Emergency Departments (EDs). The researchers used data from 2010-2019 to estimate testing rates for these infections and analyzed trends based on various characteristics. The study found that testing rates increased for all infections during the study period, but co-testing patterns were inconsistent. The researchers suggest that co-testing may improve diagnosis and linkage to care, particularly in areas with higher infection rates. [Extracted from the article]

A study from Baylor College of Medicine explores the contemporary epidemiology of liver cancer, specifically focusing on risk factors and surveillance strategies. The research highlights a shift in the main risk factors for liver cancer, with less common but highly virulent factors such as hepatitis C and B being replaced by more common but weaker risk factors like alcohol and metabolic syndrome. The study emphasizes the importance of risk stratification to target prevention and early detection of liver cancer, as well as the limitations of current surveillance practices. The researchers suggest the use of multidimensional predictive algorithms and advanced imaging methods to improve risk stratification and early detection of liver cancer. [Extracted from the article]

A recent systematic review and meta-analysis conducted by researchers at Geisinger Medical Center in Danville, Pennsylvania, explored the impact of direct-acting antiviral (DAA) agents on glycemic control in patients with diabetes and chronic Hepatitis C Virus (HCV) infection. The study found that successful clearance of HCV with DAA agents led to improved glycemic control, as evidenced by a significant reduction in haemoglobin A1c (HbA1c) levels. This extrahepatic benefit of HCV eradication highlights the potential of DAA treatment in managing diabetes in patients with HCV infection. The research has been peer-reviewed and published in the Journal of Viral Hepatitis. [Extracted from the article]

A recent study conducted by researchers at the Veterans Health Administration (VHA) examined the rates and correlates of lifetime screening for hepatitis B (HBV) and hepatitis C (HCV) infections among low-income US veterans. The study found that fewer than one-third of low-income veterans had ever been screened for HBV or HCV, with lower screening rates among those less likely to be exposed to viral hepatitis. The research highlights the need for interventions to promote screening, treatment, and vaccinations for HBV and HCV among this population. The study was supported by the US Department of Veterans Affairs and has been peer-reviewed. [Extracted from the article]

A patent has been issued to Arbutus Biopharma Corporation for targeted compositions that can be used to deliver therapeutic nucleic acids, such as siRNA, to specific organs in living subjects. The invention provides nucleic acid molecules and compounds that can target the liver, among other organs. The patent includes specific siRNA molecules and pharmaceutical compositions that can be used to treat hepatitis B viral infections. This patent offers potential advancements in the field of biopharmaceuticals and healthcare biotechnology. [Extracted from the article]

A recent study conducted by researchers from the University of the Philippines Manila highlights the need for reliable data on viral hepatitis in the Philippines. The study focuses on the development of a standardized data dictionary for viral hepatitis, which would allow for the analysis and interoperability of data from different electronic medical records. Through a series of workshops involving experts in epidemiology, hepatology, and informatics, the researchers mapped 125 unique data elements to international standard code sets, resulting in a draft Philippine Viral Hepatitis Data Dictionary. This research is crucial for improving disease control and access to quality data in the country. [Extracted from the article]

A recent study conducted by researchers at the National Center for HIV has examined the impact of Medicaid expansion and restriction policies on the treatment rates for hepatitis C. The study found that Medicaid nonexpansion jurisdictions, as well as fibrosis and sobriety restrictions, were associated with a reduction in the number of Medicaid recipients receiving treatment for hepatitis C. The researchers suggest that removing these restrictions could increase access to treatment for individuals diagnosed with hepatitis C. This information is important for policymakers and healthcare providers seeking to improve access to lifesaving treatment for hepatitis C. [Extracted from the article]

A recent study conducted at the Medical University of Plovdiv in Bulgaria explored the use of point shear wave elastography (pSWE) to assess liver fibrosis in patients with chronic viral hepatitis. The researchers examined the stiffness of the liver and spleen in 90 patients with chronic viral hepatitis B and C, and correlated these measurements with histological assessments of liver fibrosis. The study found that spleen stiffness measured by pSWE can be a useful diagnostic tool for intermediate stages of liver fibrosis in patients with chronic hepatitis B and C. The research highlights the potential of pSWE as a more accurate indicator for the diagnosis of liver fibrosis. [Extracted from the article]

A recent study conducted by the University of Texas Southwestern Medical Center examined the impact of acetaminophen (APAP) use on acute liver failure (ALF) in patients with acute viral hepatitis (AVH). The study found that APAP use is common in AVH-induced ALF and may negatively affect outcomes compared to little or no APAP exposure. However, further research is needed to determine the safest and most effective dose of APAP for patients with AVH. This information is important for individuals conducting research on liver diseases and conditions, particularly those related to viral hepatitis. [Extracted from the article]

A study conducted by the National Institute of Technology in Bandung, Indonesia, focused on the identification of hepatitis using backward elimination and extreme gradient boosting methods. Hepatitis is a contagious inflammatory disease of the liver that can be caused by viral infections, disease complications, alcohol, autoimmune diseases, and drug effects. The researchers found that using backward elimination in the XGBoost model led to faster training, improved accuracy, and decreased overfitting. The study achieved an accuracy of 98.958% and concluded that this approach could be beneficial in hepatitis identification. [Extracted from the article]

Researchers at Islamic Azad University in Tehran, Iran have developed a novel dual-vaccine candidate for immunization against hepatitis A and rotaviruses. The vaccine combines the rotavirus VP8 protein and the hepatitis A virus VP1. In experiments with mice, the fusion protein, when combined with adjuvants, elicited significantly higher immune responses compared to individual vaccines for rotavirus and hepatitis A. This study suggests that the VP8-rotavirus+AAY+HAV-VP1 fusion protein has potential as a promising dual vaccine candidate for preventing hepatitis A and rotavirus infections. [Extracted from the article]

A recent study conducted by researchers at Zhengzhou University in China focuses on the detection technology and clinical applications of serum viral products of hepatitis B virus (HBV) infection. HBV infection is a global public health concern, particularly affecting people in East Asia and Africa, the Mediterranean region, and Eastern Europe. Currently, there is no cure for HBV infection, and it can lead to chronic hepatitis B, liver cirrhosis, and hepatocellular carcinoma. The study provides an overview of classical and novel methods for detecting HBV serum viral products and discusses their clinical applications, aiming to offer insights into effective treatment for chronic HBV infection. [Extracted from the article]

Researchers at the Fred Hutchinson Cancer Research Center in Seattle, Washington have developed a new gene therapy technique to monitor the localization of engineered cells used in cancer treatment. The technique involves using a quantitative PCR assay to detect specific gene sequences in patient tissue samples. The researchers successfully detected engineered cell products in both fresh and archival tissue samples, providing a better understanding of the abundance and trafficking of therapeutic T cells. This inexpensive technique has the potential to improve treatment effectiveness and assess immune cell trafficking in cancer patients. [Extracted from the article]

A study conducted at Guangxi University in Nanning, China has developed a binary split fluorescent DNA aptasensor (bsFDA) for the analysis of Hepatitis B viral DNA. The bsFDA is able to detect specific DNA sequences related to Hepatitis B, providing a fast and reliable fluorescence readout without the need for enzymes or chemical labeling. The aptasensor has been successfully applied to analyze Hepatitis B DNA in biological samples such as human serum and cell lysate. This research holds potential for the development of functionalized aptasensors and the analysis of viral genomes in biological research. [Extracted from the article]

A recent study conducted at the University of North Carolina Chapel Hill investigated the association between psychological processes and alcohol reduction in patients with chronic hepatitis C virus (HCV) infection. The study found that opportunistic alcohol interventions led to significant reductions in alcohol consumption among patients with HCV. However, the results provided mixed support for the associations between changes in psychological processes and alcohol consumption. This research provides valuable insights into the potential effectiveness of behavioral interventions for alcohol reduction in patients with chronic liver disease. [Extracted from the article]

A study conducted in the Volta Region of Ghana assessed the knowledge and occupational practices of beauticians and barbers in relation to the transmission of hepatitis B virus (HBV) and hepatitis C virus (HCV). The study found that while awareness of viral hepatitis was high among participants, their knowledge levels were generally poor. Only a small percentage of participants practiced safe occupational activities, such as hand hygiene and sterilizing tools. The study suggests that the lack of regulatory systems and training for beauticians and barbers may contribute to the potential transmission of viral hepatitis through their activities. [Extracted from the article]

A recent report from researchers at the KMCH Institute of Health Sciences and Research in Coimbatore, India highlights the increasing recognition of viral hepatitis as a public health problem. The World Health Organization estimates that in 2019, 296 million people globally had chronic hepatitis B virus (HBV) infection, and 58 million people were living with hepatitis C virus (HCV). The researchers conducted a desk review to identify strategies for preventing viral hepatitis and developing a roadmap to achieve the Sustainable Development Goals target by 2030, particularly in low- and middle-income countries. Key interventions include hepatitis B vaccination, safe injection practices, harm reduction interventions for people who inject drugs, early diagnosis through adequate testing, and appropriate treatment. The report emphasizes the need to prioritize these interventions to prevent viral hepatitis. [Extracted from the article]

A recent study conducted at the King Faisal Specialist Hospital and Research Center in Saudi Arabia examined the burden and trends of metabolic dysfunction-associated steatotic liver disease (MASLD) and viral hepatitis in the country. The study found that MASLD prevalence in both children and adults has increased from 2012 to 2019, while hepatitis B virus (HBV) prevalence has decreased and hepatitis C virus (HCV) prevalence has remained stable. The researchers emphasized the need for early prevention and diagnosis health policies for MASLD. This information is important for library patrons conducting research on liver diseases and viral hepatitis in Saudi Arabia. [Extracted from the article]

A study conducted by researchers at Shiraz University of Medical Sciences in Iran highlights the importance of assessing glucose-6-phosphate dehydrogenase (G6PD) deficiency in patients with fulminant hepatitis A. The study found that 37% of the patients lacked G6PD, and this group had higher rates of encephalopathy and mortality, as well as elevated bilirubin levels and abnormal coagulation parameters. The researchers recommend routine G6PD level assessments and monitoring of hemolysis and encephalopathy in regions where hepatitis A is endemic to optimize clinical management and reduce morbidity and mortality. [Extracted from the article]

A study conducted at the University of Hassan 2 Casablanca in Morocco has proposed a generalized fractional hepatitis B viral infection model that considers both cell-to-cell and virus-to-cell transmissions. The model takes into account the human body's adaptive immunity and explores the existence, positivity, and boundness of the model solutions. The researchers have identified a free-disease equilibrium point and four endemic steady states, and have established the relationship between the existence of these steady states and their corresponding reproductive numbers. The study also highlights the importance of effective infection treatment in combating hepatitis B. [Extracted from the article]

A new study conducted in Kazakhstan examined the factors that affect the health-related quality of life (HRQoL) in patients with chronic viral hepatitis. The study found that patients with chronic viral hepatitis had lower HRQoL compared to patients with other liver diseases. The main factors that contributed to a decrease in HRQoL were older age, being female, advanced stage of liver fibrosis, elevated ALT levels, and high viral load. The study suggests that providing social and medical support to patients with chronic viral hepatitis, especially those in the late stage of the disease, could improve their quality of life. [Extracted from the article]

A researcher from the Chinese University of Hong Kong has published a study on the development of a scoring system to predict the risk of liver cancer among diabetes patients. The study aimed to fill a gap in liver cancer scoring systems, which typically focus on patients with preexisting liver diseases. The researchers used electronic health records from Hong Kong to develop the scoring system, which included factors such as chronic hepatitis B/C, alanine aminotransferase, age, presence of cirrhosis, and sex as predictors. The proposed scoring system may provide a useful tool for predicting liver cancer risk among diabetes patients. [Extracted from the article]

A recent study conducted by researchers at Fudan University in Shanghai, China, highlights the global health challenge posed by hepatitis C viral infections. The study emphasizes the importance of improving diagnosis and treatment rates among individuals infected with the hepatitis C virus. The advent of direct-acting antivirals, particularly pan-genotypic regimens like the combination of sofosbuvir and velpatasvir, has shown promising results in achieving a cure for hepatitis C. However, the study also highlights potential obstacles such as drug adverse effects and resistance-associated substitutions, which require careful management and monitoring. [Extracted from the article]

A multi-center cohort study conducted in Chicago investigated the association between antihistamine use and the risk of liver cancer in individuals with viral hepatitis. The study included 7,748 patients with viral hepatitis and found that the risk of new-onset liver cancer was significantly higher in patients on antihistamines compared to those without antihistamine use. Specifically, patients with hepatitis C on antihistamines had a significantly higher risk of developing liver cancer. The study suggests the need for long-term follow-up studies to validate these findings. [Extracted from the article]

A recent study conducted by researchers at the Instituto de Investigacion Hospital 12 de Octubre (i+12) examined the impact of viral hepatitis therapy on multiple myeloma (MM) and monoclonal gammopathies. The study found that subsets of MM and MGUS patients with a monoclonal immunoglobulin specific for hepatitis C virus (HCV) can benefit from antiviral treatment, which leads to improved control of clonal plasma cells. The researchers also investigated the role of hepatitis B virus (HBV) in the pathogenesis of MGUS and MM in HBV-infected patients and found that antiviral treatment significantly improved overall survival in both HBV-infected and HCV-infected MM patients. This study highlights the importance of antiviral therapy in HBV and HCV-infected patients with MGUS and MM. [Extracted from the article]

A recent study conducted in Thailand by the National Cancer Institute (NCI) has identified shared risk factors for hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (iCCA), two types of liver cancer. The study found that viral hepatitis infection, liver fluke infection, and diabetes were common risk factors for both types of cancer. Additionally, the study revealed novel associations between agricultural pesticide exposure and vulnerable drinking water sources with liver cancer. Patients with multiple risk factors had worse survival outcomes. These findings highlight the need for prevention and control measures, particularly in Thailand's large agricultural sector. [Extracted from the article]

A new report presents fresh data on the hepatitis B virus, focusing on the role of epitranscriptomic RNA modifications. The research found that the RNA of the hepatitis B virus is enriched with cytidine methylation (m5C) and other modifications, which are deposited by the cellular methyltransferase NSUN2. Loss of m5C from the virus's RNA resulted in a decrease in viral protein production and a loss of reverse transcribed viral DNA. The study suggests that targeting the m5C methyltransfer process on the virus's RNA could be a potential antiviral strategy. [Extracted from the article]

A recent report from Nazarbayev University School of Medicine evaluated the progress of Central Asian countries (Kazakhstan, Kyrgyzstan, Tajikistan, Turkmenistan, and Uzbekistan) in eliminating viral hepatitis B and C by 2030. The research found that these countries have made significant efforts towards achieving the goals set by the Global Health Sector Strategy. All countries have national programs focused on hepatitis elimination and have reached the target vaccination coverage against hepatitis B. However, the researchers recommend that countries improve harm reduction and treatment services, and that the public accessibility of collected data be enhanced. [Extracted from the article]

A recent study conducted by researchers from the National University of Cordoba in Argentina focuses on the detection of Hepatitis A virus (HAV) in human plasma pools used for the manufacture of medicinal products. HAV is primarily transmitted through the fecal-oral route but can also be transmitted through blood-derived products. The researchers developed an in-house multiplex reverse-transcription real-time PCR (RT-PCR) assay to detect HAV RNA in plasma pools. The assay demonstrated good sensitivity, specificity, and robustness, and its implementation in the production process of plasma-derived products is expected to enhance their safety. [Extracted from the article]

A new report from the University of Baghdad presents research on mathematical models of Hepatitis B and C viruses, taking into account the effects of vaccination. The study utilizes fractional and ordinary differential equations to prove the existence of equilibrium and the well-posedness of the solution. The research highlights the biological relevance of fractional derivatives and their impact on temporal behavior. Future investigations will explore the impact of regional heterogeneity on epidemiological research. [Extracted from the article]