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Researchers at the University of Naples Federico II conducted a study on bladder cancer patients, focusing on the presence of Porphyromonas somerae in their urine samples. The study utilized droplet digital Polymerase Chain Reaction (ddPCR) to confirm the association between P. somerae and bladder cancer, suggesting its potential as a biomarker for the disease. The findings indicate that ddPCR could be a suitable method for early screening and monitoring of bladder cancer. The research was published in the journal Microorganisms and can be accessed for free online. [Extracted from the article]

A recent study conducted by the National Institute of Infectious Diseases in Tokyo, Japan, focused on Porphyromonas gingivalis, a significant oral bacterial pathogen linked to severe periodontal diseases. The research introduced a simple and cost-effective transformation method for P. gingivalis using its natural DNA competence, eliminating the need for specialized equipment like electroporators and conjugative plasmids. The study found that deletion of specific genes, PGN_0421 and PGN_0519, essential for natural competence, resulted in the loss of competency. This study provides valuable insights into the genetic mechanisms of P. gingivalis pathogenicity and offers a practical approach for genetic manipulation of this bacterium. [Extracted from the article]

Researchers at Tokushima University in Japan have reported new data on Porphyromonas gingivalis, a Gram-negative bacterium associated with Alzheimer's disease. The study found that outer membrane vesicles of P. gingivalis can reach the brain, activate microglia, and induce neuroinflammation in mice. This research sheds light on the potential link between periodontal diseases and neurodegenerative conditions like Alzheimer's disease. The study was funded by the Japan Society for the Promotion of Science and Grants-in-Aid for Scientific Research. [Extracted from the article]

Researchers from Jilin University in the People's Republic of China have explored the relationship between ferroptosis and periodontitis, an inflammatory disease caused by oral opportunistic pathogens like Porphyromonas gingivalis. Their study found that ferroptosis is involved in inflammatory processes in human gingival fibroblasts stimulated with P. gingivalis-LPS, and this was confirmed in an experimental rat model of periodontitis. The findings suggest that ferroptosis plays a role in the pathogenesis of periodontitis, highlighting a potential new avenue for therapeutic interventions. [Extracted from the article]

A recent study conducted by researchers at the University of Orebro in Sweden explored the impact of the periodontal bacteria Porphyromonas gingivalis on microglia cells and its potential contribution to Alzheimer's disease pathology. The study found that stimulation of microglia cells with P. gingivalis led to the upregulation of Alzheimer's disease-associated genes, including NOX4, and resulted in the production of reactive oxygen species and inflammatory cytokines. The research suggests a potential mechanistic explanation for how P. gingivalis may trigger or worsen Alzheimer's disease progression. For more information, the full article can be accessed for free at the Frontiers in Cellular and Infection Microbiology website. [Extracted from the article]

Researchers from Chongqing Medical University have developed a handheld electrochemical bacterial sensor for accurate detection of Porphyromonas gingivalis (Pg) in saliva, a bacterium associated with various systemic diseases. The sensor utilizes a multifunctional composite hydrogel and DNA biomimetic nanowalls to enhance detection capabilities, with a limit of detection as low as 6 CFU/mL. This innovative device offers advantages in terms of time consumption and portability compared to traditional ELISA kits, presenting a novel perspective for portable bacterial detection devices. [Extracted from the article]

A recent study conducted by researchers at the University of Louisville School of Dentistry focused on Porphyromonas gingivalis, a Gram-negative, anaerobic oral pathobiont that is a common cause of periodontitis. The study involved sequencing multiple clinical isolates and comparing their genomes to laboratory strains. The researchers identified core genes present in all genomes and accessory genes that were absent in some genomes. They also identified genes that were essential for survival in specific environments, such as tobacco exposure and abscess formation. The study's findings may have implications for the development of therapeutic targets and gene mutation strategies for Porphyromonas gingivalis. [Extracted from the article]

Researchers at Rice University in Houston, Texas have discovered a potential method for controlling the growth of Porphyromonas gingivalis, a problematic bacteria associated with oral health issues. The researchers found that using phages, or viruses that infect bacteria, to target cooperating bacteria such as Streptococcus gordonii can effectively reduce the abundance of P. gingivalis. This approach also inhibited the production of harmful metabolic end products. The study suggests that indirect phage-based targeting could expand the applicability of phage-based control of pathogenic bacteria for public health protection. [Extracted from the article]

A preprint abstract from biorxiv.org discusses the potential effects of Porphyromonas gingivalis (Pg), an oral bacterial pathogen, on the developing fetal brain. The study involved treating pregnant mice with outer membrane vesicles (OMV) from Pg and measuring changes in inflammation, cortical neuron density, and Tau phosphorylation. The results showed that exposure to Pg-OMV led to a decrease in pup brain weight and modifications in cortical neuron density. These findings suggest that Pg-OMV may have deleterious effects on the embryonic brain and could impact offspring development through multiple mechanisms. However, it is important to note that this preprint has not been peer-reviewed. [Extracted from the article]

A patent has been issued to INSERM (Institut National de la Sante et de la Recherche Medicale) for methods of predicting the risk of developing pulmonary colonization or infection by Pseudomonas aeruginosa. The patent describes a method for treating or preventing Pseudomonas aeruginosa infection in individuals with cystic fibrosis by measuring the relative abundance of Porphyromonas genus bacteria in a biological sample and administering Pseudomonas aeruginosa specific antibiotics based on the results. The invention aims to identify individuals at high risk of infection and provide targeted treatment. This research may contribute to understanding the factors involved in the progression of cystic fibrosis and improving patient outcomes. [Extracted from the article]

A recent study conducted in Kuala Lumpur, Malaysia, explored the potential of mangiferin, a compound found in Cratoxylum cochinchinese leaves, to inhibit gingipain K, a protein associated with the development of Alzheimer's disease. The researchers used a simulated docking study and in vitro assays to determine the inhibitory activity of mangiferin. The results showed that mangiferin was a potential inhibitor of gingipain K and produced similar results to the positive control. The researchers concluded that further investigation of mangiferin as a treatment for Alzheimer's disease is warranted. [Extracted from the article]

A study conducted by researchers at Fudan University in Shanghai, China, explores the role of Porphyromonas gingivalis (P.gingivalis) in the development of Alzheimer's disease (AD). The study investigates the molecular mechanism behind the association between P.gingivalis and neuroinflammation in the brain, which contributes to the progression of AD. Through in vitro experiments and a mouse model, the researchers found that P.gingivalis promotes M1 polarization of microglia, a type of immune cell in the brain, through the NF-kB signaling pathway. These findings suggest that P.gingivalis-induced neuroinflammation may play a role in the development of AD. [Extracted from the article]

Researchers at Kyushu Dental University in Fukuoka, Japan have developed a novel immunochromatographic device for detecting Porphyromonas gingivalis, a pathogenic bacterium associated with periodontal disease. The device was evaluated in a study involving 72 patients with chronic periodontitis and 53 periodontally healthy volunteers. The results showed that the device had a high specificity and accuracy for detecting P. gingivalis in subgingival plaques. The researchers concluded that this device could be effectively used for rapid detection and semi-quantification of P. gingivalis in patients with periodontal disease. [Extracted from the article]

A recent study conducted by researchers at Virginia Commonwealth University explored the interaction between Porphyromonas gingivalis, a pathogen associated with periodontitis, and Streptococcus sanguinis, a commensal bacterium associated with periodontal health. The researchers developed a high-throughput strategy to measure the cell number of P. gingivalis in co-culture with S. sanguinis and identified several genes in S. sanguinis that influenced the interaction. They found that exogenous L-cysteine and compromised cysteine metabolism in S. sanguinis enhanced the growth of P. gingivalis. The study also examined the interaction between P. gingivalis and other Streptococcus species, finding that only S. pneumoniae did not inhibit the growth of P. gingivalis. Further investigation is needed to understand the influence of exogenous L-cysteine on the interaction between these bacteria in the oral cavity. [Extracted from the article]

A recent report from the University of Leeds discusses the use of liposomes as a delivery mechanism for antimicrobial peptides to combat periodontal disease caused by Porphyromonas gingivalis. The study examines the different types of liposomal formulations and their ability to associate and deliver the peptide LL17-32 to act against the pathogen. The research found that chitosan-coated liposomes demonstrated enhanced stability and decreased membrane fluidity when combined with LL17-32. However, the release of the peptide was restrained, which could be useful for future slow-release formulations. [Extracted from the article]

A recent study conducted by researchers at South China University of Technology has found that certain flavonoids, such as phloretin and its analogs, have anti-biofilm properties against Porphyromonas gingivalis, a bacterium associated with periodontitis. The study examined the effects of these flavonoids on the growth of P. gingivalis and its mixed flora with other oral pathogens. The results showed that the flavonoids reduced the biofilm amount and viability of the bacteria, and transcriptome analysis confirmed their inhibitory effect on biofilm formation. This research provides valuable insights into the potential use of flavonoids in combating P. gingivalis and its complex bacterial community. [Extracted from the article]

New research from the University of Kebangsaan in Kuala Lumpur, Malaysia has discovered the potential of probiotics derived from human milk in preventing chronic periodontitis by controlling Porphyromonas gingivalis infection. The study identified Lactiplantibacillus spp. isolated from human milk with antibacterial activities against P. gingivalis. The most potent strain, Lactiplantibacillus pentosus strain 124-2 (SUK 1), showed strong inhibitory activity and its bacteriocin could be used as an alternative material for oral hygiene care products to prevent and treat periodontal disease. This research provides new insights into the potential use of human milk-derived probiotics in oral health. [Extracted from the article]

This article discusses a study that introduces a new animal model to explore the pathogenesis of Porphyromonas gingivalis, a type of bacteria associated with gum disease. The study involved injecting mice with antibodies and infecting them with P. gingivalis. The results showed that a mixture of antibodies and P. gingivalis infection led to more reproductive damage in mice compared to infection alone. This suggests that the presence of antibodies may play a role in the development of P. gingivalis-related diseases. However, it is important to note that this study has not yet undergone peer review. [Extracted from the article]

A study conducted by researchers at Henan University of Science and Technology in China explores the potential of developing a vaccine for Porphyromonas gingivalis (Pg), a Gram-negative anaerobic bacterium responsible for chronic periodontitis. The researchers discuss the use of surface antigens of Pg as vaccine antigens to trigger immune responses and highlight advancements in mucosal adjuvants for vaccine development. The review offers new insights for the advancement and clinical implementation of Pg vaccines. The study was supported by The Key Research Project of Higher Education Institutions in Henan Province. [Extracted from the article]

A recent study conducted by researchers at Osaka Prefecture University in Japan explored the antibacterial effects of prunin laurate (Pru-C12) and its analogs on Porphyromonas gingivalis (P. gingivalis), a periodontopathogenic bacteria that causes periodontal disease. The study found that Pru-C12 and its analogs inhibited bacterial growth and biofilm formation, with Pru-C12 showing no cytotoxicity. Additionally, Pru-C12 was found to inhibit alveolar bone resorption in a mouse experimental periodontitis model. These findings have potential implications for the development of oral hygiene products to prevent and control periodontal disease. [Extracted from the article]

Researchers from Pusan National University in South Korea have conducted a study on the anti-inflammatory effects of peptides derived from human stromal cell-derived factor-1 (SDF-1) on Porphyromonas gingivalis, a bacterium associated with periodontitis. The study found that one particular peptide, S10, significantly reduced the secretion of pro-inflammatory cytokines and decreased the expression of inflammasome-related proteins. In addition, S10 suppressed the toll-like receptor (TLR) signaling pathway and mitigated alveolar bone loss in a mouse model of periodontitis. These findings suggest that S10 has potential as a therapeutic treatment for periodontitis. [Extracted from the article]

A study conducted at Fu Jen Catholic University Hospital explores the relationship between Porphyromonas gingivalis, a bacterium associated with periodontitis, and neuroinflammation and neurodegeneration. The study used in vitro models to investigate the mechanisms underlying this connection. The researchers found that Porphyromonas gingivalis outer membrane vesicles (Pg-OMVs) induced neurotoxicity in neuronal cells and inflammatory responses in microglial cells. The study suggests that gingipain, a protein produced by Porphyromonas gingivalis, mediates the neurotoxic effects of Pg-OMVs. Additionally, the study found that lipopolysaccharide (LPS) associated with Pg-OMVs triggered neuroinflammation through specific signaling pathways. [Extracted from the article]

A recent study conducted by researchers at the University of California Los Angeles School of Dentistry has found that GV1001, an anticancer vaccine, may have potential protective effects against Porphyromonas gingivalis (Pg)-induced periodontal disease, atherosclerosis, and Alzheimer's disease (AD)-like conditions. The study showed that GV1001 mitigated the development of periodontal disease, atherosclerosis, and AD-like conditions by reducing inflammation and inhibiting the accumulation of Pg DNA aggregates, Pg lipopolysaccharides (LPS), and gingipains in various tissues. These findings suggest that GV1001 could be a promising preventive agent for atherosclerosis and AD-like conditions associated with periodontal disease. [Extracted from the article]

A recent study conducted by researchers at Abdul Wali Khan University in Pakistan has identified a potential drug target in the bacterium Porphyromonas gingivalis. The study used a computational genome analysis approach to characterize the proteome and hypothetical proteins of the bacterium. Through this analysis, the researchers identified a protein called putative arginine deiminase, which is involved in the arginine and proline metabolic pathway and may serve as a target for drug development. This research provides valuable insights into potential therapeutic strategies for combating Porphyromonas gingivalis infections. [Extracted from the article]

Researchers from Feagle Co. Ltd. in South Korea have conducted a study on the use of no-ozone cold plasma (NCP) to treat periodontitis, an inflammatory disease caused by Porphyromonas gingivalis (P. gingivalis) in the oral cavity. The study found that NCP effectively inhibited the activities of inflammatory proteins and cytokines in human gingival fibroblasts (HGFs) treated with P. gingivalis-derived lipopolysaccharide (PG-LPS). Additionally, repeated treatment of periodontitis rats with NCP reduced inflammatory cells and osteoclast activity. The findings suggest that NCP may be a potential treatment for periodontitis in the future. [Extracted from the article]

A study conducted by the University of Rome Tor Vergata explores the potential impact of endodontic infections caused by Fusobacterium nucleatum or Porphyromonas gingivalis on oral carcinogenesis. The researchers found that these bacteria, which are associated with periodontitis, are present in oral squamous cell carcinoma (OSCC) tissues and oral premalignant lesions. The study suggests that infection by these bacteria triggers the production of inflammatory cytokines and growth factors, affecting the survival, proliferation, invasion, and differentiation of OSCC cells. While most of the literature does not support the idea that bacteria-induced endodontic inflammatory diseases impact oral carcinogenesis, the researchers recommend further investigations on this topic. [Extracted from the article]

A recent study conducted by researchers from Temple University in Philadelphia, Pennsylvania, investigated the impact of different dental materials and masticatory forces on the subgingival microbiome in patients with periodontal disease. The study found that restorative dental materials can potentially harbor microbial colonization and alter the oral microbiome, leading to infection. The researchers evaluated the microbiome-modulating properties of three biomaterials and found that cyclic masticatory loads were associated with enhanced biofilm viability, while static conditions increased biofilm biomass. The study provides new insights into the effects of different biomaterials on oral biofilms and their relationship with subgingival infections. [Extracted from the article]

This document provides information about a clinical trial, NCT06418945, that is investigating the effect of removing Porphyromonas gingivalis on the prognosis of esophageal cancer after radical surgery. The trial aims to eliminate Porphyromonas gingivalis using a combination of mechanical removal and antibacterial treatment, including the use of a tinidazole oral microneedle patch. The study aims to determine the effectiveness of this treatment in preventing disease progression or recurrence. The trial is in the interventional phase and is expected to be completed by December 2026. The responsible party for the study is The First Affiliated Hospital of Henan University of Science and Technology. [Extracted from the article]

Researchers from Nanjing University in China have conducted a study on Porphyromonas gingivalis, a bacterium associated with periodontal disease. The study aimed to investigate the relationship between mitochondrial reactive oxygen species (ROS) and Porphyromonas gingivalis in the process of pyroptosis in cementoblasts. The researchers found that Porphyromonas gingivalis triggered pyroptosis in cementoblasts and increased the generation of ROS in the mitochondria. Inhibition of mitochondrial ROS reduced pyroptosis, suggesting that targeting mitochondrial ROS could be a potential therapeutic strategy for periodontal regeneration. The study provides valuable insights into the mechanisms underlying periodontal disease. [Extracted from the article]

A recent study conducted by researchers at Universidad Mayor in Santiago, Chile, explores the connection between Porphyromonas gingivalis (P. gingivalis), a gram-negative oral pathogen associated with chronic periodontitis, and gastric cancer (GC). The researchers hypothesize that P. gingivalis and its virulence factors may serve as a mechanistic link between oral health and gastric carcinogenesis. The study also discusses the potential impact of P. gingivalis' virulence factors on inflammation and the response to immune checkpoint inhibitors in GC. Further research is needed to fully understand the relationship between oral health, P. gingivalis, and gastric cancer. [Extracted from the article]

A study conducted by researchers at the National Autonomous University of Mexico (UNAM) has found that cystatin C, an antimicrobial salivary peptide, inhibits the growth of Porphyromonas gingivalis, a key agent in periodontitis. The study aimed to evaluate the antimicrobial activity of cystatin C and its effects on cytokine production, nitric oxide release, reactive oxygen species production, and programmed cell death in human macrophages infected with P. gingivalis. The results showed that cystatin C inhibits the extracellular growth of P. gingivalis, reduces the production of inflammatory cytokines and nitric oxide, and decreases bacterial-induced macrophage apoptosis. These findings suggest that cystatin C could be used therapeutically against oral infections such as periodontitis. [Extracted from the article]

A recent study conducted by researchers at the University of the Pacific has found that Boswellia serrata extract, derived from frankincense produced by Boswellia trees, has antimicrobial effects on Porphyromonas gingivalis, a bacterium associated with periodontitis. The study demonstrated that the extract impaired the growth and biofilm formation of P. gingivalis, as well as decreased its intracellular infection in human gingival epithelial cells. The researchers suggest that B. serrata has the potential to prevent and/or treat periodontal diseases, and future studies will focus on identifying the specific components responsible for these effects. [Extracted from the article]

A study conducted by researchers at the University of Chile explores the differential response of human dendritic cells to encapsulated and non-encapsulated strains of Porphyromonas gingivalis, a bacterium associated with periodontitis. The study found that while both types of strains induced dendritic cell maturation, the encapsulated strains showed a higher capacity to trigger Th1 and Th17-type responses in human dendritic cells. This research provides insights into the immune response to P. gingivalis and its potential role in periodontal disease. For more information, the full article can be accessed through the International Journal of Molecular Sciences website. [Extracted from the article]

A study conducted by researchers at the First Affiliated Hospital of Xinjiang Medical University in China investigated the association between Porphyromonas gingivalis (P. gingivalis) and oral squamous cell carcinoma (OSCC). The study aimed to determine the relevance between different immunohistochemical intensities of P. gingivalis and tumor-associated macrophages (TAMs) in OSCC tissue and their clinicopathologic characteristics. The results showed that elevated expression of P. gingivalis and DOK3 (a key molecule) indicated M2-TAM infiltration and an unfavorable prognosis for OSCC. These findings suggest that P. gingivalis and DOK3 could be considered as independent risk factors for predicting the prognosis of OSCC. [Extracted from the article]

A study conducted in Tamil Nadu, India, explored the efficacy of an extract from the Indian mint plant, Plectranthus Amboinicus, against periodontal pathogens. The extract demonstrated a significant inhibitory effect on the biofilm formation of Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, and Fusobacterium nucleatum, suggesting its potential as an alternative to conventional chemical antimicrobials. The extract also exhibited a noteworthy minimum inhibitory concentration (MIC) against Aggregatibacter actinomycetemcomitans at a low concentration. This research highlights the potential of herbal derivatives in periodontics and their activity against putative periodontal pathogens. [Extracted from the article]

A study conducted by researchers at Chung Shan Medical University in Taiwan investigated the effects of Er:YAG laser on periodontitis, an inflammatory condition of the tooth-supporting structures. The study found that the laser treatment had protective effects on periodontitis in vitro by suppressing the expression of pro-inflammatory cytokines and the NLRP3 inflammasome. This research suggests that controlling the NLRP3 inflammasome may be a potential approach for treating periodontitis. The study is the first to examine the laser's implication on the NLRP3 inflammasome in periodontitis models. [Extracted from the article]

A recent report from Jan Kochanowski University in Kielce, Poland, explores the connection between Porphyromonas gingivalis, a bacterium associated with periodontitis, and the progression of rheumatoid arthritis (RA). The study suggests that the dysbiosis of the oral microbiota, specifically an increased abundance of P. gingivalis, can disrupt the homeostasis of the oral microbial community and contribute to the development and progression of RA. The research highlights the role of the immune system and the damage caused by the immune response in both chronic periodontitis and RA. Further investigation is needed to understand the specific mechanisms involved. [Extracted from the article]

A recent study conducted by researchers at the Central University of Tamil Nadu in India explored the potential use of antimicrobial peptides (AMPs) derived from Lactobacillus sp. in combating oral squamous cell carcinoma (OSCC). The study utilized in silico analysis and molecular simulation techniques to identify AMPs with potent antibacterial and anticancer properties. One particular AMP, plpl_18, was found to interact efficiently with virulence proteins of Porphyromonas gingivalis and Fusobacterium nucleatum, as well as matrix metalloproteinase-9, a regulatory protein associated with OSCC. These computational findings provide a foundation for further laboratory and clinical investigations into the use of therapeutic peptides derived from probiotics to combat OSCC. [Extracted from the article]

A recent study conducted by researchers at the State University of New York (SUNY) Buffalo has revealed new findings on Porphyromonas gingivalis, a Gram-negative anaerobic bacterium commonly found in human subgingival plaque. The study aimed to improve the accuracy of strain identification of P. gingivalis, which is associated with periodontitis and other systemic pathologies. The researchers developed a new approach using sequencing of the intergenic spacer region (ISR) to differentiate P. gingivalis strains. The study found that the avirulent strain ATCC33277/381 was the most abundant strain across all sample types, and the W83/W50 strain was significantly enriched in periodontitis. The findings have implications for the diagnosis and treatment of periodontal disease, as well as other diseases where P. gingivalis or its toxins have been implicated, such as Alzheimer's disease. [Extracted from the article]

A report from researchers at Virginia Commonwealth University discusses the role of sialidase in the pathogenicity of Porphyromonas gingivalis, an oral bacterium associated with periodontitis. The study confirms the importance of sialidases in cell surface structures, biofilm formation, resistance to complement and neutrophil killing, and host immune responses. The researchers also discuss possible molecular mechanisms involved. The findings highlight the significance of sialidases in the pathophysiology of P. gingivalis and provide a basis for further research in this area. [Extracted from the article]

Researchers from Harbin Medical University in China have developed a new method for detecting Porphyromonas gingivalis (P. gingivalis), the leading causative pathogen for periodontitis and gingivitis. The method uses surface-enhanced Raman spectroscopy (SERS) and activated silver nanoparticles to capture and identify the bacteria in clinical samples, including saliva from patients with periodontal disease. The technique is rapid, sensitive, quantifiable, and specific, and has the potential for early diagnosis and predicting disease progression in periodontal disease. The research has been peer-reviewed and holds promise for clinical applications. [Extracted from the article]