Research from State University of New York (SUNY) Buffalo Reveals New Findings on Porphyromonas gingivalis (Defining Porphyromonas gingivalis strains associated with periodontal disease).

A recent study conducted by researchers at the State University of New York (SUNY) Buffalo has revealed new findings on Porphyromonas gingivalis, a Gram-negative anaerobic bacterium commonly found in human subgingival plaque. The study aimed to improve the accuracy of strain identification of P. gingivalis, which is associated with periodontitis and other systemic pathologies. The researchers developed a new approach using sequencing of the intergenic spacer region (ISR) to differentiate P. gingivalis strains. The study found that the avirulent strain ATCC33277/381 was the most abundant strain across all sample types, and the W83/W50 strain was significantly enriched in periodontitis. The findings have implications for the diagnosis and treatment of periodontal disease, as well as other diseases where P. gingivalis or its toxins have been implicated, such as Alzheimer's disease. [Extracted from the article]