Porphyromonas gingivalis outer membrane vesicles alter neuronal architecture and Tau phosphorylation in the embryonic mouse brain.

A preprint abstract from biorxiv.org discusses the potential effects of Porphyromonas gingivalis (Pg), an oral bacterial pathogen, on the developing fetal brain. The study involved treating pregnant mice with outer membrane vesicles (OMV) from Pg and measuring changes in inflammation, cortical neuron density, and Tau phosphorylation. The results showed that exposure to Pg-OMV led to a decrease in pup brain weight and modifications in cortical neuron density. These findings suggest that Pg-OMV may have deleterious effects on the embryonic brain and could impact offspring development through multiple mechanisms. However, it is important to note that this preprint has not been peer-reviewed. [Extracted from the article]