1. Taccachatrones A-G, Highly Oxidized Steroids from the Rhizomes of Tacca chantrierii and Their Cytotoxicity Assessment.
- Author
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He J, Ma R, Li ZH, Feng T, and Liu JK
- Subjects
- Antineoplastic Agents, Phytogenic isolation & purification, Cell Line, Tumor, China, Humans, Molecular Structure, Phytochemicals isolation & purification, Phytochemicals pharmacology, Rhizome chemistry, Steroids isolation & purification, Antineoplastic Agents, Phytogenic pharmacology, Dioscoreaceae chemistry, Steroids pharmacology
- Abstract
Seven highly oxidized steroids, taccachatrones A-G ( 1 - 7 ), together with four known taccalonolides ( 8 - 11 ), were characterized from the rhizomes of Tacca chantrieri . The structures of 1 - 7 were established on the basis of spectroscopic data analysis, while the absolute configurations were determined by single-crystal X-ray diffraction. Compounds 1 - 4 may be derived from taccalonolide derivatives by the degradation of three carbon atoms. Compounds 7 , 8 , 10 , and 11 exhibited cytotoxicity to human cancer cell lines, indicating that the presence of a lactone moiety, as well as a double bond between C-22 and C-23, might play key roles in mediating their cytotoxicity.
- Published
- 2021
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