Back to Search
Start Over
Variation in cytostatic constituents of a sponge-derived Gymnascella dankaliensis by manipulating the carbon source.
- Source :
-
Journal of natural products [J Nat Prod] 2007 Nov; Vol. 70 (11), pp. 1731-40. Date of Electronic Publication: 2007 Nov 08. - Publication Year :
- 2007
-
Abstract
- The Halichondria sponge-derived fungus, Gymnacella dankaliensis, was cultured in two different media conditions. A modified malt extract medium containing soluble starch instead of glucose resulted in two extremely unusual steroids, dankasterones A (2) and B (3), while four additional unusual steroids, gymnasterones A (4), B (5), C (6), and D (7), were isolated from the original malt extract medium. Their stereostructures have been established on the basis of spectroscopic analyses along with X-ray crystal structure analyses, modified Mosher's method, CD exciton method, and a chemical transformation. All the steroids except for 4 exhibited significant growth inhibition against the murine P388 cancer cell line. Dankasterone A (2) also exhibited potent growth inhibition against human cancer cell lines.
- Subjects :
- Animals
Antineoplastic Agents pharmacology
Carbon chemistry
Crystallography, X-Ray
Drug Screening Assays, Antitumor
Humans
Japan
Leukemia P388
Mice
Molecular Conformation
Molecular Structure
Steroids pharmacology
Antineoplastic Agents chemistry
Antineoplastic Agents isolation & purification
Porifera microbiology
Steroids chemistry
Steroids isolation & purification
Subjects
Details
- Language :
- English
- ISSN :
- 0163-3864
- Volume :
- 70
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Journal of natural products
- Publication Type :
- Academic Journal
- Accession number :
- 17988094
- Full Text :
- https://doi.org/10.1021/np070165m