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Taccachatrones A-G, Highly Oxidized Steroids from the Rhizomes of Tacca chantrierii and Their Cytotoxicity Assessment.
- Source :
-
Journal of natural products [J Nat Prod] 2021 Aug 27; Vol. 84 (8), pp. 2265-2271. Date of Electronic Publication: 2021 Aug 06. - Publication Year :
- 2021
-
Abstract
- Seven highly oxidized steroids, taccachatrones A-G ( 1 - 7 ), together with four known taccalonolides ( 8 - 11 ), were characterized from the rhizomes of Tacca chantrieri . The structures of 1 - 7 were established on the basis of spectroscopic data analysis, while the absolute configurations were determined by single-crystal X-ray diffraction. Compounds 1 - 4 may be derived from taccalonolide derivatives by the degradation of three carbon atoms. Compounds 7 , 8 , 10 , and 11 exhibited cytotoxicity to human cancer cell lines, indicating that the presence of a lactone moiety, as well as a double bond between C-22 and C-23, might play key roles in mediating their cytotoxicity.
- Subjects :
- Antineoplastic Agents, Phytogenic isolation & purification
Cell Line, Tumor
China
Humans
Molecular Structure
Phytochemicals isolation & purification
Phytochemicals pharmacology
Rhizome chemistry
Steroids isolation & purification
Antineoplastic Agents, Phytogenic pharmacology
Dioscoreaceae chemistry
Steroids pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1520-6025
- Volume :
- 84
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Journal of natural products
- Publication Type :
- Academic Journal
- Accession number :
- 34355562
- Full Text :
- https://doi.org/10.1021/acs.jnatprod.1c00342