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Steroidal alkaloids from the marine sponge Corticium niger that inhibit growth of human colon carcinoma cells.
- Source :
-
Journal of natural products [J Nat Prod] 2014 Nov 26; Vol. 77 (11), pp. 2475-80. Date of Electronic Publication: 2014 Oct 22. - Publication Year :
- 2014
-
Abstract
- Bioinformatic analysis of data from the NCI-60 cell cytotoxicity screen revealed a subset of extracts that showed selective cytotoxic activity toward human colon carcinoma cell lines. Bioassay-guided fractionation of a colon cancer selective extract from a Philippines collection of the marine sponge Corticium niger provided two new steroidal alkaloids, plakinamines N (1) and O (2), along with two known compounds of the plakinamine class (3, 4). The structures of these compounds were elucidated by interpretation of combined MS and NMR spectroscopic data. Plakinamines N (1), O (2), and J (4) were tested for antiproliferative activity in the NCI-60 screen, and they showed enhanced inhibitory effects against all of the colon cell lines with mean GI50 values of 11.5, 2.4, and 1.4 μM, respectively.
- Subjects :
- Alkaloids chemistry
Alkaloids pharmacology
Animals
Colonic Neoplasms drug therapy
Drug Screening Assays, Antitumor
Humans
Marine Biology
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Philippines
Steroids chemistry
Alkaloids isolation & purification
Porifera chemistry
Steroids isolation & purification
Steroids pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1520-6025
- Volume :
- 77
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Journal of natural products
- Publication Type :
- Academic Journal
- Accession number :
- 25338277
- Full Text :
- https://doi.org/10.1021/np500556t