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Steroids and flavonoids from Physalis alkekengi var. franchetii and their inhibitory effects on nitric oxide production.
- Source :
-
Journal of natural products [J Nat Prod] 2008 Apr; Vol. 71 (4), pp. 642-6. Date of Electronic Publication: 2008 Mar 19. - Publication Year :
- 2008
-
Abstract
- Four new steroidal compounds possessing a rare 13,14-seco-16,24-cycloergostane skeleton, physalin Y ( 1), physalin Z ( 2), physalin I ( 6), and physalin II ( 7), were isolated from the 80% EtOH extract of calyces from Physalis alkekengi var. franchetii together with 11 known steroids ( 3- 5 and 8- 15) and eight flavonoids ( 16- 23). The structures of the new compounds were elucidated primarily on the basis of 1D and 2D NMR and mass spectroscopic studies. The relative configuration of the 3-OH group of 3, 4, and 5 was also established or re-established. The inhibitory effects of compounds 1- 23 on nitric oxide production in lipopolysaccaride-activated macrophages were evaluated.
- Subjects :
- Drugs, Chinese Herbal chemistry
Flavonoids chemistry
Lipopolysaccharides pharmacology
Macrophages drug effects
Macrophages metabolism
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Steroids chemistry
Drugs, Chinese Herbal isolation & purification
Drugs, Chinese Herbal pharmacology
Flavonoids isolation & purification
Flavonoids pharmacology
Nitric Oxide biosynthesis
Physalis chemistry
Plants, Medicinal chemistry
Steroids isolation & purification
Steroids pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0163-3864
- Volume :
- 71
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of natural products
- Publication Type :
- Academic Journal
- Accession number :
- 18348534
- Full Text :
- https://doi.org/10.1021/np700713r