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Endiandric Acid Analogues from the Roots of Beilschmiedia erythrophloia.
- Source :
-
Journal of natural products [J Nat Prod] 2009 Jan; Vol. 72 (1), pp. 53-8. - Publication Year :
- 2009
-
Abstract
- Investigation of the roots of Beilschmiedia erythrophloia has led to the isolation of seven new endiandric acid analogues, erythrophloins A-F (1-6) and beilcyclone A (7), together with 11 known compounds. The structures of 1-7 were determined using spectroscopic techniques. Two constituents, erythrophloin C (3) and suberosol B (8), exhibited antitubercular activity against Mycobacterium tuberculosis H37Rv, showing MIC values of 50 and 28.9 microg/mL, respectively.
- Subjects :
- Animals
Antineoplastic Agents, Phytogenic chemistry
Antineoplastic Agents, Phytogenic isolation & purification
Antineoplastic Agents, Phytogenic pharmacology
Antitubercular Agents pharmacology
Carboxylic Acids pharmacology
Drug Screening Assays, Antitumor
Leukemia P388
Mice
Microbial Sensitivity Tests
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Plant Roots chemistry
Polycyclic Aromatic Hydrocarbons pharmacology
Stereoisomerism
Steroids pharmacology
Taiwan
Antitubercular Agents chemistry
Antitubercular Agents isolation & purification
Carboxylic Acids chemistry
Carboxylic Acids isolation & purification
Lauraceae chemistry
Mycobacterium tuberculosis drug effects
Plants, Medicinal chemistry
Polycyclic Aromatic Hydrocarbons chemistry
Polycyclic Aromatic Hydrocarbons isolation & purification
Steroids chemistry
Steroids isolation & purification
Subjects
Details
- Language :
- English
- ISSN :
- 1520-6025
- Volume :
- 72
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of natural products
- Publication Type :
- Academic Journal
- Accession number :
- 19072217
- Full Text :
- https://doi.org/10.1021/np800504w