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Isolation of steroidal glycosides from the Caribbean sponge Pandaros acanthifolium.
- Source :
-
Journal of natural products [J Nat Prod] 2012 Dec 28; Vol. 75 (12), pp. 2094-100. Date of Electronic Publication: 2012 Dec 17. - Publication Year :
- 2012
-
Abstract
- Four new steroidal glycosides, acanthifoliosides G-J (1-4), were isolated as minor constituents from the Caribbean marine sponge Pandaros acanthifolium. These metabolites are characterized by a highly oxygenated D ring and the presence of a disaccharide rhamnose-glucose residue and a rhamnose at positions C-3 and C-15, respectively. Their structures were established on the basis of extensive interpretation of 1D and 2D NMR data and HRESIMS analyses. The absolute configurations of the glucose and rhamnose sugars were determined by preparing aldose o-tolylthiocarbamate derivatives and comparison to authentic standards by LC/HRESIMS. Acanthifolioside G (1) exhibited antioxidant and cytoprotective activities.
- Subjects :
- Animals
Antioxidants chemistry
Antioxidants pharmacology
Astrocytoma drug therapy
Caribbean Region
Glycosides chemistry
Glycosides pharmacology
Humans
Male
Marine Biology
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Steroids chemistry
Steroids pharmacology
Antioxidants isolation & purification
Glycosides isolation & purification
Porifera chemistry
Steroids isolation & purification
Subjects
Details
- Language :
- English
- ISSN :
- 1520-6025
- Volume :
- 75
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Journal of natural products
- Publication Type :
- Academic Journal
- Accession number :
- 23245401
- Full Text :
- https://doi.org/10.1021/np300520w