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Potent airway smooth muscle relaxant effect of cynatratoside B, a steroidal glycoside isolated from Cynanchum stauntonii.
- Source :
-
Journal of natural products [J Nat Prod] 2014 Apr 25; Vol. 77 (4), pp. 1074-7. Date of Electronic Publication: 2014 Mar 24. - Publication Year :
- 2014
-
Abstract
- The dried roots of Cynanchum stauntonii in having cough-relieving efficacy are commonly included in traditional antitussive formulas. The active components in a C. stauntonii root extract responsible for airway relaxation were isolated using an ex vivo bioassay-guided fractionation method, in which subfractions were evaluated for their inhibitory effects on the contraction of isolated rat tracheal rings by isometric tension measurements. A steroidal glycoside, cynatratoside B (1), identified by LC-MS and NMR spectroscopic analysis, was shown to have potent inhibition on acetylcholine- and carbachol-induced tracheal contractions. The present data provide scientific evidence to support the traditional use of C. stauntonii as an antitussive herbal medicine.
- Subjects :
- Animals
Carbachol pharmacology
Dose-Response Relationship, Drug
Glycosides chemistry
Hong Kong
Male
Molecular Structure
Muscle Contraction drug effects
Muscle, Smooth drug effects
Plant Roots chemistry
Rats
Rats, Sprague-Dawley
Steroids chemistry
Trachea drug effects
Cynanchum chemistry
Glycosides isolation & purification
Glycosides pharmacology
Plants, Medicinal chemistry
Steroids isolation & purification
Steroids pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1520-6025
- Volume :
- 77
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of natural products
- Publication Type :
- Academic Journal
- Accession number :
- 24761833
- Full Text :
- https://doi.org/10.1021/np4008969