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Antiproliferative Homoisoflavonoids and Bufatrienolides from Urginea depressa.
- Source :
-
Journal of natural products [J Nat Prod] 2013 May 24; Vol. 76 (5), pp. 865-72. Date of Electronic Publication: 2013 May 09. - Publication Year :
- 2013
-
Abstract
- Investigation of the South African plant Urginea depressa Baker (Asparagaceae Juss.) for antiproliferative activity against the A2780 ovarian cancer cell line led to the isolation of the six new homoisoflavonoids urgineanins A-F (1-6), the two known bufatrienolides 7 and 9, and the new bufatrienolides urginins B and C (8 and 10). Structures were elucidated based on analysis of their 1D and 2D NMR spectra, electronic circular dichroism, and mass spectrometric data. Five of the six new homoisoflavonoids had good antiproliferative activity against the A2780 ovarian cancer, A2058 melanoma, and H522-T1 human non-small-cell lung cancer cells, and urgineanin A (1) had submicromolar activity against all three cell lines. The four bufatrienolides 7-10 had strong antiproliferative activity against the same cell line, with IC50 values of 24.1, 11.2, 111, and 40.6 nM, respectively.
- Subjects :
- Antineoplastic Agents, Phytogenic chemistry
Drug Screening Assays, Antitumor
Female
Humans
Inhibitory Concentration 50
Isoflavones chemistry
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Steroids chemistry
Antineoplastic Agents, Phytogenic isolation & purification
Antineoplastic Agents, Phytogenic pharmacology
Drimia chemistry
Isoflavones isolation & purification
Isoflavones pharmacology
Steroids isolation & purification
Steroids pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1520-6025
- Volume :
- 76
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Journal of natural products
- Publication Type :
- Academic Journal
- Accession number :
- 23659371
- Full Text :
- https://doi.org/10.1021/np300900a