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Monanchosterols A and B, bioactive bicyclo[4.3.1]steroids from a Korean sponge Monanchora sp.
- Source :
-
Journal of natural products [J Nat Prod] 2015 Mar 27; Vol. 78 (3), pp. 368-73. Date of Electronic Publication: 2014 Dec 02. - Publication Year :
- 2015
-
Abstract
- Chemical investigation of a Korean marine sponge, Monanchora sp., led to the isolation of three new steroids (1-3). Compounds 1 and 2, designated as monanchosterols A and B, respectively, represent the first examples of steroids possessing the bicyclo[4.3.1] A/B ring system from a natural source. Compounds 1-3 were investigated for their anti-inflammatory activity by evaluating their inhibitory effects on the mRNA expression of IL-6, TNF-α, and COX-2 in the LPS-stimulated murine RAW264.7 macrophage cells. Compounds 2 and 3 exhibited significant inhibitory effects on the mRNA expression of IL-6 without notable cytotoxicity to the cells in a dose-dependent manner.
- Subjects :
- Animals
Anti-Inflammatory Agents chemistry
Bridged Bicyclo Compounds chemistry
Cyclooxygenase 2 metabolism
Dose-Response Relationship, Drug
Interleukin-6 genetics
Interleukin-6 metabolism
Lipopolysaccharides pharmacology
Macrophages drug effects
Marine Biology
Mice
Molecular Structure
Nitric Oxide Synthase Type II antagonists & inhibitors
Nuclear Magnetic Resonance, Biomolecular
Republic of Korea
Steroids chemistry
Steroids pharmacology
Tumor Necrosis Factor-alpha drug effects
Anti-Inflammatory Agents isolation & purification
Anti-Inflammatory Agents pharmacology
Bridged Bicyclo Compounds isolation & purification
Bridged Bicyclo Compounds pharmacology
Porifera chemistry
Steroids isolation & purification
Subjects
Details
- Language :
- English
- ISSN :
- 1520-6025
- Volume :
- 78
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of natural products
- Publication Type :
- Academic Journal
- Accession number :
- 25455409
- Full Text :
- https://doi.org/10.1021/np500760v