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Researchers from the University of Alabama at Birmingham have developed Bayesian Compositional Models for Ordinal Response, a method for analyzing data with compositional predictors and an ordinal response. Compositional data refers to data where the sum of predictors for each sample is fixed, such as the relative abundance of species in microbiome data. The proposed method outperformed existing methods in terms of parameter estimation and prediction, and was applied to a microbiome study to identify microorganisms linked to inflammatory bowel disease levels. The code and data used in the study are available for reproducibility. [Extracted from the article]

Keywords: Asia; China; Chronic Disease; Disease Attributes; Health and Medicine EN Asia China Chronic Disease Disease Attributes Health and Medicine 3337 3337 1 03/23/23 20230303 NES 230303 2023 MAR 3 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- New research on chronic disease is the subject of a new report. For more information on this research see: The Relationship between Family Doctor Contract Services Policy and Perceived Participation in Primary Health Care among Chronic Disease Patients in China: The Mediating Role of the Patient Trust. [Extracted from the article]

Keywords: Bacterial Polysaccharides; Bacterial Toxins; Biological Factors; Cardiolipins; Dehydrogenase; Endotoxins; Enzymes and Coenzymes; Haptens; Health and Medicine; Immunology; Inflammation; Lipopolysaccharides; Science EN Bacterial Polysaccharides Bacterial Toxins Biological Factors Cardiolipins Dehydrogenase Endotoxins Enzymes and Coenzymes Haptens Health and Medicine Immunology Inflammation Lipopolysaccharides Science 3592 3592 1 03/24/23 20230224 NES 230224 2023 FEB 24 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- Fresh data on science are presented in a new report. Mitochondrial fission supported lipopolysaccharide-stimulated succinate dehydrogenase subunit B degradation but not sequestration. [Extracted from the article]

A recent report from Peking Union Medical College in Beijing, China, discusses research on quaternary ammonium compounds, specifically focusing on reducing the hygroscopicity of betaine through the synthesis of three co-crystals. Betaine, commonly found in natural products, is used to treat homocysteine methyltransferase and has additional benefits such as hepatoprotective and neuroprotective properties. The research findings highlight significant improvements in betaine's hygroscopicity with the synthesized co-crystals, particularly betaine-3-hydroxybenzoic acid. The study was funded by various organizations, including the National Natural Science Foundation of China and the Chinese Pharmacopoeia Commission Drug Standard Promoting Fund. [Extracted from the article]

Researchers from Peking University School and Hospital of Stomatology conducted a study on tooth mobility in stage III/IV grade C periodontitis patients aged 35 years. The study found that premolar mobility is influenced by variations in root length, alveolar bone resorption, and probing depth. The bone-level crown-to-root ratio (CRR) was identified as an effective predictor for assessing tooth mobility in these patients. The research provides valuable insights into the factors influencing tooth mobility in individuals with severe periodontal disease. [Extracted from the article]

A recent study conducted by researchers at Southwest Minzu University in Chengdu, China, focused on the urban heat island (UHI) effect and its impact on the local climate zones (LCZs) in the city. The study utilized remote sensing data to map out the LCZs and analyze the spatial clustering effects of UHI. Findings indicated that UHII values varied based on specific conditions and were not constant, with significant spatial heterogeneity observed in Chengdu's urban morphology and UHII. The study recommended precise ecological spatial planning to mitigate the UHI effect and improve the quality of life for urban residents. [Extracted from the article]

Researchers at Shaanxi University of Science and Technology in Xi'an, China, have focused on improving the bioavailability of curcumin to enhance its anti-inflammatory properties. The study highlights the importance of understanding the intestinal barrier, signaling pathways, and transport mechanisms to increase curcumin's effectiveness in relieving inflammation. The research emphasizes the need for developing advanced nanomaterial targeting systems to optimize curcumin delivery and achieve better outcomes in inflammation therapy. This study underscores the potential of curcumin in addressing intestinal inflammation and its implications for human health. [Extracted from the article]

A recent study conducted at Peking Union Medical College Hospital in Beijing, China, introduced a new parameter called the Area Ossification Ratio (AOR) for quantitatively assessing adolescent bone age using conventional ultrasonography. The research found that AOR showed a high correlation with radiographic bone age, indicating its reliability in assessing bone age in adolescents. The study included 179 healthy adolescents and demonstrated high repeatability in measurements of AOR by different doctors and the same doctor at different times. This research provides valuable insights into the quantitative assessment of bone age in adolescents using ultrasound imaging techniques. [Extracted from the article]

Researchers from Jinan University conducted a study on the effects of exercise on high-fat diet-induced depressive-like behaviors in mice. The study found that regular exercise, specifically treadmill exercise, activated neuronal autophagy in the hippocampus, enhancing synaptic plasticity and alleviating depressive symptoms caused by the high-fat diet. The key mediator of this effect was identified as Wnt5a, and inhibiting Wnt5a reversed the positive effects of exercise. This research sheds light on the importance of Wnt5a in improving high-fat diet-induced depression through exercise. [Extracted from the article]

A recent study conducted by the Institute of Public Health in Guizhou Province, China, examined the correlation between mushroom poisoning cases and meteorological factors. The study found that mushroom poisoning is a significant food safety issue in the region, with cases primarily occurring among individuals aged 20-59. Gastrointestinal symptoms were the most common, and incidents peaked from June to October in the northeastern region of the province. The study also revealed a positive correlation between meteorological factors and the number of mushroom poisoning cases, suggesting that these factors could serve as early warning indicators for prevention and control. [Extracted from the article]

A recent study conducted in Chongqing, China aimed to assess the geriatric nursing competencies of clinical nursing staff in the city's hospitals. The study surveyed 10,692 nurses from 204 hospitals and found that the overall geriatric nursing competence score was at a lower-middle level. Factors such as the department of medicine, age of nurses, professional title, and certification influenced the competence levels in different hospital levels. The study concluded that further clinical training in geriatric nursing is needed, with a focus on necessary clinical skills and managing comprehensive geriatric syndromes. [Extracted from the article]

A new report from the National Institutes of Health (NIH) discusses the alarming trend of earlier puberty in girls and investigates the potential influence of environmental factors. The researchers screened a compound library and identified musk ambrette as a kisspeptin receptor (KISS1R) agonist, which led to increased expression of Gnrh1 in hypothalamic cells. They also identified a group of cholinergic agonists as gonadotropin-releasing hormone receptor (GnRHR) agonists. This research provides insights into the potential environmental compounds that may trigger early female puberty by activating human Gnrhr and Kiss1r. [Extracted from the article]

A recent study conducted at Shenzhen University in China has proposed a new method for emotion recognition using electroencephalography (EEG) data. The researchers developed a time-aware sampling network (TAS-Net) using deep reinforcement learning (DRL) to detect key emotion fragments in the EEG time series. By training a time-aware agent through DRL, the method is able to preserve relevant emotion fragments and discard irrelevant parts, leading to improved unsupervised emotion recognition. The results of the study suggest that this approach has the potential to enhance affective brain-computer interfaces in dynamic and label-free situations. [Extracted from the article]

Researchers at Nanjing University of Chinese Medicine have conducted a study on the effects of a Chinese herbal medicine formula called Shizao decoction (SZD) on malignant ascites. The researchers found that SZD, which includes Fructus Jujubae (FJ) along with other herbs, reduced intestinal injury and alleviated ascites by modulating gut microbiota and metabolic homeostasis. The study also identified potential fecal metabolites and correlations between gut microbiota and short-chain fatty acids. These findings provide a scientific basis for the clinical application of FJ and the safe usage of SZD. [Extracted from the article]

A new report from the Second Affiliated Hospital of Xi'an Jiaotong University in China explores the practice of narrative nursing among registered nurses. Narrative nursing is a humanistic approach that has been shown to improve health outcomes for both patients and nurses. The study found that narrative nursing in China is at a medium level and is influenced by personal and environmental factors. The researchers emphasize the importance of nursing management in promoting narrative nursing practices and suggest specialized training and supportive environments for nurses to enhance their narrative nursing skills. [Extracted from the article]

A study conducted in Sichuan, China, examined the knowledge levels of nursing staff in tertiary general hospitals regarding pressure injuries (PIs), also known as pressure ulcers. The study found that there were three distinct profiles of nurses' PI knowledge: weak foundation type (46.3%), strengthening foundation type (42.7%), and special improvement type (11.0%). The research concluded that there is an urgent need to improve the PI knowledge level of nursing staff in district and county tertiary general hospitals. The study suggests that nursing managers should prioritize the management and quality of PI training to enhance the quality of healthcare for inpatients. [Extracted from the article]

A recent study conducted at the Second Hospital of Shandong University in China explored the association between serum total bilirubin (TBIL) levels and the prognosis of Disorders of Consciousness (DoC). The study included 168 patients with DoC, and their clinical characteristics and blood samples were collected. The researchers found that higher TBIL levels were significantly associated with a better recovery outcome at 1, 3, and 6 months. However, further research is needed to understand the underlying causal relationship between TBIL levels and DoC. This study provides valuable insights for clinicians and families in predicting the recovery of DoC. [Extracted from the article]

A recent study conducted by researchers at the University of California examined the impact of debt on the well-being of medical students. The study found that nearly three-quarters of medical students in the United States graduate with six-figure debt amounts, which negatively affects their emotional and academic well-being, as well as their career choices. The researchers used a mixed methods approach, combining quantitative survey analysis with human-centered design exploration, to identify risk factors for debt-related stress and potential interventions. The study highlights the need for system-level solutions to address the impact of debt on medical students' well-being. [Extracted from the article]

A new study conducted by researchers at the Affiliated Kunshan Hospital of Jiangsu University explores the potential relationship between the atherogenic index of plasma (AIP) and kidney stones in US adults. The study, which analyzed data from the National Health and Nutrition Examination Survey (NHANES) from 2007 to 2018, found that higher AIP index tertile intervals were associated with an increased risk of kidney stones. The researchers concluded that the AIP index may be a useful tool for understanding the role of dyslipidemia in the development of kidney stones in US adults. [Extracted from the article]

Researchers from Guangdong Polytechnic Normal University in Guangzhou, China have conducted a systematic literature review on the use of machine learning (ML) in the analysis of psoriasis. The review focused on three categories: lesion localization and segmentation, lesion recognition, and lesion severity and area scoring. The researchers summarized 53 publications and discussed the most common models and datasets for psoriasis analysis, as well as the key challenges and future trends in ML within this field. The aim of the research is to provide directions for future studies. [Extracted from the article]

A new study from the Center for Reproductive Medicine explores the use of a workflow-based RFID tag system to improve efficiency and reduce errors in IVF laboratories. The study found that the RFID tag system corrected 100% of tag errors and shortened the time for data entry, without negatively impacting embryo quality or pregnancy outcomes. However, the cost of RFID tags was significantly higher compared to paper labels. Overall, the study suggests that integrating RFID tag witnessing with real-time information entry can enhance operational safety and improve work efficiency in reproductive medicine. [Extracted from the article]

A recent study conducted by researchers at Southwest Medical University in Sichuan, China, explored the effects of naringenin (NAR) on the osteogenic differentiation of human periodontal ligament stem cells (hPDLSCs) and its potential for repairing alveolar bone defects. The study found that NAR activates the nitric oxide (NO)-cyclic guanosine monophosphate (cGMP)-protein kinase G (PKG) signaling pathway by binding to AKT, which promotes the osteogenic differentiation of hPDLSCs. The researchers used various techniques such as mRNA sequencing, western blotting, and immunofluorescence to evaluate gene and protein expression levels and observe the osteogenic capacity of hPDLSCs. Micro-CT and Masson staining confirmed that the NAR gavage group exhibited more new bone formation at the defect site. The study suggests that NAR could be a potential therapeutic agent for bone regeneration. [Extracted from the article]

A recent study conducted at the Third Hospital of Shanxi Medical University in China has investigated the antibacterial behavior and mechanism of nitrogen and silicon-doped amphiphilic carbon dots (CDs). The researchers prepared these CDs using citric acid and silane coupling agent as raw materials. The study found that the CDs possessed an average particle size of 1.75 nm and a negative surface potential of -2.71 mV. They exhibited antibacterial properties against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus), with minimum bactericidal concentrations of 500 mg/mL and 400 mg/mL, respectively. The CDs also showed the ability to inhibit biofilm formation and demonstrated excellent biocompatibility. The researchers concluded that these co-doped CDs could be used as a new material in the antibacterial field. [Extracted from the article]

A recent study conducted by researchers at the Shengli Clinical Medical College of Fujian Medical University in China has found that wasp venom injections can cause damage to various organs, particularly the kidneys. The study focused on a 55-year-old patient with hypertension who experienced acute kidney injury (AKI) after being stung by multiple wasps. The patient's kidney biopsy revealed a combination of acute tubular necrosis (ATN) and chronic glomerular sclerosis, suggesting that the underlying cause of the renal damage may have been a combination of hypertension and the wasp venom. This research highlights the complex pathophysiological processes involved in wasp sting-induced AKI and the need for further investigation in this area. [Extracted from the article]

A recent study conducted by researchers at Capital Medical University explored the knowledge, attitudes, and practices (KAP) related to tooth loss and dentures among patients with dental arch deficiencies. The study found that patients with dental arch deficiencies had insufficient knowledge, positive attitudes, and moderate practice regarding tooth loss and dentures. The study also identified several demographic factors that may influence these KAP scores. This research provides valuable insights for dental healthcare providers, policymakers, and researchers. [Extracted from the article]

A study conducted by researchers at Xi'an Jiaotong University in China explored how anxiety and stress affect the decision-making process of soccer referees. The study involved 76 experienced referees who were divided into high anxiety and low anxiety groups. The researchers used Event-Related Potential (ERP) technology to compare the brain signals of referees with different anxiety levels when facing foul play under different pressure environments. The study found that referees with high levels of anxiety displayed larger brain signal amplitudes in a low-pressure environment, but no significant differences were observed under high-pressure conditions. The findings highlight the importance of understanding and managing the psychological state of referees in competitive sports to improve the quality of their decisions. [Extracted from the article]

A study conducted by investigators from Shenzhen Polytechnic in Shenzhen, People's Republic of China, explores the potential effects of gallic acid on psoriasis. Psoriasis is a chronic autoimmune disease, and gallic acid is a natural compound known for its antioxidant, anticancer, antiviral, and antibacterial properties. The study found that gallic acid can alleviate psoriasis by regulating the expression of bromodomain-containing protein 4 (BRD4), which affects cell migration, proliferation, inflammatory response, and apoptosis. This research provides valuable insights into potential treatments for psoriasis. [Extracted from the article]

A recent study conducted at the General Hospital of the Chinese People's Liberation Army in Beijing, China, focused on the management of renal fibrosis, a challenging condition due to complex cell signaling redundancy in diseased kidneys. The study found that renal fibrosis involves an immune response dominated by macrophages, which activate myofibroblasts in fibrotic niches. The researchers aimed to eliminate specific macrophage subsets that drive the profibrotic immune response in the kidney. They identified a major profibrotic macrophage subset and developed a 12-mer glycopeptide called bioactivated in vivo assembly PK (BIVA-PK) to deplete these cells. BIVA-PK effectively reshaped the renal microenvironment and suppressed profibrotic immune responses, highlighting its potential as a therapy for patients with chronic kidney disease. [Extracted from the article]

A study conducted by researchers at the Southern University of Science and Technology Hospital in Shenzhen, China, has found that exposure to polystyrene nanoplastics (PS-NPs) can cause erectile dysfunction in rats. The study established a rat model of oral exposure to PS-NPs and found that high doses of PS-NPs triggered erectile dysfunction, while low doses did not. The toxicological effects of PS-NPs on erectile function include fibrosis in the corpus cavernosum, endothelial dysfunction, reduction in testosterone levels, elevated oxidative stress, and apoptosis. This study provides new insights into the toxicity of PS-NPs. [Extracted from the article]

A recent report from Zhejiang University in Hangzhou, China, discusses a study on the transcriptional landscape of lacrimal gland cell populations in a mouse model of graft-versus-host disease (GVHD). The researchers used single-cell RNA sequencing and bioinformatic analysis to identify 23 cell populations belonging to 11 cell types. They found that certain cell populations, such as acinar cells and myoepithelial cells, were decreased in GVHD lacrimal glands, while T cells and macrophages were expanded. The study provides new insights into the development of ocular GVHD. [Extracted from the article]

A recent study conducted at the Second Affiliated Hospital of Dalian Medical University in China explores the role of ghrelin, a peptide hormone, in promoting catch-up growth and maintaining metabolic homeostasis in small-for-gestational-age (SGA) infants. SGA infants are at risk for adverse perinatal outcomes, increased neonatal morbidity and mortality, and long-term health issues such as metabolic disorders and cardiovascular and endocrine diseases. The researchers suggest that understanding the signaling pathways regulated by ghrelin could help identify high-risk groups for SGA metabolic disorders and develop targeted interventions to prevent related diseases in adulthood. The study is available in the journal Frontiers in Pediatrics. [Extracted from the article]

Researchers from Agilent Technologies Inc. conducted a study on the stability of mRNA loaded lipid nanoparticles (mRNA-LNPs) in human plasma and serum. They used size-exclusion chromatography coupled with dual-angle light scattering (SEC-MALS) to assess the stability of mRNA-LNPs. The study found that both serum and plasma had different impacts on the molecular weight and radius of gyration of mRNA-LNPs, suggesting the involvement of clotting factors in desorption of lipids from mRNA-LNPs. The researchers concluded that SEC-MALS could be a useful tool for optimizing and quality control of lipid nanoparticle formulations. [Extracted from the article]

A recent study conducted at Peking University Third Hospital in Beijing, China, explored the use of suspensory traction as a preoperative treatment for cervical kyphosis. The researchers used a finite element model to analyze the stress on the cervical spine under suspensory traction and found that increasing the weight of the traction led to a decrease in the overall kyphosis of the spine. The study also identified the role of shear effect and tension on the anterior longitudinal ligament in correcting cervical kyphosis. This research provides new insights into the treatment of this musculoskeletal condition. [Extracted from the article]

A recent study conducted by researchers at the Affiliated Hospital of Qingdao University in China explored the biomechanical effects of different posterior fixation techniques on stability and adjacent segment degeneration in treating thoracolumbar burst fractures with osteoporosis. The study used finite element analysis to analyze range of motion, stress on intervertebral discs and facet joints, and other factors. The results showed that long-segmented pedicle screw fixation provided the greatest stability, while cortical bone screw fixation provided the least stability. However, the study also found that the increased stress on adjacent intervertebral discs and facet joints after long-segmented pedicle screw fixation increased the risk of adjacent segment degeneration. Cement-augmented pedicle screw fixation and combined cortical bone screw and pedicle screw fixation were found to provide moderate fixation strength while reducing stress on the intervertebral discs and facet joints. [Extracted from the article]

A recent report from Wuhan University discusses the role of mechanical strain in exocytosis, the process by which intracellular vesicles fuse with the cell membrane. The researchers developed a stretchable microelectrode that allowed them to monitor real-time quantitation of strain-induced vesicular exocytosis from a single cell. They found that mechanical strain can cause calcium influx and increase the release of catecholamines during exocytosis. This study provides valuable insights into the regulatory effects of mechanical stimuli on vesicular exocytosis. [Extracted from the article]

Researchers at Wuhan University in China have conducted a study on synaptic plasticity, which is the ability of synapses to modulate synaptic strength in response to changes in the environment. The researchers used nanoelectrochemistry to monitor the release of dopamine in synapses and found that the presynaptic terminal recruits vesicles and changes the dynamics of exocytosis to maintain synaptic strength. They also discovered that dense core vesicles are involved in sustaining neurotransmitter levels during repetitive stimuli. This study provides new insights into the regulatory mechanisms of vesicle release and synaptic plasticity. [Extracted from the article]

A study conducted by researchers at the General Hospital of the Chinese People's Liberation Army in Beijing, China, focused on rhabdomyolysis, a condition that leads to dysfunction in the kidneys, lungs, and heart. The researchers established a rhabdomyolysis model in rats and observed significant damage in these organs. They also analyzed the differentially expressed proteins in the organs and found that Serpina3n, a secreted protein, may play a key role in multiple organ damage caused by rhabdomyolysis and could be a potential biomarker. The study provides a comprehensive understanding of the structural and functional changes in these organs and highlights the importance of Serpina3n in rhabdomyolysis-induced injury. [Extracted from the article]

Researchers from the First Affiliated Hospital of Shandong First Medical University in China have developed a stacking ensemble prediction model for hyperuricemia (HUA), a condition characterized by high levels of uric acid in the blood. The model, which combines three individual models using machine learning techniques, outperformed the individual models in predicting HUA. The researchers also identified several risk factors for HUA, including being female, younger, and having higher levels of uric acid, body mass index, g-glutamyl transpeptidase, total protein, triglycerides, creatinine, and fasting blood glucose. The model's performance was validated in a separate cohort of subjects. [Extracted from the article]

A recent study from the University of Michigan Medical School explores the role of iron in regulating the quiescence of naive CD4 T cells. The researchers found that iron homeostasis is crucial for maintaining these cells in a quiescent state. Naive CD4 T cells with iron overload exhibited increased spontaneous proliferation and hyperactive mitochondria, while also showing defects in proliferation and mitochondrial functions upon activation. The study highlights the essential role of iron in controlling mitochondrial function and cellular metabolism in naive CD4 T cells. [Extracted from the article]

A study conducted by the College of Food Science and Engineering provides new insights into hyperuricemic nephropathy, a condition associated with high levels of uric acid in the blood. The research found that quercetin, a compound found in certain foods, can reduce uric acid levels and improve kidney function in mice and cells. Quercetin achieves this by inhibiting the activity of xanthine oxidase, reducing uric acid absorption, and enhancing the expression of certain proteins involved in uric acid transport. These findings contribute to a better understanding of hyperuricemic nephropathy and suggest that quercetin may have potential therapeutic benefits. [Extracted from the article]

A study conducted at Guangdong University of Technology in Guangzhou, China, has developed a highly sensitive and precise electrochemical immunosensor for protein marker detection. The immunosensor uses thionine-labeled antibodies to accurately quantify protein biomarkers, resulting in enhanced detection sensitivity, improved accuracy, and specificity. The method also achieved low limits of detection for tumor necrosis factor-alpha, cardiac troponin I, and interleukin-6. The proposed electrochemical immunosensor demonstrated high selectivity, repeatability, and sensitivity, making it a promising tool for clinical applications. [Extracted from the article]

Researchers from Macau University of Science & Technology have conducted a study on Gastrodia elata Blume, a plant commonly used in traditional medicine for neurological disorders like Alzheimer's disease. The researchers discovered seven novel derivatives of gastrodin, including a unique gastrodin isocitrate, which showed neuroprotective effects in a cell injury model. The study not only enriched the chemical diversity of G. elata but also identified potential active components. This research provides valuable insights into the medicinal properties of G. elata. [Extracted from the article]

A report from Shenzhen University in China discusses the accuracy evaluation of brain source localization technology and its practical applications. Brain source localization technology aims to identify neural activity in the brain using EEG and MEG signals on the scalp surface. The report explains the two processes involved in brain source localization, the forward problem and the inverse problem, and discusses various methods and algorithms used to improve accuracy. The report also highlights the impact of different recording methods, electrode numbers, and head models on source positioning accuracy. The application of brain source localization technology in time-frequency analysis and connectivity analysis is also explored. The report concludes by discussing scientific problems related to accuracy evaluation and aims to provide references and support for the development and application of brain source localization technology. [Extracted from the article]

A recent study conducted by researchers from Capital Medical University in Beijing, China, has proposed a multitask learning architecture for accurate tooth segmentation and numbering in panoramic X-ray images. The study utilized a graph convolution network for automatic annotation, a modified convolutional neural network-based detection subnetwork for tooth recognition and boundary regression, and an effective region segmentation subnetwork for region segmentation. The results showed impressive performance in multiple evaluation metrics, indicating that this framework has the potential to enhance the clinical efficiency of dentists in tooth segmentation and numbering tasks. The full article can be accessed for free through the Diagnostics journal website. [Extracted from the article]

A recent study conducted by Nanjing University Medical School in China examined the effects of dietary provision on the clinical outcomes of patients with malnutrition. The study analyzed data from nutritionDay surveys conducted between 2010 and 2020, including 5,821 adult in-patients. The results showed that malnourished patients who received dietary provision had a higher chance of a good 30-day outcome and a shorter length of hospital stay compared to those who did not receive dietary provision. These findings emphasize the importance of targeted nutrition care for in-patients and provide valuable insights for implementing effective nutrition interventions. [Extracted from the article]

A recent report from the Chinese Academy of Sciences discusses a new immunoassay system based on the technology of time-resolved fluorescence resonance energy transfer (TR-FRET). The system aims to enhance specificity and sensitivity, reduce costs, and enable the detection of multiple indicators. The researchers used a xenon flash lamp and a photomultiplier tube as the light source and detector, respectively, and presented test results for procalcitonin, C-reactive protein, and interleukin-6. The study concludes that the technical and instrumental solutions are feasible. For more information, readers can refer to the journal article published in Sensors. [Extracted from the article]

A recent study conducted at the National Institutes of Health focused on toxicology and specifically on skin sensitization, which can lead to allergic contact dermatitis. The study used in vitro assays and in silico analysis to assess the skin sensitization potential of compounds in the Tox21 10K compound library. The researchers screened the entire library and prioritized 288 compounds for further testing. The study provides a large dataset on skin sensitization and associated tools for chemical assessments. For more information, the full article can be accessed for free at the provided link. [Extracted from the article]