1. A thermoresponsive nanocarrier for mitochondria-targeted drug delivery
- Author
-
Jimin Gao, Young-Tae Chang, Yi Hu, Mengxue Zhou, Dongqing Wang, Hui Huang, Zhifang Chai, Huiru Lu, and Jun Chen
- Subjects
Drug ,Paclitaxel ,Cell Survival ,media_common.quotation_subject ,Mitochondrion ,010402 general chemistry ,01 natural sciences ,Catalysis ,Cell Line ,Mice ,Structure-Activity Relationship ,chemistry.chemical_compound ,Neoplasms ,Materials Chemistry ,Animals ,Humans ,Structure–activity relationship ,Medicine ,Cell Proliferation ,media_common ,Drug Carriers ,Dose-Response Relationship, Drug ,010405 organic chemistry ,business.industry ,Temperature ,Metals and Alloys ,General Chemistry ,Antineoplastic Agents, Phytogenic ,Mitochondria ,0104 chemical sciences ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,chemistry ,Cell culture ,Cancer cell ,Drug delivery ,Ceramics and Composites ,Cancer research ,Nanoparticles ,Drug Screening Assays, Antitumor ,Nanocarriers ,business - Abstract
Mitochondria emerge as an important target for cancer therapy. Herein, by taking advantage of the recently reported high temperature of mitochondria, a well-tuned thermoresponsive nanocarrier was developed for specifically delivering the anticancer drug, paclitaxel (PTX), to mitochondria in cancer cells. The temperature-dependent delivery of drugs to mitochondria represents a novel anticancer strategy.
- Published
- 2019