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Solid phase combinatorial synthesis of a xanthone library using click chemistry and its application to an embryonic stem cell probe
- Source :
- Chemical Communications. 47:7488
- Publication Year :
- 2011
- Publisher :
- Royal Society of Chemistry (RSC), 2011.
-
Abstract
- We report the first solid phase synthesis of a xanthone library CX and its application to embryonic stem cell probe development. The CX library was further derivatised with an activated ester resin to provide an acetylated CX (CXAC) library. Screening of these libraries led to the discovery of a novel fluorescent mESC probe, CDb8.
- Subjects :
- Xanthones
Catalysis
Small Molecule Libraries
Mice
chemistry.chemical_compound
Solid-phase synthesis
Phase (matter)
Xanthone
Materials Chemistry
Animals
Combinatorial Chemistry Techniques
Fluorescein
Embryonic Stem Cells
Fluorescent Dyes
Metals and Alloys
General Chemistry
Embryonic stem cell
Combinatorial chemistry
Fluorescence
Surfaces, Coatings and Films
Electronic, Optical and Magnetic Materials
chemistry
Acetylation
Ceramics and Composites
Click chemistry
Click Chemistry
Subjects
Details
- ISSN :
- 1364548X and 13597345
- Volume :
- 47
- Database :
- OpenAIRE
- Journal :
- Chemical Communications
- Accession number :
- edsair.doi.dedup.....37e068bed42dee5bf8aefedf2ea124fb