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A thermoresponsive nanocarrier for mitochondria-targeted drug delivery
- Source :
- Chemical Communications. 55:4051-4054
- Publication Year :
- 2019
- Publisher :
- Royal Society of Chemistry (RSC), 2019.
-
Abstract
- Mitochondria emerge as an important target for cancer therapy. Herein, by taking advantage of the recently reported high temperature of mitochondria, a well-tuned thermoresponsive nanocarrier was developed for specifically delivering the anticancer drug, paclitaxel (PTX), to mitochondria in cancer cells. The temperature-dependent delivery of drugs to mitochondria represents a novel anticancer strategy.
- Subjects :
- Drug
Paclitaxel
Cell Survival
media_common.quotation_subject
Mitochondrion
010402 general chemistry
01 natural sciences
Catalysis
Cell Line
Mice
Structure-Activity Relationship
chemistry.chemical_compound
Neoplasms
Materials Chemistry
Animals
Humans
Structure–activity relationship
Medicine
Cell Proliferation
media_common
Drug Carriers
Dose-Response Relationship, Drug
010405 organic chemistry
business.industry
Temperature
Metals and Alloys
General Chemistry
Antineoplastic Agents, Phytogenic
Mitochondria
0104 chemical sciences
Surfaces, Coatings and Films
Electronic, Optical and Magnetic Materials
chemistry
Cell culture
Cancer cell
Drug delivery
Ceramics and Composites
Cancer research
Nanoparticles
Drug Screening Assays, Antitumor
Nanocarriers
business
Subjects
Details
- ISSN :
- 1364548X and 13597345
- Volume :
- 55
- Database :
- OpenAIRE
- Journal :
- Chemical Communications
- Accession number :
- edsair.doi.dedup.....e1377d7bb5b2605803b7fb9f1dfe6d27