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The small molecule probe PT-Yellow labels the renal proximal tubules in zebrafish.
- Source :
- Chemical Communications; 1/7/2015, Vol. 51 Issue 2, p395-398, 4p
- Publication Year :
- 2015
-
Abstract
- We report the development of a small fluorescent molecule, BDNCA3-D2, herein referred to as PT-Yellow. Soaking zebrafish embryos in PT-Yellow or intraperitoneal injection into adults results in non-toxic in vivo fluorescent labeling of the renal proximal tubules, the major site of blood filtrate reabsorption and a common target of injury in acute kidney injury. We demonstrate the applicability of this new compound as a rapid and simple readout for zebrafish kidney filtration and proximal tubule reabsorption function. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 13597345
- Volume :
- 51
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Chemical Communications
- Publication Type :
- Academic Journal
- Accession number :
- 99883789
- Full Text :
- https://doi.org/10.1039/c4cc08075k