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Imaging histamine in live basophils and macrophages with a fluorescent mesoionic acid fluoride
- Source :
- Chemical Communications. 48:7401
- Publication Year :
- 2012
- Publisher :
- Royal Society of Chemistry (RSC), 2012.
-
Abstract
- Histamine is a biogenic amine with fundamental roles in circulatory and immune systems. We report a fluorescent small molecule (Histamine Blue) for imaging intracellular histamine in live basophils and macrophages. Histamine Blue is a fluorescent mesoionic acid fluoride that turns on upon reaction with histamine. The selective response of Histamine Blue enabled the visualization of intracellular histamine under different physiological conditions.
- Subjects :
- Diagnostic Imaging
Catalysis
Cell Line
Fluorides
Mice
chemistry.chemical_compound
Immune system
Cell Line, Tumor
Biogenic amine
Materials Chemistry
Animals
Fluorescent Dyes
chemistry.chemical_classification
Macrophages
Metals and Alloys
Mesoionic
General Chemistry
Small molecule
Fluorescence
Basophils
Rats
Surfaces, Coatings and Films
Electronic, Optical and Magnetic Materials
chemistry
Biochemistry
Ceramics and Composites
Fluoride
Intracellular
Histamine
Subjects
Details
- ISSN :
- 1364548X and 13597345
- Volume :
- 48
- Database :
- OpenAIRE
- Journal :
- Chemical Communications
- Accession number :
- edsair.doi.dedup.....0cba56e7393e61c8c730e05b871ffd72