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Development of a fluorescent chalcone library and its application in the discovery of a mouse embryonic stem cell probe
- Source :
- Chemical Communications. 48:6681
- Publication Year :
- 2012
- Publisher :
- Royal Society of Chemistry (RSC), 2012.
-
Abstract
- We report the first fluorescent diamino-chalcone library and its application in the discovery of a mouse embryonic stem cell (mESC) probe. CDg4, a novel green fluorescent mESC probe was discovered through a high-content image based screening of 160 members of the chalcone library. Interestingly, the molecular binding target of CDg4 was identified as the glycogen of the stem cell colony surface, rather than a conventional protein target from an intracellular source.
- Subjects :
- Chalcone
Molecular binding
Catalysis
Small Molecule Libraries
Mice
chemistry.chemical_compound
Materials Chemistry
Animals
Embryonic Stem Cells
Fluorescent Dyes
Microscopy, Confocal
Molecular Structure
Chemistry
Metals and Alloys
General Chemistry
Embryonic stem cell
Fluorescence
Molecular biology
Surfaces, Coatings and Films
Electronic, Optical and Magnetic Materials
Cell biology
Ceramics and Composites
Stem cell
Mouse Embryonic Stem Cell
Intracellular
Subjects
Details
- ISSN :
- 1364548X and 13597345
- Volume :
- 48
- Database :
- OpenAIRE
- Journal :
- Chemical Communications
- Accession number :
- edsair.doi.dedup.....c7403197c8e367d907870b313bf3edbe