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Beet and cane molasses are produced worldwide as a by-product of sugar extraction and are widely used in animal nutrition. Due to their composition, they are fed to ruminants as an energy source. However, molasses has not been properly characterized in the literature; its description has been limited to the type (sugarcane or beet) or to the amount of dry matter (DM), total or water-soluble sugars, crude protein, and ash. Our objective was to better characterize the composition of cane and beet molasses, examine possible differences, and obtain a proper definition of such feeds. For this purpose, 16 cane and 16 beet molasses samples were sourced worldwide and analyzed for chemical composition. The chemical analysis used in this trial characterized 97.4 and 98.3% of the compounds in the DM of cane and beet molasses, respectively. Cane molasses contained less DM compared with beet molasses (76.8 ± 1.02 vs. 78.3 ± 1.61%) as well as crude protein content (6.7 ± 1.8 vs. 13.5 ± 1.4% of DM), with a minimum value of 2.2% of DM in cane molasses and a maximum of 15.6% of DM in beet molasses. The amount of sucrose differed between beet and cane molasses (60.9 ± 4.4 vs. 48.8 ± 6.4% of DM), but variability was high even within cane molasses (39.2–67.3% of DM) and beet molasses. Glucose and fructose were detected in cane molasses (5.3 ± 2.7 and 8.1 ± 2.8% of DM, respectively), showing high variability. Organic acid composition differed as well. Lactic acid was more concentrated in cane molasses than in beet molasses (6.1 ± 2.8 vs. 4.5 ± 1.8% of DM), varying from 1.6 to 12.8% of DM in cane molasses. Dietary cation-anion difference showed numerical differences among cane and beet molasses (7 ± 53 vs. 66 ± 45 mEq/100 g of DM, on average). It varied from −76 to +155 mEq/100 g of DM in the cane group and from +0 to +162 mEq/100 g of DM in the beet group. Data obtained in this study detailed differences in composition between sources of molasses and suggested that a more complete characterization could improve the use of molasses in ration formulation. [ABSTRACT FROM AUTHOR]

The purpose of the present study was to examine adult psychological lack of time, and physical barriers to physical activity (PA) and exercise in a group of Canadian adults. We employed a mixed methodology approach, conducted in two phases. In Phase I, we facilitated group discussions with 234 adults, from 13 diverse focus groups, regarding their perception of PA and exercise as well as the PA barriers prevalent in their daily lives. Using the transcriptions from phase I, we designed a survey and administered it to participants of the same community groups in Phase II of the study in order to quantify feedback. Two hundred seventy-seven adults provided survey responses. The number one barrier, overall, with both the men and women was the psychological barrier: "There are so many other things for me to do, it's easy to make excuses." The most significant lack of time barrier was, "Other things are more important and require my time and energy." Winter weather (physical barrier) was significant, particularly among females. We advocate that identifying the most common PA barriers will help tailor interventions to increase PA in adults. [ABSTRACT FROM AUTHOR]

Angiotensin converting enzyme-2 (ACE2) receptors mediate the entry into the cell of three strains of coronavirus: SARS-CoV, NL63 and SARS-CoV-2. ACE2 receptors are ubiquitous and widely expressed in the heart, vessels, gut, lung (particularly in type 2 pneumocytes and macrophages), kidney, testis and brain. ACE2 is mostly bound to cell membranes and only scarcely present in the circulation in a soluble form. An important salutary function of membrane-bound and soluble ACE2 is the degradation of angiotensin II to angiotensin 1-7. Consequently, ACE2 receptors limit several detrimental effects resulting from binding of angiotensin II to AT1 receptors, which include vasoconstriction, enhanced inflammation and thrombosis. The increased generation of angiotensin 1-7 also triggers counter-regulatory protective effects through binding to G-protein coupled Mas receptors. Unfortunately, the entry of SARS-CoV2 into the cells through membrane fusion markedly down-regulates ACE2 receptors, with loss of the catalytic effect of these receptors at the external site of the membrane. Increased pulmonary inflammation and coagulation have been reported as unwanted effects of enhanced and unopposed angiotensin II effects via the ACE→Angiotensin II→AT1 receptor axis. Clinical reports of patients infected with SARS-CoV-2 show that several features associated with infection and severity of the disease (i.e., older age, hypertension, diabetes, cardiovascular disease) share a variable degree of ACE2 deficiency. We suggest that ACE2 down-regulation induced by viral invasion may be especially detrimental in people with baseline ACE2 deficiency associated with the above conditions. The additional ACE2 deficiency after viral invasion might amplify the dysregulation between the 'adverse' ACE→Angiotensin II→AT1 receptor axis and the 'protective' ACE2→Angiotensin 1-7 →Mas receptor axis. In the lungs, such dysregulation would favor the progression of inflammatory and thrombotic processes triggered by local angiotensin II hyperactivity unopposed by angiotensin 1-7. In this setting, recombinant ACE2, angiotensin 1-7 and angiotensin II type 1 receptor blockers could be promising therapeutic approaches in patients with SARS-CoV-2 infection. [ABSTRACT FROM AUTHOR]

BACKGROUND Men represent a growing segment of the facial aesthetic market. OBJECTIVE To evaluate investigator-assessed efficacy, patient-reported outcomes, and safety after onabotulinumtoxinA treatment of forehead lines (FHL) in men. METHODS Subjects with moderate to severe FHL received onabotulinumtoxinA (frontalis: 20 U; glabellar complex: 20 U, with/without 24 U in crow's feet regions) or placebo in 6-month, double-blind periods of 2 pivotal trials. Results for men were pooled. RESULTS Men comprised 12% (140/1,178) of subjects. Day 30 male responder rates for achieving at least 1-grade Facial Wrinkle Scale (FWS) improvement at maximum eyebrow elevation and at rest were 98.2% and 93.3%, respectively; a significant difference in responder rates was maintained versus placebo (p < .05) through Day 150. Despite men having proportionately more severe FHL at baseline, 81.8% and 79.8% achieved Day 30 FWS ratings of none or mild at maximum eyebrow elevation and at rest, respectively (p < .05); significance versus placebo was maintained through Day 120. Men reported high satisfaction rates and improved psychological impacts. No new safety signals were detected. CONCLUSION Standard dosing and administration of onabotulinumtoxinA significantly improved static and dynamic FHL appearance, despite men having proportionately more severe FHL at baseline. Men reported high satisfaction and appearance-related psychological impact improvements. [ABSTRACT FROM AUTHOR]

BACKGROUND VYC-12 is a novel hyaluronic acid-based dermal filler designed to treat fine lines and improve skin quality. A specialist digital camera and proprietary Digital Analysis of the Cutaneous Surface (DACS) software have previously been used to objectively measure changes in skin features. OBJECTIVE To assess the effect of facial treatment with VYC-12 on skin texture using the specialist camera. MATERIALS AND METHODS This was a prospective, open-label, 2-center study of 40 women aged 35 to 60 years treated with multiple, microdepot intradermal injections of VYC-12 (2 mL in the face; 1 mL in the neck if required). Eight patients (20.0%) required a touch-up at Day 45. Images were acquired using the specialist camera at baseline and 45 days and 6 months after treatment, and were analyzed by DACS. Clinical improvements were also assessed subjectively using the Global Aesthetic Improvement Scale (GAIS). RESULTS VYC-12 improved skin texture from baseline after 45 days (mean improvement: 25.9% 6 9.2%) and 6 months (mean improvement: 30.7% 6 18.2%). Improvements were also evident using the GAIS. There were no major adverse events. CONCLUSIONS VYC-12 improves skin quality, as measured using an objective, fast, and reproducible measuring tool. VYC-12 represents a valuable addition to the treatment armamentarium. [ABSTRACT FROM AUTHOR]

The intervention of a nonparty in pending litigation represents a crucial moment in civil proceedings. Intervention transforms bilateral proceedings into multiparty proceedings such that the interests of the original parties tend to conflict with the interests of the intervenor. This article aims to analyze intervention--and particularly so-called intervention of right--in existing litigation by surveying the main regulatory regimes within civil law and common law systems. Even if the comparative perspective emphasizes similarities and differences among American, French, German, and Italian legal systems, the application of Article Ill's standing requirements per the U.S. Supreme Court's jurisprudence reinforces the role played by a nonparty's interest in intervening in existing litigation. That interest reveals itself as a crucial criterion fo r determining the types of intervention in which multiparty litigation is consistent with policy considerations concerning the length of time and the expense of economic resources by the parties within civil proceedings. [ABSTRACT FROM AUTHOR]

Summary: The accumulation of secondary metabolites and the regulation of tissue acidity contribute to the important traits of grape berry and influence plant performance in response to abiotic and biotic factors. In several plant species a highly conserved MYB–bHLH–WD (MBW) transcriptional regulatory complex controls flavonoid pigment synthesis and transport, and vacuolar acidification in epidermal cells. An additional component, represented by a WRKY‐type transcription factor, physically interacts with the complex increasing the expression of some target genes and adding specificity for other targets. Here we investigated the function of MBW(W) complexes involving two MYBs (VvMYB5a and VvMYB5b) and the WRKY factor VvWRKY26 in grapevine (Vitis vinifera L.). Using transgenic grapevine plants we showed that these complexes affected different aspects of morphology, plant development, pH regulation, and pigment accumulation. Transcriptomic analysis identified a core set of putative target genes controlled by VvMYB5a, VvMYB5b, and VvWRKY26 in different tissues. Our data indicated that VvWRKY26 enhances the expression of selected target genes induced by VvMYB5a/b. Among these targets are genes involved in vacuolar hyper‐acidification, such as the P‐type ATPases VvPH5 and VvPH1, and trafficking, and genes involved in the biosynthesis of flavonoids. In addition, VvWRKY26 is recruited specifically by VvMYB5a, reflecting the functional diversification of VvMYB5a and VvMYB5b. The expression of MBWW complexes in vegetative organs, such as leaves, indicates a possible function of vacuolar hyper‐acidification in the repulsion of herbivores and/or in developmental processes, as shown by defects in transgenic grape plants where the complex is inactivated. Significance Statement: The two R2R3‐MYB paralogs VvMYB5a and VvMYB5b and the WRKY‐type transcription factor VvWRKY26 are involved in the regulation of vacuolar hyper‐acidification during early development of grapevine organs and the alteration of their expression affects morphology, plant development, and pigment accumulation. VvWRKY26 is part of the MYB5‐driven MBWW complexes, enhances the expression of VvMYB5a and VvMYB5b target genes, and is apparently recruited specifically by VvMYB5a, therefore contributing to the functional diversification of VvMYB5a and VvMYB5b. [ABSTRACT FROM AUTHOR]

We develop a numerical algorithm for simulation of wave propagation in linear nonisothermal poroelastic media, based on Biot theory and a generalized Fourier law of heat transport in analogy with Maxwell model of viscoelasticity. A plane wave analysis indicates the presence of the classical P and S waves and two slow waves, namely, the Biot and the thermal slow modes of propagation, which present diffusive behavior under certain conditions, depending on viscosity, frequency, and the thermoelastic constants. The wavefield is computed with a direct meshing method using the Fourier differential operator to calculate the spatial derivatives. We propose two alternative time‐stepping algorithms, namely, a first‐order explicit Crank‐Nicolson method and a second‐order splitting method. The Fourier differential operator provides spectral accuracy in the calculation of the spatial derivatives. Modeling the thermal diffusive mode is relevant for high‐temperature high‐pressure fields and since it leads to mesoscopic attenuation by mode conversion of the fast waves to the thermal waves. Key Points: The differential equations of dynamic thermoporoelasticity are solved with a direct grid methodThe solver is based on the Fourier pseudospectral method to compute the spatial derivativesThe simulation reveals the behavior of four wave modes, namely, the fast P, slow P, S, and the thermal wave-diffusion field [ABSTRACT FROM AUTHOR]

Abstract Multivariate exploratory data analysis allows revealing patterns and extracting information from complex multivariate data sets. However, highly complex data may not show evident groupings or trends in the principal component space, e.g. because the variation of the variables are not grouped but rather continuous. In these cases, classical exploratory methods may not provide satisfactory results when the aim is to find distinct groupings in the data. To enhance information extraction in such situations, we propose a novel approach inspired by the concept of combining weak classifiers, but in the unsupervised context. The approach is based on the fusion of several adjacency matrices obtained by different distance measures on data from different analytical platforms. This paper is intended to present and discuss the potential of the approach through a benchmark data set of beer samples. The beer data were acquired using three spectroscopic techniques: Visible, near-Infrared and Nuclear Magnetic Resonance. The results of fusing the three data sets via the proposed approach are compared with those from the single data blocks (Visible, NIR and NMR) and from a standard mid-level data fusion methodology. It is shown that, with the suggested approach, groupings related to beer style and other features are efficiently recovered, and generally more evident. Graphical abstract Image 1 Highlights • A new approach to enhance information extraction from highly complex datasets is proposed. • The approach is based on the fusion of adjacency matrices obtained from different clustering strategies. • Information extracted from different data blocks is fused, so the approach can also be a method for high-level data fusion. • Visible, NIR and NMR data of beer samples are used as a benchmark for testing the approach. • The approach can highlight groups in a better way than the single-block and mid-level data-fusion approaches. [ABSTRACT FROM AUTHOR]

Aim: To assess the predictive validity of the Functional Evaluation of Eating Difficulties Scale (FEEDS) on long-term eating developmental outcomes in infants with neurodevelopmental disorders.Method: In total, 144 infants (69 females, 75 males) aged 0 to 12 months (mean [SD] 5.34mo [3.42]) with neurodevelopmental disorders and requiring enteral nutrition support, hospitalized between January 2004 and December 2017, were included. The FEEDS was administered at the onset of hospitalization. Follow-up evaluations of feeding modalities occurred at discharge and at 6 months, 12 months, and 24 months after discharge. FEEDS score was tested as a predictor of infants' feeding modality (percutaneous endoscopic gastrostomy, nasogastric tube, mixed, oral feeding) and time to autonomous oral feeding. Percentages of false-positive and negative cases were checked.Results: Lower FEEDS scores significantly predicted infants' feeding modality (0.40≤R2 ≤0.61). A 1-point increase in FEEDS score was associated with increased risk (6%-14%; p<0.05) of being non-autonomous feeders at the different follow-up points in infants who had a FEEDS score above the clinical cut-off.Interpretation: The FEEDS appears to be a clinically valid assessment to predict the presence of eating difficulties in infants with neurodevelopmental disabilities.What This Paper Adds: Functional Evaluation of Eating Difficulties Scale (FEEDS) significantly predicted eating difficulties in infants with neurodevelopmental disabilities. Lower FEEDS score is significantly associated with autonomous feeding at the 24-month follow-up. FEEDS cut-off identified infants at low-risk and high-risk for eating disorder. [ABSTRACT FROM AUTHOR]

The crosstalk of two major heart cell groups, cardiomyocytes and fibroblasts, relies on direct electromechanical cellular coupling as well as indirect mechanical signal transmission through the surrounding viscoelastic extracellular matrix. Upon injury of cardiac tissue, this communication becomes unbalanced: fibrosis is initiated leading to increased collagen deposition, accompanied by an activation of fibroblasts – the key players of fibrosis. They undergo a reorganization or partial transformation to myofibroblasts during this process, which precedes scar formation within the infarcted heart in vivo. Here, we induce wound formation in an in vitro system as a model for these fibrotic conditions: we assessed the dynamics of wound healing in co-cultures of fibroblasts and myocytes upon targeted wound initiation using Electric Cell Substrate Impedance Sensing (ECIS) under optical control. We discovered distinct wound closure dynamics for mono- and co-cultures of myocytes and fibroblasts and observed a cessation of the contractile behavior for recovering cardiomyocyte cultures. We furthermore identified a change of cellular impedance for recovering fibroblasts and the presence of α-SMA, suggesting a partial transformation into myofibroblasts. This was concomitant with a modulation of connectivity, cell-substrate dynamics and membrane capacitance of all wounded cell cultures. Qualitatively, connexin 43 observation confirmed the ECIS trend found for cell-cell connectivity. Finally, we were able to validate the ECIS based wounding approach against an ECIS based barrier assay – the so-called electric fence. In particular the cell-cell connectivity and thus cell layer integrity dominates the healing dynamics within the two intrinsically different assays. [ABSTRACT FROM AUTHOR]

Purpose: This study seeks to understand the mediating effects of mindfulness on self-efficacy, academic performance and ability to cope with pain. It further examines the effect of mindfulness on the capacity to cope with pain-induced stress. Whilst there are physiological changes which occur due to mindfulness, it is still not clearly understood how the mechanisms behind mindfulness work or whether the role of self-efficacy is an agent of mindfulness which may impact on performance and stress coping. Participants and methods: A three-part study (n=92) was conducted to test the relationship between mindfulness, self-efficacy and well-being factors, alongside academic performance in university students. Part one involved data collection one month prior to an experiment where trait scores for all factors were used to check pain and well-being behaviors. Part two consisted of participant randomization into three intervention groups (control, sham, mindfulness) and then an exposure to a fear induction task followed by cognitive tasks. The third part consisted of investigating the effect of a short mindfulness intervention on self-efficacy, pain and well-being in students. Results: The results indicate that self-efficacy had a positive effect on well-being factors (study 1 & 3) and in the experiment (study 2). Conclusion: Self-efficacy influenced pain intensity and pain unpleasantness and significantly predicted academic performance. Mindfulness had mixed results in how it influenced self-efficacy. While it influenced well-being and lowered stress (study 1 & 2) in the long term, the mindfulness intervention significantly decreased self-efficacy. [ABSTRACT FROM AUTHOR]

The electrical properties of high-purity 4H–SiC epitaxial layers are investigated. The current density versus applied voltage curves shows that some specimens have space charge limited transport behavior. Lampert–Mark model for trap-controlled electron transport in semi-insulating materials demonstrated the presence of an intragap state at 0.26 eV below the conduction band. Photodeep level transient spectroscopy has confirmed the presence of a deep level at about 0.3 eV below the conduction band only in samples with non-Ohmic behavior. Cathodoluminescence imaging has revealed the presence of high luminescent areas related to stacking faults (SFs) under the devices showing non-Ohmic behavior. The presence of single-layer SFs was detected by cathodoluminescence spectroscopy due to the typical emission at 2.95 eV. Thus, we demonstrated that the SFs modified the charge transport from Ohmic conduction to space charge limited conduction of the affected samples. [ABSTRACT FROM AUTHOR]

The potential energy curves of the ground state and of some excited states of the manganese dimer have been calculated over a wide range of internuclear distances using the second order n-electron valence state perturbation theory applied to a complete active space self-consistent field reference wave function. The ground state of Mn2, for which also the third order NEVPT has been used, is calculated to be a singlet belonging to the Σg+ symmetry, characterized by a large equilibrium internuclear distance Re of 3.7–3.8 Å, by a low dissociation energy De of 0.07–0.08 eV, and by a small harmonic frequency ωe of 43 cm-1. The experimental evidence that Mn2 is a van der Waals molecule is thus confirmed. Among the excited states, 11Πu, which is usually indicated as the ground state by density functional theory studies, appears as a low-lying state with Re=2.50 Å, De=1.35 eV, and ωe=246 cm-1. [ABSTRACT FROM AUTHOR]

Toxoplasmosis, caused by the protozoan parasite Toxoplasma gondii, is a globally distributed zoonotic infection with significant implications for human and animal health. This study investigated the prevalence of T. gondii infection in a population of beef cattle at three different stages of their productive lifespan and examined the impact of T. gondii serological status on blood parameters. A commercial beef fattening unit in Italy was the setting for this research, which involved a biosecurity assessment upon cattle arrival, blood sampling at three time points and Toxoplasma-specific serological testing using indirect fluorescent antibody tests (IFAT). Results revealed a dynamic pattern of T. gondii seropositivity in cattle, with an initial prevalence of 30.6% at arrival (T0) that increased to 44.6% at 14 days (T1) and then decreased slightly to 39.3% at slaughter after 5 months (T2). Interestingly, seroconversion was observed during the study, indicating ongoing infections, and antibody waning occurred in some animals. In terms of blood parameters, seropositive cattle exhibited significantly lower mean corpuscular volume (MCV) and a higher neutrophil–lymphocyte (N/L) ratio, suggesting an activation of the innate immune response. Furthermore, cattle with higher antibody titres displayed higher neutrophil counts. However, all blood parameters with a statistical significance were within the reference range. This study provides for the first time a longitudinal investigation on the serological status for T. gondii in naturally exposed beef cattle. These findings provide valuable insights into the clinico-pathological aspects of natural T. gondii exposure in cattle and underscore the importance of monitoring and managing T. gondii infection in livestock production systems. [ABSTRACT FROM AUTHOR]

Simple Summary: The tiger beetle, Cicindelidia haemorrhagica (LeConte), occurs in the western USA and is associated with wet salt lakes. However, in Yellowstone National Park (YNP) it was observed in a thermal pool in 1891. We examined multiple thermal and non-thermal areas in YNP and discovered that C. haemorrhagica was exclusively associated with thermal springs, both alkaline (as high as pH 9.5) and acid (as low as pH 2.7) and at temperatures as high as 70 °C. Ultimately, we identified 17 locations with C. haemorrhagica populations. We estimated population sizes at multiple springs as greater than 500 individuals at each site. Additionally, we noted that beetles occurred both in the (hot) water of thermal springs and within 8 m of the spring. We observed the tiger beetle species, Cicindelidia haemorrhagica (LeConte), foraging in and reproducing near the thermal pools of Yellowstone National Park (YNP). Although this species was recorded in YNP more than 130 years ago, its distribution, ecology, and association with thermal features are unknown. Therefore, we examined the distribution and habitat characteristics of C. haemorrhagica and evaluated methods for studying its abundance. Given the extreme environments in which these beetles live, typical methods to estimate abundance are challenging. We used a series of presence/absence studies and observations to assess distribution and recorded temperature and pH measurements to determine habitat characteristics. We also conducted visual counts, light trapping, and mark/recapture experiments to assess abundance. The inability to capture C. haemorrhagica with lights led to a phototaxis experiment, which showed minimal attraction to light. Cicindelidia haemorrhagica was found throughout YNP, but it was exclusively associated with thermal springs. The thermal springs ranged from pH 2.7 to 9.0 with temperatures from 29.1 to 75.0 °C and had varying metal concentrations in soil and water. However, all thermal springs with C. haemorrhagica had barren soil with a gradual slope toward the thermal water. Specifically, habitats were thermal pools with gradual margins (a less than five-degree slope) and thermal (i.e., heated) soils for larval burrows by thermal springs or pools. Population sizes of C. haemorrhagica ranged between 500 and 1500 individuals based on visual counts. [ABSTRACT FROM AUTHOR]

The potential energy curves of the molecules Mo2, W2, and CrMo have been studied ab initio using large basis sets and the “n-electron valence state perturbation theory” up to the third order in the energy. The third order results for Mo2 and W2 reproduce the equilibrium distances re and the harmonic frequencies ωe in fairly good accordance with the experimental values but tend to underestimate the dissociation energy. The CrMo molecule, for which experimental dissociation energy data do not exist yet, is predicted to have a value for De of ≈2.5 eV. [ABSTRACT FROM AUTHOR]

The effects of low-temperature annealing in 8.2 MeV electron-irradiated 4H-SiC Schottky diodes were investigated. Deep-level transient spectroscopy and minority-carrier diffusion length (Ld) measurements were carried out on not-irradiated samples and on irradiated samples before and after thermal treatments up to T=450 °C. We found that several deep levels in the upper half band gap (S1 with enthalpy ET=0.27 eV, S2 with ET=0.35 eV, S4 with ET=0.71 eV, and S5 with ET=0.96 eV) anneal out or modify at temperature values lower or equal to T=450 °C, whereby their progressive annealing out is accompanied by a net increase of Ld, up to 50% of the value in the as-irradiated sample. We drew some conclusions regarding the microscopic nature of the defects related to the deep levels, according to their annealing behavior. [ABSTRACT FROM AUTHOR]

The Source for Production of Ions of Deuterium Extracted from a Radiofrequency plasma (SPIDER) is the 100 keV full-size Ion Source prototype of the International Thermonuclear Experimental Reactor (ITER) Neutral Beam Injectors (NBI), currently in operation at Consorzio RFX in Padova, Italy. The SPIDER vacuum pumping system is designed to operate at a nominal gas pressure of 0.3 Pa inside the Beam Source (BS), and it consists of two primary pumping groups, four turbo-molecular pumps, and eight cryogenic pumps. However, during the first three years of SPIDER operations, it was found that increasing the BS pressure to 0.6 Pa was necessary to achieve nominal performance. Additionally, a specific experimental study conducted in 2019 revealed the existence of a pressure limit in the SPIDER Vacuum Vessel (VV) that must be respected to reduce the probability of Radio Frequency breakdown. These two factors have necessitated an upgrade to the current vacuum pumping system. To address the issue of limited space for installing new pumps, a Vacuum Enhancement Module (VEM) will be added to the existing SPIDER Vacuum Vessel (VV). The VEM will house up to 512 Non-Evaporable Getter (NEG) pump cartridges in 16 × 32 modules. The pumps will need to be regenerated at temperatures up to 600 °C for up to 72 h to extract the hydrogen isotopes absorbed during operation. To prevent the heating of surrounding parts, such as the SPIDER Beam Source (BS) and electrical connections, a dedicated cooling system is required to cool down the VEM components during the NEG regeneration process. This paper presents a thermal-hydraulic study, design, and analysis of the cooling system for the VEM using Computational Fluid Dynamics (CFD) analyses. [ABSTRACT FROM AUTHOR]

The effects on 4H-silicon carbide epilayers of irradiation with protons and electrons having particle energies, respectively, of 6.5 and 8.2 MeV were carefully studied and critically compared. In detail, the electronic levels associated with the irradiation-induced defects were analyzed by current-voltage characteristics and deep-level transient spectroscopy (DLTS) measurements up to 550 K. In the same temperature range the apparent free-carrier concentration was measured by capacitance-voltage characteristics in order to monitor compensation effects due to the deep levels associated with the induced defects. Introduction rate, enthalpy, and capture cross section of such deep levels were compared. We found that a set of deep levels (at ET=0.39 eV, ET=0.65 eV, and ET=0.75 eV) is the same in both cases of proton and electron irradiations, whereas two other pairs of levels (S1, ET=0.20 eV and S1*, ET=0.23 eV; S5, ET=1.09 eV and S5*, ET=0.89 eV) appearing in the same temperature range within the DLTS spectra should be associated with different defect complexes according to the irradiation type. Some conclusions regarding the microscopic nature of the defects related to the deep levels have been drawn. [ABSTRACT FROM AUTHOR]

The distribution of the electric field and its spatial extent are key predictors of the charge collection efficiency of particle detectors. The electric field is strictly related to the electrically active defects, which are significantly modified by irradiation. In this paper we analyze the native and radiation-induced defects and infer the mechanisms controlling the electrical properties of semi-insulating GaAs Schottky diodes. The correlation between the electric-field distribution and deep levels confirms that the compensation mechanisms are mainly due to the donorlike centers and to their enhanced neutralization, which occurs for moderately high electric fields. Moreover, taking into account the charge balance among native and irradiation-induced defects, the active region extent is predicted. [ABSTRACT FROM AUTHOR]

The features of current deep level transient spectroscopy (I-DLTS) spectra are investigated in AlGaAs/GaAs heterostructure field-effect transistors both through experiments and two-dimensional numerical device simulations. Differently from electron traps located in the n-type semiconductor bulk, which can only be detected in emission-mode by I-DLTS, deep levels located at the ungated device surface are shown to be revealed both in emission and capture transients by I-DLTS. Experimental and simulation results indicate that this behavior originates from inherent physical properties of surface deep levels interacting with holes attracted at the ungated surface by the negative charge associated with ionized traps. © 2003 American Institute of Physics. [ABSTRACT FROM AUTHOR]

We present a study of the effects of high and low energy neutron irradiation on CdTe and CdZnTe high resistivity detector grade material. The evolution of the defect states under increasing irradiation fluence has been monitored by means of photoinduced current transient spectroscopy analyses. Particular attention is placed on the comparison and correlation between the results from the two materials under the two different neutron irradiation energies. The behavior of the observed deep traps associated with defect states allowed us to attribute an origin to most of them and to understand the role they play in the charge carrier collection process and in the degradation of material spectroscopic capabilities. © 2003 American Institute of Physics. [ABSTRACT FROM AUTHOR]

This article concerns the existence of a double-junction effect in proton-irradiated silicon p[sup +] υ-n[sup +] (pin) diodes demonstrated by surface potential and optical-beam-induced current (OBIC) investigations. By increasing the diode biasing, the junctions existing at both ends in the irradiated devices move towards each other up to join, hence, causing a full depletion of the diodes. Due to the inhomogeneity of the electric field, however, the charge-carrier collection is strongly dependent on the position. The extent of the diode depletion layers at both ends and the shape of the electric field within the p[sup +]-υ-n[sup +] diodes are determined as a function of the bias applied. Three-dimensional photocurrent maps obtained by OBIC profiles allow for imaging the double junction. The deep level analysis evidences the presence of irradiation-induced defects, which are responsible for the double-junction effect. [ABSTRACT FROM AUTHOR]

Presents information on the study which investigated the electrical and optical characteristics of Erbium-doped silicon by liquid phase epitaxy. Experimental details; Results and discussion; Conclusions.

Cancer progression is strictly dependent on the relationship between tumor cells and the surrounding stroma, which supports cancer malignancy promoting several crucial steps of tumor progression, including the execution of the epithelial to mesenchymal transition (EMT) associated with enhancement in cell invasion, resistance to both anoikis and chemotherapeutic treatments. Recently it has been highlighted the central role of microRNAs (miRNAs) as regulators of tumor progression. Notably, in several tumors a strong deregulation of miRNAs is observed, supporting proliferation, invasion, and metabolic reprogramming of tumor cells. Here we demonstrated that cancer‐associated fibroblasts induce a downregulation of miR‐1247 in prostate cancer (PCa) cells. We proved that miR‐1247 repression is functional for the achievement of EMT and increased cell invasion as well as stemness traits. These phenomena contribute to promote the metastatic potential of PCa cells as demonstrated by increased lung colonization in in vivo experiments. Moreover, as a consequence of miR‐1247 downregulation, we observed a correlated increased expression level of neuropilin‐1, a miR‐1247 target involved as a coreceptor in the epidermal growth factor receptor signaling. Taken together, our data highlight miR‐1247 as a potential target for molecular therapies aimed to block the progression and diffusion of PCa. Diagrammatic summary of the molecular basis of miR‐1247 action in prostate cancer (PCa) cells. Cancer‐associated fibroblast (CAF)‐induced miR‐1247 downregulation promotes invasion, stemness, and metastatic dissemination of PC3 cells, thus sustaining tumor progression [ABSTRACT FROM AUTHOR]

We provide a new derivation of the Kramers-Kronig relations on the basis of the Sokhotski-Plemelj equation with detailed mathematical justifications. The relations hold for a causal function, whose Fourier transform is regular (holomorphic) and square-integrable. This implies analyticity in the lower complex plane and a Fourier transform that vanishes at the high-frequency limit. In viscoelasticity, we show that the complex and frequency-dependent modulus describing the stiffness does not satisfy the relation but the modulus minus its high-frequency value does it. This is due to the fact that despite its causality, the modulus is not square-integrable due to a non-null instantaneous response. The relations are obtained in addition for the wave velocity and attenuation factor. The Zener, Maxwell, and Kelvin-Voigt viscoelastic models illustrate these properties. We verify the Kramers-Kronig relations on experimental data of sound attenuation in seabottoms sediments. [ABSTRACT FROM AUTHOR]

Background: The existing classifications of varicocoeles have poor predictive value regarding the effects of surgery on sperm count. Objective: To develop a new grading system for varicocoeles, useful as an indication for surgery. Materials and methods: This is a three‐center prospective study which examined 173 men having clinically detectable left varicocoeles and oligo ± astheno ± terato‐spermia. The patients underwent medical history collection, objective examination, duplex Doppler ultrasound scrotal examination, hormonal profiles, two semen analyses before surgery, and two semen analyses after surgery. Sperm concentration, motility, and morphology (standard semen parameters) were evaluated 6 months after surgery in function of the following preoperative variables: patient age, follicle‐stimulating hormone, clinical grade of varicocoele, right and left testicular volume, extension of venous reflux, and semen parameters. The venous reflux was graded in two centers using duplex Doppler ultrasound: reflux visible only with Valsalva and continuous reflux. Spearman's rank semiquantitative analysis was used. All patients had their varicocoeles corrected according to the Colpi technique. Results: The variables capable of determining an improvement in semen parameters after varicocoele correction were in order of decreasing importance: venous reflux extent assessed by scrotal duplex Doppler ultrasound examination, varicocoele clinical grade, basal semen parameters, and follicle‐stimulating hormone. Male age did not influence postoperative semen quality. Only patients with continuous reflux had their standard semen parameters improved after surgery. Discussion: Venous reflux extent is the most critical variable capable of predicting semen improvement after varicocoelectomy. Conclusions: A correct duplex Doppler assessment of venous reflux is mandatory for predicting postoperative improvement of the sperm count. [ABSTRACT FROM AUTHOR]

Background: Photo‐numeric scales could lack precision and objectivity on evaluating the improvements on wrinkles after a treatment with botulinum toxin type A. The authors suggest a new digital evaluation method to analyze its effectiveness. Objectives: This study aims to investigate retrospectively the effect of intramuscular injection of botulinum toxin type A on skin texture in the lateral peri‐orbital region with a new objective method. Methods: Skin texture roughness (STR) in the lateral peri‐orbital region is evaluated with a multi‐directional light beam by light emitting diodes of different wavelengths (Antera 3D®), before and after injections of 12 units of botulinum toxin type A. The wrinkles and lines deeper than 0.5 mm are filtered to measure accurately skin texture. Results: We observed an improvement of STR in all cases treated with botulinum toxin type A. A significant decrease of STR was recorded as follows: 17.08% (P < .0001) at 4 weeks and 12.14% at 4 months (P = .001). Conclusion: Botulinum toxin type A treatment of crow's feet was able to improve STR. The Antera® device and software are a valuable, objective, easy and reproducible method to assess the effects of the toxin. [ABSTRACT FROM AUTHOR]

Background: Although physical treatment is recognized as being beneficial for patients with Parkinson's disease (PD), there is scant literature on the type of rehabilitation program most useful for patients with PD. The aim of the present study was to investigate the effects of two different training protocols (aerobic treadmill training, AER and whole body vibration training, WBVT) on energy cost and adaptations after exercise and recovery phases, by means of the oxygen consumption measurement and the assay of metabolic biochemical substrates.Methods: Twenty male patients with idiopathic Parkinson's disease, aged 51-66 years, were enrolled. Patients were randomly assigned to the training groups. The total work time was 20 min per group for 4 weeks, four times a week. In both groups, training intensity was monitored by the ratings of perceived exertion (RPE). Workload was gradually increased until patients worked up to the exertion level of 13 to 15 on the 20-point Borg scale RPE. The outcome measures were oxygen consumption, free fatty acid (FFA), and amino acid (AA) levels.Results: The oxygen consumption during exercises does not show significant differences between the two training groups. Instead, only in the AER group, excess post-exercise oxygen consumption measurements increased significantly (p < 0.01) as well as FFA availability (p < 0.01).Conclusion: The WBVT does not appear to require a long time of recovery and leads to less feeling of fatigue, whereas AER needs an appropriate recovery time after the training session. [ABSTRACT FROM AUTHOR]

Abstract Spin crossover compounds are multifunctional switching materials that change their spin state and many other physical properties, such as colour, magnetic susceptibility, electric conductivity, dielectric constant and mechanical properties, upon external stimuli. Spin crossover materials have been proposed for a variety of technological applications that require the elaboration of highly controlled thin films and patterns. Here, we present a brief overview of the most diffused approaches for thin film growth and patterning, showing both conventional and unconventional approaches and the most recent advancement in their applications, highlighting the most promising cases and the most critical problems. [ABSTRACT FROM AUTHOR]

Limiting feeding time has been a concept used in growing and nonlactating ruminant animals with good success, especially in improving feed efficiency while maintaining normal rumen function and fiber digestibility. This study evaluated the physiological and productive responses of cows fed a total mixed ration (TMR) available for 24 or 19 h/d with or without access to additional long hay. Eight multiparous Holstein cows were used in a replicated 4 × 4 Latin square design with 21-d periods. Rations were formulated to mimic a TMR used in the Parmigiano Reggiano cheese production area of Italy, consisting of all dry and nonfermented components. Intakes were reduced by 2.49 kg/d in cows with restricted TMR access and 1.16 kg/d without supplemental hay. Rumen characteristics were similar for all groups with improvements in energy-corrected milk. The results show that once cows adapted to diet changes, few differences were observed when offering TMR continuously or with limited access. Energy-corrected milk feed efficiency was improved in cows having access to feed 19 versus 24 h/d. In addition, the presence of long hay during the TMR restriction offered the optimal conditions for ruminal function and pH stability, yet no effects were observed on body weight change. A Latin square with 21-d periods could have a carry-over effect on energy storage, and mobilization of fat reserves might be able to mask negative energy balance during restriction. Restricted feeding could be used as a strategy to manage feed availability according to cow production and metabolic condition, to maximize the use of nutrient resources, reducing the cost of milk production and improving the cows' welfare and health. [ABSTRACT FROM AUTHOR]

Abstract Although the cross-kingdom transfer of vegetable miRNAs (miRNAs) in mammalian species, including humans, is still controversial, recent studies have rejected this theory. Based on these recent studies, we hypothesized that artichoke-derived miRNAs (cca-miRNAs) are not adsorbed into human intestinal cells after cooking and in vitro digestion. In order to test this hypothesis, we evaluated miRNA (cca-miRNAs) in the edible part of globe artichokes (head portion), after cooking and digestion by an in vitro digestion system. The cca-miRNA levels were analyzed by real-time PCR (RT-qPCR), and those that withstood cooking and digestion conditions were further analyzed for their bioavailability using an in vitro system (Caco-2/TC7 cell clone). We detected 20 cca-miRNAs after cooking, 5 of which were statistically down-regulated in comparison with uncooked samples. Only 4 cca-miRNAs were found after in vitro digestion. By using scanning electron microscopy (SEM), we also evaluated the extracellular vesicles (EVs) in homogenized artichoke as possible miRNA transporters. However, approximately 81% were degraded after cooking, while the remaining EVs had changed shape from round to elliptical. Finally, we detected no cell-free cca-miRNAs, miRNAs bound to protein complex, and no cca-miRNAs encapsulated in EVs inside Caco-2 cells or in basolateral medium after bioavailability experiments. In conclusion, the data from the present study agrees with recent findings that the human small intestine does not uptake dietary miRNAs from raw or cooked artichoke heads. [ABSTRACT FROM AUTHOR]

Summary: Background: The aesthetic treatment of facial and neck wrinkles with botulinum toxin is constantly increasing, thus making it necessary to collect procedures guidelines for the use of botulinum toxin in the treatment of wrinkles and/or cosmetic defects. Methods: A group of nine Italian doctors, plastic and maxillo‐facial surgeons, dermatologists and aesthetic physicians, experts in face and neck aesthetic treatments with onabotulinum toxin A, discussed on procedures used in their clinical practice. From the data collected and discussed by the board, some recommendations on aesthetic treatment with onabotulinum toxin A were developed. Results: Recommendations have been made on pretreatment, reconstitution of onabotulinum toxin A, as well as on treatment procedures, in terms of injection sites and total dose of onabotulinum toxin A for the following indications: glabellar lines, crown's feet lines, forehead lines, eyebrow shaping, lower orbicularis oculi hypertrophy, bunny lines, sagging nasal tip, gummy smile, masseter hypertrophy, perioral lines, marionette lines, hypertonic mentalis, and platysma bands. Conclusions: The use of onabotulinum toxin A in the aesthetic field requires careful initial assessment of the patient in its complexity and individuality. Moreover, this treatment needs the use of standardized procedures to achieve the effectiveness and safety of onabotulinum toxin A in clinical practice. [ABSTRACT FROM AUTHOR]

Presents an experiment which investigated the levels which are present in semiconducting Cadiminum/Tellurium (Cd/Te) and semi-insulating Cd/Te:Chlorine and (Cd0.8Zn0.2Te) by means of cathodoluminescence. Indepth look at the experiment; What the results showed.

Presents a study that investigated the EL2 trap in highly doped gallium arsenide:tellurium. Method of the study; Results and discussion; Conclusion.

Presents a study which investigated the distribution in liquid-encapsulated-Czochralski GaAs:Te wafers of point and complex defects together with their influence on the minority-carrier diffusion length. Characteristics of the wafers of liquid-encapsulated-Czochralski gallium arsenide tellurium doped; Methods used; Results of the study.

Investigates the defective states induced in floating zone silicon by the heavy diffusion of dopants by means of the electron beam-induced current (EBIC) method. Evolution of the electrical and morphological properties of the induced defects; Role of aluminum in the electrical activity of bulk defective states; Sample mounting geometries utilized for EBIC analyses.

Presents information on a study that determined the diffusion length and surface recombination velocity of the minority carriers from electron beam induced current profiles on a semiconductor containing a barrier perpendicular to the scanned surface. Methodology of the study; Results and discussion on the study.

Presents a study which obtained the diffusion length of minority in n-type floating-zone silicon samples with the electron-beam-induced current technique in planar configuration. Background on the moment method; Experimental procedures; Results of the study.

• PSG is a reliable and safe tool that allows the precise quantification of night rest and to evaluate its architecture. • Changes in sleep architecture appear to be sensitive markers of clinical changes during a manic episode of bipolar disorder. • Sleep management during the manic episode is confirmed as a primary clinical objective. Sleep plays a key role in the pathogenesis and clinical presentation of mood disorders. However, only a few studies have investigated sleep architecture during the manic episodes of Bipolar Disorder (BD) and changes in sleep parameters that follow clinical variations. Twenty-one patients (8 males, 13 females) affected by BD, manic phase, underwent polysomnographic recordings (PSG) at the beginning of the admission in our ward (T 0) and after three weeks of hospital treatment (T 1). All participants were clinically evaluated using Young Mania Rating Scale (YMRS), Pittsburgh Sleep Quality Index (PSQI) and Morningness-Eveningness Questionnaire (MEQ). During the admission, we observed an increase in both quantity (Total Sleep Time - TST) and quality (Sleep Efficiency - SE) of sleep. In addition, clinical improvement, evaluated with YMRS and PSQI scales, was accompanied by a significant increase in the percentage of REM sleep. According to our findings, the improvement of manic symptoms is accompanied by an increase in "REM pressure" (increase in REM% and REM density, reduction of REM latency). Overall, changes in sleep architecture appear to be markers sensitive to clinical variations during manic phases of Bipolar Disorder. [ABSTRACT FROM AUTHOR]

Background: Supraventricular tachycardias (SVTs), despite having various anatomical substrates and pathophysiological mechanisms, frequently show similar electrocardiographic presentations. Objectives: To locate and characterize atrial deflections (ADs) on 12‐lead electrocardiograms in dogs with sustained rapid SVT and assess the utility of different electrocardiographic variables in differentiating types of tachycardia. Animals: Ninety‐two dogs with orthodromic atrioventricular reciprocating tachycardia, 17 with atrial flutter, 33 with focal atrial tachycardia recorded and confirmed by electrophysiological study, and 40 dogs with sinus tachycardia. Methods: Atrial deflection position on the 12‐lead surface electrocardiogram was assessed according to the sequence of intracardiac activation. Its features were evaluated together with the relationship between AD and QRS complex interval (AD‐R) and QRS complex and AD interval (R‐AD). Results: Orthodromic atrioventricular reciprocating tachycardia was characterized by an AD‐AD interval of 213 ± 30 ms, mean electrical axis (MEA) of AD of −90 (−90/−78)°, R‐AD interval of 75 (65‐80) ms, and R‐AD/AD‐R of 0.54 (0.45‐0.64). Atrial flutter was characterized by an AD‐AD interval of 199 ± 57 ms, MEA of 76° (72/81), R‐AD of 120 (72‐144) ms, and R‐AD/AD‐R of 0.81 (0.63‐1.13). Focal atrial tachycardia was characterized by an AD‐AD interval of 270 ± 38 ms, MEA of 49 (−72/76)°, R‐AD of 160 (120‐200) ms, and R‐AD/AD‐R of 1.45 (0.92‐1.67). Sinus tachycardia was characterized by an AD‐AD interval of 292 ± 31 ms, MEA of 66° (52/73), R‐AD of 215 (192‐222) ms, and R‐AD/AD‐R of 2.68 (2.25‐3.08). Conclusions and Clinical Importance: Analyzing AD on 12‐lead electrocardiogram is helpful in differentiating the most common SVTs in dogs. [ABSTRACT FROM AUTHOR]

The reliability of low-voltage inverter-fed motors is highly dependent on the inception of partial discharges. The effect of impulsive waveform parameters must be investigated to predict the repetitive partial discharge inception voltage (RPDIV) and define test procedures that can indicate properly the behavior in service of the insulation system. This paper focuses on the RPDIV of magnet wires using twisted pairs subjected to repetitive unipolar impulsive voltage waveforms. The effects of supply frequency (5 to 200 kHz) at pressure levels that are typical for aircraft (20 to 100 kPa) is examined. Results show that RPDIV steadily decreases with frequency up to 100 kHz where it reaches a plateau. This behavior is explained as an effect of the oscillations that inevitably exist in the applied voltage waveform. Therefore, a conservative estimate of the RPDIV could be achieved by raising the supply frequency well above the operation frequency. In the experiments, the RPDIV is decreasing linearly with pressure. If this behavior could be confirmed for other insulation systems, the design of systems working at pressures typical of aircraft would result relatively easy. [ABSTRACT FROM AUTHOR]

B-cell receptor (BCR) signaling is a key determinant of variable clinical behavior and a target for therapeutic interventions in chronic lymphocytic leukemia (CLL). Endogenously produced H2O2 is thought to fine-tune the BCR signaling by reversibly inhibiting phosphatases. However, little is known about how CLL cells sense and respond to such redox cues and what effect they have on CLL. We characterized the response of BCR signaling proteins to exogenous H2O2 in cells from patients with CLL, using phosphospecific flow cytometry. Exogenous H2O2 in the absence of BCR engagement induced a signaling response of BCR proteins that was higher in CLL with favorable prognostic parameters and an indolent clinical course. We identified low catalase expression as a possible mechanism accounting for redox signaling hypersensitivity. Decreased catalase could cause an escalated accumulation of exogenous H2O2 in leukemic cells with a consequent greater inhibition of phosphatases and an increase of redox signaling sensitivity. Moreover, lower levels of catalase were significantly associated with a slower progression of the disease. In leukemic cells characterized by redox hypersensitivity, we also documented an elevated accumulation of ROS and an increased mitochondrial amount. Taken together, our data identified redox sensitivity and metabolic profiles that are linked to differential clinical behavior in CLL. This study advances our understanding of the redox and signaling heterogeneity of CLL and provides the rationale for the development of therapies targeting redox pathways in CLL. [ABSTRACT FROM AUTHOR]

Objectives Recurrent varicose veins following surgery is a common, complex and costly problem in vascular surgery. Treatment for RVV is technically more difficult to perform and patient satisfaction is poorer than after primary interventions. Nevertheless, traditional vein surgery has largely been replaced by percutaneous office-based procedures, and the patients with recurrent varicose veins have not benefited from the same advantages. In this paper, we propose an endovascular laser treatment that allows reducing the invasiveness and complications in case of SFJ and SPJ reflux after ligation and stripping of the great and small saphenous vein. Methods 8 SFJ and 1 SPJ stumps were treated by endovascular laser treatment in out-patient clinic. Endovascular laser treatment was performed with a 1470 nm diode laser and a 400 µc radial slim™ fiber. Intraoperative ultrasoud was used to guide the fiber position and the delivery of tumescent anesthesia. The gravity of chronic venous disease was determined according to the CEAP classification and the severity of symptoms was scored according to the revised Venous Clinical Severity Score (VCSS). Results The average linear endovenous energy density was 237 J/cm. Patients return to daily activities after a mean of 1.9 days after. The VCSS improved drastically from a mean of 8 pre-interventional to 1 at day 30 and until one year. During the follow-up period (mean 8 months, range: 5–17 months), all the stumps except one were occluded. All patients were very satisfied or satisfied with the method. No severe complications occurred. Conclusions Office-based endovascular laser treatment of groin and popliteal recurrent varicose veins with 1470 nm diode laser and radial-slim fiber is a safe and highly effective option, with a high success rate in the early post-operative period. [ABSTRACT FROM AUTHOR]

Family history events have been shown to be reliable predictors of eating and body image concerns; however, little is known regarding how family history events compare in a clinical sample, or if these events differ by gender. The current study addresses this paucity, focusing on 3,129 university students seeking clinical services. Having a family member with an eating problem was the most consistent family history predictor across all severity levels. Men and women demonstrated different family history predictors, indicating possible separate pathways to eating or body image concerns based on gender. [ABSTRACT FROM PUBLISHER]