286 results on '"Hideaki Nakagawa"'
Search Results
2. Characteristics of smoking cessation in former smokers in a rural area of Japan
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Koshi Nakamura, Masaru Sakurai, Muneko Nishijo, Yuko Morikawa, and Hideaki Nakagawa
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Counseling ,Japan ,motivation ,pharmacological therapy ,smoking cessation ,Medicine - Abstract
Objectives: Japan has a relatively high prevalence of smoking in men. Despite the importance of behavioral patterns on successful smoking cessation, only limited information is available in Japan. The present study collected data from former smokers in a rural community in Japan in order to identify health status at the time of cessation, predominant motivating factors, and the role of smoking cessation aids in individuals who successfully stopped smoking. Methods: This cross-sectional study collected data using a self-reported questionnaire from 149 randomly-selected former smokers (119 men and 30 women, aged 20-79 years) who were residents of Nanao, Ishikawa Prefecture, Japan. Results: Of the male participants, 14.3% quit due to serious personal health problems, including cardiovascular disease, cancer, or respiratory tract disease, while 20.8% of former smokers experienced mild personal health problems or were pregnant at the time of cessation. An approximately equal number stopped smoking due to fear of illness in the absence of immediate health concerns. Compared to personal health motivations, a smaller number of male smokers quit due to anti-smoking social pressure or expense. We also observed a marked increase in former smokers who quit for these reasons in recent years. Smoking lost its appeal in 19.3% of male and 10.0% of female smokers. Approximately, 95% of quitters did not utilize health professional counseling or pharmacological therapy. Conclusions: Personal health concerns in former smokers in Nanao, Japan were the predominant motivation for quitting smoking, with the vast majority of former smokers achieving successful smoking cessation by themselves.
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- 2012
3. Urinary amino acid alterations in 3-year-old children with neurodevelopmental effects due to perinatal dioxin exposure in Vietnam: a nested case-control study for neurobiomarker discovery.
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Muneko Nishijo, Pham The Tai, Nguyen Thi Nguyet Anh, Tran Ngoc Nghi, Hideaki Nakagawa, Hoang Van Luong, Tran Hai Anh, Yuko Morikawa, Tomoo Waseda, Teruhiko Kido, and Hisao Nishijo
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Medicine ,Science - Abstract
In our previous study of 3-year-old children in a dioxin contamination hot spot in Vietnam, the high total dioxin toxic equivalent (TEQ-PCDDs/Fs)-exposed group during the perinatal period displayed lower Bayley III neurodevelopmental scores, whereas the high 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-exposed group displayed increased autistic traits. In autistic children, urinary amino acid profiles have revealed metabolic alterations in the amino acids that serve as neurotransmitters in the developing brain. Therefore, our present study aimed to investigate the use of alterations in urinary amino acid excretion as biomarkers of dioxin exposure-induced neurodevelopmental deficits in highly exposed 3-year-old children in Vietnam. A nested case-control study of urinary analyses was performed for 26 children who were selected from 111 3-year-old children whose perinatal dioxin exposure levels and neurodevelopmental status were examined in follow-up surveys conducted in a dioxin contaminated hot spot. We compared urinary amino acid levels between the following 4 groups: (1) a high TEQ-PCDDs/Fs and high TCDD-exposed group; (2) a high TEQ-PCDDs/Fs but low TCDD-exposed group; (3) a low TEQ-PCDDs/Fs exposed and poorly developed group; and (4) a low TEQ-PCDDs/Fs exposed and well-developed group. Urinary levels of histidine and tryptophan were significantly decreased in the high TEQ-PCDDs/Fs and high TCDD group, as well as in the high TEQ-PCDDs/Fs but low TCDD group, compared with the low TEQ-PCDDs/Fs and well-developed group. However, the ratio of histidine to glycine was significantly lower only in the high TEQ-PCDDs/Fs and high TCDD group. Furthermore, urinary histidine levels and the ratio of histidine to glycine were significantly correlated with neurodevelopmental scores, particularly for language and fine motor skills. These results indicate that urinary histidine is specifically associated with dioxin exposure-induced neurodevelopmental deficits, suggesting that urinary histidine may be a useful marker of dioxin-induced neurodevelopmental deficits and that histaminergic neurotransmission may be an important pathological contributor to dioxin-mediated neurotoxicity.
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- 2015
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4. Associations between rice, noodle, and bread intake and sleep quality in Japanese men and women.
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Satoko Yoneyama, Masaru Sakurai, Koshi Nakamura, Yuko Morikawa, Katsuyuki Miura, Motoko Nakashima, Katsushi Yoshita, Masao Ishizaki, Teruhiko Kido, Yuchi Naruse, Kazuhiro Nogawa, Yasushi Suwazono, Satoshi Sasaki, and Hideaki Nakagawa
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Medicine ,Science - Abstract
Previous studies have shown that a diet with a high-glycemic index is associated with good sleep quality. Therefore, we investigated the association of sleep quality with the intake of 3 common starchy foods with different glycemic indexes-rice, bread, and noodles-as well as the dietary glycemic index in a Japanese population.The participants were 1,848 men and women between 20 and 60 years of age. Rice, bread, and noodle consumption was evaluated using a self-administered diet history questionnaire. Sleep quality was evaluated by using the Japanese version of the Pittsburgh Sleep Quality Index, and a global score >5.5 was considered to indicate poor sleep.Multivariate-adjusted odds ratios (95% confidence intervals) for poor sleep across the quintiles of rice consumption were 1.00 (reference), 0.68 (0.49-0.93), 0.61 (0.43-0.85), 0.59 (0.42-0.85), and 0.54 (0.37-0.81) (p for trend = 0.015); those for the quintiles of noodle consumption were 1.00 (reference), 1.25 (0.90-1.74), 1.05 (0.75-1.47), 1.31 (0.94-1.82), and 1.82 (1.31-2.51) (p for trend = 0.002). Bread intake was not associated with sleep quality. A higher dietary glycemic index was significantly associated with a lower risk of poor sleep (p for trend = 0.020).A high dietary glycemic index and high rice consumption are significantly associated with good sleep in Japanese men and women, whereas bread intake is not associated with sleep quality and noodle consumption is associated with poor sleep. The different associations of these starchy foods with sleep quality might be attributable to the different glycemic index of each food.
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- 2014
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5. Nicotine dependence and cost-effectiveness of individualized support for smoking cessation: evidence from practice at a worksite in Japan.
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Koshi Nakamura, Masaru Sakurai, Katsuyuki Miura, Yuko Morikawa, Shin-ya Nagasawa, Masao Ishizaki, Teruhiko Kido, Yuchi Naruse, Yasushi Suwazono, and Hideaki Nakagawa
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Medicine ,Science - Abstract
Given the lack of economic studies evaluating the outcomes of smoking cessation programs from the viewpoint of program sponsors, we conducted a case study to provide relevant information for worksites. The present study was carried out between 2006 and 2008 at a manufacturing factory in the Toyama Prefecture of Japan and included subjects who voluntarily entered a smoking cessation program. The program included face-to-face counselling followed by weekly contact to provide encouragement over six months using e-mail or inter-office mail. Nicotine patches were available if required. All 151 participants stopped smoking immediately. Over the 24-month study period, self-report showed 49.7% abstained continuously from smoking. The rate of 24-month consecutive abstinence was higher in participants with lower Fagerström Test scores for Nicotine Dependence at baseline than in those with higher scores (63.6% for 0-2 points vs. 46.5% for 3-6 points vs. 43.8% for 7-10 points; chi-square test p = 0.19). A logistic regression model showed a significant linear trend for the association between the score and abstinence status after adjustment for possible confounding factors (p = 0.03). The crude incremental cost for one individual to successfully quit smoking due to the support program was ¥46,379 (i.e., ¥100 = $1.28, £0.83, or €1.03 at foreign exchange rates). The corresponding costs for the three categories of the Fagerström Test score for Nicotine Dependence were ¥31,953, ¥47,450 and ¥64,956, respectively. When a sensitivity analysis was conducted based on the 95% confidence interval of the success rate, the variance in the corresponding costs was ¥25,514-45,034 for 0-2 points, ¥38,344-61,824 for 3-6 points, and ¥45,698-108,260 for 7-10 points. The degree of nicotine dependence may therefore be an important determinant of the cost-effectiveness of smoking cessation programs.
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- 2013
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6. Correction: Observation of Live Ticks () by Scanning Electron Microscopy under High Vacuum Pressure.
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Yasuhito Ishigaki, Yuka Nakamura, Yosaburo Oikawa, Yasuhiro Yano, Susumu Kuwabata, Hideaki Nakagawa, Naohisa Tomosugi, and Tsutomu Takegami
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Medicine ,Science - Published
- 2012
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7. Impact of perinatal dioxin exposure on infant growth: a cross-sectional and longitudinal studies in dioxin-contaminated areas in Vietnam.
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Muneko Nishijo, Pham The Tai, Hideaki Nakagawa, Shoko Maruzeni, Nguyen Thi Nguyet Anh, Hoang Van Luong, Tran Hai Anh, Ryumon Honda, Yuko Morikawa, Teruhiko Kido, and Hisao Nishijo
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Medicine ,Science - Abstract
Dioxin exposure levels remain elevated in residents living around former US Air Force bases in Vietnam, indicating potential adverse impacts on infant growth. In this study, 210 mother-infant pairs in dioxin-contaminated areas in Vietnam were recruited at the infants' birth and followed up for 4 months. Perinatal dioxin exposure levels were estimated by measurement of polychlorinated dibenzo-p-dioxins/furans toxic equivalent (PCDDs/Fs-TEQ) in breast milk. The infants' size was measured at birth and 1 and 4 months after birth, and neurodevelopment was evaluated using the Bayley Scales III at 4 months of age. Among 4 dioxin groups (
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- 2012
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8. Observation of live ticks (Haemaphysalis flava) by scanning electron microscopy under high vacuum pressure.
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Yasuhito Ishigaki, Yuka Nakamura, Yosaburo Oikawa, Yasuhiro Yano, Susumu Kuwabata, Hideaki Nakagawa, Naohisa Tomosugi, and Tsutomu Takegami
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Medicine ,Science - Abstract
Scanning electron microscopes (SEM), which image sample surfaces by scanning with an electron beam, are widely used for steric observations of resting samples in basic and applied biology. Various conventional methods exist for SEM sample preparation. However, conventional SEM is not a good tool to observe living organisms because of the associated exposure to high vacuum pressure and electron beam radiation. Here we attempted SEM observations of live ticks. During 1.5×10(-3) Pa vacuum pressure and electron beam irradiation with accelerated voltages (2-5 kV), many ticks remained alive and moved their legs. After 30-min observation, we removed the ticks from the SEM stage; they could walk actively under atmospheric pressure. When we tested 20 ticks (8 female adults and 12 nymphs), they survived for two days after SEM observation. These results indicate the resistance of ticks against SEM observation. Our second survival test showed that the electron beam, not vacuum conditions, results in tick death. Moreover, we describe the reaction of their legs to electron beam exposure. These findings open the new possibility of SEM observation of living organisms and showed the resistance of living ticks to vacuum condition in SEM. These data also indicate, for the first time, the usefulness of tick as a model system for biology under extreme condition.
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- 2012
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9. The relationship between cadmium exposure and renal volume in inhabitants of a cadmium-polluted area of Japan
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Naoki Ohno, Hideaki Nakagawa, Akie Ichimori, Kazuhiro Nogawa, Yuko Morikawa, Satoshi Kobayashi, Rie Okamoto, Muneko Nishijo, Toshiaki Miyati, Masaru Sakurai, Masao Ishizaki, Teruhiko Kido, Xian Liang Sun, and Yasushi Suwazono
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Male ,Health, Toxicology and Mutagenesis ,Renal cortex ,Urinary system ,chemistry.chemical_element ,Physiology ,010501 environmental sciences ,Kidney ,01 natural sciences ,Cadmium poisoning ,chemistry.chemical_compound ,Japan ,Renal tubular dysfunction ,Acetylglucosaminidase ,medicine ,Humans ,Environmental Chemistry ,0105 earth and related environmental sciences ,Creatinine ,Cadmium ,medicine.diagnostic_test ,business.industry ,Magnetic resonance imaging ,Environmental Exposure ,General Medicine ,medicine.disease ,Pollution ,medicine.anatomical_structure ,chemistry ,Female ,beta 2-Microglobulin ,business ,Biomarkers ,Follow-Up Studies - Abstract
This follow-up study was conducted over 30 years in a cadmium-polluted area of Japan. Urinary cadmium (U-Cd) concentration decreased by nearly half from 1986 to 2008 in men and women. However, it increased from 2008 to 2014 and maintained similar levels in 2016. Because renal atrophy may induce an increase in U-Cd, kidney volumes were determined using magnetic resonance imaging (MRI) scans in 2018. Based on the MRI results, we divided the participants into two groups, namely the normal group (n = 6, three men and three women) and the lesion group (n = 6, three men and three women). The level of urinary N-acetyl-β-d-glucosaminidase/creatinine (U-NAG/Cr) in the lesion group was significantly higher than in the normal group. The level of serum alkaline phosphatase (Al-P) was positively associated with U-Cd. Age and renal cortex volumes showed significantly negative associations. However, U-Cd and renal cortex and kidney volumes showed no significant associations. These results suggest that U-NAG and serum Al-P were sensitive biomarkers to reflect renal tubular dysfunction and bone damage caused by cadmium poisoning. Individuals chronically exposed to Cd should be observed carefully, due to the increased effect of aging on renal cortex volumes.
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- 2021
10. Relationships of Alcohol Consumption with Coronary Risk Factors and Macro- and Micro-Nutrient Intake in Japanese People: The INTERLIPID Study
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Hiromi Matsumoto-Yamauchi, Kamal Masaki, Queenie Chan, Paul Elliott, Katsushi Yoshita, Keiko Kondo, Hideaki Nakagawa, Sachiko Tanaka-Mizuno, Katsuyuki Miura, Naoko Miyagawa, Hirotsugu Ueshima, Hiroyoshi Segawa, Seiko Ohno, Yukiko Okami, Jeremiah Stamler, Nagako Okuda, Kiyomi Sakata, Akira Okayama, Shigeyuki Saitoh, and Maryam Zaid
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Male ,Alcohol Drinking ,Cross-sectional study ,non-drinkers ,Medicine (miscellaneous) ,Alcohol ,Nutrient intake ,Eating ,chemistry.chemical_compound ,Japan ,Risk Factors ,Environmental health ,mental disorders ,cross-sectional study ,Humans ,Medicine ,coronary heart disease ,Nutrition and Dietetics ,heavy-drinkers ,nutrient intake ,business.industry ,Coronary risk factors ,Cholesterol, LDL ,Micronutrient ,Coronary heart disease ,Blood pressure ,chemistry ,Female ,business ,Alcohol consumption - Abstract
Several studies have reported a J-shaped relationship between alcohol consumption and coronary heart disease (CHD) risk. However, the mechanisms of this relationship remain unclear. This study aimed to evaluate the relationships of alcohol consumption with established CHD risk factors and with macro-/micro-nutrient intake among Japanese people. Participants were 1,090 Japanese men and women aged 40-59 y enrolled in the INTERLIPID study, excluding former drinkers. Based on two 7-d alcohol records, participants were classified as non-drinkers (0 g/wk), light-drinkers (
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- 2021
11. Relationship between urinary β2‐microglobulin concentration and mortality in a cadmium‐polluted area in Japan: A 35‐year follow‐up study
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Muneko Nishijo, Hideaki Nakagawa, Teruhiko Kido, Yasushi Suwazono, Masaru Sakurai, Kazuhiro Nogawa, Yuko Morikawa, Masao Ishizaki, and Yuuka Watanabe
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0303 health sciences ,Creatinine ,medicine.medical_specialty ,Kidney ,business.industry ,Proportional hazards model ,Urinary system ,Mortality rate ,Hazard ratio ,010501 environmental sciences ,Toxicology ,01 natural sciences ,Gastroenterology ,03 medical and health sciences ,chemistry.chemical_compound ,medicine.anatomical_structure ,chemistry ,Renal tubular dysfunction ,Internal medicine ,Relative risk ,medicine ,business ,030304 developmental biology ,0105 earth and related environmental sciences - Abstract
The relationship between urinary β2 -microglobulin (β2 -MG) and the risk of all-cause mortality and cause-specific mortality in a cadmium (Cd)-polluted area was investigated in 3139 inhabitants (1404 men and 1735 women) of the Kakehashi River basin in Japan at 35-year follow-up. The subjects had been participants in the 1981-1982 health impact survey that assessed Cd-induced renal dysfunction, as measured by the urinary β2 -MG concentration. Hazard ratios were calculated to assess the risk of all-cause and cause-specific mortality according to the urinary β2 -MG concentrations. Risk ratios (RRs) were assessed using the Fine and Gray regression model to account for competing risks of cause-specific mortality. The mortality rate was significantly higher in participants with urinary β2 -MG concentrations >1000 μg/g creatinine (Cr) for men and >300 μg/g Cr for women. In the proportional hazard model, higher urinary β2 -MG concentrations were associated with higher risks of circulatory disease, digestive system diseases, and kidney and urinary tract diseases in men and women, and with senility for women. However, when competing risk was accounted for, the RRs were significantly higher only for kidney and urinary tract diseases in men and women (RR for each increment of 1000 μg/g Cr [95% confidence interval]: 1.02 [1.00-1.04] for men, and 1.01 [1.00-1.02] for women). The long-term prognosis of participants with renal tubular dysfunction was poor, most likely due to kidney and renal tract diseases.
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- 2020
12. Relationship between cancer mortality and environmental cadmium exposure in the general Japanese population in cadmium non-polluted areas
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Yuko Morikawa, Muneko Nishijo, Masao Ishizaki, Hideaki Nakagawa, Masaru Sakurai, Yasushi Suwazono, Kazuhiro Nogawa, Yuuka Watanabe, and Teruhiko Kido
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Male ,Risk ,Urinary system ,chemistry.chemical_element ,Physiology ,010501 environmental sciences ,01 natural sciences ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Japan ,Neoplasms ,Odds Ratio ,medicine ,Humans ,Longitudinal Studies ,030212 general & internal medicine ,Aged ,0105 earth and related environmental sciences ,Cadmium ,Creatinine ,business.industry ,Mortality rate ,Public Health, Environmental and Occupational Health ,Cancer ,Environmental Exposure ,Middle Aged ,medicine.disease ,Confidence interval ,chemistry ,Relative risk ,Environmental Pollutants ,Female ,business ,Cohort study - Abstract
The aim of the present study was to evaluate the effect of environmental cadmium (Cd) exposure indicated by urinary Cd (U-Cd) on cancer mortality in the general Japanese population. A 19-year cohort study was conducted in 1107 men and 1697 women who lived in three Cd non-polluted areas in Japan. Mortality risk ratio and 95% confidence interval (95%CI) for continuous U–Cd were estimated for all malignant neoplasms and specific cancers using a Fine and Gray competing risks regression model. The all-cause, including cancer and non-cancer mortality rates per 1000 person-years were 29.8 and 13.9 in men and women, respectively. By using Fine and Gray's method, continuous U–Cd adjusted for creatinine (+1 μg/g cre) was significantly related to mortalities for all malignant neoplasms (risk ratio = 1.06, 95%CI: 1.02–1.11) and pancreas (risk ratio = 1.13, 95%CI: 1.03–1.24) in women. In the present study, U–Cd was significantly associated with increased cancer mortality in the general Japanese population, indicating that environmental Cd exposure adversely affects the life prognosis in Cd non-polluted areas in Japan.
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- 2020
13. Risk Classification for Metabolic Syndrome and the Incidence of Cardiovascular Disease in Japan With Low Prevalence of Obesity: A Pooled Analysis of 10 Prospective Cohort Studies
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Koutaro Yokote, Shigeyuki Saito, Toshiharu Ninomiya, Kazuwa Nakao, Masahiko Kiyama, Michiko Yamada, Chikako Ito, Michio Shimabukuro, Hiroyasu Iso, Iseki Takamoto, Hideaki Nakagawa, Makoto Daimon, Takamasa Kayama, Takashi Kadowaki, Masaru Sakurai, Mitsuhiko Noda, Aya Higashiyama, Sadayoshi Ito, Moritake Higa, Kazuaki Shimamoto, Tomonori Okamura, Isao Saito, Yoshihiro Miyamoto, Toshimasa Yamauchi, Renzhe Cui, and Yutaka Kiyohara
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Adult ,Male ,medicine.medical_specialty ,Population ,Overweight ,Risk Assessment ,metabolic syndrome ,Japan ,cardiovascular disease ,Internal medicine ,Prevalence ,cohort study ,medicine ,Humans ,Diseases of the circulatory (Cardiovascular) system ,Obesity ,Prospective Studies ,Risk factor ,education ,Prospective cohort study ,Abdominal obesity ,Aged ,education.field_of_study ,business.industry ,Hazard ratio ,Middle Aged ,medicine.disease ,Cardiovascular Diseases ,RC666-701 ,incidence ,Female ,medicine.symptom ,Metabolic syndrome ,Cardiology and Cardiovascular Medicine ,business ,risk classification ,Cohort study - Abstract
Background It is uncertain whether risk classification under the nationwide program on screening and lifestyle modification for metabolic syndrome captures well high‐risk individuals who could benefit from lifestyle interventions. We examined the validity of risk classification by linking the incidence of cardiovascular disease (CVD). Methods and Results Individual‐level data of 29 288 Japanese individuals aged 40 to 74 years without a history of CVD from 10 prospective cohort studies were used. Metabolic syndrome was defined as the presence of high abdominal obesity and/or overweight plus risk factors such as high blood pressure, high triglyceride or low high‐density lipoprotein cholesterol levels, and high blood glucose levels. The risk categories for lifestyle intervention were information supply only, motivation‐support intervention, and intensive support intervention. Sex‐ and age‐specific hazard ratios and population attributable fractions of CVD, which were also further adjusted to consider non–high density lipoprotein cholesterol levels, were estimated with reference to nonobese/overweight individuals, using Cox proportional hazard regression. Since the reference category included those with risk factors, we set a supernormal group (nonobese/overweight with no risk factor) as another reference. We documented 1023 incident CVD cases (565 men and 458 women). The adjusted CVD risk was 60% to 70% higher in men and women aged 40 to 64 years receiving an intensive support intervention, and 30% higher in women aged 65 to 74 years receiving a motivation‐support intervention, compared with nonobese/overweight individuals. The population attributable fractions in men and women aged 40 to 64 years receiving an intensive support intervention were 17.7% and 6.6%, respectively, while that in women aged 65 to 74 years receiving a motivation‐support intervention was 9.4%. Compared with the supernormal group, nonobese/overweight individuals with risk factors had similar hazard ratios and population attributable fractions as individuals with metabolic syndrome. Conclusions Similar CVD excess and attributable risks among individuals with metabolic syndrome components in the absence and presence of obesity/overweight imply the need for lifestyle modification in both high‐risk groups.
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- 2021
14. Prediction of Lifetime Risk of Cardiovascular Disease Deaths Stratified by Sex in the Japanese Population
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Yukiko Imai, Sachiko Mizuno Tanaka, Michihiro Satoh, Takumi Hirata, Yoshitaka Murakami, Katsuyuki Miura, Takashi Waki, Aya Hirata, Toshimi Sairenchi, Fujiko Irie, Mizuki Sata, Toshiharu Ninomiya, Takayoshi Ohkubo, Shizukiyo Ishikawa, Yoshihiro Miyamoto, Hirofumi Ohnishi, Shigeyuki Saitoh, Akiko Tamakoshi, Michiko Yamada, Masahiko Kiyama, Hiroyasu Iso, Kiyomi Sakata, Hideaki Nakagawa, Akira Okayama, Hirotsugu Ueshima, Tomonori Okamura, Yutaka Imai, Akihiko Kitamura, Yutaka Kiyohara, Akiko Harada, Masaru Sakurai, Takeo Nakayama, Ichiro Tsuji, Yoshihiro Kokubo, and Hiroshi Yatsuya
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Adult ,Male ,Population ,Disease ,Risk Assessment ,smoking ,Cohort Studies ,Japan ,cardiovascular disease ,Diabetes mellitus ,medicine ,Diseases of the circulatory (Cardiovascular) system ,Humans ,Young adult ,Sex Distribution ,education ,education.field_of_study ,diabetes ,business.industry ,total cholesterol ,blood pressure ,Middle Aged ,medicine.disease ,Blood pressure ,Cardiovascular Diseases ,RC666-701 ,Observational study ,Lifetime risk ,Female ,Cardiology and Cardiovascular Medicine ,business ,Demography ,Cohort study - Abstract
Background Lifetime risk is an informative estimate for driving lifestyle and behavioral changes especially for young adults. The impact of composite risk factors for cardiovascular disease on lifetime risk stratified by sex has not been investigated in the Japanese population, which has a much lower mortality of coronary heart disease compared with the Western population. We aimed to estimate lifetime risk of death from cardiovascular disease attributable to traditional risk factors. Methods and Results We analyzed pooled individual data from the Evidence for Cardiovascular Prevention from Observational Cohorts in a Japanese cohort study. A modified Kaplan–Meier approach was used to estimate the remaining lifetime risk of cardiovascular death. In total, 41 002 Japanese men and women with 537 126 person‐years of follow‐up were included. The lifetime risk at the index‐age of 45 years for those with optimal risk factors (total cholesterol Conclusions The magnitude and the number of risk factors were progressively associated with increased lifetime risk even in individuals in early adulthood who tend to have low short‐term risk. The degree of established cardiovascular risk factors can be converted into lifetime risk. Our findings may be useful for risk communication in the early detection of future cardiovascular disease risk.
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- 2021
15. The Relationship between the Urinary Cadmium Concentration and Cause-Specific Mortality in Subjects without Severe Renal Damage: A 35-Year Follow-Up Study in a Cadmium-Polluted Area of Japan
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Kazuka Yoneda, Kazuhiro Nogawa, Yuuka Watanabe, Teruhiko Kido, Masaru Sakurai, Yasushi Suwazono, Masao Ishizaki, Muneko Nishijo, Yuko Morikawa, and Hideaki Nakagawa
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Male ,medicine.medical_specialty ,Health, Toxicology and Mutagenesis ,Urinary system ,010501 environmental sciences ,Kidney ,01 natural sciences ,Article ,renal tubular dysfunction ,03 medical and health sciences ,Renal tubular dysfunction ,Japan ,Internal medicine ,Cause of Death ,cohort study ,Medicine ,Humans ,urinary cadmium ,mortality ,030304 developmental biology ,0105 earth and related environmental sciences ,Cause of death ,0303 health sciences ,business.industry ,Hazard ratio ,Public Health, Environmental and Occupational Health ,Environmental Exposure ,medicine.disease ,Confidence interval ,Pneumonia ,Heart failure ,Female ,business ,beta 2-Microglobulin ,Cohort study ,Cadmium ,Follow-Up Studies - Abstract
We evaluated the association between urinary cadmium concentration (uCd, μg/g Cr) and risk of cause-specific mortality according to urinary β2-microglobulin (MG) concentration. Participants were 1383 male and 1700 female inhabitants of the Cd-polluted Kakehashi River basin. The uCd and β2-MG were evaluated in a survey in 1981–1982, where those participants were followed-up over 35 years later. Among the participants with a urinary β2-MG < 1000, the hazard ratios (HRs) (95% confidence interval) for mortality were significantly higher in those with a uCd of ≥10.0 compared with
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- 2021
16. Impact of Proteinuria and Low eGFR on Lifetime Risk of Cardiovascular Disease Death: A Pooled Analysis of Data From the Evidence for Cardiovascular Prevention From Observational Cohorts in Japan Study
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Shigeyuki Saitoh, Toshimi Sairenchi, H Ueshima, Hideaki Nakagawa, Toshiharu Ninomiya, F Irie, M. Kiyama, Yoshitaka Murakami, Yukiko Imai, Tomonori Okamura, Shizukiyo Ishikawa, Y Kiyohara, Katsuyuki Miura, Aya Hirata, and Masaru Sakurai
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medicine.medical_specialty ,Proteinuria ,Epidemiology ,business.industry ,Disease ,Pooled analysis ,Cardiovascular prevention ,Internal medicine ,Medicine ,Observational study ,Lifetime risk ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business - Abstract
Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main funding source(s): H20–Junkankitou [Seishuu]–Ippan–013; H23–Junkankitou [Seishuu]–Ippan–005; H26-Junkankitou [Seisaku]-Ippan-001; H29–Junkankitou–Ippan–003 and 20FA1002 OnBehalf EPOCH-JAPAN Introduction Absolute risk of Lifetime risk (LTR) is useful estimate for risk communication compared with short term risk or relative risk especially for young people. Proteinuria is leading cause of end-stage kidney disease (ESKD) and independent risk factor for cardiovascular disease (CVD). Although nonproteinuric renal disease is global burden of ESKD, it has been poorly focused. To date, there have been no reports of impact of proteinuria and low eGFR on LTR with the outcome of CVD death in Asian population. Purpose We aimed to estimate LTR of CVD death stratified by the status of proteinuria and low eGFR. Methods We used modified Kaplan-Meier approach to estimate the remaining lifetime risk of cardiovascular death based on EPOCH-JAPAN(Evidence for Cardiovascular Prevention From Observational Cohorts in Japan) database. LTR was estimated at each index age starting from 40 years for those with proteinuria and without proteinuria stratified by low eGFR, which is defined as eGFR Results A total of 47,292 participants from 9 cohorts was included in the analysis. Mean follow-up period was 14.6 years with 690,463 person years and total CVD death was 1,075 in men and 1,193 in women. The LTRs at the index age of 40 years were as follows: 17.7% (95% confidence interval: 15.4 – 19.0%) in Proteinuria (-)/Low eGFR (-) group, 26.2% (20.2 – 31.1%) in Proteinuria (-)/low eGFR (+) group, 24.5% (15.1 – 29.3%) in Proteinuria (+) group for men; 15.3%(13.7 – 16.5%), 29.9%(14.7 – 46.8%) , 28.3%(19.4 – 34.7%) for women. Conclusions We observed that those without proteinuria with low eGFR have equivalently high LTR with those with proteinuria. These results indicate that even in the absence of proteinuria, low eGFR has high impact on LTR. Lifestyle modification from young age is necessary to prevent from renal dysfunction.
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- 2021
17. Associations of Overweight, Obesity, and Underweight With High Serum Total Cholesterol Level Over 30 Years Among the Japanese Elderly: NIPPON DATA 80, 90, and 2010
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Yutaka Kiyohara, Y. Saito, Hideaki Nakagawa, Yasuyuki Nakamura, Mieko Nakamura, Akira Fujiyoshi, Toshiyuki Ojima, Kazuyo Kuwabara, Naoko Miyagawa, Akira Okayama, Yosuke Shibata, Takayoshi Ohkubo, Hirotsugu Ueshima, Katsuyuki Miura, Tomonori Okamura, and Aya Kadota
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Male ,Epidemiology ,hyperlipidemias ,Population ,body mass index ,thinness ,030209 endocrinology & metabolism ,Overweight ,Logistic regression ,03 medical and health sciences ,0302 clinical medicine ,Japan ,Risk Factors ,Hyperlipidemia ,Humans ,overweight ,Medicine ,Obesity ,030212 general & internal medicine ,education ,Aged ,lcsh:R5-920 ,education.field_of_study ,business.industry ,nutritional and metabolic diseases ,social sciences ,General Medicine ,Odds ratio ,Middle Aged ,medicine.disease ,Health Surveys ,Confidence interval ,Cholesterol ,Others ,Original Article ,Female ,medicine.symptom ,Underweight ,lcsh:Medicine (General) ,business ,Body mass index ,Demography - Abstract
BACKGROUND:The trend of association between overweight and high serum total cholesterol (TC)among the elderly is unclear. In addition, there is little evidence of risk of underweightfor high TC. Therefore, we examined the trend of association of overweight or underweight with high TC among Japanese elderly people using nationwide population-based data., METHODS:Data of the National Survey on Circulatory Disorders and National Health and NutritionSurvey for 1980, 1990, 2000, and 2010 were used in the analysis. High TC was definedas 220 mg/dL and above. For participants aged ≥50 years, sex-specific odds ratios (ORs)of overweight or underweight compared with normal body mass index participants forhigh TC were calculated using a logistic regression model adjusted for age, smoking, drinking, exercise, food, and treatment of hyperlipidemia., RESULTS:A total of 5,014, 4,673, 5,059, and 2,105 participants enrolled in these surveys in 1980,1990, 2000, and 2010, respectively. Although overweight was positively and significantlyassociated with high TC in 1980, the association has gradually weakened since (ORs in 1980 and 2010 were 2.44; 95% confidence interval [CI], 1.83-3.24 and 0.92; 95% CI, 0.66-1.27 among men and 1.43; 95% CI, 1.18-1.72 and 1.08; 95% CI, 0.81-1.44 among women, respectively). While underweight was inversely and significantlyassociated with high TC in 1980, the association also gradually weakened among women(ORs in 1980 and 2010 were 0.28; 95% CI, 0.12-0.60 and 0.37; 95% CI, 0.10-1.28 among men and 0.39; 95% CI, 0.26-0.57 and 0.96; 95% CI, 0.58-1.57 among women,respectively)., CONCLUSIONS:These findings provide evidence that high TC prevention efforts must expand the target to not only overweight but also to normal and underweight people.
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- 2019
18. The Relationship of Dietary Cholesterol with Serum Low-Density Lipoprotein Cholesterol and Confounding by Reverse Causality:The INTERLIPID Study
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Nagako Okuda, Shigeyuki Saitoh, Sohel Reza Choudhury, Katsushi Yoshita, Akira Okayama, Intermap, Hirotsugu Ueshima, Katsuyuki Miura, Hideaki Nakagawa, Yasuyuki Nakamura, Yukiko Okami, Queenie Chan, Jeremiah Stamler, Paul Elliott, Kiyomi Sakata, National Institutes of Health, and Medical Research Council (MRC)
- Subjects
Lifestyle modification ,Reverse causality ,Male ,Cross-sectional study ,Physiology ,Coronary Disease ,030204 cardiovascular system & hematology ,Cholesterol, Dietary ,chemistry.chemical_compound ,0302 clinical medicine ,Medicine ,LESS EDUCATION ,2. Zero hunger ,Confounding ,Middle Aged ,Prognosis ,Cholesterol ,lipids (amino acids, peptides, and proteins) ,Original Article ,Female ,FATTY-ACIDS ,Cardiology and Cardiovascular Medicine ,Life Sciences & Biomedicine ,Dietary Cholesterol ,Cohort study ,Employment ,Adult ,Inverse Association ,ATHEROSCLEROTIC CARDIOVASCULAR-DISEASES ,Education ,03 medical and health sciences ,Internal Medicine ,Humans ,CORONARY-HEART-DISEASE ,Science & Technology ,JAPAN ,ALCOHOL INTAKE ,business.industry ,Biochemistry (medical) ,Cholesterol, LDL ,Confidence interval ,EGG CONSUMPTION ,Cross-Sectional Studies ,Peripheral Vascular Disease ,Cardiovascular System & Hematology ,chemistry ,Cardiovascular System & Cardiology ,RISK-FACTORS ,CIGARETTE-SMOKING ,business ,INTERMAP and INTERLIPID Research Groups ,030217 neurology & neurosurgery ,Biomarkers ,HIGHER BLOOD-PRESSURE ,Follow-Up Studies - Abstract
Aim: The positive relationship between dietary cholesterol and serum cholesterol has been questioned by a set of recent cohort studies. This study aimed to investigate how employment status and education years relate to the association between dietary cholesterol and serum low-density lipoprotein cholesterol (LDL-C) in a Japanese population. Methods: A population-based, random sample, cross-sectional study (INTERLIPID) was performed. Among 1,145 Japanese individuals aged 40–59 years, 106 were excluded because of special diets, use of lipid-lowering drugs, hormone replacement, and missing data, leaving 1,039 individuals (533 men and 506 women). Dietary cholesterol was assessed from four 24-h dietary recalls, and LDL-C was measured enzymatically with an autoanalyzer. A standard questionnaire inquired about employment status and education years. Results: In men, a 1 standard deviation (SD) higher dietary cholesterol was associated with 3.16 mg/dL lower serum LDL-C (P = 0.009; unadjusted model). After adjustment for covariates, higher serum LDL-C was estimated per 1 SD higher intake of dietary cholesterol in nonemployed men [self-employed, homemakers, farmers, fishermen, and retired employees; β = +9.08, 95% confidence interval (CI) = +0.90–+17.27] and less educated men (β = +4.46, 95% CI = −0.97–+9.90), whereas an inverse association was observed in employed men (β = −3.02, 95% CI= −5.49–−0.54) and more educated men (β = −3.66, 95% CI = −6.25–−1.07). Conclusions: In men who were nonemployed and less educated, a higher intake of dietary cholesterol was associated with elevated concentrations of serum LDL-C, whereas an inverse association was observed in men who were employed and more educated.
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- 2019
19. Androgen disruption by dioxin exposure in 5-year-old Vietnamese children: Decrease in serum testosterone level
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Hoang Duc Phuc, Dao Van Tung, Dang Duc Nhu, Seijiro Honma, Nguyen Hung Minh, Nguyen Thi Phuong Oanh, Teruhiko Kido, Le Thai Anh, Vo Van Chi, Rie Okamoto, Yuko Oyama, Ngo Van Toan, Ho Dung Manh, Hideaki Nakagawa, Shoji F. Nakayama, and Nguyen Hoang Viet
- Subjects
0301 basic medicine ,medicine.medical_specialty ,Polychlorinated Dibenzodioxins ,Environmental Engineering ,medicine.drug_class ,medicine.medical_treatment ,Dehydroepiandrosterone ,Endocrine Disruptors ,010501 environmental sciences ,Breast milk ,Dioxins ,01 natural sciences ,Steroid ,03 medical and health sciences ,Internal medicine ,medicine ,Humans ,Environmental Chemistry ,Endocrine system ,Testosterone ,Androstenedione ,Child ,Waste Management and Disposal ,0105 earth and related environmental sciences ,business.industry ,Environmental Exposure ,Lyase ,Androgen ,Pollution ,030104 developmental biology ,Endocrinology ,Vietnam ,Child, Preschool ,Androgens ,Environmental Pollutants ,Female ,business ,Hormone - Abstract
Dioxins have been suspected to be potential substances causing endocrine disruptions in humans. We are conducting the research in one of three dioxin exposure areas (hotspots) in Vietnam. We previously reported that the salivary dehydroepiandrosterone (DHEA) level decreased in 3-year-old Vietnamese children and that it was significantly inversely correlated with polychlorinated dibenzodioxin/dibenzofuran levels in their mother's breast milk. In this study, we investigated the influence of exposure to dioxin on steroid hormone biosynthesis in the same children when they reached 5 years of age, focusing on androgens. Thirty-five and 50 mother–child pairs from dioxin hotspot and non-sprayed areas, respectively, participated in this study. Maternal breast milk was donated at 4 to 16 weeks postpartum in 2008 to measure dioxin levels by gas chromatography/high-resolution mass spectrometry. Serum was collected from 5-year-old children in 2013. Seven steroid hormones were measured by liquid chromatography/mass spectrometry. Most dioxin congeners in breast milk were 2- to 10-fold higher in the hotspot than in the non-sprayed area. DHEA and testosterone (T) were significantly lower in the hotspot and showed negative correlations with most dioxin congeners. Similar results were observed for the activities of cytochrome P450-17, 20 lyase (CYP17 lyase), and 17β-hydroxysteroid dehydrogenase (HSD). Conversely, the elevated androstenedione (A-dione) level and 3β-HSD activity in children from the hotspot were positively correlated with dioxin levels. Moreover, a positive correlation was shown between T and 17β-HSD. It is possible that dioxin inhibits 17β-HSD activity, leading to a decrease in the T level. Multiple regression analysis indicated that dioxin had a strong association with the DHEA, A-dione, and T levels. In conclusion, the present study suggests that dioxin is associated with low levels of DHEA and T and inhibition of the activity of steroidogenic enzymes such as CYP17 lyase and 17β-HSD in 5-year-old children.
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- 2018
20. The Association between Anthropometric Indices of Obesity and Chronic Kidney Disease in Middle-aged Japanese Men and Women: A Cohort Study
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Naruhiro Yamasaki, Kazuhiro Nogawa, Junji Kobayashi, Yuchi Naruse, Teruhiko Kido, Yasushi Suwazono, Masaru Sakurai, Masao Ishizaki, Hideaki Nakagawa, and Yuko Morikawa
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Male ,Waist ,sex difference ,body mass index ,030204 cardiovascular system & hematology ,abdominal obesity ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Japan ,Risk Factors ,cohort study ,Internal Medicine ,medicine ,Humans ,Obesity ,Renal Insufficiency, Chronic ,Abdominal obesity ,business.industry ,Incidence (epidemiology) ,Hazard ratio ,General Medicine ,Middle Aged ,Anthropometry ,medicine.disease ,Cross-Sectional Studies ,Original Article ,epidemiology ,Female ,030211 gastroenterology & hepatology ,Waist Circumference ,medicine.symptom ,business ,Body mass index ,Demography ,Kidney disease ,Cohort study - Abstract
Objective This study investigated associations between three indices of obesity-the body mass index (BMI), waist circumference (WC), and waist-to-height ratio (WHtR)-and the incidence of chronic kidney disease (CKD). Methods The employees of a company in Japan (1,725 men, 1,186 women; aged 35-55 years) had BMI, WC, and WHtR measured in health examinations. The incidence of CKD was determined at annual medical examinations over a six-year period. The hazard ratios for CKD were calculated using proportional hazard models, and the χ2 statistic was used to compare the strengths of the associations. Results The mean BMI (kg/m2), WC (cm), and WHtR were 23.6, 84.3, and 0.49 for men and 22.3, 79.7, and 0.50 for women, respectively. The incidence of CKD (/1,000 person-years) was 18.1 for men and 8.4 for women. In men, positive linear associations were observed between the BMI, WC, and WHtR and the risk of CKD, even after adjusting for the presence of metabolic abnormalities (p for trend
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- 2021
21. Frequency of consumption of balanced meals, bodyweight gain and incident risk of glucose intolerance in Japanese men and women: A cohort study
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Chiaki Okamoto, Atsushi Hozawa, Yuchi Naruse, Yuuka Watanabe, Yuko Morikawa, Kazuhiro Nogawa, Hideaki Nakagawa, Masao Ishizaki, Katsushi Yoshita, Masaru Sakurai, Yuki Nakashima, Teruhiko Kido, and Yasushi Suwazono
- Subjects
0301 basic medicine ,Adult ,Male ,Japanese meal ,Endocrinology, Diabetes and Metabolism ,Lower risk ,Weight Gain ,Diet Surveys ,Diseases of the endocrine glands. Clinical endocrinology ,Cohort Studies ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Japan ,Risk Factors ,Diabetes mellitus ,Surveys and Questionnaires ,Glucose Intolerance ,Internal Medicine ,medicine ,Humans ,030212 general & internal medicine ,Obesity ,Meals ,Meal ,030109 nutrition & dietetics ,Nutritional epidemiology ,business.industry ,Incidence (epidemiology) ,Incidence ,General Medicine ,Feeding Behavior ,Articles ,Middle Aged ,medicine.disease ,RC648-665 ,Clinical Science and Care ,chemistry ,Female ,Original Article ,Glycated hemoglobin ,Diet, Healthy ,business ,Cohort study ,Demography - Abstract
Aims/Introduction This cohort study assessed the risk for bodyweight gain and development of glucose intolerance based on the frequency of consumption of balanced meals including grain, fish or meat and vegetables. Materials and Methods The participants (8,573 men, 3,327 women) were employees of a company in Japan. A self‐administered questionnaire was used to evaluate the frequency of balanced meal consumption. Bodyweight changes and the incidence of glucose intolerance (glycated hemoglobin >6.0%) during the 3‐year follow‐up period were determined through annual health examinations. Results The mean bodyweight change over a period of 3 years was 0.78 kg for men and 0.84 kg for women. A lower frequency of balanced meals was associated with a higher bodyweight gain for men (P for trend = 0.004), but not for women. During the study, 464 men and 115 women developed glucose intolerance. Overall, the frequency of balanced meals was not associated with the risk of glucose intolerance in either sex. However, the interaction between the frequency of balanced meals and degree of obesity had a significant effect on the incidence of glucose intolerance in men (P = 0.005), with less frequent consumption of balanced meals being associated with a higher risk for glucose intolerance among men with a BMI ≥25.0 kg/m2 (P for trend = 0.007). Conclusions A higher frequency of balanced meals, including grain, fish or meat and vegetable dishes – important components of healthy Japanese food – was associated with a lower risk of glucose intolerance in obese men, but not in non‐obese men and women., We evaluated the risk for development of glucose intolerance based on the frequency of consumption of balanced meals including grain, fish and meat, and vegetable dishes. A lower frequency of balanced meals was associated with a higher risk of glucose intolerance in obese men.
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- 2020
22. Environmental cadmium exposure and noncancer mortality in a general Japanese population in cadmium nonpolluted regions
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Masao Ishizaki, Masaru Sakurai, Muneko Nishijo, Yasushi Suwazono, Hideaki Nakagawa, Kazuhiro Nogawa, Yuuka Watanabe, Yuko Morikawa, and Teruhiko Kido
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Male ,Longitudinal study ,Cadmium Poisoning ,Urinary system ,chemistry.chemical_element ,Physiology ,010501 environmental sciences ,Toxicology ,01 natural sciences ,03 medical and health sciences ,chemistry.chemical_compound ,Japan ,Medicine ,Humans ,Longitudinal Studies ,Mortality ,030304 developmental biology ,0105 earth and related environmental sciences ,Aged ,Proportional Hazards Models ,0303 health sciences ,Creatinine ,Cadmium ,business.industry ,Hazard ratio ,Environmental Exposure ,Middle Aged ,Confidence interval ,chemistry ,Quartile ,Environmental Pollutants ,Female ,business ,Cohort study - Abstract
The objective of this study was to assess the effect of environmental cadmium exposure according to urinary cadmium concentration (U-Cd) on noncancer mortality in a general Japanese population. We conducted a longitudinal study for 19 years in 2804 inhabitants (1107 men and 1697 women) in some cadmium nonpolluted regions in Japan. The participants were classified into quartiles based on U-Cd (μg/g cre) adjusted for urinary creatinine. Hazard ratio (HR) and 95% confidence interval (95% CI) for continuous U-Cd or the quartiles of U-Cd were calculated for noncancer mortality. By applying a Fine and Gray competing risk model, continuous U-Cd (+1 μg/g cre) showed significant HR for cardiocerebrovascular diseases (HR 1.05, 95% CI: 1.00-1.11), cerebrovascular diseases (HR 1.08, 95% CI: 1.01-1.16), and cerebral infarction (HR 1.11, 95% CI: 1.04-1.20) in men. However, notable significant HR for continuous and quartered U-Cd were not observed in women. In this study, U-Cd was associated with increased cardiocerebrovascular mortality in a general Japanese population, suggesting that environmental cadmium exposure is detrimental to the life prognosis in cadmium nonpolluted regions in Japan.
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- 2020
23. Food Sources of Dietary Potassium in the Adult Japanese Population: The International Study of Macro-/Micronutrients and Blood Pressure (INTERMAP)
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Jeremiah Stamler, Katsushi Yoshita, Paul Elliott, Naoko Miyagawa, Hideaki Nakagawa, Hirotsugu Ueshima, Kiyomi Sakata, Nagako Okuda, Shigeyuki Saitoh, Queenie Chan, Katsuyuki Miura, Akira Okayama, and National Institutes of Health
- Subjects
Adult ,Male ,Potassium intake ,Potassium ,chemistry.chemical_element ,lcsh:TX341-641 ,030204 cardiovascular system & hematology ,Article ,Excretion ,03 medical and health sciences ,Food Preferences ,0302 clinical medicine ,Animal science ,Asian People ,Japan ,Medicine ,Humans ,030212 general & internal medicine ,Micronutrients ,24-hr urine ,Risk factor ,Nutrition and Dietetics ,business.industry ,Potassium, Dietary ,Feeding Behavior ,Middle Aged ,Micronutrient ,24-hr dietary recall ,Dietary Potassium ,Blood pressure ,nutrition ,Quartile ,chemistry ,potassium intake ,1111 Nutrition and Dietetics ,Female ,epidemiology ,business ,Energy Intake ,lcsh:Nutrition. Foods and food supply ,0908 Food Sciences ,Food Science - Abstract
A lower-than-recommended potassium intake is a well-established risk factor for increased blood pressure. Although the Japanese diet is associated with higher sodium intake and lower potassium intake, few studies have examined the source foods quantitatively. Studies on dietary patterns in association with potassium intake will be useful to provide dietary advice to increase potassium intake. Twenty-four-hour (hr) dietary recall data and 24-hr urinary potassium excretion data from Japanese participants (574 men and 571 women) in the International Study of Macro/Micronutrients and Blood Pressure (INTERMAP) were used to calculate food sources of potassium and compare food consumption patterns among quartiles of participants categorized according to 24-hr urinary potassium excretion per unit of body weight (UK/BW). The average potassium intake was 2791 mg/day per participant, and the major sources were vegetables and fruits (1262 mg/day), fish (333 mg/day), coffee and tea (206 mg/day), and milk and dairy products (200 mg/day). Participants in the higher UK/BW quartile consumed significantly more vegetables and fruits, fish, and milk and dairy products, and ate less rice and noodles. Conclusion: Advice to increase the intake of vegetables and fruits, fish, and milk may be useful to increase potassium intake in Japan.
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- 2020
24. Associations of High-Density Lipoprotein Particle and High-Density Lipoprotein Cholesterol With Alcohol Intake, Smoking, and Body Mass Index ― The INTERLIPID Study ―
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Queenie Chan, Katsuyuki Miura, Beatriz L. Rodriguez, Jeremiah Stamler, Tomonori Okamura, Paul Elliott, Naoko Miyagawa, Hideaki Nakagawa, Kamal Masaki, Nagako Okuda, Akira Okayama, Maryam Zaid, Katsushi Yoshita, Sohel Reza Choudhury, Shigeyuki Saitoh, Bradley J. Willcox, Kiyomi Sakata, and Hirotsugu Ueshima
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Adult ,Male ,medicine.medical_specialty ,Alcohol Drinking ,Alcohol ,030204 cardiovascular system & hematology ,Article ,Body Mass Index ,Coronary artery disease ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,High-density lipoprotein ,Japan ,Risk Factors ,Internal medicine ,Humans ,Medicine ,030212 general & internal medicine ,Life Style ,medicine.diagnostic_test ,business.industry ,Cholesterol ,Cholesterol, HDL ,Smoking ,nutritional and metabolic diseases ,General Medicine ,Middle Aged ,High-density lipoprotein particle ,medicine.disease ,Cross-Sectional Studies ,Endocrinology ,chemistry ,Female ,lipids (amino acids, peptides, and proteins) ,Lipoproteins, HDL ,Cardiology and Cardiovascular Medicine ,business ,Lipid profile ,Body mass index ,Lipoprotein - Abstract
BACKGROUND: Recently, high-density lipoprotein particles (HDL-P) have been found to be more strongly inversely associated with coronary artery disease (CAD) risk than their counterpart, HDL cholesterol (HDL-C). Given that lifestyle is among the first targets in CAD prevention, we compared the associations of HDL-P and HDL-C with selected lifestyle factors. METHODS AND RESULTS: We examined 789 Japanese participants of the INTERLIPID Study: men (n=386) and women (n=403) aged 40–59 years in 1996–1998. Participants treated for dyslipidemias were excluded. Lifestyle factors included alcohol intake, smoking amount, and body mass index (BMI). Multivariable linear regression was used for cross-sectional analyses of these factors with HDL-P, HDL-C, HDL-P size subclasses (small, medium and large) and mean HDL-P size. In men, higher alcohol intake was associated with higher HDL-P and higher HDL-C. The associations of alcohol, however, were strongest with HDL-P. A higher smoking amount tended to be associated with lower HDL-P and HDL-C. In contrast, BMI was not associated with HDL-P, but was strongly inversely associated with HDL-C. While alcohol intake favored larger mean HDL-P size, smoking and BMI favored a lipid profile with smaller HDL-P subclasses and overall smaller mean HDL-P size. Similar, but generally weaker results were observed in women. CONCLUSIONS: Although both HDL-P and HDL-C are parameters of HDL, they have different associations with alcohol, smoking and BMI.
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- 2018
25. Factors Related to Participation in Health Examinations for Japanese National Health Insurance: NIPPON DATA2010
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Haruhiko Imamura, Yoshikuni Kita, Nobuo Nishi, Mana Kogure, Nagako Okuda, Hirotsugu Ueshima, Atsushi Hozawa, Katsuyuki Miura, Yoshitaka Murakami, Tomonori Okamura, Akira Okayama, Takayoshi Ohkubo, Hideaki Nakagawa, and Aya Kadota
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Adult ,Male ,National Health Programs ,Epidemiology ,030204 cardiovascular system & hematology ,03 medical and health sciences ,symbols.namesake ,0302 clinical medicine ,Japan ,Negatively associated ,Medicine ,health examination ,Humans ,030212 general & internal medicine ,Poisson regression ,Socioeconomic status ,Physical Examination ,Aged ,lcsh:R5-920 ,NIPPON DATA2010 ,business.industry ,General Medicine ,Middle Aged ,Japanese National Health Insurance ,Confidence interval ,Educational attainment ,Social Epidemiology ,Cross-Sectional Studies ,Quartile ,National health insurance ,Socioeconomic Factors ,symbols ,Marital status ,Original Article ,Female ,Yes ,lcsh:Medicine (General) ,business ,Demography - Abstract
Background This study investigated relationships among socioeconomic factors and participation in health examinations for Japanese National Health Insurance (NHI) using a representative Japanese population. Methods We used the linkage database of NIPPON DATA2010 and Comprehensive Survey of Living Conditions 2010. Participants with NHI aged 40-74 years were included in the analysis. Prevalence ratios (PRs) for participation in health examinations in the past year were set as an outcome. Participant characteristics, including sex, age, socioeconomic factors (educational attainment, employment, equivalent household expenditure [EHE], house ownership, and marital status), laboratory measures, and lifestyle were included in an age-stratified modified Poisson regression analysis to examine relationships. Results The number of study participants was 812, and 564 (69.5%) participated in health examinations in the past year. Among those aged 40-64 years, there was no significant PR for socioeconomic factors. Among those aged 65-74 years, high (≥13 years) educational attainment (adjusted PR, 1.22; 95% confidence interval [CI], 1.05-1.41) and house ownership (PR 1.40; 95% CI, 1.11-1.77) were positively associated with participation, while high (4th quartile) EHE (PR 0.84; 95% CI, 0.73-0.97) was negatively associated. Conclusion These results suggest that high educational attainment, house ownership, and low EHE were positive factors for participation in health examinations among those aged 65-74 years.
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- 2018
26. Dietary tofu intake and long-term risk of death from stroke in a general population
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Hirotsugu Ueshima, Robert D. Abbott, Akira Fujiyoshi, Akira Okayama, Naoko Miyagawa, Kiyomi Sakata, Nagako Okuda, Naoyuki Takashima, Hideaki Nakagawa, Toshiyuki Ojima, Yusuke Arai, Katsushi Yoshita, Ho N. Nguyen, Takayoshi Ohkubo, Katsuyuki Miura, Tomonori Okamura, and Aya Kadota
- Subjects
Adult ,Male ,medicine.medical_specialty ,Population ,030204 cardiovascular system & hematology ,Critical Care and Intensive Care Medicine ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Japan ,Environmental health ,medicine ,Humans ,030212 general & internal medicine ,Prospective cohort study ,education ,Stroke ,Aged ,education.field_of_study ,Nutrition and Dietetics ,business.industry ,Proportional hazards model ,Hazard ratio ,Soy Foods ,Middle Aged ,Nutrition Surveys ,medicine.disease ,Diet ,Saturated fatty acid ,Physical therapy ,Female ,business ,Body mass index ,Cohort study - Abstract
Although dietary soy intake is linked with health benefits, a relation with stroke has not been established. The present study examined the association between the intake of tofu, the richest source of dietary soy, with stroke mortality in a general population cohort of Japanese men and women.Data comprise 9244 Japanese enrolled in the National Nutrition Survey of Japan in 1980. Participants were free of cardiovascular disease and followed for 24 years. Dietary intake was estimated from 3-day weighed food records. Multivariable Cox regression models were used to estimate hazard ratios across levels of tofu intake.During follow-up, there were 417 deaths due to stroke (88 cerebral hemorrhage [CH], 245 cerebral infarction [CI], and 84 of other subtypes). Among all men, and in women aged 65 years or more, tofu intake was unrelated to each form of stroke. For young women (65 years of age), a significantly lower risk of CH in the top versus bottom quartile of tofu intake was observed (Multivariable-adjusted HR = 0.26, 95% CI: 0.08-0.85).In this large prospective study with long follow-up of Japanese men and women, consumption of tofu was unrelated to the risk of stroke except for CH in women65 years of age. Whether the association in younger women is real or due to chance alone warrants further study.
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- 2018
27. Decreased serum testosterone levels associated with 17β-hydroxysteroid dehydrogenase activity in 7-year-old children from a dioxin-exposed area of Vietnam
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Nguyen Hung Minh, Dang Duc Nhu, Teruhiko Kido, Vo Van Chi, Nguyen Thi Phuong Oanh, Yuko Oyama, Seijiro Honma, Rie Okamoto, Le Thai Anh, Nguyen Xuan Hung, Hoang Duc Phuc, Ho Dung Manh, Ngo Thi Minh Tan, Hideaki Nakagawa, Pham Van Thuc, Shizuko Omote, Ngo Van Toan, and Dao Van Tung
- Subjects
Male ,Polychlorinated Dibenzodioxins ,Environmental Engineering ,17-Hydroxysteroid Dehydrogenases ,010504 meteorology & atmospheric sciences ,medicine.drug_class ,medicine.medical_treatment ,Dehydroepiandrosterone ,Physiology ,010501 environmental sciences ,Breast milk ,Dioxins ,01 natural sciences ,Tandem Mass Spectrometry ,medicine ,Humans ,Environmental Chemistry ,Testosterone ,Hydroxysteroid dehydrogenase ,Child ,Waste Management and Disposal ,0105 earth and related environmental sciences ,business.industry ,Androgen ,Pollution ,Steroid hormone ,Vietnam ,Environmental Pollutants ,Female ,Dibenzofurans ,business ,Chromatography, Liquid ,Cohort study ,Hormone - Abstract
Since 2008, we have conducted epidemiological cohort studies on the relationship between dioxin exposure and disruption with children in the area sprayed with defoliants during the Vietnam War. In a long-term survey of children through the age of five, we observed androgen disruption due to decreased dehydroepiandrosterone (DHEA) and testosterone levels. In this study of 7-year-old, we separately elucidated androgen disruption for boys and girls, and discussed with respect to hormone disruption with sex differences on the steroid hormone biosynthesis process. This follow-up was conducted with 96 mother-child pairs in Vietnam (hotspot area: 45, non-sprayed area: 51). We took a questionnaire, the physical measurement and assayed 7 steroid hormones in their serum by LC-MS/MS. We examined the relationship between the hormone levels in the serum and dioxin levels in the maternal breast milk. The results showed that the serum DHEA level in the 7-year-old children in the hotspot recovered to levels in the non-sprayed area. The testosterone level of 66.5 pg/mL for boys in the non-sprayed area was 1.5 times the girls level of 44.6 pg/mL, a male-dominant effect. The testosterone level in boys and girls from the hotspot were significantly lower than in the non-sprayed area with no sex difference. The 17β-hydroxysteroid dehydrogenase (17β-HSD) activity was significantly higher in boys than in the girls from the non-sprayed area, but was significantly lower in the hotspot boys than in the non-sprayed area boys. Both the testosterone level and 17β-HSD activity in the boys were inversely correlated with the TEQ total PCDD/Fs in the maternal breast milk. These results indicated that dioxin delayed the expression of the testosterone level and 17β-HSD activity with growth in the 7-year-old boys. The serum DHEA in the 7-year-old children recovered to the levels of the children in the non-sprayed area.
- Published
- 2021
28. Skipping breakfast and 5-year changes in body mass index and waist circumference in Japanese men and women
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Hideaki Nakagawa, Teruhiko Kido, Yuchi Naruse, Koshi Nakamura, Sin-ya Nagasawa, Masao Ishizaki, Satoshi Sasaki, Yasushi Suwazono, Toshinari Takamura, Kazuhiro Nogawa, Katsuyuki Miura, Katsushi Yoshita, Masaru Sakurai, and Yuko Morikawa
- Subjects
0301 basic medicine ,030109 nutrition & dietetics ,Nutrition and Dietetics ,Waist ,Body volume index ,business.industry ,Endocrinology, Diabetes and Metabolism ,digestive, oral, and skin physiology ,Anthropometry ,Circumference ,Annual change ,03 medical and health sciences ,Medicine ,business ,Generalized estimating equation ,Body mass index ,Cohort study ,Demography - Abstract
SummaryObjective This study investigated the relationship between frequency of skipping breakfast and annual changes in body mass index (BMI) and waist circumference (WC). Methods The participants were 4,430 factory employees. BMI and WC were measured repeatedly at annual medical examinations over a 5-year period. The association between frequency of skipping breakfast at the baseline examination and annual changes in anthropometric indices was evaluated using the generalized estimating equation method. Results The mean (standard deviation) BMI was 23.3 (3.0) kg m−2 for men and 21.9 (3.6) kg m−2 for women; and the mean WC was 82.6 (8.7) cm for men and 77.8 (9.8) cm for women. During the follow-up period, mean BMI increased by 0.2 kg m−2 for men and women, and mean WC increased by 1.1 cm for men and 1.0 cm for women. The annual change in the BMI of men who skipped breakfast four to six times per week was 0.061 kg m−2 higher, and that of those who skipped breakfast seven times per week was 0.046 kg m−2 higher, compared with those who did not skip breakfast. Annual changes in the WC of male participants who skipped breakfast seven times per week was 0.248 cm higher than that of those who did not skip breakfast. Skipping breakfast was not associated with changes in BMI or WC in women. Conclusions Skipping breakfast was closely associated with annual changes in BMI and WC among men, and eating breakfast more than four times per week may prevent the excessive body weight gain associated with skipping breakfast.
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- 2017
29. Age-specific impact of diabetes mellitus on the risk of cardiovascular mortality: An overview from the evidence for Cardiovascular Prevention from Observational Cohorts in the Japan Research Group (EPOCH-JAPAN)
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Yutaka Kiyohara, Yoichiro Hirakawa, Akira Okayama, Hideaki Nakagawa, Yoshitaka Murakami, Akiko Tamakoshi, Toshiharu Ninomiya, Katsuyuki Miura, Shigeyuki Saitoh, Tomonori Okamura, Kiyomi Sakata, and Hirotsugu Ueshima
- Subjects
Adult ,Male ,Pediatrics ,medicine.medical_specialty ,Epidemiology ,Coronary Disease ,Disease ,030204 cardiovascular system & hematology ,Pooled analysis ,Cohort Studies ,Diabetes Complications ,03 medical and health sciences ,0302 clinical medicine ,Diabetes mellitus ,Japan ,Cardiovascular prevention ,Risk Factors ,Collaborative cohort study ,Humans ,Medicine ,030212 general & internal medicine ,EPOCH (chemotherapy) ,Risk factor ,Aged ,Proportional Hazards Models ,Cardiovascular mortality ,Aged, 80 and over ,lcsh:R5-920 ,business.industry ,Age Factors ,General Medicine ,Middle Aged ,medicine.disease ,Age specific ,Stroke ,Age-specified cardiovascular risk ,Cardiovascular Diseases ,Cardiovascular death ,Female ,Original Article ,Observational study ,Medical emergency ,business ,lcsh:Medicine (General) - Abstract
Background Diabetes mellitus is a strong risk factor for cardiovascular disease. However, the age-specific association of diabetes with cardiovascular risk, especially in the elderly, remains unclear in non-Western populations. Methods A pooled analysis was conducted using 8 cohort studies (mean follow-up period, 10.3 years) in Japan, combining the data from 38,854 individual participants without history of cardiovascular disease. In all, 1867 of the participants had diabetes, defined based on the 1998 World Health Organization criteria. The association between diabetes and the risk of death from cardiovascular disease, coronary heart disease (CHD), and stroke was estimated using a stratified Cox model, accounting for variability of baseline hazard functions among cohorts. Results During the follow-up, 1376 subjects died of cardiovascular disease (including 268 of coronary heart disease and 621 of stroke). Diabetes was associated with an increased risk of cardiovascular death after multivariable adjustment (hazard ratio [HR] 1.62; 95% confidence interval [CI], 1.35–1.94). Similarly, diabetes was a risk factor for CHD (HR 2.13; 95% CI, 1.47–3.09) and stroke (HR 1.40; 95% CI, 1.05–1.85). In the age-stratified analysis of the risk of cardiovascular death, the relative effects of diabetes were consistent across age groups (p for heterogeneity = 0.18), whereas the excess absolute risks of diabetes were greater in participants in their 70s and 80s than in younger subjects. Conclusions The management of diabetes is important to reduce the risk of death from cardiovascular disease, not only in midlife but also in late life, in the Japanese population., Highlights • We conducted meta-analysis of individual data from 8 Japanese cohorts (n = 38,854). • Diabetes raised cardiovascular mortality in Japan. • Impact of diabetes on cardiovascular death was similar across 10-year age groups.
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- 2017
30. Effects of aging on cadmium concentrations and renal dysfunction in inhabitants in cadmium-polluted regions in Japan
- Author
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Hideaki Nakagawa, Hoang Duc Phuc, Kazuhiro Nogawa, Akie Ichimori, Le Thai Anh, Teruhiko Kido, Yuko Oyama, Nguyen Thi Phuong Oanh, Rie Okamoto, Yasushi Suwazono, and Ho Dung Manh
- Subjects
0301 basic medicine ,Albumin concentrations ,Cadmium ,Bone disease ,Beta-2 microglobulin ,business.industry ,Urinary system ,Albumin ,chemistry.chemical_element ,Physiology ,Urine ,010501 environmental sciences ,Toxicology ,medicine.disease ,01 natural sciences ,03 medical and health sciences ,030104 developmental biology ,chemistry ,Renal tubular dysfunction ,Medicine ,business ,0105 earth and related environmental sciences - Abstract
The absorption of cadmium (Cd) may lead to Cd-related diseases such as renal tubular dysfunction and bone disease, and it is known to take around 10-30 years to reduce Cd concentrations to half their original levels. Urinary β2 -microglobulin (β2 -MG), N-acetyl-β-D-glucosaminidase (NAG), protein, glucose and albumin were used as indicators of renal dysfunction caused by Cd exposure. Our previous study found that urinary Cd concentrations had increased recently and that age was more strongly associated with urinary β2 -MG concentration than recent Cd body burden. Therefore, the purpose of the present study was to investigate the effect of aging on Cd concentrations and renal dysfunction. The Cd, β2 -MG, NAG, protein, glucose and albumin concentrations in the urine of 40 Japanese subjects (20 females and 20 males) environmentally exposed to Cd were collected. They lived in the Kakehashi River basin and were divided into three age categories: 50-69, 70-79 and 80-99 years. Significant differences in urinary Cd and β2 -MG concentrations were found among age groups, with urinary Cd levels tending to increase with age in both sexes. No significant correlations were found between urinary Cd and any indicators of renal dysfunction. The correlation between age, Cd and indicators of renal dysfunction was observed more clearly in females than in males. Age is more strongly correlated with indicators of renal dysfunction than Cd body burden. Copyright © 2017 John Wiley & Sons, Ltd.
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- 2017
31. Threshold limit values of the cadmium concentration in rice in the development of itai-itai disease using benchmark dose analysis
- Author
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Hideaki Nakagawa, Teruhiko Kido, Masaru Sakurai, Kazuhiro Nogawa, Masao Ishizaki, and Yasushi Suwazono
- Subjects
021110 strategic, defence & security studies ,Entire population ,Veterinary medicine ,Cadmium ,Threshold limit value ,Incidence (epidemiology) ,0211 other engineering and technologies ,food and beverages ,chemistry.chemical_element ,02 engineering and technology ,010501 environmental sciences ,Biology ,Toxicology ,Logistic regression ,Itai-itai disease ,medicine.disease ,01 natural sciences ,Lower limit ,chemistry ,medicine ,0105 earth and related environmental sciences - Abstract
The aim of this study was to estimate the benchmark dose (BMD) as the threshold limit level of the cadmium (Cd) concentration in rice for itai-itai disease and/or suspected disease; it was based on the data that previously evaluated the association for such diseases with the Cd concentration in rice by using a logistic regression model. From 1971 to 1976, a total of 2446 rice samples were analyzed across the 88 hamlets in the Jinzu river basin. The mean Cd concentration in rice in each hamlet was used as the index of external Cd exposure of the entire population of the hamlet. We employed the incidence of itai-itai disease and/or suspected disease obtained from the available 55 hamlets. As the threshold, the lower limit of the BMD (BMDL) of the Cd concentration in rice for itai-itai disease and/or suspected disease was estimated using a logistic model, setting the benchmark response at 1% or 2%. The estimated BMDLs of the Cd concentration in rice for itai-itai disease and/or suspected disease were 0.62–0.76 and 0.27–0.56 mg kg−1 in men and women, respectively. The lowest BMDL was 0.27 mg kg−1 in women. In the present study, the threshold limit level of the Cd concentration in rice for itai-itai disease, which is the most severe form of chronic Cd poisoning, was estimated for the first time. This result provides important information about the worldwide standard for the Cd concentration in rice. Copyright © 2017 John Wiley & Sons, Ltd.
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- 2017
32. Estimation of Benchmark Dose of Lifetime Cadmium Intake for Adverse Renal Effects Using Hybrid Approach in Inhabitants of an Environmentally Exposed River Basin in Japan
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Kazuhiro Nogawa, Hideaki Nakagawa, Keiko Kubo, Yasushi Suwazono, Muneko Nishijo, and Teruhiko Kido
- Subjects
0301 basic medicine ,Cadmium ,business.industry ,Beta-2 microglobulin ,Environmental engineering ,chemistry.chemical_element ,Environmental exposure ,Urine ,010501 environmental sciences ,Hybrid approach ,01 natural sciences ,Confidence interval ,03 medical and health sciences ,030104 developmental biology ,Animal science ,chemistry ,Physiology (medical) ,Reference level ,Metallothionein ,Medicine ,Safety, Risk, Reliability and Quality ,business ,0105 earth and related environmental sciences - Abstract
The aim of this study is to estimate the reference level of lifetime cadmium intake (LCd) as the benchmark doses (BMDs) and their 95% lower confidence limits (BMDLs) for various renal effects by applying a hybrid approach. The participants comprised 3,013 (1,362 men and 1,651 women) and 278 (129 men and 149 women) inhabitants of the Cd-polluted and nonpolluted areas, respectively, in the environmentally exposed Kakehashi River basin. Glucose, protein, aminonitrogen, metallothionein, and β2 -microglobulin in urine were measured as indicators of renal dysfunction. The BMD and BMDL that corresponded to an additional risk of 5% were calculated with background risk at zero exposure set at 5%. The obtained BMDLs of LCd were 3.7 g (glucose), 3.2 g (protein), 3.7 g (aminonitrogen), 1.7 g (metallothionein), and 1.8 g (β2 -microglobulin) in men and 2.9 g (glucose), 2.5 g (protein), 2.0 g (aminonitrogen), 1.6 g (metallothionein), and 1.3 g (β2 -microglobulin) in women. The lowest BMDL was 1.7 g (metallothionein) and 1.3 g (β2 -microglobulin) in men and women, respectively. The lowest BMDL of LCd (1.3 g) was somewhat lower than the representative threshold LCd (2.0 g) calculated in the previous studies. The obtained BMDLs may contribute to further discussion on the health risk assessment of cadmium exposure.
- Published
- 2017
33. P6234The relationship of alcohol consumption with risk factors of coronary heart disease and the intake of macro- and micro-nutrients in Japanese: the INTERLIPID study
- Author
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Katsushi Yoshita, Hideaki Nakagawa, Hiromi Yamauchi, H Ueshima, Kiyomi Sakata, Paul Elliott, Q. Chan, Shigeyuki Saitoh, Katsuyuki Miura, Nagako Okuda, Kamal Masaki, Jeremiah Stamler, A Okayama, Keiko Kondo, and Sachiko Tanaka
- Subjects
business.industry ,Environmental health ,Medicine ,Macro ,Cardiology and Cardiovascular Medicine ,business ,Micronutrient ,Alcohol consumption ,Coronary heart disease - Abstract
Background Many studies have reported the J-shaped relationship between alcohol consumption and coronary heart disease (CHD) risk; therefore, light-drinkers is generally recognized to be associated with the lower risk of CHD. However, the mechanisms of lower risk for CHD in light-drinkers are still unclear. Alcohol drinking status is likely to be associated with not only CHD risk factors but also dietary intake. Nevertheless, few studies report these relationships in detail. Purpose The purpose of this study is to evaluate the relationships of alcohol drinking status with CHD classical risk factors and the intake of macro- and micro- nutrients in Japanese. Methods Study participants were 1,090 Japanese men and women aged 40–59 years from The INTERLIPID study excepted for 55 individuals who had missing data (n=26) and were past-drinkers (n=29). Alcohol consumption was assessed with two 7-day alcohol records, and average ethanol intake (per week) was calculated. Participants were classified into following 4 groups: non-drinkers (0g/week), light-drinkers ( Results Serum HDL cholesterol levels increased and LDL cholesterol levels decreased with increasing alcohol consumption. Systolic and diastolic BP increased with increasing alcohol consumption. J-shaped relationships with alcohol consumption were observed for the proportion of current smoker, number of cigarettes, and the prevalence of hypertension; that is, light-drinkers was lowest among all groups. The prevalence of dyslipidemia was the highest in non-drinkers, and decreased with increasing alcohol consumption. In heavy-drinkers, total energy (kcal/day) was the highest, but energy intake without alcohol (kcal/day) was the lowest. For macronutrients, the intake of carbohydrate (%kcal) decreased, and the intakes of total and animal protein (%kcal) increased with increasing alcohol consumption. The intakes of total cholesterol (mg/1000kcal) and sodium (mg/1000kcal) increased, and total fiber (g/1000kcal) decreased with increasing alcohol consumption. These associations were similar in men and women. Conclusions Alcohol consumption was related with not only CHD classical risk factors but also the intake of macro- and micro-nutrients. Non-drinkers had a higher proportion of some CHD risk factors than light-drinkers. These results might influence on J-shaped relationship between alcohol consumption and CHD risk. Acknowledgement/Funding 1: Ministry of Education, Science, Sports, and Culture of Japan, 2: National Institutes of Health, Bethesda, MD, USA
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- 2019
34. Health status of workers approximately 60 years of age and the risk of early death after compulsory retirement: A cohort study
- Author
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Hideaki Nakagawa, Yuchi Naruse, Kazuhiro Nogawa, Koji Nogawa, Yasushi Suwazono, Yuko Morikawa, Motoko Nakashima, Masao Ishizaki, Teruhiko Kido, Masaru Sakurai, and Katsuyuki Miura
- Subjects
Male ,Health Status ,medicine.medical_treatment ,Cohort Studies ,elderly workers ,Japan ,Risk Factors ,Cause of Death ,cohort study ,medicine ,Humans ,Mortality ,Risk factor ,compulsory retirement ,Proportional Hazards Models ,Retirement ,business.industry ,Hazard ratio ,Public Health, Environmental and Occupational Health ,Original Articles ,Middle Aged ,medicine.disease ,Obesity ,Confidence interval ,all‐cause mortality ,risk factor ,Smoking cessation ,Original Article ,Female ,Metabolic syndrome ,business ,Dyslipidemia ,Cohort study ,Demography - Abstract
Objectives The increasing number of working elderly people has enhanced the importance of workplace health promotion activities. We investigated the association between the health status of workers approximately 60 years of age and the risk of all‐cause mortality after compulsory retirement in Japan. Methods The 2026 participants (1299 males and 727 females) had retired from a metal‐products factory at ≥60 years of age. Baseline health examinations were conducted at 60 years of age and included questions about medical history and lifestyle factors; the participants also underwent a physical examination. The participants were followed up annually by mail for an average of 7.4 years. The association between health status at age 60 years and the risk of all‐cause mortality was assessed by Cox proportional hazards regression analysis. Results During the study, 71 deaths were reported. The age‐ and sex‐adjusted hazard ratio (HR [95% confidence interval]) for all‐cause mortality was higher for males (HR, 3.41 [1.73‐6.69]) compared with females, participants with a low body mass index (
- Published
- 2019
35. Effects of Cadmium Exposure on Life Prognosis
- Author
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Muneko Nishijo and Hideaki Nakagawa
- Subjects
Cadmium ,business.industry ,Urinary system ,chemistry.chemical_element ,Physiology ,Disease ,Environmental exposure ,Itai-itai disease ,medicine.disease ,CADMIUM EXPOSURE ,chemistry ,Renal tubular dysfunction ,medicine ,Respiratory system ,business - Abstract
The increased cancer incidence and mortality associated with cadmium (Cd) exposure have been investigated worldwide, but the findings are often inconsistent. The increased mortality from cardiovascular and other non-cancer diseases has also been reported in populations exposed to Cd. In Japanese Cd-polluted areas, including one where itai-itai disease is endemic, levels of urinary Cd and renal tubular dysfunction induced by Cd exposure are associated with an increased mortality in both sexes (women > men), particularly from cardiovascular and renal diseases. However, deaths from respiratory and digestive diseases have also been recorded in patients with itai-itai disease. Significant association between Cd in rice and mortality was found only in the most polluted part of the Jinzu River basin, Toyama in Japan. These findings indicate that high-level Cd exposure, whether environmental or occupational, may adversely affect life prognosis, but more studies are required to characterize the effects of low-level Cd exposure indicated by urinary or blood Cd in general populations with different dietary and lifestyle habits.
- Published
- 2019
36. Serum Ferritin, Insulin Resistance, and β-cell Dysfunction: A Prospective Study in Normoglycemic Japanese Men
- Author
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Teruhiko Kido, Hideaki Nakagawa, Kazuhiro Nogawa, Katsuyuki Miura, Shin-ya Nagasawa, Yasushi Suwazono, Masaru Sakurai, Yuko Morikawa, Yuchi Naruse, Masao Ishizaki, Koshi Nakamura, and Motoko Nakashima
- Subjects
Adult ,Male ,0301 basic medicine ,medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,Population ,030209 endocrinology & metabolism ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,Insulin resistance ,Asian People ,Japan ,Insulin-Secreting Cells ,Internal medicine ,Internal Medicine ,medicine ,Humans ,Mass index ,Prospective Studies ,education ,Prospective cohort study ,education.field_of_study ,business.industry ,Confounding ,General Medicine ,Middle Aged ,medicine.disease ,030104 developmental biology ,Ferritins ,Median body ,Insulin Resistance ,business ,Body mass index ,Follow-Up Studies ,Cohort study - Abstract
Objectives: The present cohort study investigated the relationship between serum ferritin levels and indices of insulin resistance and β-cell dysfunction in a normoglycemic population without iron overload disorders. Methods: The study participants included 575 normoglycemic Japanese men aged 35–57 years with serum ferritin levels of 400 μg/L or less. Insulin resistance and β-cell dysfunction were estimated at baseline and after 3 years by the homeostasis model assessments of insulin resistance and β-cell function (HOMA-IR and HOMA-β, respectively). To compare the subsequent changes in HOMA-IR and HOMA-β over a 3-year follow-up period among 3 groups based on tertiles of baseline serum ferritin levels (4.9–87.1, 87.2–140.5, and 140.6–396.8 μg/L), the geometric mean HOMA-IR and HOMA-β values at year 3 were calculated for each group using analysis of covariance, incorporating the respective log-transformed parameters at baseline in addition to age, body mass index and major confounding factors. Results: The multivariate-adjusted geometric mean HOMA-IR at year 3 was significantly higher in those in the highest and middle serum ferritin tertiles (1.24 and 1.22, respectively), compared with the lowest tertile (1.07) (p=0.009). When the total study participants were stratified by median body mass index (22.72 kg/m2), similar positive relationships were observed between serum ferritin levels and HOMA-IR for both obese and non-obese participants. However, the adjusted geometric mean HOMA-β at year 3 was similar among the 3 serum ferritin groups. Conclusions: Elevated serum ferritin levels predicted a subsequent increase in HOMA-IR in normoglycemic Japanese men without iron overload disorders.
- Published
- 2016
37. Sex Differences in Associations Among Obesity, Metabolic Abnormalities, and Chronic Kidney Disease in Japanese Men and Women
- Author
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Yasuo Takeda, Hideaki Nakagawa, Masaru Sakurai, Junji Kobayashi, Jun-ichi Yamakawa, Hiroshi Mabuchi, Junji Moriya, and Shin-ya Nagasawa
- Subjects
sex differences ,Adult ,Male ,medicine.medical_specialty ,Epidemiology ,030232 urology & nephrology ,MEDLINE ,abdominal obesity ,chronic kidney disease ,metabolic syndrome ,030204 cardiovascular system & hematology ,urologic and male genital diseases ,腹部肥満 ,03 medical and health sciences ,0302 clinical medicine ,Japan ,Internal medicine ,Cardiovascular Disease ,medicine ,Humans ,Obesity ,Renal Insufficiency, Chronic ,Sex Distribution ,Abdominal obesity ,Aged ,Metabolic Syndrome ,lcsh:R5-920 ,性差 ,business.industry ,General Medicine ,Health Status Disparities ,Middle Aged ,medicine.disease ,Endocrinology ,慢性腎臓病 ,メタボリックシンドローム ,Original Article ,Female ,medicine.symptom ,Metabolic syndrome ,business ,lcsh:Medicine (General) ,Kidney disease - Abstract
Aims: The present study aimed to investigate relationships among abdominal obesity, metabolic abnormalities, and the prevalence of chronic kidney disease (CKD) in relatively lean Japanese men and women. Participants and methods: The participants included 8133 men and 15 934 women between 40 and 75 years of age recruited from the government health check-up center in Kanazawa City, Japan. The prevalence of abdominal obesity, high blood pressure, dyslipidemia, and high fasting plasma glucose levels were assessed according to the Japanese criteria for metabolic syndrome. The estimated glomerular filtration rate (eGFR) was calculated using the modified Modification of Diet in Renal Disease equation for the Japanese population, and participants with an eGFR
- Published
- 2016
38. A 28-year observational study of urinary cadmium and β2-microglobulin concentrations in inhabitants in cadmium-polluted areas in Japan
- Author
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Hoang Duc Phuc, Akie Ichimori, Le Thai Anh, Nguyen Thi Phuong Oanh, Kazuhiro Nogawa, Teruhiko Kido, Rie Okamoto, Yasushi Suwazono, Hideaki Nakagawa, and Ho Dung Manh
- Subjects
0301 basic medicine ,Cadmium ,Beta-2 microglobulin ,business.industry ,Urinary system ,Early detection ,chemistry.chemical_element ,Physiology ,Urine ,Environmental exposure ,010501 environmental sciences ,Toxicology ,01 natural sciences ,03 medical and health sciences ,030104 developmental biology ,Renal tubular dysfunction ,chemistry ,Adverse health effect ,Immunology ,Medicine ,business ,0105 earth and related environmental sciences - Abstract
The biological half-life of cadmium (Cd) is as long as 10-30 years. Exposure to this element induces renal tubular dysfunction, which is considered irreversible. β2 -microglobulin (β2 -MG) is a low-molecular-weight protein, and urinary β2 -MG is one of the most useful and critical indicators for the early detection of renal tubular dysfunction. However, very little research has been published concerning the long-term observation of Cd-induced adverse health effects. As such, this follow-up study was conducted for 28 years to clarify the relationship between the concentration of Cd and β2 -MG in the urine of 28 inhabitants (14 male and 14 female) living in the Kakehashi River basin, Ishikawa prefecture (Japan), previously one of the most highly Cd-polluted regions in this country. All subjects were over 60 years old in 2014 and participated in all six health examinations conducted over 28 years (1986-2014). Urine was collected at the appropriate time and kept frozen to analyze urinary Cd and β2 -MG concentrations. The urinary Cd concentration was found to decrease by nearly half between 1986 and 2008 in both male and female subjects, whereas it increased significantly from 2008 to 2014 in males. In contrast, urinary β2 -MG concentrations tended to increase over the 28-year study period in both sexes. Urinary Cd and β2 -MG concentrations in females were significantly higher than those in males in this Cd-polluted region. Age is more strongly associated with urinary β2 -MG concentration than recent Cd body burden. Copyright © 2016 John Wiley & Sons, Ltd.
- Published
- 2016
39. Influence of dioxin exposure upon levels of prostate-specific antigen and steroid hormones in Vietnamese men
- Author
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Seijiro Honma, Rie Okamoto, Shoko Maruzeni, Takeshi Nakano, Nguyen Ngoc Hung, Eitetsu Koh, Muneko Nishijo, Le Ke Son, Hideaki Nakagawa, Teruhiko Kido, Ho Dung Manh, Dang Duc Nhu, Takumi Takasuga, and Xian Liang Sun
- Subjects
Male ,Polychlorinated Dibenzodioxins ,Health, Toxicology and Mutagenesis ,medicine.medical_treatment ,Polychlorinated dibenzodioxins ,Polychlorinated dibenzofurans ,010501 environmental sciences ,urologic and male genital diseases ,01 natural sciences ,Prostate cancer ,chemistry.chemical_compound ,0302 clinical medicine ,Testosterone ,heterocyclic compounds ,Gonadal Steroid Hormones ,Agent Orange ,General Medicine ,Middle Aged ,Pollution ,Polychlorinated dibenzo-p-dioxins ,Prostate-specific antigen ,Vietnam ,030220 oncology & carcinogenesis ,Environmental Pollutants ,Steroids ,2,4-Dichlorophenoxyacetic Acid ,medicine.medical_specialty ,Dehydroepiandrosterone ,Vietnamese men ,Dioxins ,Steroid ,03 medical and health sciences ,Polychlorinated biphenyls ,Internal medicine ,medicine ,Humans ,Environmental Chemistry ,Furans ,Aged ,Benzofurans ,0105 earth and related environmental sciences ,Steroid hormones ,2,4,5-Trichlorophenoxyacetic Acid ,business.industry ,Prostatic Neoplasms ,medicine.disease ,Endocrinology ,chemistry ,business ,Hormone - Abstract
Most studies on the relationship between Agent Orange and prostate cancer have focused on US veterans of the Vietnam War. There have been few studies focusing on the relationship between levels of prostate-specific antigen (PSA) and dioxins or steroid hormones in Vietnamese men. In 2009–2011, we collected blood samples from 97 men who had resided in a “dioxin hotspot” and 85 men from a non-sprayed region in Vietnam. Then levels of PSA, dioxins, and steroid hormones were analyzed. Levels of most dioxins, furans, and non-ortho polychlorinated biphenyls were higher in the hotspot than those in the non-sprayed region. Levels of testosterone, dehydroepiandrosterone, and estradiol differed significantly between the hotspot and the non-sprayed region, but there were no correlations between levels of PSA and steroid hormones and dioxins in either of the two regions. Our findings suggest that PSA levels in Vietnamese men are not associated with levels of dioxin or steroid hormones in these two regions. © 2016 Springer-Verlag Berlin Heidelberg, Embargo Period 12 months
- Published
- 2016
40. Attenuation of Urinary Cadmium in Inhabitants of the Environmentally Exposed Jinzu River Basin Determined by Applying a Mixed Linear Model
- Author
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Yasushi Suwazono, Hideaki Nakagawa, Keiko Aoshima, Muneko Nishijo, Masao Ishizaki, Rie Okamoto, Kazuhiro Nogawa, and Teruhiko Kido
- Subjects
Male ,Health, Toxicology and Mutagenesis ,Urinary system ,Drainage basin ,Mineralogy ,chemistry.chemical_element ,010501 environmental sciences ,Toxicology ,Slow component ,Models, Biological ,01 natural sciences ,03 medical and health sciences ,0302 clinical medicine ,Japan ,Rivers ,Mixed linear model ,Humans ,Medicine ,Aged ,0105 earth and related environmental sciences ,Cadmium ,geography ,geography.geographical_feature_category ,business.industry ,Attenuation ,General Medicine ,Middle Aged ,Pollution ,chemistry ,030220 oncology & carcinogenesis ,Linear Models ,Environmental Pollutants ,Female ,business ,Environmental Monitoring ,Half-Life ,Demography - Abstract
Half-life of urinary cadmium level (U-Cd) was estimated in inhabitants whose initial U-Cd was ≥5 μg/L (131 men and 177 women) or ≥5 μg/gcr (195 men and 246 women), using a linear mixed model adjusted for the baseline age. To clarify the effect of initial U-Cd, the target participants were divided into higher or lower initial U-Cd group. In the higher groups, the half-lives were 15.4 and 13.1 years for unadjusted U-Cd and 19.0 and 23.0 years for creatinine-adjusted U-Cd, in men and women, respectively. In the lower groups, the half-lives were 38.0 and 26.0 years for unadjusted U-Cd in men and women. For creatinine-adjusted U-Cd, it was 42.9 years in men. For attenuation of U-Cd, there were an early fast component shown in the higher group and late slow component shown in the lower group. The attenuation of U-Cd is slower in the longer time compared to that previously reported.
- Published
- 2016
41. Food sources of dietary sodium in the Japanese adult population: the international study of macro-/micronutrients and blood pressure (INTERMAP)
- Author
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Katsushi Yoshita, Kiyomi Sakata, Queenie Chan, Akira Okayama, Hirotsugu Ueshima, Naoko Miyagawa, Shigeyuki Saito, Paul Elliott, Jeremiah Stamler, Hideaki Nakagawa, Katsuyuki Miura, and Nagako Okuda
- Subjects
Adult ,Male ,Food intake ,Adult population ,Medicine (miscellaneous) ,Blood Pressure ,030204 cardiovascular system & hematology ,Article ,Food group ,03 medical and health sciences ,0302 clinical medicine ,Dietary Sodium ,Asian People ,Japan ,Surveys and Questionnaires ,Humans ,Medicine ,Micronutrients ,030212 general & internal medicine ,Food science ,Nutrition and Dietetics ,business.industry ,Body Weight ,Sodium ,digestive, oral, and skin physiology ,Sodium, Dietary ,Middle Aged ,Micronutrient ,Diet ,Nutrition Assessment ,Blood pressure ,Hypertension ,Mental Recall ,Potassium ,Female ,business ,Food Analysis - Abstract
PURPOSE: It is often reported that Na intake levels are higher in Japan than in western countries. Detailed analysis of food intake and its association with Na intake are necessary for supporting further decreases in Na consumption in Japan. We investigated the association between Na and food intake by food group using data from the Japanese participants of the INTERMAP Study. METHOD: Results from the Japanese participants of the INTERMAP Study who did not use antihypertensive medication and/or consume a reduced Na diet were used (531 men and 518 women, aged 40–59 years), obtained from four 24-h dietary recalls and two 24-h urine collections from each participant. We developed a classification system with 46 food group classifications; food consumption and Na intake from these groups were compared across quartiles of participants determined by 24-h urinary Na excretion per unit of body weight (UNa/BW). RESULTS: Average daily Na intake from Japanese high-Na foods was 2552 mg/day. Participants with a higher UNa/BW consumed a significantly greater amount of high-Na Japanese foods, such as salted fish (P = 0.001) and miso soup (P < 0.001). They also had greater amount of rice (P = 0.001). Participants with lower UNa/BW consumed a significantly greater amount of western foods, such as bread (P < 0.001) and milk and dairy products (P < 0.001). CONCLUSIONS: Detailed analyses of various Japanese and western food intakes in addition to Na intake were performed. These results can be used to help draw up effective programs for the reduction in Na intake and prevention of prehypertension/hypertension in the Japanese population.
- Published
- 2016
42. Relationship of Consumption of Meals Including Grain, Fish and Meat, and Vegetable Dishes to the Prevention of Nutrient Deficiency: The INTERMAP Toyama Study
- Author
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Katsushi Yoshita, Hirotsugu Ueshima, Masaru Sakurai, Jeremiah Stamler, Tatsuya Koyama, Hideaki Nakagawa, Katsuyuki Miura, Akira Okayama, Yuchi Naruse, and Nagako Okuda
- Subjects
Male ,0301 basic medicine ,Medicine (miscellaneous) ,Ascorbic Acid ,Recommended Dietary Allowances ,Body Mass Index ,chemistry.chemical_compound ,Japan ,Vegetables ,Micronutrients ,Food science ,Vitamin A ,Whole Grains ,education.field_of_study ,Nutrition and Dietetics ,Vitamin A Deficiency ,digestive, oral, and skin physiology ,Fishes ,Middle Aged ,Micronutrient ,Dietary Reference Intake ,Female ,Diet, Healthy ,Adult ,Vitamin ,Meat ,Population ,03 medical and health sciences ,Animal science ,Asian People ,medicine ,Animals ,Humans ,education ,030109 nutrition & dietetics ,Vitamin C ,business.industry ,Body Weight ,Malnutrition ,Ascorbic acid ,medicine.disease ,Calcium, Dietary ,Vitamin A deficiency ,Nutrition Assessment ,Seafood ,chemistry ,Mental Recall ,Ascorbic Acid Deficiency ,Energy Intake ,business - Abstract
A Japanese-style diet consists of meals that include grain (shushoku), fish and meat (shusai), and vegetable dishes (fukusai). Little is known about the association of such meals (designated well-balanced meals hereafter) with nutrient intake. We therefore examined the frequency of well-balanced meals required to prevent nutrient deficiency. Participants were Japanese people, ages 40 to 59 y, from Toyama, recruited for INTERMAP, in an international population-based study. Each person provided 4 in-depth 24-h dietary recalls (149 men, 150 women). The prevalence of risk ratios of not meeting the Dietary Reference Intakes for Japanese (2015) was calculated. Well-balanced diets were assessed by the Japanese Food Guide Spinning Top. We counted the frequencies of meals in which participants consumed 1.0 or more servings of all 3 dishes categories. We divided the frequency of consumption of well-balanced meals into the following 4 groups
- Published
- 2016
43. Lifetime Cadmium Exposure and Mortality for Renal Diseases in Residents of the Cadmium-Polluted Kakehashi River Basin in Japan
- Author
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Hideaki Nakagawa, Muneko Nishijo, Kazuhiro Nogawa, Teruhiko Kido, Yasushi Suwazono, and Masaru Sakurai
- Subjects
cadmium ,Health, Toxicology and Mutagenesis ,Urinary system ,chemistry.chemical_element ,Physiology ,010501 environmental sciences ,lcsh:Chemical technology ,Toxicology ,a follow-up study ,01 natural sciences ,Article ,03 medical and health sciences ,0302 clinical medicine ,Medicine ,lcsh:TP1-1185 ,030212 general & internal medicine ,lifetime cadmium intake ,0105 earth and related environmental sciences ,Cadmium ,Chemical Health and Safety ,business.industry ,mortality ,CADMIUM EXPOSURE ,chemistry ,Relative risk ,renal diseases ,urinary cadmium ,business - Abstract
Very few studies have investigated the dose–response relationship between external cadmium (Cd) exposure and mortality. We aim to investigate the relationship between lifetime Cd intake (LCd) and mortality in the Cd-polluted Kakehashi River basin in Japan. Mortality risk ratios for a unit of increase of LCd and urinary Cd were analyzed using Cox’s proportional model. LCd was estimated based on residency and Cd in rice produced in their living areas. In men, mortality for all causes was significantly increased for a 10-μg/g Cr increase in urinary Cd, but not for a 1-g increase in LCd. In women, mortality risks for all causes and renal diseases, particularly renal failure, were significantly increased for a 10-μg/g Cr increase in urinary Cd. Similarly, mortality risks for renal diseases and renal failure were significantly increased for a 1-g increase of LCd in women. Comparing the contribution of two exposure markers to increased mortality in women, LCd was more effective for increasing mortality risks for renal diseases and renal failure, while urinary Cd contributed more to increased mortality risk for all causes. LCd may show a better dose–response relationship with mortality risk for renal diseases in women.
- Published
- 2020
44. Association of dioxin in maternal breast milk and salivary steroid hormone levels in preschool children: A five-year follow-up study of a Vietnam cohort
- Author
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Xian Liang Sun, Shoji F. Nakayama, Le Thai Anh, Hoang Duc Phuc, Rie Okamoto, Hoang Viet Nguyen, Ngo Thi Minh Tan, Nguyen Thi Phuong Oanh, Seijiro Honma, Teruhiko Kido, Shoko Maruzeni, Dang Duc Nhu, Hideaki Nakagawa, Ho Dung Manh, Dao Van Tung, and Le Minh Giang
- Subjects
Male ,Environmental Engineering ,Health, Toxicology and Mutagenesis ,medicine.medical_treatment ,0208 environmental biotechnology ,Dehydroepiandrosterone ,Physiology ,02 engineering and technology ,010501 environmental sciences ,Breast milk ,Dioxins ,01 natural sciences ,Cohort Studies ,medicine ,Humans ,Environmental Chemistry ,Testosterone ,Saliva ,0105 earth and related environmental sciences ,Milk, Human ,business.industry ,Public Health, Environmental and Occupational Health ,Five year follow up ,Infant ,Salivary testosterone ,General Medicine ,General Chemistry ,Pollution ,020801 environmental engineering ,Steroid hormone ,Vietnam ,Child, Preschool ,Cohort ,Environmental Pollutants ,Female ,Steroids ,business ,Follow-Up Studies ,Hormone - Abstract
Recent studies have found elevated dioxin levels inside some former US military air bases in Vietnam, known as hotspots. The aim of the present study was to evaluate the association of dioxin exposure and steroid hormone in preschool children in Vietnam. In 2010, 2011, 52 primiparae mother–infant pairs in the hotspot and 52 pairs in a non-exposure region were enrolled. For the final analysis, 26 vs 26 pairs were selected, who participated at all three surveys. Univariable and multivariable linear regressions were used to evaluate associations between hormone and dioxin congeners. Geometric mean total TEQ of PCDD/DFs in the hotspot were significantly higher than in the non-exposure region, 8.7 and 3.4 pg TEQ/g lipid, respectively. In the hotspot, salivary dehydroepiandrosterone (DHEA) was significantly higher in 1-year-old children (Boys = 123 pg/mL, Girls = 120 pg/mL) than in the non-exposure region (Boys = 28 pg/mL, Girls = 27 pg/mL). In contrast, DHEA was significantly lower in 5-year-old children (Boys = 70 pg/mL, Girls = 106 pg/mL) in the hotspot than in the non-exposure region (Boys = 496 pg/mL, Girls = 654 pg/mL). Salivary testosterone was significantly lower in the hotspot (Boys = 1.9 pg/mL, Girls = 1.9 pg/m; Boys = 1.0 pg/mL, Girls = 1.1 pg/mL, respectively) than in the non-exposure region (Boys = 3.7 pg/mL, Girls = 3.8 pg/m; Boys = 5.7 pg/mL, Girls = 7.0 pg/mL, respectively) at 3 years and 5 years of age. Higher levels of highly chlorinated dioxins in breast milk were associated with higher DHEA in 1-year-old and lower DHEA and testosterone levels in 5-year-old children. Our findings indicated that dioxins were associated with changes of DHEA and testosterone levels in preschool Vietnamese children.
- Published
- 2020
45. Factors associated with intra-individual visit-to-vist variability in blood pressure in four countries: The INTERMAP Study
- Author
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Naoyuki Takashima, Shigeyuki Saito, Queenie Chan, Jeremiah Stamler, Katsuyuki Miura, Akira Okayama, Nagako Okuda, Hirotsugu Ueshima, Hideaki Nakagawa, Sohel Reza Choudhury, Liancheng Zhao, Naoko Miyagawa, Kiyomi Sakata, Paul Elliott, Takayoshi Ohkubo, National Institutes of Health, and Medical Research Council (MRC)
- Subjects
Male ,Population ,Blood Pressure ,030204 cardiovascular system & hematology ,Article ,DISEASE ,03 medical and health sciences ,0302 clinical medicine ,AGE ,RISK-FACTOR ,Internal Medicine ,medicine ,Humans ,030212 general & internal medicine ,Risk factor ,education ,CARDIOVASCULAR EVENTS ,Stroke ,POPULATION ,ALL-CAUSE MORTALITY ,education.field_of_study ,Science & Technology ,biology ,business.industry ,Confounding ,INTERMAP Study Group ,Blood Pressure Determination ,Angiotensin-converting enzyme ,1103 Clinical Sciences ,ADULTS ,Middle Aged ,medicine.disease ,Intra individual ,Pulse rate ,Blood pressure ,Peripheral Vascular Disease ,Cardiovascular System & Hematology ,biology.protein ,Cardiovascular System & Cardiology ,Female ,business ,Life Sciences & Biomedicine ,STROKE ,Demography - Abstract
Several studies demonstrated that visit-to-visit variability of blood pressure (BP) predicted future events of total death, stroke and cardiovascular disease. Little is known about factors associated with visit-to-visit BP variability in different countries. We recruited participants aged 40–59 years from four countries (Japan, the People’s Republic of China [PRC], the United Kingdom [UK] and the United States [US]). At each study visit, BP was measured twice by trained observers using random zero sphygmomanometers after five minutes resting. We defined visit-to-visit BP variability as variation independent of mean (VIM) by using average systolic BP of 1st and 2nd measurement across four study visits. Data on 4680 men and women were analyzed. Mean ± standard deviation of VIM values among participants in Japan, the PRC, the UK and the US were 5.44 ± 2.88, 6.85 ± 3.49, 5.65 ± 2.81 and 5.84 ± 3.01, respectively; VIM value in the PRC participants was significantly higher. Sensitivity analyses among participants without antihypertensive treatment or past history of cardiovascular disease yielded similar results. Higher VIM value was associated with older age, female gender, lower pulse rate and urinary sodium excretion and use of antihypertensive agents such as angiotensin converting enzyme inhibitors, beta blockers and calcium channel blockers. The difference of visit-to-visit BP variability between PRC and other countries remained significant after adjustment for possible confounding factors. In this large international study across four countries, visit-to-visit BP variability in the PRC was higher than in the other three countries. Reproducibility and mechanisms of these findings remain to be elucidated.
- Published
- 2018
46. Macronutrient Intake and Socioeconomic Status: NIPPON DATA2010
- Author
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Hideaki Nakagawa, Akira Okayama, Katsuyuki Miura, Hirotsugu Ueshima, Takayoshi Ohkubo, Yoshihiro Miyamoto, Hisatomi Arima, Nagako Okuda, Tomonori Okamura, Aya Kadota, Yasuyuki Nakamura, Katsushi Yoshita, Masaru Sakurai, and Nobuo Nishi
- Subjects
0301 basic medicine ,Adult ,Male ,household income ,Epidemiology ,Affect (psychology) ,socioeconomic status ,03 medical and health sciences ,Age Distribution ,Japan ,Dietary Carbohydrates ,Medicine ,Humans ,Sex Distribution ,Socioeconomic status ,Carbohydrate intake ,Aged ,National health ,lcsh:R5-920 ,Family Characteristics ,030109 nutrition & dietetics ,business.industry ,General Medicine ,Japanese population ,Middle Aged ,Dietary Fats ,Social Epidemiology ,nutritional epidemiology ,Cross-Sectional Studies ,macronutrient intake ,Occupation type ,Social Class ,Cohort ,Income ,Household income ,Female ,Original Article ,Yes ,business ,lcsh:Medicine (General) ,Energy Intake ,Demography - Abstract
Background: This study examined the relationships among household income, other SES indicators, and macronutrient intake in a cross-sectional study of a representative Japanese population. Methods: In 2010, we established a cohort of participants in the National Health and Nutrition Survey (NHNS) from 300 randomly selected areas throughout Japan. A total of 2,637 participants (1,145 men and 1,492 women) were included in the study. Data from NHNS2010 and the Comprehensive Survey of Living Conditions 2010 (CSCL2010) were merged, and relationships among macronutrient intake and SES were evaluated. Additionally, socioeconomic factors associated with a risk of a higher carbohydrate/lower fat intake beyond dietary recommendations were evaluated. Results: Household income was positively associated with fat intake (P = 0.001 for men and
- Published
- 2018
47. Socioeconomic Status Associated With Urinary Sodium and Potassium Excretion in Japan: NIPPON DATA2010
- Author
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Akira Fujiyoshi, Akira Okayama, Aya Kadota, Katsuyuki Miura, Toshiro Takezaki, Naoyuki Takashima, Tomonori Okamura, Nobuo Nishi, Takayoshi Ohkubo, Naoko Miyagawa, Nagako Okuda, Hideaki Nakagawa, and Hirotsugu Ueshima
- Subjects
Male ,Epidemiology ,Urinary system ,Urine ,030204 cardiovascular system & hematology ,Excretion ,Cohort Studies ,socioeconomic status ,03 medical and health sciences ,0302 clinical medicine ,Japan ,Medicine ,Humans ,030212 general & internal medicine ,Sex Distribution ,Socioeconomic status ,sodium ,sodium-to-potassium ratio ,Aged ,National health ,lcsh:R5-920 ,Urinary sodium ,business.industry ,potassium ,Potassium, Dietary ,Sodium, Dietary ,General Medicine ,Middle Aged ,Nutrition Surveys ,urine ,Social Epidemiology ,Cross-Sectional Studies ,Social Class ,Cohort ,Potassium excretion ,Original Article ,Female ,Yes ,business ,lcsh:Medicine (General) ,Demography - Abstract
Background: Although socioeconomic status (SES) may affect food and nutrient intakes, few studies have reported on sodium (Na) and potassium (K) intakes among individuals with various SESs in Japan. We investigated associations of SES with Na and K intake levels using urinary specimens in a representative Japanese population. Methods: This was a cross-sectional study of 2,560 men and women (the NIPPON DATA2010 cohort) who participated in the National Health and Nutrition Survey Japan in 2010. Casual urine was used to calculate estimated excretion in 24-hour urinary Na (E24hr-Na) and K (E24hr-K). The urinary sodium-to-potassium (Na/K) ratio was calculated from casual urinary electrolyte values. An analysis of covariance was performed to investigate associations of aspects of SES, including equivalent household expenditure (EHE), educational attainment, and job category, with E24hr-Na, E24hr-K, and the Na/K ratio for men and women separately. A stratified analysis was performed on educational attainment and the job category for younger (
- Published
- 2018
48. Increase of lifetime cadmium intake dose-dependently increased all cause of mortality in female inhabitants of the cadmium-polluted Jinzu River basin, Toyama, Japan
- Author
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Masaru Sakurai, Teruhiko Kido, Muneko Nishijo, Hideaki Nakagawa, Yuuka Watanabe, Kazuhiro Nogawa, Yuko Morikawa, Masao Ishizaki, and Yasushi Suwazono
- Subjects
0301 basic medicine ,Male ,Cadmium Poisoning ,Drainage basin ,chemistry.chemical_element ,Food Contamination ,010501 environmental sciences ,Competing risks ,01 natural sciences ,Biochemistry ,03 medical and health sciences ,Sex Factors ,Japan ,Rivers ,Environmental health ,medicine ,Humans ,Mortality ,0105 earth and related environmental sciences ,General Environmental Science ,Aged ,Kidney ,geography ,Cadmium ,geography.geographical_feature_category ,Proportional hazards model ,business.industry ,Oryza ,Environmental Exposure ,Middle Aged ,030104 developmental biology ,medicine.anatomical_structure ,chemistry ,Relative risk ,Smoking status ,Female ,Kidney Diseases ,business ,All cause mortality - Abstract
Background Exposure to cadmium (Cd) via food is supposed to affect life prognosis of inhabitants of Cd-polluted area in Japan. However, there have been few reports demonstrating a significant relationship between the amount of Cd intake and mortality. We aimed to investigate the relationship between mortality and individual lifetime Cd intake (LCd) in inhabitants of the polluted Jinzu River basin, Toyama, Japan. Methods We conducted a 26-year follow-up survey in 2407 inhabitants (1208 men and 1199 women) who participated in health examinations for screening of renal dysfunction from 1979 to 1984. The calculation of LCd in each inhabitant was based on the formula of Nogawa (Nogawa et al., 1989): (mean Cd concentration in rice of the present hamlet × 333.5 g/day + 34 μg/day) × 365 days/year × number of years of residence in the present hamlet + 50 μg/day × 365 days/year × number of years living in Cd non-polluted regions. In this formula, 333.5 g/day is the 1970 average daily intake of rice in this area, 34 µg/day is the Cd intake from foods other than rice in this area, and 50 μg/day is the average intake of Cd in non-polluted areas in Japan. Mortality risk ratios of LCd for all and specific causes were estimated after adjustments for age at baseline, smoking status, and history of hypertension using a Cox hazard model or Fine and Gray competing risks regression model. Results The mortality risk ratios of LCd (+ 1 g) for all causes in women were significantly dose-dependently increased (risk ratio: 1.08). Relative risk of LCd for kidney and urinal tract disease, renal diseases, renal failure and toxic effects of cadmium were significantly higher in women. Conclusions The present study documents that individual LCd dose-dependently decreased life prognosis over long-term observation in women. LCd was significantly related to the increased mortality for renal disease and toxic effect of Cd in women. The result provides clear evidence that life prognosis was adversely affected by Cd-exposure, especially in women.
- Published
- 2017
49. Dietary carbohydrate intake, presence of obesity and the incident risk of type 2 diabetes in Japanese men
- Author
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Shin-ya Nagasawa, Katsushi Yoshita, Koshi Nakamura, Masaru Sakurai, Yuchi Naruse, Yasushi Suwazono, Teruhiko Kido, Kazuhiro Nogawa, Motoko Nakashima, Satoshi Sasaki, Toshinari Takamura, Yuko Morikawa, Hideaki Nakagawa, Masao Ishizaki, and Katsuyuki Miura
- Subjects
Adult ,Male ,medicine.medical_specialty ,Calorie ,Endocrinology, Diabetes and Metabolism ,Physiology ,030209 endocrinology & metabolism ,Type 2 diabetes ,Cohort Studies ,Dietary carbohydrates ,03 medical and health sciences ,0302 clinical medicine ,Japan ,Risk Factors ,Diabetes mellitus ,Internal medicine ,Internal Medicine ,medicine ,Humans ,Obesity ,030212 general & internal medicine ,business.industry ,Incidence ,Incidence (epidemiology) ,Hazard ratio ,Articles ,General Medicine ,Middle Aged ,medicine.disease ,Clinical Science and Care ,Endocrinology ,Diabetes Mellitus, Type 2 ,Original Article ,Energy Intake ,Cohort study ,business ,Body mass index - Abstract
The present cohort study assessed the risk among Japanese men for developing type 2 diabetes, based on the percentage of energy intake from carbohydrates and degree of obesity. Participants and Methods: The participants were 2,006 male factory employees, and the macronutrient intake of each patient was measured using a self-administered diet history questionnaire. The incidence of diabetes was determined in annual blood examinations over a 10-year period. Results: During the study, 232 participants developed diabetes. The crude incidence rates (/1,000 person-years) for different levels of carbohydrate intake as a percentage of calories consumed (65.0% of energy intake) were 16.5, 14.4, 12.7 and 17.6. Overall, carbohydrate intake was not associated with the risk of diabetes. However, there was significant interaction between carbohydrate intake and degree of obesity on the incidence of diabetes (P for interaction = 0.024). Higher carbohydrate intake was associated with elevated risk for diabetes among participants with a body mass index ≥25.0 kg/m2 (P for trend = 0.034). For obese participants, the multivariate-adjusted hazard ratio for those with carbohydrate intakes >65% energy was 2.01 (95% confidence interval 1.08-3.71), which was significantly higher than that of participants with carbohydrate intakes 50.0-57.4% energy. Conclusions: Higher carbohydrate intake was associated with higher risk of diabetes in obese participants, but not in non-obese participants. Obese participants with carbohydrate intakes >65% energy should reduce their intakes to levels within the desirable carbohydrate energy proportion for Japanese (50-65% energy) to prevent development of type 2 diabetes. © 2016 Asian Association for the Study of Diabetes and John Wiley & Sons Australia, Ltd.
- Published
- 2015
50. All-cause mortality increased by environmental cadmium exposure in the Japanese general population in cadmium non-polluted areas
- Author
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Yasushi Suwazono, Hideaki Nakagawa, Yuko Morikawa, Kazuhiro Nogawa, Teruhiko Kido, Muneko Nishijo, Etsuko Kobayashi, and Koji Nogawa
- Subjects
Cadmium ,education.field_of_study ,Creatinine ,business.industry ,Mortality rate ,Population ,Hazard ratio ,chemistry.chemical_element ,Toxicology ,Confidence interval ,chemistry.chemical_compound ,chemistry ,Quartile ,Medicine ,education ,business ,Demography ,Cohort study - Abstract
The aim of the present study was to evaluate the effect of environmental cadmium (Cd) exposure indicated by urinary Cd on all-cause mortality in the Japanese general population. A 19-year cohort study was conducted in 1067 men and 1590 women aged 50 years or older who lived in three cadmium non-polluted areas in Japan. The subjects were divided into four quartiles based on creatinine adjusted U-Cd (µg g−1 cre). The hazard ratio (HR) and 95% confidence interval (CI) for continuous U-Cd or the quartiles of U-Cd were estimated for all-cause mortality using a proportional hazards regression.The all-cause mortality rates per 1000 person years were 31.2 and 15.1 in men and women, respectively. Continuous U-Cd (+1 µg g−1 cre) was significantly related to the all-cause mortality in men (HR 1.05, 95% CI: 1.02–1.09) and women (HR 1.04, 95% CI: 1.01–1.07). Furthermore in men, the third (1.96–3.22 µg g−1 cre) and fourth quartile (≥3.23 µg g−1 cre) of U-Cd showed a significant, positive HR (third: HR 1.35, 95% CI: 1.03–1.77, fourth: HR 1.64, 95% CI: 1.26–2.14) for all-cause mortality compared with the first quartile (
- Published
- 2014
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