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Relationship between cancer mortality and environmental cadmium exposure in the general Japanese population in cadmium non-polluted areas
- Source :
- International Journal of Hygiene and Environmental Health. 223:65-70
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- The aim of the present study was to evaluate the effect of environmental cadmium (Cd) exposure indicated by urinary Cd (U-Cd) on cancer mortality in the general Japanese population. A 19-year cohort study was conducted in 1107 men and 1697 women who lived in three Cd non-polluted areas in Japan. Mortality risk ratio and 95% confidence interval (95%CI) for continuous U–Cd were estimated for all malignant neoplasms and specific cancers using a Fine and Gray competing risks regression model. The all-cause, including cancer and non-cancer mortality rates per 1000 person-years were 29.8 and 13.9 in men and women, respectively. By using Fine and Gray's method, continuous U–Cd adjusted for creatinine (+1 μg/g cre) was significantly related to mortalities for all malignant neoplasms (risk ratio = 1.06, 95%CI: 1.02–1.11) and pancreas (risk ratio = 1.13, 95%CI: 1.03–1.24) in women. In the present study, U–Cd was significantly associated with increased cancer mortality in the general Japanese population, indicating that environmental Cd exposure adversely affects the life prognosis in Cd non-polluted areas in Japan.
- Subjects :
- Male
Risk
Urinary system
chemistry.chemical_element
Physiology
010501 environmental sciences
01 natural sciences
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Japan
Neoplasms
Odds Ratio
medicine
Humans
Longitudinal Studies
030212 general & internal medicine
Aged
0105 earth and related environmental sciences
Cadmium
Creatinine
business.industry
Mortality rate
Public Health, Environmental and Occupational Health
Cancer
Environmental Exposure
Middle Aged
medicine.disease
Confidence interval
chemistry
Relative risk
Environmental Pollutants
Female
business
Cohort study
Subjects
Details
- ISSN :
- 14384639
- Volume :
- 223
- Database :
- OpenAIRE
- Journal :
- International Journal of Hygiene and Environmental Health
- Accession number :
- edsair.doi.dedup.....00ae45a374f48c3b5abe0ebee89f8328