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The relationship between cadmium exposure and renal volume in inhabitants of a cadmium-polluted area of Japan
- Source :
- Environmental Science and Pollution Research. 28:22372-22379
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- This follow-up study was conducted over 30 years in a cadmium-polluted area of Japan. Urinary cadmium (U-Cd) concentration decreased by nearly half from 1986 to 2008 in men and women. However, it increased from 2008 to 2014 and maintained similar levels in 2016. Because renal atrophy may induce an increase in U-Cd, kidney volumes were determined using magnetic resonance imaging (MRI) scans in 2018. Based on the MRI results, we divided the participants into two groups, namely the normal group (n = 6, three men and three women) and the lesion group (n = 6, three men and three women). The level of urinary N-acetyl-β-d-glucosaminidase/creatinine (U-NAG/Cr) in the lesion group was significantly higher than in the normal group. The level of serum alkaline phosphatase (Al-P) was positively associated with U-Cd. Age and renal cortex volumes showed significantly negative associations. However, U-Cd and renal cortex and kidney volumes showed no significant associations. These results suggest that U-NAG and serum Al-P were sensitive biomarkers to reflect renal tubular dysfunction and bone damage caused by cadmium poisoning. Individuals chronically exposed to Cd should be observed carefully, due to the increased effect of aging on renal cortex volumes.
- Subjects :
- Male
Health, Toxicology and Mutagenesis
Renal cortex
Urinary system
chemistry.chemical_element
Physiology
010501 environmental sciences
Kidney
01 natural sciences
Cadmium poisoning
chemistry.chemical_compound
Japan
Renal tubular dysfunction
Acetylglucosaminidase
medicine
Humans
Environmental Chemistry
0105 earth and related environmental sciences
Creatinine
Cadmium
medicine.diagnostic_test
business.industry
Magnetic resonance imaging
Environmental Exposure
General Medicine
medicine.disease
Pollution
medicine.anatomical_structure
chemistry
Female
beta 2-Microglobulin
business
Biomarkers
Follow-Up Studies
Subjects
Details
- ISSN :
- 16147499 and 09441344
- Volume :
- 28
- Database :
- OpenAIRE
- Journal :
- Environmental Science and Pollution Research
- Accession number :
- edsair.doi.dedup.....489724db50c0868c33046d19a8b46882