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Associations of High-Density Lipoprotein Particle and High-Density Lipoprotein Cholesterol With Alcohol Intake, Smoking, and Body Mass Index ― The INTERLIPID Study ―
- Source :
- Circulation Journal. 82:2557-2565
- Publication Year :
- 2018
- Publisher :
- Japanese Circulation Society, 2018.
-
Abstract
- BACKGROUND: Recently, high-density lipoprotein particles (HDL-P) have been found to be more strongly inversely associated with coronary artery disease (CAD) risk than their counterpart, HDL cholesterol (HDL-C). Given that lifestyle is among the first targets in CAD prevention, we compared the associations of HDL-P and HDL-C with selected lifestyle factors. METHODS AND RESULTS: We examined 789 Japanese participants of the INTERLIPID Study: men (n=386) and women (n=403) aged 40–59 years in 1996–1998. Participants treated for dyslipidemias were excluded. Lifestyle factors included alcohol intake, smoking amount, and body mass index (BMI). Multivariable linear regression was used for cross-sectional analyses of these factors with HDL-P, HDL-C, HDL-P size subclasses (small, medium and large) and mean HDL-P size. In men, higher alcohol intake was associated with higher HDL-P and higher HDL-C. The associations of alcohol, however, were strongest with HDL-P. A higher smoking amount tended to be associated with lower HDL-P and HDL-C. In contrast, BMI was not associated with HDL-P, but was strongly inversely associated with HDL-C. While alcohol intake favored larger mean HDL-P size, smoking and BMI favored a lipid profile with smaller HDL-P subclasses and overall smaller mean HDL-P size. Similar, but generally weaker results were observed in women. CONCLUSIONS: Although both HDL-P and HDL-C are parameters of HDL, they have different associations with alcohol, smoking and BMI.
- Subjects :
- Adult
Male
medicine.medical_specialty
Alcohol Drinking
Alcohol
030204 cardiovascular system & hematology
Article
Body Mass Index
Coronary artery disease
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
High-density lipoprotein
Japan
Risk Factors
Internal medicine
Humans
Medicine
030212 general & internal medicine
Life Style
medicine.diagnostic_test
business.industry
Cholesterol
Cholesterol, HDL
Smoking
nutritional and metabolic diseases
General Medicine
Middle Aged
High-density lipoprotein particle
medicine.disease
Cross-Sectional Studies
Endocrinology
chemistry
Female
lipids (amino acids, peptides, and proteins)
Lipoproteins, HDL
Cardiology and Cardiovascular Medicine
business
Lipid profile
Body mass index
Lipoprotein
Subjects
Details
- ISSN :
- 13474820 and 13469843
- Volume :
- 82
- Database :
- OpenAIRE
- Journal :
- Circulation Journal
- Accession number :
- edsair.doi.dedup.....854b20ae6cbe53e63e792281bfc878a2