1. Human Embryonic Stem Cell Banking for Clinical Applications—20 Years from Their Isolation
- Author
-
Paul A. De Sousa
- Subjects
Source material ,Preimplantation Embryos ,Translational research ,Good manufacturing practice ,Epigenetics ,Biology ,Bioinformatics ,Clinical evaluation ,Embryonic stem cell ,Reprogramming - Abstract
Twenty years on from the first reported isolation of pluripotent human embryonic stem cells (hESC) from in vitro fertilised preimplantation embryos, clinical evaluation of derivative cell products is ongoing. Contrary to expectations that pluripotency induction by genetic reprogramming would replace commitment to hESC source material basic and translational research and application has continued. Here we update on current clinical, translational and scientific progress and issues in human embryonic stem cell banking. These reflect transformation of an academically lead research into quality assured good manufacturing practice grade cell banking underpinning active clinical investigations.
- Published
- 2021