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Carbon nanotubes as novel nanomaterials, which are widely used in biomedical field. Through the respiratory tract, digestive tract, and circulation, carbon nanotubes can come into contact with vascular endothelial cells and damage the endothelial cells. In this paper, the factors effecting the damage of carbon nanotubes to endothelial cells was reviewed, and the effects of carbon nanotubes on endothelial cell inflammation, monocyte adhesion, lipid accumulation, endothelial permeability, angiogenesis, and pro-coagulant ability were reviewed. Meanwhile, this paper reviewed that carbon nanotubes promote the formation of atherosclerotic plaques and the impairment of blood-brain barrier function by damaging endothelial cells in animal experiments, so as to provide a reference for decision-making on the application of carbon nanotubes in biomedical field [ABSTRACT FROM AUTHOR]

Endoscopic retrograde cholangiopancreatography (ERCP) is an important endoscopic technology in the field of digestive endoscopy. It is mainly used to diagnose biliary diseases in the early stage, and now it has developed into the diagnosis and treatment of biliary and pancreatic diseases. Compared with the general endoscopic treatment, its operation time is longer and its anesthesia risk is greater. ERCP under sedation/anesthesia can enhance patients′ tolerance and create better diagnosis and treatment conditions for digestive endoscopists, but there is also the risk of anesthesia-related hypoxemia, so airway management during operation is particularly important. In this paper, the ventilation strategies of ERCP patients under sedation/anesthesia were reviewed in combination with the related research in recent years. [ABSTRACT FROM AUTHOR]

There is extensive peripheral nerve infiltration and tumor innervation in head and neck cancer, which promotes tumor progress and brings worse prognosis. Schwann cells (SCs) are a type of glial cells that are widely distributed in the peripheral nervous system and are involved in nerve injury repair. In recent years, more and more studies have shown that SCs play an important role in the tumor microenvironment (TME). Reprogrammed SCs promote peripheral nerve infiltration and tumor innervation through signal interaction with tumor and nerves on the one hand, and directly act on TME components and promote tumor progression on the other hand. This paper mainly discusses the cross-talk patterns of SCs and cancer-nerve signals, as well as the mechanism of action of SCS-related signals in TME, and explore potential targets for therapeutic intervention in SCS-related head and neck cancer. [ABSTRACT FROM AUTHOR]

Catalytic hairpin assembly (CHA) is an efficient nucleic acid amplification method that does not depend on enzyme biocatalysis and temperature cycling, and is characterized by good biocompatibility, simple operation, and mild reaction conditions. By combining CHA with various signal output modes, highly sensitive detection of various biological targets (nucleic acids, small molecules, proteins, cells) can be realized, which shows great potential for application in disease diagnosis. Therefore, this paper focuses on classical CHA, modified CHA, and several cascade reactions based on the CHA strategy with other isothermal enzyme-free amplification methods, and briefly reviews their applications in disease diagnosis. In addition, the challenges and application prospects of current CHA strategies in disease diagnosis are discussed. [ABSTRACT FROM AUTHOR]

Regular premenopausal endometrial withdrawal bleeding can avoid the occurrence of endometrial cancer. However, when the endometrium cannot be completely withdrawn, the risk of endometrial lesions begins to appear. However, due to the physiological characteristics of menstruation, it is allowed to change within a certain range. This range will be the most important basis for clinical differentiation and prevention of endometrial cancer. In this paper, the menstrual correlation characteristics of endometrial cancer are summarized into three categories: menstrual pattern, female sex hormone and endocrine metabolism. The research progress is reviewed, and the viewpoints and conclusions of different literatures on this topic are discussed. [ABSTRACT FROM AUTHOR]

Macrophages, as one of infiltrating immune cells, are closely related to the tumour microenvironment (TME), and they possess remarkable plasticity, transforming into phenotypes with opposite effects under different stimuli. Exosomes as carriers of biological information, are rich in activity and can fulfil the mutual communication between cells. Studies have shown that cancer cell-derived exosomes can carry biological information from source cells to regulate macrophage function and influence the TME by mediating macrophage polarisation, which in turn affects tumour progression. Hepatocellular carcinoma (HCC)-associated macrophages are a group of macrophages existing in the tumour immune microenvironment, influencing various malignant behaviours of hepatocellular carcinoma cells and the immune escape state within the tumour, which in turn affects the progression of hepatocellular carcinoma. In this paper, we reviewed the role of exosome-mediated macrophage polarisation in the TME of hepatocellular carcinoma to provide new directions for the treatment of hepatocellular carcinoma. [ABSTRACT FROM AUTHOR]

Inflammatory bowel disease (IBD) is a chronic non-specific recurrent inflammatory disease of the gastrointestinal tract. The emergence of antitumor necrosis factor-a (TNF-α) monoclonal antibody has greatly improved the prognosis of IBD patients, but also increased the risk of active tuberculosis. China is a country with high burden of tuberculosis and clinicians should attach great importance to the risk of tuberculosis caused by anti-TNF-α monoclonal antibody. This paper reviews the mechanism of latent tuberculosis infection and reactivation, the risk of tuberculosis caused by anti-TNF-α monoclonal antibody, and the diagnosis and treatment recommendations of domestic and foreign guidelines. It is expected to provide some references for IBD patients with latent tuberculosis infection when using anti-TNF-α monoclonal antibody. [ABSTRACT FROM AUTHOR]

Polycystic ovary syndrome (PCOS) affects about 6%-10% of women all over the world and is characterized by hyperandrogenism, menstrual irregularities, infertility, and ultrasonographic polycystic ovaries. In addition, PCOS is related to most of endocrine and metabolic disorders, including insulin resistance, obesity and diabetes, hypertension, dyslipidemia, and metabolic syndrome, all of which increase the risk of subclinical cardiovascular disease(CVD), but only with changes in vascular endothelial function without significant CVD symptoms. By searching the latest literature, this paper summarized the relevant evidence of the relationship between PCOS patients and subclinical CVD, including flow-mediated dilation (FMD), arterial stiffness, coronary artery calcium (CAC) score, visceral and epicardial fat and carotid intima-media thickness (CIMT) and so on, to better illustrate the relationship and the latest research progress between the PCOS patients with subclinical CVD. [ABSTRACT FROM AUTHOR]

Piezol protein as a novel mechanosensitive ion channel closely related to mechanical stress stimulation signals, plays a significant role in responding to mechanical stimulation and motion effects. This protein is widely distributed in the organs and tissues of the body and has been widely concerned by the aca- demic community since its discovery. A number of highly successful scientific studies have shown that Piezol has important implications for the treatment of vascular, neurological, skeletal, immune, tumor and other dis- eases. Therefore, this paper reviewed the biological characteristics of Piezol and its correlation with clinical diseases, which provides new ideas and prospects for the study of the pathogenesis, diagnosis, treatment and prognosis monitoring of clinically related diseases. [ABSTRACT FROM AUTHOR]

Intravenous blood collection is a common nursing operation in pediatrics, but this operation will bring fear, anxiety and other adverse psychological reactions to children, increase the difficulty of blood collection, and affect the physical and mental health. Therefore, in addition to routine operation techniques, the psychological state of children. In recent years, domestic and foreign scholars have conducted extensive research on psychological interventions for venous blood collection in children. This paper reviewed the possible adverse psychological reactions during venous blood sampling in children of different ages, and summarizes the influencing factors of fear psychology. According to the characteristics of children of different ages, nursing staff take effective psychological intervention measures aimed at reducing children′s fear and improving the success rate and efficiency of puncture. These research advances provide valuable information for clinical nursing practice and nursing research. [ABSTRACT FROM AUTHOR]

In order to solve the problems of high cost of microemulsion use and the limitation of microe- mulsion application in high temperature and high salt strata, this paper conducted a systematic research on the development of chemically driven microemulsions and the unique properties of nanoparticles, and summarized the synergistic effect between nanoparticles and microemulsions, the effect of nanoparticle incorporation on the applicability of salinity to the microemulsions as well as the influence on the rheological properties. The current status of nanoparticle synergistic microemulsion research at home and abroad is summarized and reviewed, and the synergistic effect between nanoparticles and microemulsions is summarized to produce mechanisms such as low interfacial tension, change of wettability, reduction of chemical adsorption, enhancement of stability, and improvement of rheological ratio. At present, the application of nanoparticles in microemulsions is still in the exploratory stage, which requires further theoretical analysis and experimental research. [ABSTRACT FROM AUTHOR]

BACKGROUND: The application of orthodontic force triggers autophagy in the periodontal tissue via diverse signaling pathways, augmenting or attenuating the activity of relevant cell types such as periodontal ligament cells, osteocytes, osteoclasts, and osteoblasts, thus facilitating the process of periodontal remodeling. OBJECTIVE: To review the research progress in orthodontic force mediated autophagy in periodontal tissue and its impact on orthodontic tooth movement. METHODS: The PubMed, Web of Science, China Biology Medicine disc and CNKI were searched for literature published from 2010 to 2023 to summarize the progress in orthodontics-related autophagy. And 76 papers were finally included in the analysis and discussion. RESULTS AND CONCLUSION: Orthodontic force can trigger a series of biochemical signal changes through periodontal mechanical receptors and aseptic inflammation they cause, leading to autophagy in periodontal tissue. Subsequently, autophagy generates corresponding feedback through cascaded amplified signaling pathways such as Phosphoinositide 3-kinase/protein kinase B, Hippo, and mitogen-activated protein kinase pathways, promoting periodontal tissue remodeling and ultimately achieving tooth movement and stability. Orthodontic force-induced autophagy can differentially regulate bone resorption on the tooth pressure side and bone formation on the tension side. Related targets have good prospects in the clinical application of orthodontic treatment. Orthodontics and autophagy have complex mechanisms. However, existing research has only focused on exploring the role of autophagy in orthodontic tooth movement. Further exploration is needed to investigate the mutual regulatory effects between autophagy and orthodontic tooth movement, as well as the interactions between upstream mechanical receptors and signaling pathways involved in related pathways. [ABSTRACT FROM AUTHOR]

Rheumatoid arthritis(RA) is one of the ten most difficult chronic diseases in the world. among which the most common hand and joint care is particularly important closely affecting the quality of life of patients. Among them, reducing pain, maintaining function and delaying degeneration are the key to the health management of hand joint. With the rapid development of medical science and technology under the current new medical background, digital intelligent gloves are gradually widely used in the combination of home care and health management of RA. This paper systematically reviewed and analyzed smart gloves related to RA, in order to provide new ideas and references for promoting intelligent care for patients with RA, and lay a foundation for follow-up research on RA [ABSTRACT FROM AUTHOR]

Diabetes mellitus is a common basic metabolic disease in clinical practice, and the incidence of diabetes mellitus is on the rise year by year as people's dietary patterns change, When diabetes is combined with other diseases, the level of blood glucose has a great impact on the treatment of the disease, While controlling blood glucose with medication, the role played by Chinese medicine nursing in diabetes and its comorbidities is also very important. This paper summarizes the research progress of TCM nursing in diabetes mellitus and its comorbidities in recent years, and further discusses the trend of TCM nursing in diabetes mellitus patients in the future, with a view to providing certain guidance for the care of diabetes mellitus patients in the future. [ABSTRACT FROM AUTHOR]

Acute bone loss refers to the rapid decline of local and systemic bone mass when patients need to be immobilized for several days to weeks, or even longer. Clinically, it is often lack of early intervention because of its hidden development, unobvious performance and lack of attention of doctors, which eventually leads to osteoporosis, osteoporosis and other complications. The occurrence and development of acute bone loss is closely related to osteoporosis. This paper aims to explore the relationship between acute bone loss and osteoporosis, raise clinical workers' attention to acute bone loss, and to advocate early prevention and treatment of acute bone loss, so as to improve the quality of life of patients and save medical resources. [ABSTRACT FROM AUTHOR]

Amyloid β-protein(Aβ) is considered to be the key factor that mediates the occurrence and development of Alzheimer's disease(AD). The imbalance between the generation and elimination of Aβ will lead to the accumulation of Aβ in the brain, which will cause damage to neurons, cognitive impairment and dementia symptoms. In order to effectively treat AD, in recent years, a large number of clinical studies have been carried out with Aβ as the target, including strategies such as inhibiting Aβ production, inhibiting Aβ aggregation, and promoting Aβ clearance, but the related studies have been frustrated repeatedly. By searching domestic and foreign literatures in recent years, this paper discusses and sorts out the biological effects and clinical research status of Aβ in the development of AD. in order to provide ideas for targeted therapy strategies of Aβ. [ABSTRACT FROM AUTHOR]

In recent years, with the continuous advancement of wound healing research, it has become a consensus that wet wound treatment can effectively promote healing. The wound microenvironment plays a crucial role in all stages of wound healing and is a key factor for successful wound management. The “moisture balance” theory provides a novel perspective on managing wound moisture. However, further research is required to determine the optimal moisture level required for wound healing. This paper reviewed the benefits of wet wound healing and its impact on effective wound management. It is recommended to assess and monitor the moisture levels of wounds in order to regulate their moisture management and achieve optimal healing outcomes. [ABSTRACT FROM AUTHOR]

Ischemic stroke is a cerebrovascular disease with high incidence and disability rate. After ischemic stroke, different parts of the nervous system injury may lead to different degrees of diaphragmatic dysfunction, which not only affects the respiratory function and physical stability of patients, but also restricts the overall rehabilitation process of patients. According to the characteristics of diaphragmatic dysfunction at different stages after ischemic stroke, selecting appropriate rehabilitation treatment techniques will effectively improve diaphragmatic function, enhance lung function reserve and physical stability, and provide a basis for motor function rehabilitation. According to the clinical characteristics of ischemic stroke in different periods, this paper reviewed the research progress and comprehensive application of diaphragmatic rehabilitation treatment techniques in different periods, in order to provide reference for the formulation of clinical treatment strategies. [ABSTRACT FROM AUTHOR]

The adherence of rehabilitation exercise of rotator cuff repair patients is very important for the recovery of shoulder joint function, but the situation is not ideal. By searching the literature of domestic and foreign databases, this paper reviewed the status quo of rehabilitation exercise compliance of patients with rotator cuff repair, analyzed the influence of physiological and psychological factors, rehabilitation exercise load, social support and medical support on rehabilitation exercise adherence of patients with rotator cuff repair, and explained relevant nursing intervention modes, aiming at providing reference for improving rehabilitation exercise adherence of patients with rotator cuff repair. [ABSTRACT FROM AUTHOR]

Oxidative stress is closely linked to the decline inof female fertility caused by various factors. Antioxidants, which can counteract oxidative stress. have been increasingly used as adjunctive therapy for women with reduced fertility. However, there are limited clinical studies on whether antioxidants can enhance fertility in women with low reproductive capacity and improve pregnancy outcomes, with inconsistent results and generally low-quality evidence. This paper reviewed the impact of oxidative stress on female fertility and discusses the progress of research on the application of antioxidants in common conditions that lead to reduced female fertility and are closely associated with oxidative stress, such as polycystic ovary syndrome, endometriosis, and unexplained infertility, aiming to provide a reference for clinical treatment. [ABSTRACT FROM AUTHOR]

Digestive tract malignant tumor refers to the general term of malignant tumor occurring in digestive tract, including esophageal cancer, gastric cancer, colorectal cancer, liver cancer and pancreatic cancer. Narrative nursing is a kind of nursing measure developed from narrative medicine with the characteristics of holistic nursing concept and humanistic care. This paper reviwed the application research progress of narrative nursing in clinical nursing of patients with digestive tract malignant tumor, and put forward relevant suggestions, so as to provide basis for follow-up nurses to implement narrative nursing intervention for patients with digestive tract malignant tumor and provided reference for further improvement of narrative nursing intervention. [ABSTRACT FROM AUTHOR]

Asthma is one of the most common chronic diseases in childhood, and its pathogenesis is not yet clear. In recent years, the imbalance of intestinal flora has attracted more and more attention to the occurrence and development of childhood asthma. Traditional Chinese medicine believes that the lung and the large intestine are interrelated, and the occurrence of childhood asthma is closely related to the dysfunction of the lung and the large intestine, while Western medicine believes that the occurrence of childhood asthma is related to various factors. Among them, pulmonary immune imbalance caused by intestinal flora disorder is one of the important causes of its occurrence. This paper discussed the occurrence of childhood asthma by focusing on pulmonary and intestinal pathophysiology, so as to provide new targets or therapeutic ideas for the prevention and treatment of childhood asthma. [ABSTRACT FROM AUTHOR]

Vitamin D is an indispensable fat-soluble vitamin in the human body, mainly in the form of vitamin D2 and vitamin D3,which can be synthesized by the skin and ingested in the diet. Vitamin D deficiency is currently a global public health problem, with approximately one billion people worldwide suffering from vitamin D deficiency, and pregnant women are at high risk. Gestational diabetes mellitus（GDM） refers to normal glucose metabolism before pregnancy, and abnormal glucose tolerance of different degrees occurs for the first time during pregnancy, which is one of the complications of pregnancy. Continuous studies have proved that vitamin D deficiency during pregnancy is closely related to GDM,which can affect glucose balance through various mechanisms, leading to an increased risk of GDM. In addition, GDM increases the incidence of maternal and infant complications such as hyperamniotic fluid, pregnancy-induced hypertension, premature rupture of membranes, premature delivery, macrosomia, low body weight, and teratoma, which threatens maternal and infant health. In recent years, the research on the correlation between vitamin D and GDM has been increasing, and its correlation has been paid more and more attention by more and more scholars. This paper reviewed the research progress on the correlation between vitamin D and GDM. [ABSTRACT FROM AUTHOR]

Alcohol use disorder, as the fifth largest risk factor worldwide, is an important component of stroke prevention. In recent years, a large number of epidemiological and clinical studies have shown that there is a correlation between alcohol and stroke. Alcohol can affect cardiovascular and cerebrovascular health through various ways, resulting in stroke and even death. At the same time, some studies have shown that there may be different associations between alcohol and stroke, light drinking may be a cardiovascular and cerebrovascular protective factor, and moderate and heavy drinking may induce and aggravate stroke. This paper analyzed the current prevalence of stroke complicated with alcohol use disorder, reviewed the possible pathogenesis of alcohol use disorder affecting the incidence of stroke, and summarized alcohol intake monitoring biomarkers and treatments related to alcohol use disorder, in order to further explore the correlation between stroke and alcohol use disorder and provide ideas for clinical diagnosis and treatment. [ABSTRACT FROM AUTHOR]

This paper analyzes the literature on virtual reality (VR) technology interventions for autistic children published from 2014 to 2022. It shows that different VR systems in these studies have improved different symptoms of autism, and points out the feasibility of VR technology interventions for autistic children [ABSTRACT FROM AUTHOR]

Alzheimer′s disease (AD) is a neurodegenerative disease with a hidden onset and complex pathology. The clinical diagnosis of AD has probably developed to the middle or late stage. The relative protein biomarkers in the cerebrospinal fluid can pass through the blood-brain barrier and participate the peripheral circulation in the very early stage of AD. Peripheral blood biomarker detection has the characteristics of convenient collection and minimal trauma, and is expected to become the most promising early screening and follow-up method. However, the traditional immunoassay methods cannot meet the demand for the accurate quantitative analysis of ultra-trace protein biomarkers in peripheral blood. In recent years, the newly developed immunoassay techniques in recent years have been widely applied in the analysis of ultra trace protein biomarkers. The paper reviews the recent research progress and analysis methods of early peripheral blood biomarkers of AD. [ABSTRACT FROM AUTHOR]

Heat shock protein 70(HSP70) is a protein that can inhibit cell protein denaturation or expansion under stress or high temperature. It plays a key role in the expression of inflammatory factors, inhibition of apoptosis, and inhibition of protein aggregation. HSP70 is a protein that can inhibit cell protein denaturation or expansion under stress or high temperature. It plays a key role in the expression of inflammatory factors, inhibition of apoptosis, and inhibition of protein aggregation. This paper expounds the close relationship between heat shock protein 70 and the pathogenesis of lung diseases such as lung cancer, pneumonia, pulmonary tuberculosis and asthma, and provides a new idea for the rapid diagnosis of lung diseases. [ABSTRACT FROM AUTHOR]

A patent foramen ovale(PFO) is a cardiac anatomical abnormality that usually fails to close normally at birth, resulting in the blood flow channel between the left ventricle and the right ventricle still existing. In recent years, a growing number of studies have shown that there is a correlation between PFO and migraine, especially in migraine patients with aura. With the continuous development of interventional techniques in cardiology, interventional closure has become an effective method for the treatment of PFO. Studies have shown that the closure of PFO by using a closure device can reduce the risks associated with patent foramen ovale, such as stroke. More encouragingly, some studies have found that PFO closure may help reduce the frequency and severity of migraine attacks. Anxiety and depression are common mental complications in migraine patients. Percutaneous PFO closure has shown favorable results in alleviating migraine symptoms and improving psychological status and quality of life. This review will also discuss the safety and efficacy of PFO closure, as well as the mechanisms associated with migraine, in order to further explore the clinical advances in this field. Finally, this paper emphasize the necessity of screening and managing the mental health status of patients, and expects that future research can provide more clear guidance for PFO closure in the treatment of migraine. [ABSTRACT FROM AUTHOR]

Post-stroke cognitive impairment （PSCI）, refers to a range of clinical syndromes of cognitive impairment caused by stroke. Although its specific pathogenesis is still unclear, many studies have confirmed that endoplasmic reticulum-mitochondria interaction has become a key hub for intracellular signal transduction and substance metabolism, and its regulation of various biological processes, such as Ca2+ balance, lipid metabolism, mitochondrial dynamics, autophagy, and neuroinflammation, is closely related to the development of PSCI. Therefore, in this paper, we will review the various functions of endoplasmic reticulum-mitochondrial interactions and explore their specific roles in PSCI, in order to discover new therapeutic targets and provide new theoretical basis and references for the development of PSCI-targeted drugs in the future. [ABSTRACT FROM AUTHOR]

[Purpose/Significance] Identifying potential technological opportunities will help countries and enterprises seize scientific and technological opportunities, which is particularly important for innovation entities to enhance their core competitiveness and gain competitive advantages in scientific and technological innovation and application. A systematic review of existing research is provided on technology opportunity identification, discriminating current limitations and research prospects to provide theoretical support for further research and practice on technology opportunity identification. [Method/Process] This paper first clarifies the connotation and types of technology opportunities, and the research holds that technology opportunities can be divided into three types: emerging technology, blank technology and fusion technology. It then sorts out the research status of three different types of technology opportunity identification at home and abroad through literature review, and focuses on the summary of the characteristics of different types of technology opportunity identification. It includes the core ideas, main methods, representative literature, and each type of data sources, and evaluates the existing research results. Finally, the limitations of the current research, and the development direction of future are discussed. [Results/Conclusions] Diversified types of technology opportunity identification are found and rich research methods are used in the literature, and a relatively standardized and systematic research paradigm has come into being. By analyzing each type of technology opportunity, some common elements can be found, including representative methods, method principles, data sources, knowledge representation units, technology opportunity definitions, technology opportunity evaluation, advantages and disadvantages, and other characteristics. The main limitations of the existing research are summarized as follows. First, the existing research is primarily carried out from a single perspective view, and a complete system of cross-domain technology identification and reference methods has not yet been formed. Second, in terms of data sources, most of the data sources of technology opportunity identification are papers or patent data, and there is a lack of research on the integration of multi-source data and study on multiple relationships. In terms of identification methods, the representative technology is primarily at a macro or micro level, and the semantic relationship between words is seldom considered. Finally, in terms of post-evaluation, there is a lack of a comprehensive and systematic evaluation system. The possible research work in the future may focus on the following aspects: cross-field and cross-topic technology opportunity identification to achieve cross convergence among more technology elements will become the development trend; more diversified and targeted data sources, research methods, and research content are expected; the analysis framework and process will be more standardized, and the post-evaluation system will be improved. [ABSTRACT FROM AUTHOR]

The patient-reported outcome measurement information system can help doctors make decisions, promote nursing-patient communication and improve patient compliance, which has been widely used in lung cancer clinical practice in Western countries and has become the most valuable tool for evaluating outcome indicators in lung cancer patients. This paper reviewed the current status of the application of patient-reported outcome measurement information system for lung cancer patients both domestically and internationally, aiming to provide reference for clinical nursing research and improve the quality of life of lung cancer patients. The patient-reported outcome measurement information system still has great development potential in the field of lung cancer in China, and it was expected that more practical explorations to promote its true implementation and development in China. [ABSTRACT FROM AUTHOR]

Osteoporosis (OP) is one of the main problems affecting the health of middle-aged and elderly people, and its most serious complication is osteoporotic fracture (OPF), which also has a high disability and mortality rate. The accurate screening and diagnosis of OP mainly rely on imaging analysis, and the diagnosis result rely on the subjective judgment of doctors. Therefore, the traditional imaging method of OP have certain challenges to the accurate screening, diagnosis and differentiation of OP. The cross-fusion of machine learning (ML) and imaging images effectively improves the diagnostic efficiency of clinicians, while realizing the prediction of unknown diseases (such as OPF). Recently, significant progress has been made in the screening and diagnosis of OP and in the diagnosis and prediction of OPF. This paper will review the recent related studies on ML model-assisted screening and diagnosis of OP based on imaging data, so as to provide new ideas for accurate clinical diagnosis and treatment of OP. [ABSTRACT FROM AUTHOR]

Alzheimer's disease (AD) is a persistent neurological disorder, its main pathological changes are age spots and neurofibrillary tangles, there is no treatment to prevent its progression currently. Autophagy is an intracellular degradation pathway that maintains cellular homeostasis by removing large insoluble proteins. With the deepening of related studies, it is found that the dysfunction of autophagy is related to the pathological process of AD. Hydrogen sulfide (H2S) can regulate autophagy and play a protective role in AD, but the specific mechanism is not fully understood. This paper reviewed the role of H2S in regulating autophagy in the pathological process of AD in recent years, providing new ideas for the prevention and treatment of AD. [ABSTRACT FROM AUTHOR]

Vascular endothelial injury is the initiating factor in atherosclerosis Currently, western medical treatment is ineffective and has many adverse effects. It has been found that flavonoids, the active ingredients of Chinese medicine, can regulate endothelial cell function by reducing inflammation, inhibiting oxidative stress, improving apoptosis and autophagy. They have the advantages of multiple pathways, links and targets in the prevention and treatment of atherosclerosis, and have great potential for development. This paper reviewed the recent studies on the mechanism of flavonoids in improving endothelial injury, and provided reference and theoretical basis to promote the discovery of new drug candidates for vascular endothelial injury and the wide application of flavonoids. [ABSTRACT FROM AUTHOR]

At present, cardiovascular and cerebrovascular diseases are currently one of the chronic diseases with the heaviest disease burden in China. With the gradual aging of China's population, the traditional chronic disease management mode of "disease-centered" can no longer meet the health service needs of current residents. The chronic disease management model based on the concept of "active health" is a new type of "health-centered" chronic disease health management model. This mode has established a closer, more convenient and affordable communication mode between residents and family doctor teams.It saves the time, manpower and economic cost of family doctor team service, and is conducive to improving the quality and efficiency of chronic disease management and residents' health literacy. Taking cardiovascular and cerebrovascular diseases as an example, this paper discusseed the chronic disease management mode and research content based on the concept of "active health" aiming to explore the form and standard of "active health" chronic disease management mode, and provide reference for the promotion of this mode [ABSTRACT FROM AUTHOR]

Pericardial effusion is a potentially life-threatening complication after hematopoietic stem cell transplantation (HSCT) in children. The incidence of pericardial effusion in children was 4.4% to 37.8%.The occurrence of pericardial effusion is related to many risk factors such as transplant-related thrombomicroangiopathy, pretreatment drugs, graft-versus-host disease, graft type, immunosuppressant, infection and so on. The treatment of pericardial effusion lacks a unified protocol, mainly focus onsupportive treatment, etiologic treatment and pericardial puncture. his paper reviewed the risk factors and treatment of pericardial effusion after HSCT in recent years, and provided suggestions for improving the early identification, diagnosis and treatment of pericardial effusion after HSCT in children. [ABSTRACT FROM AUTHOR]

Acute pulmonary embolism (APE) is one of the common acute and critical cardiovascular diseases. Currently, the methods used to diagnose APE rely on imaging and laboratory tests. The commonly used imaging detection methods are complex, consuming time, inconvenient handling for acute and severe patients and high examination cost. Therefore, exploring a simple, economical and effective evaluation method for acute non-high-risk pulmonary embolism patients has important clinical significance. Immune/inflammatory response plays an important role in the pathogenesis of vascular disease. Representative indicators in blood include neutrophil/lymphocyte ratio, monocyte-related indicators, platelet/lymphocyte ratio, systemic immune/inflammatory index, etc. This paper focused on the value of novel inflammatory markers in predicting the diagnosis and prognosis of APE patients. [ABSTRACT FROM AUTHOR]

BACKGROUND: In cartilage degeneration in osteoarthritis, cytokines and signaling pathways that target chondrocytes play an important role. OBJECTIVE: To review the latest research progress of osteoarthritis related cytokines and signaling pathways in recent years, such as the mechanism of action and treatment modalities, in order to provide a basis for future exploration of new therapeutic targets and modalities. METHODS: Literature search was conducted on CNKI, WanFang, VIP, PubMed, Web of Science, and Medline databases. Chinese search terms were “osteoarthritis, cytokines, signal pathway, chondrocyte, inflammation, treatment”. Finally, 60 papers were included for review. RESULTS AND CONCLUSION: (1) In current studies, it is believed that the specific mechanism of osteoarthritis is not clear, and a large number of studies have shown that osteoarthritis is strongly associated with cytokines and signaling pathways, which is a complex process of action. Relevant studies taking cytokines and signaling pathways as therapeutic breakthroughs are also the current hot spot. (2) The receptor antagonists of pro-inflammatory factors such as interleukin 1 are not effective in the treatment of osteoarthritis, and more studies turn to gene therapy. (3) The therapeutic methods of transforming growth factor β, recombinant factors of Wnt signaling pathway, gene therapy and mesenchymal stem cells have obtained positive research results. However, basic and clinical studies on safety and efficacy are likely to be conducted in future studies. (4) At present, relevant therapeutic methods such as platelet-rich plasma have been widely used in clinical practice, while recombinant factor, gene therapy and mesenchymal stem cell therapy are all in the research stage, among which mesenchymal stem cell therapy and gene therapy are expected to make breakthroughs in the field of cartilage repair and regeneration, and are worthy of expectation in the future. However, more clinical and basic studies are needed to verify its effectiveness and safety, explore its mechanism of action and scope of application, and set standards for its clinical use. [ABSTRACT FROM AUTHOR]

Parkinson′s disease (PD) is a neurodegenerative disease commonly in the elderly, which is mainly characterized by resting tremor, bradykinesia, and muscle tonus. Caenorhabditis elegans has its unique advantages in the study of neurological diseases and is a widely used model organism. The paper briefly summarized the characteristics of the Caenorhabditis elegans model and focuses on the application of Caenorhabditis elegans in the study of PD, which provided reference and options for the study of PD mechanism and the development of new drugs. [ABSTRACT FROM AUTHOR]

BACKGROUND: Currently, electrospun nanofibers, which are biomimetic materials of natural extracellular matrix and contain a three-dimensional network of interconnected pores, have been successfully used as scaffolds for various tissue regeneration, but are still faced with the challenge of extending the biomaterials into three-dimensional structures to reproduce the physiological, chemical as well as mechanical properties of the tissue microenvironment. OBJECTIVE: To summarize the process and principles of electrostatic spinning and to explore the applications of the resulting electrospun nanofibers in tissue regeneration of skin, blood vessels, nerves, bone, cartilage and tendons/ligaments. METHODS: With “electrospinning, electrospun nanofibers, electrospun nanofiber scaffolds, tissue regeneration” as the Chinese and English search terms, Google Academic Database, PubMed, and CNKI were searched, and finally 88 articles were included for review. RESULTS AND CONCLUSION: (1) The electrospun nanofibers are a natural fibrous extracellular matrix mimetic material and contain a three-dimensional network of interconnected pores that have been successfully used as scaffolds for a variety of tissue regeneration applications. (2) Several papers have described the great potential of electrospun nanofiber scaffolds applied to the regeneration of skin, blood vessels, nerves, bones, cartilage and tendons/ ligaments, providing a solid theoretical basis for its final application in clinical disease treatment, or for its transformation into practical products to enter the market. (3) However, the current research results are mostly based on cell experimental research results in vitro, and whether it can be finally applied to human body still needs clinical verification. (4) At present, many kinds of electrospun products for various clinical needs have been commercialized in and outside China, indicating that the research field of electrospun nanofiber scaffolds for soft and hard tissue regeneration has great research value and application potential. [ABSTRACT FROM AUTHOR]

Every link in the occurrence and development of malignant tumors is closely related to immune regulation. In recent years, the research of Ferroptosis and the killing of tumor cells by PD-1/PD-L1 inhibitors is a hot spot. Because of the effect of its precise treatment of tumors, it has been more and more applied in clinical treatment. However, there is still no study on the combination of PD-1/PD-L1 inhibitors and Ferroptosis treatment of tumor cells. In this paper, mechanism of Ferroptosis, relationship between Ferroptosis and tumor, and PD-1/PD-L1 immunotherapy of tumor are reviewed. [ABSTRACT FROM AUTHOR]

Refeeding syndrome (RFS) is a series of life-threatening clinical symptoms caused by abnormal metabolism in the early stage of re-intake of nutrition in the patients with chronic malnutrition. Due to the lack of specificity it is difficult to identify, and has higher mortality in ICU patients. At present, there are few studies on the management and prognosis of RFS by domestic scholars, moreover the specific management measures are still controversial. In addition, there are also differences in the methods and conclusions of RFS prognostic studies. Thus this paper systematically reviews the diagnostic criteria, occurrence status, management status and disease prognosis of RFS, aiming at offering the experience to medical staffs on RFS management and providing reference for follow-up related research. [ABSTRACT FROM AUTHOR]

Anterior cruciate ligament (ACL) injury of knee joint is a common sports injury, which can lead to instability of knee joint, reduce the movement ability of the patients, and affect the quality of life of the patients. This paper reviews the anatomy, injury risk factors, imaging findings and treatment of the anterior cruciate ligament of the knee aiming to provide further understanding for clinical prevention and treatment of anterior cruciate ligament injury. [ABSTRACT FROM AUTHOR]

This paper aims to review treatment delay in first-episode schizophrenia, depression, and bipolar disorder, and to compare related factors of treatment delay in the three first-episode mental disorders. It is found that increased patient responsibility, stigma, lack of disease-related knowledge, lack of access to resources, and insufficient medical support lead to delay treatment, and making patients to have longer course, heavier symptoms, and lower social functions. [ABSTRACT FROM AUTHOR]

With more and more orthopedic instruments and implants used to treat damaged human joints and other tissues, finite element analysis has been more widely used in the field of orthopedic engineering. The finite element analysis method can divide the complex structure into small interacting elements to further reflect the stress and strain of the whole structure. Based on the application background of finite element analysis in orthopedic instruments and implants, this paper summarized and sorted out the application research progress of finite element method in modeling process, material structure selection of implants, implant approach, etc., prospected the application prospect of finite element method in orthopedic engineering, and pointed out the existing shortcomings. In order to provide reference for orthopedic transplantation before, during and after surgery. [ABSTRACT FROM AUTHOR]

Preeclampsia is a pregnancy-specific complication, and hypertension is the main feature of preeclampsia.At present, preeclampsia is still an important cause of maternal and fetal morbidity and mortality, and its pathogenesis is still unclear.The immune intolerance of pregant women to allogeneic embryos is one of the important mechanisms of preeclampsia.miR-155 has important value in the regulation of immune function and can accurately regulate the expression of interleukin-17A.Suppressor of cytokine signaling 1（SOCS1） has been reported to be the only direct target of miR-155 in CD4+T cells and has the biological function of regulating T cell differentiation.This paper preliminarily expounded that miR-155 in placental-derived exosomes affects the differentiation of Treg cells and Th17 cells and the production of IL-17 by inhibiting SOCS1 and regulating JAK/STAT pathway, which provided theoretical guidance for the prevention, diagnosis and treatment of preeclampsia. [ABSTRACT FROM AUTHOR]

At present, the nursing intervention methods of anticipatory grief (AG) in caregivers of patients with chronic diseases mainly include narrative intervention, psychosocial intervention, cognitive behavioral therapy, mindfulness intervene, family dignity intervention, and expressive writing. This paper reviews the relevant research at home and abroad, in order to provide reference for the development of AG nursing intervention programs for caregivers of patients with chronic diseases in China. [ABSTRACT FROM AUTHOR]

Duhuo Jisheng Decoction affects the synthesis and apoptosis of bone and cartilage by inhibiting the expression of ASFla and HIRA, reducing the levels of cytochrome C and nitric oxide, and regulating some inflammatory factors. The application examples of Duhuo Jisheng Decoction in different bone trauma and reconstruction have confirmed that it has a good effect in the application of common orthopedic diseases such as lumbocrural pain, arthritis, and scapulohumeral periarthritis. Based on the pharmacological analysis of Duhuo Jisheng Decoction, this paper reviews the clinical application of Duhuo Jisheng Decoction in the treatment of orthopedic diseases. [ABSTRACT FROM AUTHOR]

BACKGROUND: Ischemic stroke is one of the main causes of death and long-term disability, and the incidence is still rising year by year, seriously affecting the quality of life. Blood-brain barrier injury is an important pathological process that leads to a poor prognosis of cerebral ischemia reperfusion injury. However, due to the limited treatment methods and limitations of multiple factors, it is urgent to find new treatment methods to repair blood-brain barrier injury. OBJECTIVE: To review the relevant mechanisms of traditional Chinese medicine combined with bone marrow mesenchymal stem cells in regulating the blood-brain barrier after cerebral ischemia reperfusion injury, to further explore new ways to protect the blood-brain barrier and provide assistance for clinical treatment. METHODS: The keywords were “traditional Chinese medicine, bone marrow mesenchymal stem cells, blood-brain barrier, cerebral ischemia reperfusion injury” in Chinese and English. WanFang, CNKI, PubMed, and Web of Science databases from 2012 to 2022 were retrieved for articles regarding the related mechanism of the blood-brain barrier damage and the related mechanism of Chinese medicine combined with bone marrow mesenchymal stem cells in regulating the blood-brain barrier. The obsolete and unqualified articles were excluded and 97 articles were included for analysis and summary. RESULTS AND CONCLUSION: (1) The physiological structure of the blood-brain barrier and the pathological changes of the blood-brain barrier structure after cerebral ischemia reperfusion injury were combed. (2) This paper summarized the mechanism of traditional Chinese medicine combined with bone marrow mesenchymal stem cells in regulating the blood-brain barrier after cerebral ischemia reperfusion injury, including regulating the expression of tight junction protein, inhibiting the activity of aquaporin-4 and matrix metalloproteinase-9, promoting angiogenesis, inhibiting the release of inflammatory mediators, and regulating exosomes. (3) It is concluded that traditional Chinese medicine combined with bone marrow mesenchymal stem cells can improve the permeability of the damaged blood-brain barrier and provide assistance for clinical treatment. [ABSTRACT FROM AUTHOR]

Asthma is one of the most common respiratory diseases in the world. According to the latest statistics, the incidence of asthma is increasing year by year, but the effective control rate is only 45%. Its recurrent nature seriously affects people′s physical and mental health. Currently, the asthma guidelines recommend the control of medication is still to inhaled glucocorticosteroids and beta agonists is given priority to, although it is true that recent years the emergence of the biological preparation makes severe asthma control, due to economic factors in patients with difficult to sustain, lead to drug is difficult to popularize, asthma clinical control effect is still poor, and even can be life threatening. Therefore, it is necessary to develop new drugs for asthma. In recent years, Suzi-Jiangqi decoction has significant curative effect in the treatment of asthma with few side effects. This paper reviewed the mechanism of action of the active ingredients of Suzi-Jiangqi decoction in the treatment of asthma, in order to provide new ideas for the treatment of asthma. [ABSTRACT FROM AUTHOR]