中药联合骨髓间充质干细胞调控脑缺血再灌注损伤后血脑屏障的作用机制.

BACKGROUND: Ischemic stroke is one of the main causes of death and long-term disability, and the incidence is still rising year by year, seriously affecting the quality of life. Blood-brain barrier injury is an important pathological process that leads to a poor prognosis of cerebral ischemia reperfusion injury. However, due to the limited treatment methods and limitations of multiple factors, it is urgent to find new treatment methods to repair blood-brain barrier injury. OBJECTIVE: To review the relevant mechanisms of traditional Chinese medicine combined with bone marrow mesenchymal stem cells in regulating the blood-brain barrier after cerebral ischemia reperfusion injury, to further explore new ways to protect the blood-brain barrier and provide assistance for clinical treatment. METHODS: The keywords were “traditional Chinese medicine, bone marrow mesenchymal stem cells, blood-brain barrier, cerebral ischemia reperfusion injury” in Chinese and English. WanFang, CNKI, PubMed, and Web of Science databases from 2012 to 2022 were retrieved for articles regarding the related mechanism of the blood-brain barrier damage and the related mechanism of Chinese medicine combined with bone marrow mesenchymal stem cells in regulating the blood-brain barrier. The obsolete and unqualified articles were excluded and 97 articles were included for analysis and summary. RESULTS AND CONCLUSION: (1) The physiological structure of the blood-brain barrier and the pathological changes of the blood-brain barrier structure after cerebral ischemia reperfusion injury were combed. (2) This paper summarized the mechanism of traditional Chinese medicine combined with bone marrow mesenchymal stem cells in regulating the blood-brain barrier after cerebral ischemia reperfusion injury, including regulating the expression of tight junction protein, inhibiting the activity of aquaporin-4 and matrix metalloproteinase-9, promoting angiogenesis, inhibiting the release of inflammatory mediators, and regulating exosomes. (3) It is concluded that traditional Chinese medicine combined with bone marrow mesenchymal stem cells can improve the permeability of the damaged blood-brain barrier and provide assistance for clinical treatment. [ABSTRACT FROM AUTHOR]