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31,247 results on '"Centrale Lille"'

1. Bus network decomposition for fault detection and isolation through power line communication

Author

Abdel Karim Abdel Karim, M. Amine Atoui, Virginie Degardin, Pierre Laly, Vincent Cocquempot, Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 (CRIStAL), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Télécommunication, Interférences et Compatibilité Electromagnétique - IEMN (TELICE - IEMN), Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Université catholique de Lille (UCL)-Université catholique de Lille (UCL)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Université catholique de Lille (UCL)-Université catholique de Lille (UCL), Plateforme de Caractérisation Multi-Physiques - IEMN (PCMP - IEMN), This research work is done in the framework of the ELSAT2020 project which is co-financed by the European Union with the European Regional Development Fund, the French state and the Hauts-de-France Region Council, and PCMP C2EM

Subjects
Network decomposition, Applied Mathematics, Fault isolation, [SPI.TRON]Engineering Sciences [physics]/Electronics, Computer Science Applications, [INFO.INFO-NI]Computer Science [cs]/Networking and Internet Architecture [cs.NI], Power line communication, Control and Systems Engineering, Residual, [INFO.INFO-AU]Computer Science [cs]/Automatic Control Engineering, Electrical and Electronic Engineering, Fault detection, [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing, Instrumentation
Abstract

International audience; This paper deals with fault detection and isolation (FDI) in complex embedded wired communication networks. The considered faults are soft faults which do not prevent the communication, but may evolve into hard faults, i.e. short or open circuit. A novel FDI method based on power line communication (PLC) transmission systems is proposed. In these PLC systems, the transmission coefficients between the source and each receiver are estimated for communication purposes using orthogonal frequency division multiplexing (OFDM). Health indicators and residuals are computed by comparing the online estimated transmission coefficients with the reference coefficients. A methodology for dealing with complex networks, such as bus networks, is proposed. It is based on the decomposition of the network into several Y-shaped sub-networks. Each of these sub-networks is monitored to detect the presence of a fault. The FDI method is first validated using real data extracted from a Y-shaped network test bench. Then, the proposed approach is validated on a more complex network using realistic simulated data.

Published
2023

2. Pressure-induced antiferromagnetic-tetragonal to nonmagnetic-collapse-tetragonal insulator-metal transition in ThMnAsN

Author

Smritijit Sen, Houria Kabbour, Haranath Ghosh, Université de Lille, CNRS, Centrale Lille, ENSCL, Univ. Artois, Unité de Catalyse et Chimie du Solide - UMR 8181 [UCCS], Unité de Catalyse et Chimie du Solide (UCCS) - UMR 8181, Unité de Catalyse et Chimie du Solide - UMR 8181 (UCCS), Université d'Artois (UA)-Centrale Lille-Institut de Chimie du CNRS (INC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), ANR-16-IDEX-0004,ULNE,ULNE(2016), and ANR-21-CE08-0051,MultiPhos,Reseau polyanionique pour des propriétés multiferoiques(2021)

Subjects
Condensed Matter - Materials Science, Condensed Matter::Materials Science, Mechanics of Materials, Mechanical Engineering, Materials Science (cond-mat.mtrl-sci), FOS: Physical sciences, Condensed Matter::Strongly Correlated Electrons, General Materials Science, [CHIM.INOR]Chemical Sciences/Inorganic chemistry
Abstract

We report first principles numerical discovery of hydrostatic pressure driven tetragonal to collapsed tetragonal transition in 1111-type material ThMnAsN accompanied by simultaneous magneto-structural, insulator to metal transition together with complete collapse of Mn moment. We present detailed evolution of various structural parameters, magnetism and electronic structures of ThMnAsN with increasing hydrostatic pressure. All the structural parameters show anomalies at a critical pressure P$_c \sim$ 9 GPa; c-lattice parameter, out of plane As-As bond length, anion height (h$_{As}$) undergo drastic modification compared to the in-plane parameters which is manifested in an iso-structural phase transition from tetragonal to a collapsed tetragonal (cT) phase. These modifications in "local structural correlations" due to pressure destroys usually localized nature of Mn moments and gets completely quenched. Apart from that the elastic constant, the electronic structures also bear the finger prints of insulator-metal and magneto-structural transition at higher pressures accompanying a total collapse of magnetic moment at the vicinity of 9 GPa. The critical value of the pressure P$_c$ at which tetragonal to collapse tetragonal phase transition occurs, remains robust with respect to the on-site Hubbard correlation (U). The dynamical stability of the compound at higher pressures are affirmed through detailed computations of phonon dispersion curves endowed with positive phonon frequency through out the Brillouin zone. The effect of magnetic spin structure on the electronic band structures are obtained through band unfolding. The electronic structure of ThMnAsN at higher pressures "orbital selectively" influences bands, band gap and closely resembles with the electronic structure of Fe-based superconductors with the occurrences of orbital selective Lifshitz transition., Comment: 13 pages, 21 figures

Published
2023

3. Memristor-Based Cryogenic Programmable DC Sources for Scalable In Situ Quantum-Dot Control

Author

Pierre-Antoine Mouny, Yann Beilliard, Sébastien Graveline, Marc-Antoine Roux, Abdelouadoud El Mesoudy, Raphaël Dawant, Pierre Gliech, Serge Ecoffey, Fabien Alibart, Michel Pioro-Ladrière, Dominique Drouin, Institut Interdisciplinaire d'Innovation Technologique [Sherbrooke] [3IT], Laboratoire Nanotechnologies et Nanosystèmes [Sherbrooke] [LN2], Institut Quantique [Sherbrooke] [UdeS], Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 [IEMN], Nanostructures, nanoComponents & Molecules - IEMN [NCM - IEMN], Institut Interdisciplinaire d'Innovation Technologique [Sherbrooke] (3IT), Université de Sherbrooke (UdeS), Laboratoire Nanotechnologies et Nanosystèmes [Sherbrooke] (LN2), Université de Sherbrooke (UdeS)-École Centrale de Lyon (ECL), Université de Lyon-Université de Lyon-École Supérieure de Chimie Physique Électronique de Lyon (CPE)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Institut Quantique [Sherbrooke] (UdeS), Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Université catholique de Lille (UCL)-Université catholique de Lille (UCL), Nanostructures, nanoComponents & Molecules - IEMN (NCM - IEMN), Université catholique de Lille (UCL)-Université catholique de Lille (UCL)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), ACKNOWLEDGMENTData Availability: The Python library that was developed to simulate the control performed by the proposed dc source is available at GitHub. Data supporting this work will be uploaded to an online repository.This work was supported in part by the Natural Sciences and Engineering Research Council of Canada(NSERC), in part by the Canada First Research Excellence Fund, in part by the Canada First Research Excellence Fund in part by Laboratoire Nanotechnologies Nanosystèmes (LN2), which is aFrench–Canadian Joint International Research Laboratory (IRL-3463), funded and co-operated by Centre National de la Recherche Scientifique (CNRS), Université de Sherbrooke, Université de Grenoble Alpes (UGA), École Centrale Lyon (ECL), and Institut National des Sciences Appliquées (INSA) Lyon, and and in part by the Fonds de Recherche du Québec Nature et Technologie (FRQNT).

Subjects
FOS: Computer and information sciences, Power dissipation, Quantum Physics, Cryogenics, Resistance, FOS: Physical sciences, Voltage, Logic gates, [SPI.TRON]Engineering Sciences [physics]/Electronics, Electronic, Optical and Magnetic Materials, Hardware Architecture (cs.AR), Qubit, Electrical and Electronic Engineering, Quantum Physics (quant-ph), Memristors, Computer Science - Hardware Architecture
Abstract

Current quantum systems based on spin qubits are controlled by classical electronics located outside the cryostat at room temperature. This approach creates a major wiring bottleneck, which is one of the main roadblocks toward truly scalable quantum computers. Thus, we propose a scalable memristor-based programmable DC source that could be used to perform biasing of quantum dots inside of the cryostat (i.e. in-situ). This novel cryogenic approach would enable to control the applied voltage on the electrostatic gates by programming the resistance of the memristors, thus storing in the latter the appropriate conditions to form the quantum dots. In this study, we first demonstrate multilevel resistance programming of a TiO2-based memristors at 4.2 K, an essential feature to achieve voltage tunability of the memristor-based DC source. We then report hardwarebased simulations of the electrical performance of the proposed DC source. A cryogenic TiO2-based memristor model fitted on our experimental data at 4.2 K was used to show a 1 V voltage range and 100 uV in-situ memristor-based DC source. Finally, we simulate the biasing of double quantum dots enabling sub-2 minutes in-situ charge stability diagrams. This demonstration is a first step towards more advanced cryogenic applications for resistive memories such as cryogenic control electronics for quantum computers.

Published
2023

4. Private Sampling with Identifiable Cheaters

Author

Sabater, César, Hahn, Florian, Peter, Andreas, Ramon, Jan, Machine Learning in Information Networks (MAGNET), Inria Lille - Nord Europe, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 (CRIStAL), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS), University of Twente, University of Oldenburg, Chair TIP project, ANR-20-CE23-0013,PMR,Recherche en Medicine respectant la vie Privée(2020), European Project: 101070038,TRUMPET, and Machine Learning in Information Networks [MAGNET]

Subjects
sampling, Cybersecurity, differential privacy, zero knowledge proofs, multiparty computation, [INFO.INFO-LG]Computer Science [cs]/Machine Learning [cs.LG], Horizon Europe, General Earth and Planetary Sciences, Private Sampling, General Environmental Science
Abstract

International audience; In this paper we study verifiable sampling from probability distributions in the context of multi-party computation. This has various applications in randomized algorithms performed collaboratively by parties not trusting each other. One example is differentially private machine learning where noise should be drawn, typically from a Laplace or Gaussian distribution, and it is desirable that no party can bias this process. In particular, we propose algorithms to draw random numbers from uniform, Laplace, Gaussian and arbitrary probability distributions, and to verify honest execution of the protocols through zero-knowledge proofs. We propose protocols that result in one party knowing the drawn number and protocols that deliver the drawn random number as a shared secret.

Published
2023

5. Small grains from Ryugu: handling and analysis pipeline for infrared synchrotron microspectroscopy

Author

Stefano Rubino, Zélia Dionnet, Alice Aléon-Toppani, Rosario Brunetto, Tomoki Nakamura, Donia Baklouti, Zahia Djouadi, Cateline Lantz, Obadias Mivumbi, Ferenc Borondics, Stephane Lefrançois, Christophe Sandt, Francesco Capitani, Eva Héripré, David Troadec, Megumi Matsumoto, Kana Amano, Tomoyo Morita, Hisayoshi Yurimoto, Takaaki Noguchi, Ryuji Okazaki, Hikaru Yabuta, Hiroshi Naraoka, Kanako Sakamoto, Shogo Tachibana, Seiichiro Watanabe, Yuichi Tsuda, Institut d'astrophysique spatiale (IAS), Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), Tohoku University [Sendai], Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), Synchrotron SOLEIL (SSOLEIL), Centre National de la Recherche Scientifique (CNRS), DISCO beamline, Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de mécanique des sols, structures et matériaux (MSSMat), CentraleSupélec-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Université catholique de Lille (UCL)-Université catholique de Lille (UCL), Centrale de Micro Nano Fabrication - IEMN (CMNF - IEMN), Université catholique de Lille (UCL)-Université catholique de Lille (UCL)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Hokkaido University [Sapporo, Japan], Kyushu University, Hiroshima University, Japan Aerospace Exploration Agency [Sagamihara] (JAXA), Tokyo National University of Fine Arts and Music (Tokyo Geijutsu Daigaku) (GEIDAI), Nagoya University, This work has been funded by the CNES-France (Hayabusa2 mission) and by the ANR project CLASSY (Grant ANR-17-CE31-0004-02). The micro-spectroscopy measurements were supported by grants from Region Ile-de-France (DIM-ACAV) and SOLEIL., Renatech Network, CMNF, and ANR-17-CE31-0004,CLASSY,Composition des surfaces du Système Solaire de bas albédo(2017)

Subjects
[SPI]Engineering Sciences [physics]
Abstract

preprint: https://doi.org/10.21203/rs.3.rs-1622610/v2; International audience; Sample-return missions allow the study of materials collected directly from celestial bodies, unbiased by atmospheric entry effects and/or terrestrial alteration and contamination phenomena, using state-of-the-art techniques which are available only in a laboratory environment—but only if the collected material stays pristine. The scarcity of outer-space unaltered material recovered until now makes this material extremely precious for the potential scientific insight it can bring. To maximize the scientific output of current and future sample-return missions, the scientific community needs to plan for ways of storing, handling, and measuring this precious material while preserving their pristine state for as long as the ‘invasiveness’ of measurements allows. In July 2021, as part of the Hayabusa2 (JAXA) “Stone” preliminary examination team, we received several microscopic particles from the asteroid Ryugu, with the goal of performing IR hyper-spectral imaging and IR micro-tomography studies. Here, we describe the sample transfer, handling methods and analytical pipeline we implemented to study this very precious material while minimizing and surveilling their alteration history on Earth.

Published
2023

6. 15. GaN-Based Lateral and Vertical Devices

Author

Meneghini, Matteo, Chowdhury, Srabanti, Derluyn, Joff, Medjdoub, Farid, Ji, Dong, Chun, Jaeyi, Kabouche, Riad, de Santi, Carlo, Zanoni, Enrico, Meneghesso, Gaudenzio, Università degli Studi di Padova = University of Padua (Unipd), Stanford University, EpiGaN, EpiGaN nv, Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Université catholique de Lille (UCL)-Université catholique de Lille (UCL), WIde baNd gap materials and Devices - IEMN (WIND - IEMN), Université catholique de Lille (UCL)-Université catholique de Lille (UCL)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Massimo Rudan, Rossella Brunetti, Susanna Reggiani, Renatech Network, and CMNF

Subjects
[PHYS]Physics [physics], [SPI]Engineering Sciences [physics]
Abstract

chapter 15; International audience; In the last decade, GaN has emerged as an excellent material for application in power electronics. The wide energy gap of gallium nitride (3.4 eV) enables high-temperature operation, while the large breakdown field (3.3 MV/cm, 11 times higher than silicon) allows to reach kV-range operation while maintaining a low on-resistance. Thanks to the high mobility of the two-dimensional electron gas at the AlGaN/GaN interface, lateral GaN transistors have a very low on-resistance; commercial products are already on the market, and new technologies are being developed, targeting the 650 V/900 V ranges. Recently, the attention toward vertical GaN transistors has constantly increased: a vertical layout allows to substantially increase current density while taking advantage of the wide bandgap and high breakdown field of GaN. Vertical transistors based on GaN are expected to find application in converters with medium high power levels (>5 to 10 kW), once the technology reaches maturity.This chapter reviews the main properties of GaN-based materials and devices. The first part focuses on the main challenges related to the growth of high-quality GaN epitaxial stacks. The second and the third parts focus on GaN lateral and vertical devices, respectively. Finally, the fourth section describes the trapping and degradation processes that limit the performance and the reliability of GaN transistors, and the related physical mechanisms. This chapter represents an ideal guide for a reader willing to enter the world of GaN devices.

Published
2023

7. On Stability of Homogeneous Systems in Presence of Parasitic Dynamics

Author

Jesus Mendoza-Avila, Denis Efimov, Leonid Fridman, Jaime A. Moreno, Finite-time control and estimation for distributed systems (VALSE), Inria Lille - Nord Europe, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 (CRIStAL), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS), ITMO University [Russia], Facultad de Ingeniería, Universidad Nacional Autónoma de México = National Autonomous University of Mexico (UNAM), This work was supported in part by Homogeneity Tools for Sliding Mode Control and Estimation (HoTSMoCE) INRIA associate team program, by CONACyT (Consejo Nacional de Ciencia y Tecnologia) project 241171, 282013 and CVU 711867, by PAPIIT-UNAM (Programa de Apoyo a Proyectos de Investigacion e Innovacion Tecnologica) IN 115419 and IN 113617., Finite-time control and estimation for distributed systems [VALSE], and Universidad Nacional Autónoma de México = National Autonomous University of Mexico [UNAM]

Subjects
Singular Perturbations, Control and Systems Engineering, Chattering Analysis, Homogeneity, Electrical and Electronic Engineering, Interconnected Systems, Computer Science Applications, [SPI.AUTO]Engineering Sciences [physics]/Automatic
Abstract

International audience; Usually, singularly perturbed models are used to justify the decomposition of the interconnected systems into the Main Dynamics (MD) and the Parasitic Dynamics (PD). In this paper, the effect of a homogeneous PD on the stability of a homogeneous MD, when Homogeneity Degrees (HD) are possibly different, is studied via ISS approach in the framework of singular perturbations. Thus, the possibilities to reduce the order of the interconnected system considering only Reduced-Order Dynamics (ROD) and neglecting PD are examined. Proposed analysis discovers three kinds of stability in the behavior of such an interconnection by assuming that both, ROD and unforced PD, are Globally Asymptotically Stable (GAS). In the first case, when the HD of both systems coincide and the Singular Perturbation Parameter (SPP) is small enough, GAS of the interconnection can be concluded. In the second case, when the HD of ROD is greater, only local stability of interconnection can be ensured. Moreover, proposed approach allows to estimate the domain of attraction for the trajectories of the interconnection as a function of the SPP. In the third case, when the HD of ROD is smaller than the HD of PD, only practical stability can be concluded, and a kind of chattering phenomenon can arise when the HD of ROD is negative. Furthermore, the asymptotic bound of the system's trajectories is also estimated in terms of the SPP.

Published
2023

8. Advances on Microsupercapacitors: Real Fast Miniaturized Devices toward Technological Dreams for Powering Embedded Electronics?

Author

Pascal Roussel, Christophe Lethien, Khac Huy Dinh, Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Université catholique de Lille (UCL)-Université catholique de Lille (UCL), Unité de Catalyse et Chimie du Solide - UMR 8181 (UCCS), Université d'Artois (UA)-Centrale Lille-Institut de Chimie du CNRS (INC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Circuits Systèmes Applications des Micro-ondes - IEMN (CSAM - IEMN ), Université catholique de Lille (UCL)-Université catholique de Lille (UCL)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Réseau sur le stockage électrochimique de l'énergie (RS2E), Aix Marseille Université (AMU)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Collège de France (CdF (institution))-Université de Picardie Jules Verne (UPJV)-Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Pau et des Pays de l'Adour (UPPA)-Institut de Chimie du CNRS (INC)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA)-Université Grenoble Alpes (UGA)-Nantes Université (Nantes Univ)-Université de Montpellier (UM)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM), Université de Montpellier (UM), This project has received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement no. 847568. The authors thank the French National Research Agency (STORE-EX Labex Project ANR-10-LABX-76-01). The French RENATECH network and the University of Lille are greatly acknowledged for supporting the Center of MicroNanoFabrication (CMNF) facility from IEMN., Renatech Network, ANR-10-LABX-0076,STORE-EX,Laboratory of excellency for electrochemical energy storage(2010), and European Project: 847568,H2020,H2020-MSCA-COFUND-2018,PEARL(2019)

Subjects
General Chemical Engineering, General Chemistry, [SPI.NANO]Engineering Sciences [physics]/Micro and nanotechnologies/Microelectronics
Abstract

International audience; Electrochemical lithium (de)intercalation in an atomic layer deposited (ALD) TiO2 anatase thin film deposited on a planar Si /Al2O3/Pt substrate is investigated by Raman spectroscopy. An initial discharge capacity of 63 µAh cm−2 µm−1 (0.5 Li+ mole−1) is reached at C/10 rate, which increases up to 77 µAh cm−2 µm−1 upon further cycles. An excellent capacity retention is achieved over at least 100 cycles, showing the good adherence of the ALD thin film. Raman spectra of LixTiO2 (0 ≤ x ≤ 0.5) thin film electrodes point to the nucleation of the orthorhombic lithiated titanate (LT) Li0.5TiO2 phase from x = 0.1. This LT phase coexists with tetragonal TiO2 in the 0.1 ≤ x ≤ 0.4 composition domain to be pure for x = 0.5. A fully reversible transformation from orthorhombic LT to tetragonal TiO2 is observed upon the charge. The high quality of the Raman spectra allows identifying for the first time 12 modes in the 100–800 cm−1 region for the electrochemically formed LT phase. Furthermore, an appropriate Raman spectra analysis allows a reliable and quantitative determination of the thin film composition during discharge and charge. These results illustrate Raman spectroscopy is a powerful probe to scrutinize the Li insertion/extraction mechanism in TiO2 thin films.

Published
2023

9. Hyperexponential and Fixed-Time Stability of Time-Delay Systems: Lyapunov–Razumikhin Method

Author

Artem N. Nekhoroshikh, Denis Efimov, Andrey Polyakov, Wilfrid Perruquetti, Igor B. Furtat, National Research University of Information Technologies, Mechanics and Optics [St. Petersburg] (ITMO), Finite-time control and estimation for distributed systems (VALSE), Inria Lille - Nord Europe, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 (CRIStAL), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 (CRIStAL), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Institute of Mechanical Engineering Problems [St. Petersburg] (IPME), Russian Academy of Sciences [Moscow] (RAS), and The results of Section IV are supported by the Russian Science Foundation under grant no. 18-79-10104 (https://rscf.ru/en/project/18-79-10104/) at IPME RAS. The results of Section V are supported by the Russian Science Foundation under grant no. 21-71-10032 at ITMO University.

Subjects
implicit theorem, Lyapunov-Razumikhin theorem, Control and Systems Engineering, Fixed-time and hyperexponential stability, ComputingMethodologies_SYMBOLICANDALGEBRAICMANIPULATION, Electrical and Electronic Engineering, linear matrix inequalities, time-delay systems, [SPI.AUTO]Engineering Sciences [physics]/Automatic, Computer Science Applications
Abstract

International audience; Razumikhin-like theorems on hyperexponential and fixed-time stability of time-delay systems are proposed for both explicitly and implicitly defined Lyapunov functions. While the former method is useful for stability analysis, the latter approach is more suitable for control synthesis. Examples of systems that can be stabilized hyperexponentially and in fixed time are given. The control parameters tuning algorithm is presented in the form of linear matrix inequalities. The numerical simulations illustrate the theoretical results.

Published
2023

10. Influence of the Size and Charge of Carbon Quantum Dots on Their Corneal Penetration and Permeation Enhancing Properties

Author

Inès De Hoon, Alexandre Barras, Tomasz Swebocki, Bernd Vanmeerhaeghe, Bram Bogaert, Cristina Muntean, Amar Abderrahmani, Rabah Boukherroub, Stefaan De Smedt, Félix Sauvage, Sabine Szunerits, Universiteit Gent = Ghent University (UGENT), Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Université catholique de Lille (UCL)-Université catholique de Lille (UCL), NanoBioInterfaces - IEMN (NBI - IEMN), Université catholique de Lille (UCL)-Université catholique de Lille (UCL)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Financial support from the 'Programme Investissement d’Avenir' (I-SITE ULNE / ANR-16-IDEX-0004 ULNE) managed by the 'Agence Nationale de la Recherche' is acknowledged. In addition, this project has received funding from the European Union’s Horizon 2020 research and innovation program under the 'Marie Sklodowska-Curie grant' (agreement No 847568). Financial support from theCentre National de la Recherche Scientifique (CNRS) and the University of Lille is acknowledged in addition. F. Sauvage is a post-doctoral fellow of the Research Foundation-Flanders (grant number 12X3222N, FWO, Belgium). This work was partly supported by the French Renatech network. The authors would like to thank Maya Marinova for her help in carrying out the work on the electron microscopy facility of the Advanced Characterization Platform of the Chevreul Institute. The Chevreul Institute is thanked for help in the development of this work through the ARCHI-CM project supported by the 'Ministère de l’Enseignement Supérieur de la Recherche et de l’Innovation,' the region 'Hauts-de-France,' the ERDF program of the European Union, and the 'Métropole Européenne de Lille.', Renatech Network, ANR-16-IDEX-0004,ULNE,ULNE(2016), and European Project: 847568,H2020,H2020-MSCA-COFUND-2018,PEARL(2019)

Subjects
[SPI]Engineering Sciences [physics], endothelium, cornea, General Materials Science, fluorescence spectroscopy, epithelium, carbon quantum dots
Abstract

International audience; Reaching the corneal endothelium through the topical administration of therapeutic drugs remains a challenge in ophthalmology. Besides, endothelial cells are not able to regenerate, and diseases at this site can lead to corneal blindness. Targeting the corneal endothelium implies efficient penetration through the three corneal layers, which still remains difficult for small molecules. Carbon quantum dots (CQDs) have demonstrated great potential for ocular nanomedicine. This study focuses on the corneal penetration abilities of differently charged CQDs and their use as permeation enhancers for drugs. Excised whole bovine eyes were used as an ex vivo model to investigate corneal penetration of CQDs derived from glucosamine using β-alanine, ethylenediamine, or spermidine as a passivation agent. It was found that negatively charged CQDs have limited corneal penetration ability, while positively charged CQDs derived from glucosamine hydrochloride and spermidine (CQD-S) penetrate the entire corneal epithelium all the way down to the endothelium. CQD-S were shown to enhance the penetration of FITC-dextran 150 kDa, suggesting that they could be used as efficient penetration enhancers for therapeutic delivery to the corneal endothelium.

Published
2023

11. Vibrotactile Thresholds on the Wrist for Vibrations Normal to the Skin

Author

Quentin Consigny, Nathan Ouvrai, Arthur Paté, Claudia Fritz, Jean-Loïc Le Carrou, Lutheries - Acoustique - Musique (IJLRDA-LAM), Institut Jean Le Rond d'Alembert (DALEMBERT), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Sorbonne Université (SU), Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Université catholique de Lille (UCL)-Université catholique de Lille (UCL), Acoustique - IEMN (ACOUSTIQUE - IEMN), Université catholique de Lille (UCL)-Université catholique de Lille (UCL)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Music Acoustics / School of Physics (MUSIC ACOUSTICS), University of New South Wales [Sydney] (UNSW), This work was funded by a grant from the French National Research Agency (ANR) as part of the 'Staccato' Project (ANR–19–CE38–0008–01)., and ANR-19-CE38-0008,STACCATO,Médiation vibrotactile pour la pratique musicale partagée(2019)

Subjects
[PHYS]Physics [physics], Human-Computer Interaction, [SPI]Engineering Sciences [physics], Sensitivity, Frequency measurement, Particle measurements, Vibrations, Wrist, Atmospheric measurements, Skin, Computer Science Applications
Abstract

International audience; In order to facilitate the development of wrist-worn vibrotactile devices, detailed knowledge about how vibrations are perceived by the users is needed. In particular, perceptual thresholds in amplitude are really important. Thresholds have been measured in the literature for other areas of the body, but given the variability reported between areas (shape of the threshold curve, position of maximum sensitivity), thresholds on the wrist can not be inferred from previous measurements and must be measured. The amplitude thresholds for vibrations normal to the skin surface were evaluated on 28 participants, with a three interval forced choice method. They were measured for 7 frequencies that are classical in the literature about vibrotactile perception (25, 40, 80, 160, 250, 320, and 640 Hz). The classical U-shape of the amplitude-threshold curve is observed, with a maximum sensitivity at around 160 Hz, which differs from other body areas, but confirms recent results obtained for vibrations parallel to the skin surface of the same body area. The sensitivity thresholds of vibrotactile signals appear to be in the micrometer range.

Published
2023

12. Nanoscale electronic transport at graphene/pentacene van der Waals interfaces

Author

Michel Daher Mansour, Jacopo Oswald, Davide Beretta, Michael Stiefel, Roman Furrer, Michel Calame, Dominique Vuillaume, Nanostructures, nanoComponents & Molecules - IEMN [NCM - IEMN], Swiss Federal Laboratories for Materials Science and Technology [Dübendorf] [EMPA], Nanostructures, nanoComponents & Molecules - IEMN (NCM - IEMN), Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Université catholique de Lille (UCL)-Université catholique de Lille (UCL)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Université catholique de Lille (UCL)-Université catholique de Lille (UCL), and Swiss Federal Laboratories for Materials Science and Technology [Dübendorf] (EMPA)

Subjects
[PHYS]Physics [physics], Condensed Matter - Mesoscale and Nanoscale Physics, graphene, Mesoscale and Nanoscale Physics (cond-mat.mes-hall), conductive-AFM, FOS: Physical sciences, pentacene, Van der Waals, General Materials Science, electron transport, molecular junction
Abstract

We report a study on the relationship between structure and electron transport properties of nanoscale graphene/pentacene interfaces. We fabricated graphene/pentacene interfaces from 10-30 nm thick needle-like pentacene nanostructures down to two-three layers (2L-3L) dendritic pentacene islands, and we measured their electron transport properties by conductive atomic force microscopy (C-AFM). The energy barrier at the interfaces, i.e. the energy position of the pentacene highest occupied molecular orbital (HOMO) with respect to the Fermi energy of the graphene and the C-AFM metal tip, are determined and discussed with the appropriate electron transport model (double Schottky diode model and Landauer-Buttiker model, respectively) taking into account the voltage-dependent charge doping of graphene. In both types of samples, the energy barrier at the graphene/pentacene interface is slightly larger than that at the pentacene/metal tip interface, resulting in 0.47-0.55 eV and 0.21-0.34 eV, respectively, for the 10-30 nm thick needle-like pentacene islands, and in 0.92-1.44 eV and 0.67-1.05 eV, respectively, for the 2L-3L thick dendritic pentacene nanostructures. We attribute this difference to the molecular organization details of the pentacene/graphene heterostructures, with pentacene molecules lying flat on the graphene in the needle-like pentacene nansotructures, while standing upright in 2L-3L dendritic islands, as observed from Raman spectroscopy., Comment: Paper and its supplementary information

Published
2023

13. Waste PET upcycling to conductive carbon-based composite through laser-assisted carbonization of UiO-66

Author

Dmitry Kogolev, Oleg Semyonov, Nadezhda Metalnikova, Maxim Fatkullin, Raul D. Rodriguez, Petr Slepicka, Yusuke Yamauchi, Olga Guselnikova, Rabah Boukherroub, Pavel S. Postnikov, Tomsk Polytechnic University [Russie] (UPT), University of Queensland [Brisbane], University of Chemistry and Technology Prague (UCT Prague), Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Université catholique de Lille (UCL)-Université catholique de Lille (UCL), NanoBioInterfaces - IEMN (NBI - IEMN), Université catholique de Lille (UCL)-Université catholique de Lille (UCL)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), and The authors thank the central laboratories of TPU (Analytical center) for the XPS measurements and Tomsk Regional Core Shared Research Facilities Center of National Research Tomsk State University for the SEM, ICP-MS and CHNS measurements. The research has been supported by the Russian-French project No. 075-15-2022-244 in the frame of PHC 'Kholmogorov'. R. B. acknowledges financial support from the CPER 'Wavetech'. This work was performed in part at the Queensland node of the Australian National Fabrication Facility, a company established under the National Collaborative Research Infrastructure Strategy to provide nano and microfabrication facilities for Australia’s researchers.

Subjects
Renewable Energy, Sustainability and the Environment, General Materials Science, [CHIM.MATE]Chemical Sciences/Material chemistry, General Chemistry
Abstract

International audience; The upcycling of waste polymers into novel materials with high added value is a vital task for modern chemical engineering. Here, we propose diversifying waste polyethylene terephthalate (PET) upcycling to materials with enhanced photothermal properties by laser-assisted carbonization of surface-grown UiO-66. The UiO-66 homogenous layer was formed using a solvo-thermal procedure on the surface of recycled PET sheets. The treatment by a 405 nm laser system allowed the formation of a carbonaceous layer with enhanced electrical conductivity and photothermal properties due to the presence of zirconium carbide and graphene. The developed approach opens new perspectives in the application of upcycled PET-based materials.

Published
2023

14. Grain growth of NpO2 and UO2 nanocrystals

Author

Viktoria Baumann, Karin Popa, Marco Cologna, Murielle Rivenet, Olaf Walter, Université de Lille, CNRS, Centrale Lille, ENSCL, Univ. Artois, European Commission - Joint Research Centre [Karlsruhe] [JRC], Unité de Catalyse et Chimie du Solide - UMR 8181 [UCCS], Unité de Catalyse et Chimie du Solide (UCCS) - UMR 8181, Unité de Catalyse et Chimie du Solide - UMR 8181 (UCCS), Université d'Artois (UA)-Centrale Lille-Institut de Chimie du CNRS (INC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), and European Commission - Joint Research Centre [Karlsruhe] (JRC)

Subjects
General Chemical Engineering, [CHIM.MATE]Chemical Sciences/Material chemistry, General Chemistry
Abstract

International audience; We report on the crystallite growth of nanometric NpO2 and UO2 powders. The AnO2 nanoparticles (An = U and Np) were synthesized by hydrothermal decomposition of the corresponding actinide(IV) oxalates. NpO2 powder was isothermally annealed between 950 °C and 1150 °C and UO2 between 650 °C and 1000 °C. The crystallite growth was then followed by high-temperature X-ray diffraction (HT-XRD). The activation energies for the growth of crystallites of UO2 and NpO2 were determined to be 264(26) kJ mol−1 and 442(32) kJ mol−1, respectively, with a growth exponent n = 4. The value of the exponent n and the low activation energy suggest that the crystalline growth is rate-controlled by the mobility of the pores, which migrate by atomic diffusion along the pore surfaces. We could thus estimate the cation self-diffusion coefficient along the surface in UO2, NpO2 and PuO2. While data for surface diffusion coefficients for NpO2 and PuO2 are lacking in the literature, the comparison with literature data for UO2 supports further the hypothesis of a surface diffusion controlled growth mechanism.

Published
2023

15. Energetically optimal finite-time stabilization of generalized homogeneous linear systems

Author

Andrey Polyakov, Denis Efimov, Xubin Ping, Finite-time control and estimation for distributed systems [VALSE], Xidian University, Finite-time control and estimation for distributed systems (VALSE), Inria Lille - Nord Europe, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 (CRIStAL), and Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)

Subjects
nonlinear control, stability of nonlinear systems, optimal control, Control and Systems Engineering, [INFO.INFO-AU]Computer Science [cs]/Automatic Control Engineering, Electrical and Electronic Engineering, Computer Science Applications
Abstract

International audience; The problem of finite-time stabilization of a linear plant with an optimization of both a settling time and an averaged/weighted control energy is studied using the concept of generalized homogeneity. It is shown that the optimal finite-time stabilizing control in this case can be designed by means of solving a simple linear algebraic equation. Robustness of the obtained control law is studied.

Published
2023

16. Studying the Energy Consumption of Stream Processing Engines in the Cloud

Author

KP, Govind, Pierre, Guillaume, Rouvoy, Romain, Design and Implementation of Autonomous Distributed Systems (MYRIADS), Inria Rennes – Bretagne Atlantique, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-SYSTÈMES LARGE ÉCHELLE (IRISA-D1), Institut de Recherche en Informatique et Systèmes Aléatoires (IRISA), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université de Bretagne Sud (UBS)-École normale supérieure - Rennes (ENS Rennes)-Institut National de Recherche en Informatique et en Automatique (Inria)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Institut de Recherche en Informatique et Systèmes Aléatoires (IRISA), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université de Bretagne Sud (UBS)-École normale supérieure - Rennes (ENS Rennes)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Self-adaptation for distributed services and large software systems (SPIRALS), Inria Lille - Nord Europe, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 (CRIStAL), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Institut Universitaire de France (IUF), Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.), IEEE, and Grid5000

Subjects
Energy consumption, Green computing, Data stream processing, [INFO]Computer Science [cs], Reproducibility
Abstract

International audience; Reducing the energy consumption of the global IT industry requires one to understand and optimize the large software infrastructures the modern data economy relies on. Among them are the data stream processing systems that are deployed in cloud data centers by companies, such as Twitter, to process billion of events per day in real time. However, studying the energy consumption of such infrastructures is difficult because they rely on a complex virtualized software ecosystem where attributing energy consumption to individual software components is a challenge, and because the space of possible configurations is large. We present GreenFlow, a principled methodology and tool designed to automate the deployment of energy measurement experiments for data stream processing systems in cloud environments. GreenFlow is designed to deliver reproducible results while remaining flexible enough to support a wide range of experiments. We illustrate its usage and show in particular that consolidating a DSP system in the smallest number of servers that are capable of processing it is an effective way to reduce energy consumption.

Published
2023

17. Earliest Query Answering for Deterministic Stepwise Hedge Automata

Author

Al Serhali, Antonio, Niehren, Joachim, Linking Dynamic Data (LINKS), Inria Lille - Nord Europe, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 (CRIStAL), and Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)

Subjects
[INFO.INFO-TT]Computer Science [cs]/Document and Text Processing, [INFO.INFO-FL]Computer Science [cs]/Formal Languages and Automata Theory [cs.FL], Nested words, Query answering, Streaming, Automata
Abstract

International audience; Earliest query answering (EQA) is the problem to enumerate certain query answers on streams at the earliest events. We consider EQA for regular monadic queries on hedges or nested words defined by deterministic stepwise hedge automata (dShas). We present an EQA algorithm for dShas that requires time O(c m) per event, where m is the size of the automata and c the concurrency of the query. We show that our EQA algorithm runs efficiently on regular XPath queries in practice.

Published
2023

18. Subhedge Projection for Stepwise Hedge Automata

Author

Al Serhali, Antonio, Niehren, Joachim, Linking Dynamic Data (LINKS), Inria Lille - Nord Europe, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 (CRIStAL), and Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)

Subjects
[INFO.INFO-TT]Computer Science [cs]/Document and Text Processing, [INFO.INFO-FL]Computer Science [cs]/Formal Languages and Automata Theory [cs.FL], Nested words, Query answering, Streaming, Automata
Abstract

International audience; We show how to evaluate stepwise hedge automata (SHAs) with subtree projection. Since this requires to pass finite state information top-down, we introduce the notion of downward stepwise hedge automata. We then use them in order to define an in-memory and a streaming evaluator with subhedge projection for SHAs. We tune the streaming evaluator so that it can decide membership at the earliest time point. We apply our algorithms to the problem of answering regular XPath queries on XML streams. Our experiments show that subhedge projection can indeed speed up earliest query answering on XML streams.

Published
2023

19. Condition for periodic attractor in 4-dimensional repressilators

Author

Sun, Honglu, Folschette, Maxime, Magnin, Morgan, Méthodes Formelles pour la Bioinformatique (LS2N - équipe MéForBio), Laboratoire des Sciences du Numérique de Nantes (LS2N), Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-École Centrale de Nantes (Nantes Univ - ECN), Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes université - UFR des Sciences et des Techniques (Nantes univ - UFR ST), Nantes Université - pôle Sciences et technologie, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Sciences et technologie, Nantes Université (Nantes Univ)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Nantes Université (Nantes Univ), BioComputing, Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 (CRIStAL), and Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)

Subjects
Decision tree, Discrete dynamical system, [INFO.INFO-BI]Computer Science [cs]/Bioinformatics [q-bio.QM], Periodic attractor, Repressilator, Gene regulatory networks
Abstract

One of the key questions about gene regulatory networks is how to predict complex dynamical properties based on the influence graph's topology. Earlier theoretical studies have identified conditions for complex dynamical properties, like multistability or oscillations, based on topological features, like the presence of a positive (negative) feedback loop. This work follows this path and aims to find a sufficient and necessary condition for the existence of a periodic attractor in 4-dimensional (4 genes) repressilators based on a discrete modeling framework under some dynamical assumptions. These networks are extensions of the widely studied 3-dimensional repressilator, which has been used in synthetic biology to produce synthetic oscillations. While other researchers have explored specific extensions of the 3-dimensional repressilator to improve synthetic oscillation control, our work investigates all 4-dimensional networks with only inhibitions. By uncovering new insights about periodic attractors in these small networks, our findings could aid the design of new synthetic oscillations. We search for condition for period attractor in an exhaustive manner with the guide of a decision tree model. Our major contributions include: 1) discovering that, with one exception, the relations between gene regulation thresholds do not impact the existence of periodic attractors in any of the influence graphs considered in this study; 2) identifying a sufficient and necessary condition of simple form for the existence of a periodic attractor when the exception is ignored; 3) identifying new topological features of influence graphs that are necessary for predicting the existence of periodic attractor in 4-dimensional repressilators.

Published
2023

20. Core SBML and its Formal Semantics

Author

Niehren, Joachim, Lhoussaine, Cédric, Vaginay, Ahténaïs, BioComputing, Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 (CRIStAL), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Linking Dynamic Data (LINKS), Inria Lille - Nord Europe, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 (CRIStAL), Laboratoire Lorrain de Recherche en Informatique et ses Applications (LORIA), Institut National de Recherche en Informatique et en Automatique (Inria)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), ANR-21-CE45-0017,MIGAD,Modélisation de l'absorption intestinale de glucose dans le diabète(2021), Linking Dynamic Data [LINKS], and Laboratoire Lorrain de Recherche en Informatique et ses Applications [LORIA]

Subjects
[SCCO.COMP]Cognitive science/Computer science
Abstract

International audience; The systems biology markup language (SBML) permits to represent biological models mixing reaction networks, algebraic equations, differential equations, and events. Its main objective is to exchange biological models between various tools for simulation and analysis. Such tools are, for example, Copasi, BioCham, CellDesigner, as well as more general-purpose languages such as Julia. While an XML schema formally defines the concrete syntax of SBML, there is no formal semantics. This makes it often difficult to understand the models and to design and implement correct and general interfaces from and to SBML, i.e., to use SBML as an exchange formalism for systems biology. In the present paper, we propose Core SBML, a novel language covering a large subset of SBML with clear formal semantics. Besides giving a formal definition, we define an XML syntax for Core SBML by an XML schema. We then present a compiler of a large fragment of SBML to Core SBML. We also distinguish a fragment of Core SBML with a provably correct compiler to BioCham.

Published
2023

21. Passive sensor network resycnhronization applied for SHM

Author

Bouchakour, Omar, Chehami, Lynda, Moulin, Emmanuel, Transduction, Propagation et Imagerie Acoustique - IEMN (TPIA - IEMN), INSA Institut National des Sciences Appliquées Hauts-de-France (INSA Hauts-De-France), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Université catholique de Lille (UCL)-Université catholique de Lille (UCL)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Université catholique de Lille (UCL)-Université catholique de Lille (UCL), and Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN)

Subjects
[SPI]Engineering Sciences [physics]
Abstract

Communication orale; International audience

Published
2023

22. Monitoring of generalised corrosion: Ultrasonic coda wave interferometry technique applied to steel corrosion in aqueous NaCl solutions

Author

Cyril Nicard, Maxime Farin, Emmanuel Moulin, David Balloy, Ingrid Proriol Serre, Unité Matériaux et Transformations - UMR 8207 (UMET), Centrale Lille-Institut de Chimie du CNRS (INC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut Langevin - Ondes et Images (UMR7587) (IL), Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Université catholique de Lille (UCL)-Université catholique de Lille (UCL), Transduction, Propagation et Imagerie Acoustique - IEMN (TPIA - IEMN), INSA Institut National des Sciences Appliquées Hauts-de-France (INSA Hauts-De-France), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Université catholique de Lille (UCL)-Université catholique de Lille (UCL)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), SOCORRO, and This study was supported by our institutes and partially by the European Union. This work was a part of the European project Interreg 2 Seas, Seeking Out Corrosion, before it is too late (SOCORRO). This work was supported by Lille University (France) and the French National Center for Scientific Research.

Subjects
[PHYS]Physics [physics], [SPI]Engineering Sciences [physics], Generalised corrosion, Electrochemical experiments, Non-destructive testing, CWI, General Materials Science, Condensed Matter Physics, Sensor
Abstract

International audience; This paper investigates a Non-Destructive Testing based on ultrasonic Coda Wave Interferometry technique to determine if it can be an efficient way to continuously and quantitatively measure the thickness loss due to corrosion on an S355 grade steel in 3 wt% NaCl distilled water. To do so, several electrochemical experiments in open circuit potentials and imposed anodic dissolutions (from few to tens of micrometers) are performed at stable and varying temperatures (20–30 ◦C) in aqueous NaCl. The thickness loss and corrosion rate are continuously measured with CWI thanks to a piezoelectric trasducer and verified post-experiment with an optical depth profile measurement.

Published
2023

23. GAP: Differentially Private Graph Neural Networks with Aggregation Perturbation

Author

Sajadmanesh, Sina, Shahin Shamsabadi, Ali, Bellet, Aurélien, Gatica-Perez, Daniel, IDIAP Research Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), The Alan Turing Institute, Machine Learning in Information Networks (MAGNET), Inria Lille - Nord Europe, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 (CRIStAL), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS), ANR-20-CE23-0015,PRIDE,Apprentissage automatique décentralisé et préservant la vie privée(2020), Ecole Polytechnique Fédérale de Lausanne [EPFL], and Machine Learning in Information Networks [MAGNET]

Subjects
FOS: Computer and information sciences, Computer Science - Machine Learning, Computer Science - Cryptography and Security, [INFO.INFO-LG]Computer Science [cs]/Machine Learning [cs.LG], [STAT.ML]Statistics [stat]/Machine Learning [stat.ML], Cryptography and Security (cs.CR), Machine Learning (cs.LG)
Abstract

In this paper, we study the problem of learning Graph Neural Networks (GNNs) with Differential Privacy (DP). We propose a novel differentially private GNN based on Aggregation Perturbation (GAP), which adds stochastic noise to the GNN's aggregation function to statistically obfuscate the presence of a single edge (edge-level privacy) or a single node and all its adjacent edges (node-level privacy). Tailored to the specifics of private learning, GAP's new architecture is composed of three separate modules: (i) the encoder module, where we learn private node embeddings without relying on the edge information; (ii) the aggregation module, where we compute noisy aggregated node embeddings based on the graph structure; and (iii) the classification module, where we train a neural network on the private aggregations for node classification without further querying the graph edges. GAP's major advantage over previous approaches is that it can benefit from multi-hop neighborhood aggregations, and guarantees both edge-level and node-level DP not only for training, but also at inference with no additional costs beyond the training's privacy budget. We analyze GAP's formal privacy guarantees using R\'enyi DP and conduct empirical experiments over three real-world graph datasets. We demonstrate that GAP offers significantly better accuracy-privacy trade-offs than state-of-the-art DP-GNN approaches and naive MLP-based baselines. Our code is publicly available at https://github.com/sisaman/GAP., Comment: Accepted at USENIX Security '23

Published
2023
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24. High Breakdown Voltage GaN Schottky Diodes for THz Frequency Multipliers

Author

G. Di Gioia, E. Frayssinet, M. Samnouni, V. Chinni, P. Mondal, J. Treuttel, X. Wallart, M. Zegaoui, G. Ducournau, Y. Roelens, Y. Cordier, M. Zaknoune, Advanced NanOmeter DEvices - IEMN (ANODE - IEMN), Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Université catholique de Lille (UCL)-Université catholique de Lille (UCL)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Université catholique de Lille (UCL)-Université catholique de Lille (UCL), Centre de recherche sur l'hétéroepitaxie et ses applications (CRHEA), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), EPItaxie et PHYsique des hétérostructures - IEMN (EPIPHY - IEMN), LERMA Cergy (LERMA), Laboratoire d'Etude du Rayonnement et de la Matière en Astrophysique et Atmosphères = Laboratory for Studies of Radiation and Matter in Astrophysics and Atmospheres (LERMA), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-CY Cergy Paris Université (CY)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-CY Cergy Paris Université (CY), Photonique THz - IEMN (PHOTONIQUE THZ - IEMN), This work was supported by the French ANR (Agence Nationale de la Recherche), under the CE24 ‘SchoGAN’ project. This work was also supported by the CPER 'Photonics for Society', the CPER 'WAVETECH', and the Hauts de France Regional Council and the French Network RENATECH, Renatech Network, and ANR-17-CE24-0034,SchoGaN,Diodes Schottky GaN pour la génération de signaux THz(2017)

Subjects
wide band gap semiconductor, Materials Chemistry, Schottky diode, frequency multipliers, THz, Electrical and Electronic Engineering, Condensed Matter Physics, Electronic, Optical and Magnetic Materials, GaN, [SPI.TRON]Engineering Sciences [physics]/Electronics
Abstract

International audience; Quasi-vertical gallium nitride (GaN) Schottky diodes on silicon carbide (SiC) substrates were fabricated for frequency multiplier applications. The epitaxial structure employed had an n− layer of 590 nm with doping 6.6 × 1016 cm−3, while the n+ layer was 950 nm thick, with doping 2 × 1019 cm−3. Potassium hydroxide (KOH) chemical surface treatment before Schottky contact metallization was employed to study its effect in improving the diode parameters. The KOH-treated diode demonstrated a breakdown voltage of − 27.5 V, which is the highest reported for this type of diode. Cut-off frequencies around 500 GHz were obtained at high reverse bias (− 25 V) in spite of high series resistance. The result obtained in breakdown voltage value warrants further research in surface treatment and post-annealing of the Schottky contact optimization in order to decrease the series resistance.

Published
2023

25. Saturated long chain fatty acids as possible natural alternative antibacterial agents: opportunities and challenges

Author

Arellano, Helena, Nardello-Rataj, Véronique, Szunerits, Sabine, Boukherroub, Rabah, Fameau, Anne-Laure, Unité de Catalyse et Chimie du Solide - UMR 8181 (UCCS), Université d'Artois (UA)-Centrale Lille-Institut de Chimie du CNRS (INC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Université catholique de Lille (UCL)-Université catholique de Lille (UCL), NanoBioInterfaces - IEMN (NBI - IEMN), Université catholique de Lille (UCL)-Université catholique de Lille (UCL)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Unité Matériaux et Transformations - UMR 8207 (UMET), Centrale Lille-Institut de Chimie du CNRS (INC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), and no information

Subjects
Long chain saturated fatty-acids, [SPI]Engineering Sciences [physics], Formulation, Nanotechnology, Self-assembly, Antibacterial lipids
Abstract

International audience; The spread of new strains of antibiotic-resistant pathogenic microorganisms has led to the urgent need to discover and develop new antimicrobial systems. The antibacterial effects of fatty acids have been well-known and recognized since the first experiments of Robert Koch in 1881, and they are now used in diverse fields. Fatty acids can prevent the growth and directly kill bacteria by insertion into their membrane. For that, a sufficient amount of fatty acid molecules has to be solubilized in water to transfer from the aqueous phase to the cell membrane. Due to conflicting results in the literature and lack of standardization methods, it is very difficult to draw clear conclusions on the antibacterial effect of fatty acids. Most of the current studies link fatty acids' effectiveness against bacteria to their chemical structure, notably the alkyl chain length and the presence of double bonds in their chain. Furthermore, the solubility of fatty acids and their critical aggregation concentration is not only related to their structure, but also influenced by medium conditions (pH, temperature, ionic strength, etc.). There is a possibility that the antibacterial activity of saturated long chain fatty acids (LCFA) may be underestimated due to the lack of water solubility and the use of unsuitable methods to assess their antibacterial activity. Thus, enhancing the solubility of these long chain saturated fatty acids is the main goal before examining their antibacterial properties. To increase their water solubility and thereby improve their antibacterial efficacy, novel alternatives may be considered, including the use of organic positively charged counter-ions instead of the conventional sodium and potassium soaps, the formation of catanionic systems, the mixture with co-surfactants, and solubilization in emulsion systems. This review summarizes the latest findings on fatty acids as antibacterial agents, with a focus on long chain saturated fatty acids. Additionally, it highlights the different ways to improve their water solubility, which may be a crucial factor in increasing their antibacterial efficacy. We finish with a discussion on the challenges, strategies and opportunities for the formulation of LCFAs as antibacterial agents.

Published
2023

26. Au@BN-enhanced laser desorption/ionization mass spectrometry and imaging for determination of fipronil and its metabolites in food and biological samples

Author

Yanfang Zhao, Rabah Boukherroub, Guiju Xu, Huijuan Li, Ru-Song Zhao, Qin Wei, Xiang Yu, Xiangfeng Chen, China University of Geosciences [Beijing], Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Université catholique de Lille (UCL)-Université catholique de Lille (UCL), NanoBioInterfaces - IEMN (NBI - IEMN), Université catholique de Lille (UCL)-Université catholique de Lille (UCL)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Qilu University of Technology, Universität Bayreuth, DEPARTMENT OF MICROBIOLOGY AND PLANT BIOLOGY UNIVERSITY OF OKLAHOMA NORMAN USA, Partenaires IRSTEA, Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA), Key Laboratory for Apllied Technology of Sophisticated Analytical and Prevention, and Acknowledgment The research was supported by the National Natural Science Foundation of China (No. 51571183, 22106080), Jinan University and Institute Innovation Team Project (2021GXRC090), the Program for Taishan Scholars of Shandong Province (NO. tsqn 202103099, X. Chen, ts20190948, R. Zhao), and the pilot project on the integration of science education and production (2022PYI013).

Subjects
[PHYS]Physics [physics], [SPI]Engineering Sciences [physics], Food matrices, Metabolites, Au@BN, General Medicine, Fipronil, LDI-MS, Food Science, Analytical Chemistry, Imaging
Abstract

International audience; AbstractGold nanoparticles (AuNPs) represent an attractive inorganic matrix for laser desorption/ionization mass spectrometry (LDI-MS) detection of low-molecular-weight analytes; however, their direct use is hindered by severe aggregation. To limit AuNPs aggregation, hexagonal boron nitride nanosheets (h-BNNs) were employed as supports to improve their desorption/ionization efficiency. Thus, Au@BN was synthesized and systematically characterized. It showed low background noise and high sensitivity for LDI-MS of fipronil and its metabolites. Au@BN-assisted LDI-MS was validated using complex samples including blueberry juice, green tea beverage, and fish muscle, achieving low detection limits (0.05–0.20 µg·L−1 for liquid media, 0.82–1.25 ng·g−1 for fish muscle), wide linear ranges (0.2–100 µg·L−1 for liquid media, 3.00–1000 ng·g−1 for fish muscle), high reproducibility (7.55%–13.7%), and satisfactory recoveries (82.62%–109.1%). Furthermore, spatial distributions of analytes in strawberries and zebrafish were successfully imaged. This strategy allows for the quantitative analysis of other small molecules in complex substrates.

Published
2023

27. [Review] Graphene loaded with metal nanoparticles/complexes catalyzed cross-coupling reactions: A review

Author

Maryam Mirza-Aghayan, Amir Sepehr Moieni, Rabah Boukherroub, chemistry and chemical engineeting research center of Iran (CCERCI), CHEMISTRY AND CHEMICAL ENGINEERING, Islamic Azad University, Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Université catholique de Lille (UCL)-Université catholique de Lille (UCL), NanoBioInterfaces - IEMN (NBI - IEMN), Université catholique de Lille (UCL)-Université catholique de Lille (UCL)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), and NONE FOUND

Subjects
Inorganic Chemistry, [PHYS]Physics [physics], Heterogeneous catalysis, Cross-coupling reactions, [SPI]Engineering Sciences [physics], Graphene-based nanocatalysts, Organic Chemistry, Materials Chemistry, Physical and Theoretical Chemistry, Carbon-carbon bond formation, Biochemistry
Abstract

International audience; AbstractVarious catalytic reactions under suitable conditions were used for the carbon-carbon (C-C) bond formation, such as the Kumada, Mizoroki-Heck, Sonogashira, Negishi, Stille, Suzuki-Miyaura, Hiyama, andFukuyama cross-coupling reactions. Supporting metal nanoparticles or complexes on functionalizedgraphene oxide (GO) or reduced graphene oxide (rGO) compounds provides new heterogeneous catalysts with enhanced aptitude for the formation of C-C bonds. This review highlights the applications ofmetal decorated on modified GO and rGO derivatives to form C-C bonds. We discuss briefly the generalmechanistic cycle of each reaction and the recent applications of the graphene-based nanocatalysts forthe coupling reactions, along the advantages of each catalyst.

Published
2023

28. Modeling for nonlinear acoustic imaging of an isolated crack via standing waves in a 2D solid

Author

Vladislav V. Aleshin, Ravi Verma, Kevin Truyaert, Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Université catholique de Lille (UCL)-Université catholique de Lille (UCL), Acoustique Impulsionnelle & Magnéto-Acoustique Non linéaire - Fluides, Interfaces Liquides & Micro-Systèmes - IEMN (AIMAN-FILMS - IEMN), Université catholique de Lille (UCL)-Université catholique de Lille (UCL)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), and Acknowledgements The authors gratefully acknowledge the support by the I-SITE program of the University of Lille.

Subjects
[PHYS]Physics [physics], [SPI]Engineering Sciences [physics], Acoustics and Ultrasonics, Contact acoustic nonlinearity, Modeling in acoustics, Internal friction, Nonlinear acoustic nondestructive imaging
Abstract

International audience; AbstractThis paper is concerned with numerical modeling for nondestructive imaging of defects in solids via standing waves excited by a periodic sinewave signal. The stationary solution, purely sinusoidal in an intact sample, contains higher harmonics when damage is present. These harmonics are generated by contact acoustic nonlinearity and form their own standing waves whose intensity maximum usually indicates the position of damage, in a way similar to resonant vibrometry experiments. The key point of the developed numerical tool that describes those wave phenomena is a model of planar damage (crack, delamination) considered here as an inner contact with rough surfaces and friction. The corresponding boundary conditions are given by the previously developed contact model based on the Method of Memory Diagrams (MMD) capable of automating the account for hysteretic frictional effects. Combination of the MMD for boundary conditions and a finite element formulation for waves in a volume (MMD-FEM model) provides a complete description which represents a numerical code applied here for nonlinear standing waves simulations. We present a number of examples obtained for idealized 2D geometry and reveal conditions in which both position and extent of damage are clearly seen as well as cases where only partial detection is possible.

Published
2023

29. Introducing the TRUMPET project: TRUstworthy Multi-site Privacy Enhancing Technologies

Author

Pedrouzo-Ulloa, Alberto, Ramon, Jan, Duflot, Patrick, Pérez-González, Fernando, Lilova, Siyanna, Chihani, Zakaria, Gentili, Nicola, Ulivi, Paola, Hoque, Mohammad Ashadul, Mukammel, Twaha, Pritzker, Zeev, Lemesle, Augustin, Loureiro-Acuña, Jaime, Martı́nez, Xavier, Jiménez-Balsa, Gonzalo, Universidade de Vigo, Machine Learning in Information Networks (MAGNET), Inria Lille - Nord Europe, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 (CRIStAL), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Universitaire de Liège (CHU-Liège), Timelex, Laboratoire d'Intégration des Systèmes et des Technologies (LIST (CEA)), Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Technovative Solutions, Arteevo Technologies, Centro Tecnoloxico de Telecomunicacions de Galicia (Gradiant), and European Project: 101070038,TRUMPET

Subjects
Privacy Metrics, Patient Data Privacy, AI, Federated Learning Privacy Metrics Privacy Enhancing Technologies General Data Protection Regulation Clinical Cancer Research Patient Data Privacy, Healthcare, Clinical Cancer Research, [INFO]Computer Science [cs], Privacy Enhancing Technologies, Federated Learning, General Data Protection Regulation
Abstract

International audience; This paper is an overview of the EU-funded project TRUMPET (https://trumpetproject.eu/), and gives an outline of its scope and main technical aspects and objectives. In recent years, Federated Learning has emerged as a revolutionary privacy-enhancing technology. However, further research has cast a shadow of doubt on its strength for privacy protection. The goal of TRUMPET is to research and develop novel privacy enhancement methods for Federated Learning, and to deliver a highly scalable Federated AI service platform for researchers, that will enable AI-powered studies of siloed, multi-site, crossdomain, cross-border European datasets with privacy guarantees that follow the requirements of GDPR. The generic TRUMPET platform will be piloted, demonstrated and validated in the specific use case of European cancer hospitals, allowing researchers and policymakers to extract AI-driven insights from previously inaccessible cross-border, cross-organization cancer data, while ensuring the patients' privacy.

Published
2023

30. One-Shot Federated Conformal Prediction

Author

Humbert, Pierre, Bars, Batiste Le, Bellet, Aurélien, Arlot, Sylvain, Laboratoire de Mathématiques d'Orsay (LMO), Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Statistique mathématique et apprentissage (CELESTE), Inria Saclay - Ile de France, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Laboratoire de Mathématiques d'Orsay (LMO), Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Machine Learning in Information Networks (MAGNET), Inria Lille - Nord Europe, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 (CRIStAL), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 (CRIStAL), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS), ANR-20-CE23-0015,PRIDE,Apprentissage automatique décentralisé et préservant la vie privée(2020), Laboratoire de Mathématiques d'Orsay [LMO], Statistique mathématique et apprentissage [CELESTE], Machine Learning in Information Networks [MAGNET], and Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 [CRIStAL]

Subjects
FOS: Computer and information sciences, [STAT]Statistics [stat], [STAT.ML]Statistics [stat]/Machine Learning [stat.ML], Statistics - Machine Learning, Machine Learning (stat.ML)
Abstract

International audience; In this paper, we introduce a conformal prediction method to construct prediction sets in a oneshot federated learning setting. More specifically, we define a quantile-of-quantiles estimator and prove that for any distribution, it is possible to output prediction sets with desired coverage in only one round of communication. To mitigate privacy issues, we also describe a locally differentially private version of our estimator. Finally, over a wide range of experiments, we show that our method returns prediction sets with coverage and length very similar to those obtained in a centralized setting. Overall, these results demonstrate that our method is particularly well-suited to perform conformal predictions in a one-shot federated learning setting.

Published
2023

31. Debugging Video Games: A Systematic Mapping

Author

Vanègue, Adrien, Bourcier, Valentin, Petrillo, Fabio, Costiou, Steven, Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 (CRIStAL), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Analyses and Languages Constructs for Object-Oriented Application Evolution (RMOD), Inria Lille - Nord Europe, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 (CRIStAL), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Reflective Evolution of Ever-running Software Systems (EVREF), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Université de Lille-Berger-Levrault-Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 (CRIStAL), Ecole de Technologie Supérieure [Montréal] (ETS), and ANR-21-CE25-0004,OCRE,OCRE: Réduire le coût du debugging avec la première génération de debuggers orientés objet(2021)

Subjects
[INFO.INFO-SE]Computer Science [cs]/Software Engineering [cs.SE], software quality, debugging, video game, software engineering
Abstract

International audience; The video game industry is a vast and lucrative sector that generates significant revenue. However, a recurring issue within this industry is the release of games with numerous bugs. The process of debugging, a challenging and expensive undertaking in software development, becomes crucial in rectifying these issues. It is worth noting that such bugs can significantly impact the commercial performance of games in the market. Therefore, an imperative arises to foster further academic research that presents dedicated debugging techniques aimed at enhancing the process specifically within the realm of video game development. In this paper, we employ a systematic mapping study methodology to discern the existing body of knowledge concerning debugging practices for video games. Through a systematic selection process, we selected 21 relevant studies for analysis, enabling the synthesis of data and facilitating the creation of a overview that encapsulates the state of the art on debugging video games. We identified work analyzing challenges of debugging games, proposing bug detection techniques or dedicated debugging tools. However, these work are always bound to specific contexts or kinds of games. Our analysis shows that there is no academic body of knowledge about debugging video games. Thus, this initial exploration not only raises pertinent questions but also presents prospects for conducting empirical and controlled experiments to enhance our understanding of effective debugging strategies within the context of video game development. We complete our analysis with a discussion of testing and debugging techniques, and how they could help and open new research opportunities for the debugging of video games. CCS Concepts: • Software and its engineering → Maintaining software; Development frameworks and environments; Software maintenance tools; Software notations and tools.

Published
2023

32. Channel Configuration for Neural Architecture: Insights from the Search Space

Author

Thomson, Sarah, Ochoa, Gabriela, Veerapen, Nadarajen, Michalak, Krzysztof, University of Stirling, Operational Research, Knowledge And Data (ORKAD), Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 (CRIStAL), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Wroclaw University of Economics, and ACM

Subjects
Local Optima Networks (LONs), Neural Architecture Search, Local Optima Networks, Fitness Landscapes Neural Architecture Search Local Optima Networks (LONs), [INFO]Computer Science [cs], Fitness Landscapes
Abstract

International audience; We consider search spaces associated with neural network channel configuration. Architectures and their accuracy are visualised using low-dimensional Euclidean embedding (LDEE). Optimisation dynamics are captured using local optima networks (LONs). LONs are a compression of a fitness landscape: the nodes are local optima and the edges are search transitions between them. Several neural architecture search algorithms are tested on the search space and we discover that iterated local search (ILS) is a competitive algorithm for neural channel configuration. We additionally implement a landscape-aware ILS which performs well. Observations from the search and landscape space analyses bring visual clarity and insight to the science of neural network channel design: the results indicate that a high number of channels, kept constant throughout the network, is beneficial.

Published
2023

33. Randomness in Local Optima Network Sampling

Author

Thomson, Sarah, Veerapen, Nadarajen, Ochoa, Gabriela, van den Berg, Daan, University of Stirling, Operational Research, Knowledge And Data (ORKAD), Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 (CRIStAL), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Vrije Universiteit Amsterdam [Amsterdam] (VU), and ACM

Subjects
Quadratic Assignment Problem, Local Optima Networks, Iterated Local Search, [INFO]Computer Science [cs], Fitness Landscapes
Abstract

We consider statistical randomness in the construction of local optima networks (LONs) and conduct a preliminary and exploratory study into this. LONs capture a fitness landscape into network format: the nodes are local optima, and edges are heuristic search transitions between them. Problem instances from the benchmark quadratic assignment problem library are used in the analysis. LONs are constructed using an iterated local search (ILS) and several different random seeds. Metrics are computed from the networks and visualised to assess the effect of randomness. Algorithm performance models for ILS runtime are built using metrics of LONs constructed using different seeds and the results compared. The results show that some LON metrics seem consistent across seeds, while others vary substantially. Additionally, the quality of algorithm performance models using LON metrics as predictors can differ depending on randomness. Finally, LON metrics associated with separate seeds can lead to different algorithm configuration recommendations for the same instance.

Published
2023

34. Adaptive Consumption by Continuous Negotiation

Author

Beauprez, Ellie, Caron, Anne-Cécile, Morge, Maxime, Routier, Jean-Christophe, Systèmes Multi-Agents et Comportements (SMAC), Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 (CRIStAL), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS), PAAMS, Philippe Mathieu, Frank Dignum, Paulo Novais, and Fernando De la Prieta

Subjects
Agent cooperation and negotiation, [INFO.INFO-MA]Computer Science [cs]/Multiagent Systems [cs.MA], Distributed problem solving, [INFO.INFO-AI]Computer Science [cs]/Artificial Intelligence [cs.AI]
Abstract

International audience; In this paper, we study the problem of allocating concurrent jobs composed of situated tasks, underlying the distributed deployment of the MapReduce design pattern on a cluster. In order to implement our multi-agent strategy which aims at minimising the mean flowtime of jobs, we propose a modular agent architecture that allows the concurrency of negotiation and consumption. Our experiments show that our reallocation strategy, when executed continuously during the consumption process: (1) improves the flowtime; (2) does not penalise the consumption; (3) is robust against execution hazards.

Published
2023

35. The Finger in the Power: How to Fingerprint PCs by Monitoring their Power Consumption

Author

Botvinnik, Marina, Laor, Tomer, Rokicki, Thomas, Maurice, Clémentine, Oren, Yossi, Ben-Gurion University of the Negev (BGU), Intel Corporation [Haifa], Intel Corporation [USA], Security & PrIvaCY (SPICY), SYSTÈMES LARGE ÉCHELLE (IRISA-D1), Institut de Recherche en Informatique et Systèmes Aléatoires (IRISA), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université de Bretagne Sud (UBS)-École normale supérieure - Rennes (ENS Rennes)-Institut National de Recherche en Informatique et en Automatique (Inria)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Institut de Recherche en Informatique et Systèmes Aléatoires (IRISA), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Self-adaptation for distributed services and large software systems (SPIRALS), Inria Lille - Nord Europe, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 (CRIStAL), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS), This work has been partly funded by the ANR-19-CE39-0007 MIAOUS. Experiments presented in this paper were carried out using the Grid’5000 testbed, supported by a scientific interest group hosted by Inria and including CNRS, RENATER and several Universities as well as other organizations (see https://www.grid5000.fr)., Grid'5000, and ANR-19-CE39-0007,MIAOUS,Attaques sur la micro-architecture des systèmes ubiquitaires(2019)

Subjects
Side Channel, [INFO.INFO-CR]Computer Science [cs]/Cryptography and Security [cs.CR], WebAssembly, Fingerprinting, PUF
Abstract

International audience; Power analysis has long been used to tell apart different instructions running on the same machine. In this work, we show that it is also possible to use power consumption to tell apart different machines running the same instructions, even if these machines have entirely identical hardware and software configurations, and even if the power consumption measurements are carried out using low-rate software-based methods. We collected an extended dataset of power consumption traces from 291 desktop and server systems, spanning multiple processor generations and vendors (Intel and AMD). After analyzing them, we discovered that profiling the power consumption of individual assembly instructions makes it possible to create a fingerprinting agent that can identify individual machines with high accuracy. Our classifier approaches its peak accuracy after less than 10 instructions, meaning that the fingerprint can take a very short time to capture. We analyzed the stability of the fingerprint over time and discovered that, while it remains relatively stable, it is significantly affected by temperature changes. We also carried out a proof-of-concept evaluation using portable WebAssembly code, showing that our method can still be applied, albeit at a reduced accuracy, without using native instructions for the profiling step. Our method depends on the ability to measure power, which is currently restricted to highprivileged "ring 0" code on modern PCs. This limits the current use of our method to defense-only settings, such as strengthening authentication or anti-counterfeiting. Our tools and datasets are publicly released as an open-source repository. Our work highlights the importance of protecting power consumption measurements from unauthorized access.

Published
2023

36. Combining neural networks and control: potentialities, patterns and perspectives

Author

Cerf, Sophie, Rutten, Eric, Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 (CRIStAL), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Self-adaptation for distributed services and large software systems (SPIRALS), Inria Lille - Nord Europe, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 (CRIStAL), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Control for Autonomic computing systems (CTRL-A ), Inria Grenoble - Rhône-Alpes, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Laboratoire d'Informatique de Grenoble (LIG), Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), Laboratoire d'Informatique de Grenoble (LIG), and International Federation of Automatic Control

Subjects
Machine Learning, Machine learning in modelling, Data-driven control, Neural Networks, Learning for control, Reinforcement learning and deep learning in control, prediction, control and automation, [SPI.AUTO]Engineering Sciences [physics]/Automatic, [INFO.INFO-AI]Computer Science [cs]/Artificial Intelligence [cs.AI]
Abstract

International audience; Machine learning tools are widely used for knowledge extraction, modeling, and decision tasks; a range of problems that Control Theory also tackles. Their relations have been largely explored by looking at stochastic control and Markov Decision Processes, due to the proximity of their formulations. However, novel links between machine learning and deterministic control are emerging; combining both approaches, e.g. by performing identification with learning, or controlling the training process. The recent flourishing literature is vast: there is a need to identify challenges, trends and opportunities on this interface. This survey contributes i) to the compared analysis of both fields. ii) Based on literature review, a categorization of combinations of learning and control is drawn. In the control framework, learning has been used for modeling, controllers tuning or adaptation, generating a controller or as a controller itself, for translating complex objectives, or checking controlled systems. Conversely, in the learning framework, control is used for tuning hyperparameters, selecting or generating training data, as the training or decision-making algorithm itself or to guarantee learning properties. iii) Finally, discussions on the literature open novel promising combinations to be explored, such as control of neural networks' training process.

Published
2023

37. A New Finite-Time Sliding-Mode Controller for a Class of Second-Order Non-Linear Systems

Author

Ríos, Héctor, Mera, Manuel, Polyakov, Andrey, Instituto Tecnologico de la Laguna (ITL), Instituto Politechnico National (IPN), Instituto Politecnico Nacional [Mexico] (IPN), Finite-time control and estimation for distributed systems (VALSE), Inria Lille - Nord Europe, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 (CRIStAL), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Instituto Tecnologico de la Laguna [ITL], Instituto Politechnico National [IPN], and Finite-time control and estimation for distributed systems [VALSE]

Subjects
Robust Control Sliding-Mode Control Second-Order Systems, Robust Control, Sliding-Mode Control, Second-Order Systems, [INFO.INFO-AU]Computer Science [cs]/Automatic Control Engineering
Abstract

International audience; This paper contributes to the design of a new finite-time sliding-mode controller for a class of uncertain second-order non-linear systems. The proposed strategy takes into account the design of a family of sliding variables, which establishes a second-order sliding-mode and ensures the convergence of the trajectories of the system to the origin in a finite time and despite the effect of some uncertainties on the system. The straightforward structure of the controller is simple to tune and implement. The global, uniform and finite-time stability of the closed-loop dynamics is demonstrated by means of Lyapunov functions. Furthermore, the performance of the proposed approach is validated through some simulation results.

Published
2023

38. Generalized Homogeneous Unit Control

Author

Polyakov, Andrey, Finite-time control and estimation for distributed systems [VALSE], Finite-time control and estimation for distributed systems (VALSE), Inria Lille - Nord Europe, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 (CRIStAL), and Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)

Subjects
[INFO.INFO-AU]Computer Science [cs]/Automatic Control Engineering
Abstract

International audience; The methodology of the unit sliding mode control design (known since 1970s) for linear MIMO (Multiply Inputs Multiply Outputs) systems is revised based on the concept of the generalized homogeneity. The conventional restriction about a consistency of the number of control inputs with the dimension of the sliding surface is eliminated. A simple procedure for control parameters tuning is developed. The robustness of the homogeneous unit controller with respect to bounded matched perturbations is proven. The theoretical results are supported by numerical simulations.

Published
2023

39. Trajectory Tracking in Unicycle Mobile Robots:A Homogeneity-based Control Approach

Author

Zhou, Y, Ríos, H, Mera, M, Polyakov, A, Zheng, G, Dzul, A, Finite-time control and estimation for distributed systems [VALSE], Instituto Tecnologico de la Laguna [ITL], Instituto Politechnico National [IPN], Deformable Robots Simulation Team [DEFROST ], Finite-time control and estimation for distributed systems (VALSE), Inria Lille - Nord Europe, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 (CRIStAL), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Instituto Tecnologico de la Laguna (ITL), Instituto Politechnico National (IPN), Instituto Politecnico Nacional [Mexico] (IPN), and Deformable Robots Simulation Team (DEFROST )

Subjects
Unicycle Mobile Robots Trajectory Tracking Homogeneity Finite-Time, Unicycle Mobile Robots, [INFO.INFO-AU]Computer Science [cs]/Automatic Control Engineering, Trajectory Tracking, Homogeneity, Finite-Time
Abstract

International audience; This paper contributes to the design of a family of homogeneous controllers to deal with the trajectory tracking problem in unicycle mobile robots (UMRs). The control strategy is based on a cascade control paradigm, which includes the position and orientation tracking error subsystems. The proposed homogeneous controllers provide different types of convergence to zero for the tracking error dynamics, i.e., asymptotic, exponential and finite-time convergence. Simulation results illustrate the performance of the proposed family of homogeneous controllers.

Published
2023

40. On Prescribed-time Cooperative State Estimation of LTI Plants

Author

Li, M. (Min), Polyakov, A. (Andrey), Zheng, G. (Gang), Ping, X. (Xubin), Finite-time control and estimation for distributed systems (VALSE), Inria Lille - Nord Europe, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 (CRIStAL), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Deformable Robots Simulation Team (DEFROST ), Xidian University, International Federation of Automatic Control, Finite-time control and estimation for distributed systems [VALSE], and Deformable Robots Simulation Team [DEFROST ]

Subjects
Cooperative state estimation, [INFO.INFO-AU]Computer Science [cs]/Automatic Control Engineering, finite-time stability, linear homogeneity, nonlinear systems, prescribed-time stability
Abstract

International audience; The problem of prescribed-time cooperative state estimation is addressed in this paper. A network of strongly connected (linear homogenous) distributed observers are designed under the assumption that each observer can receive a time-varying scalar signal broadcasted by a supervisor. By a proper parameter tuning, the observer gains go infinity and estimation errors correspondingly reach zeros at the settling time prescribed by users.

Published
2023

41. Optimal privacy protection of mobility data: a predictive approach

Author

Molina, Emilio, Fiacchini, Mirko, Cerf, Sophie, Robu, Bogdan, GIPSA - Modelling and Optimal Decision for Uncertain Systems (GIPSA-MODUS), GIPSA Pôle Automatique et Diagnostic (GIPSA-PAD), Grenoble Images Parole Signal Automatique (GIPSA-lab), Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA)-Grenoble Images Parole Signal Automatique (GIPSA-lab), Université Grenoble Alpes (UGA), Inria Lille - Nord Europe, Institut National de Recherche en Informatique et en Automatique (Inria), Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 (CRIStAL), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Self-adaptation for distributed services and large software systems (SPIRALS), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 (CRIStAL), and Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)

Subjects
Model predictive and optimization-based control, [MATH.MATH-OC]Mathematics [math]/Optimization and Control [math.OC], Predictive control, [MATH]Mathematics [math], Security and privacy
Abstract

International audience; Location data are extensively used to provide geo-personalized contents to mobile devices users.Sharing such personal data is a major threat to privacy, with risks of re-identification or inference of sensitive information. Location data broadcasted to services can be sanitized, i.e., by adding noise to spatial coordinates.Such protection mechanisms from the literature are widely generic, e.g., not specific to a user and mobility properties. In this work, we advocate that taking into account the specificities of location data (temporal correlation, human mobility patterns, etc.) enables to gain in the privacy-utility trade-off.Specifically, using future mobility prediction greatly improves privacy. We present a novel protection mechanism, based on model predictive control (MPC). The sanitized location is optimally computed so that it maximizes privacy while guaranteeing a utility loss constraint, for present and future locations. Our formulation explicitly takes into account non-constant sampling time, due to moments when no location data is broadcasted.We evaluate experimentally our control on real mobility dataset and compare to the state of the art.Results show that with knowledge of user's future mobility over a few of minutes, we can gain up to 10% of privacy compared to state of the art, while preserving data utility.

Published
2023

42. Low Trapping Effects and High Blocking Voltage in Sub-Micron-Thick AlN/GaN Millimeter-Wave Transistors Grown by MBE on Silicon Substrate

Author

Carneiro, Elodie, Rennesson, Stéphanie, Tamariz, Sebastian, Harrouche, Kathia, Semond, Fabrice, Medjdoub, Farid, WIde baNd gap materials and Devices - IEMN (WIND - IEMN), Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Université catholique de Lille (UCL)-Université catholique de Lille (UCL)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Université catholique de Lille (UCL)-Université catholique de Lille (UCL), EasyGaN, Centre de recherche sur l'hétéroepitaxie et ses applications (CRHEA), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), RENATECH, BPI France, This research was funded by the French National grant GaNeXT ANR-11-LABX-0014, and by a BPI France aid for innovation., Renatech Network, CMNF, and ANR-11-LABX-0014,GANEX,Réseau national sur GaN(2011)

Subjects
[SPI]Engineering Sciences [physics], MBE, mm-wave, Trapping, load pull, GaN-on-Si, HEMT
Abstract

International audience; In this work, sub-micron-thick AlN/GaN transistors (HEMTs) grown on a silicon substrate for high-frequency power applications are reported. Using molecular beam epitaxy, an innovative ultrathin step-graded buffer with a total stack thickness of 450 nm enables one to combine an excellent electron confinement, as reflected by the low drain-induced barrier lowering, a low leakage current below 10 µA/mm and low trapping effects up to a drain bias V DS = 30 V while using sub-150 nm gate lengths. As a result, state-of-the-art GaN-on-silicon power performances at 40 GHz have been achieved, showing no degradation after multiple large signal measurements in deep class AB up to V DS = 30 V. Pulsed-mode large-signal characteristics reveal a combination of power-added efficiency (PAE) higher than 35% with a saturated output power density (P OUT) of 2.5 W/mm at V DS = 20 V with a gate-drain distance of 500 nm. To the best of our knowledge, this is the first demonstration of high RF performance achieved with sub-micron-thick GaN HEMTs grown on a silicon substrate.

Published
2023

43. Comprendre l'impact des stratégies de prix sur le comportement des consommateurs

Author

Vanderlynden, Jarod, Mathieu, Philippe, Warlop, Romain, Systèmes Multi-Agents et Comportements (SMAC), Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 (CRIStAL), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Entreprise fifty-five, and Maxime MORGE

Subjects
Marketing, Dynamique des prix, [INFO.INFO-MA]Computer Science [cs]/Multiagent Systems [cs.MA], Behaviors, Multi-Agents, Comportements, Agent-based, Pricing strategy, [INFO.INFO-MO]Computer Science [cs]/Modeling and Simulation, Simulation, [INFO.INFO-AI]Computer Science [cs]/Artificial Intelligence [cs.AI]
Abstract

National audience; Le marketing est un outil indispensable pour les entreprises qui souhaitent faire connaître un nouveau produit ou fidéliser des consommateurs. Néanmoins, cet outil est influencé par de nombreux facteurs qui rendent sa compréhension complexe et difficilement mesurable dans sa globalité. Nous proposons dans cet article un modèle centré individus qui nous permet de mesurer par exemple les effets des guerres des prix sur la fidélité des consommateurs, l'augmentation des ventes du produit en promotion, la baisse des ventes des concurrents ou les effets sur les consommateurs de la répétition des promotions. Ce modèle multi-agents, à la fois simple et puissant, offre la possibilité de quantifier ces phénomènes et constitue une avancée dans la compréhension et la calibration de nouvelles stratégies marketing.

Published
2023

44. Epitaxie localisée de P-GaN par EJM pour la fabrication de HEMTs AlGaN/GaN normally-off

Author

Rouly, Daniel, Tasselli, Josiane, Austin, Patrick, Cordier, Yvon, Courville, Aimeric, Vaurette, Francois, Lecestre, Aurélie, Reig, Benjamin, Isoird, Karine, Morancho, Frédéric, Équipe Intégration de Systèmes de Gestion de l'Énergie (LAAS-ISGE), Laboratoire d'analyse et d'architecture des systèmes (LAAS), Université Toulouse Capitole (UT Capitole), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université Toulouse Capitole (UT Capitole), Université de Toulouse (UT), Centre de recherche sur l'hétéroepitaxie et ses applications (CRHEA), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Université catholique de Lille (UCL)-Université catholique de Lille (UCL), Centrale de Micro Nano Fabrication - IEMN (CMNF - IEMN), Université catholique de Lille (UCL)-Université catholique de Lille (UCL)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Service Techniques et Équipements Appliqués à la Microélectronique (LAAS-TEAM), IPCEI on Microelectronics - Projet Nano2022, Ce travail a été soutenu par le programme IPCEI on Microelectronics, projet Nano2022, et par la plateforme de micro et nanotechnologies du LAAS-CNRS, membre du réseau français RENATECH. Nous remercions la plateforme RENATECH de l’IEMN pour la lithographie électronique de la HSQ et le CRHEA-CNRS pour les épitaxies localisées., Université de Lille, and Renatech Network

Subjects
simulation numérique TCAD, [SPI]Engineering Sciences [physics], P-GaN, normally-off, AlGaN/GaN HEMT, EJM, épitaxie localisée
Abstract

National audience; The technology of GaN HEMT structures is the subject of major developments for large-gap power components. However, it is necessary to develop innovative technological solutions to obtain high-performance normally-off devices. We present a new normally-off structure based on a nanostructured P-GaN multi-well gate. The design of this structure, based on numerical simulations, and the technological advances for its manufacture by localised epitaxy of P-GaN wells along the grid will be presented.; RESUME-La technologie des structures HEMT GaN fait l'objet d'importants développements pour les composants de puissance grand gap. Cependant, il est nécessaire de développer des solutions technologiques innovantes pour obtenir des composants normally-off performants. Nous présentons une nouvelle structure normally-off basée sur une grille nanostructurée à multi-puits P-GaN. La conception de cette structure issue de simulations numériques ainsi que les avancées technologiques pour sa fabrication par épitaxie localisée des caissons P-GaN le long de la grille seront exposées.

Published
2023

45. L'optimisation du covoiturage dynamique multi-saut

Author

Fèvre, Corwin, Zgaya-Biau, Hayfa, Mathieu, Phlippe, Hammadi, Slim, Systèmes Multi-Agents et Comportements (SMAC), Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 (CRIStAL), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS), and Maxime MORGE

Subjects
Optimization, Ridesharing, Covoiturage, [INFO.INFO-MA]Computer Science [cs]/Multiagent Systems [cs.MA], Optimisation, Agents, [INFO.INFO-MO]Computer Science [cs]/Modeling and Simulation, Simulation, [INFO.INFO-AI]Computer Science [cs]/Artificial Intelligence [cs.AI]
Abstract

National audience; Dans cet article, nous proposons une approche multi-agent pour résoudre le problème du covoiturage dynamique multi-saut. Dans notre système, les passagers et les conducteurs sont représentés comme des agents autonomes et rationnels en perpétuelle interaction pour satisfaire leurs propres objectifs comme leur temps d'attente ou leur temps de trajet par exemple. Dans la solution proposée, les agents conducteurs et passagers ont une perception modélisée dynamiquement en utilisant des R-Arbres. Nous modélisons leurs préférences en matière de détour et de trajet et montrons l'impact de celles-ci sur la résolution d'une instance de covoiturage dynamique. Les résultats présentés montrent que notre système permet de traiter dynamiquement des requêtes complexes de passagers tout en minimisant l'impact du partage de trajet pour les conducteurs, et ce, pour un large spectre de préférences et de comportements.

Published
2023

46. Consommation adaptative par négociation continue

Author

Beauprez, Ellie, Caron, Anne-Cécile, Morge, Maxime, Routier, Jean-Christophe, Systèmes Multi-Agents et Comportements (SMAC), Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 (CRIStAL), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS), and Maxime MORGE

Subjects
Architecture d'agent, Agent-based Negotiation, [INFO.INFO-MA]Computer Science [cs]/Multiagent Systems [cs.MA], Résolution collective de problèmes, Négociation multi-agents, Distributed Problem Solving, [INFO.INFO-MO]Computer Science [cs]/Modeling and Simulation, Agent Architecture, [INFO.INFO-AI]Computer Science [cs]/Artificial Intelligence [cs.AI]
Abstract

International audience; Nous étudions ici le problème de l'allocation de jobs concurrents, composés de tâches situées, sous-jacent au déploiement distribué du patron de conception MapReduce sur une grappe de serveurs. Afin de mettre en oeuvre notre stratégie multi-agents qui vise à minimiser le délai moyen de réalisation des jobs (flowtime), nous proposons une architecture composite d'agent qui permet la concurrence des négociations et des consommations. Nos expérimentations montrent que, lorsqu'elle est exécutée en continue lors du processus de consommation, notre stratégie de réallocation : (1) améliore le flowtime ; (2) ne pénalise pas la consommation ; (3) est robuste aux aléas d'exécution.

Published
2023

47. HEADWORK: Powering the Crowd with Tuple Artifacts

Author

Gross-Amblard, David, Tommasi, Marion, Rakotoniaina, Iandry, Thierry, Constance, Singh, Rituraj, Jacoboni, Léo, Declarative & Reliable management of Uncertain, user-generated Interlinked Data (DRUID), GESTION DES DONNÉES ET DE LA CONNAISSANCE (IRISA-D7), Institut de Recherche en Informatique et Systèmes Aléatoires (IRISA), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université de Bretagne Sud (UBS)-École normale supérieure - Rennes (ENS Rennes)-Institut National de Recherche en Informatique et en Automatique (Inria)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Institut de Recherche en Informatique et Systèmes Aléatoires (IRISA), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Self-adaptation for distributed services and large software systems (SPIRALS), Inria Lille - Nord Europe, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 (CRIStAL), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Centre d'Ecologie et des Sciences de la COnservation (CESCO), Muséum national d'Histoire naturelle (MNHN)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Muséum national d'Histoire naturelle (MNHN), Wirk [Paris], and ANR-16-CE23-0015,HEADWORK,Processus massivement participatifs d'acquisition de données et de connaissances(2016)

Subjects
crowdsourcing tuple artifacts business artifacts macro-tasks, macro-tasks, [INFO.INFO-DB]Computer Science [cs]/Databases [cs.DB], tuple artifacts, business artifacts, crowdsourcing
Abstract

In this demo we introduce Headwork, an open-source academic platform for the crowdsourcing of complex tasks. Besides classical crowdsourcing features, Headwork eases the development of crowdsourcing campaigns through a full relational abstraction of relevant concepts (participants, skills, tasks, current answers, decision procedures, GUI, etc.). It allows in particular the orchestration of complex dynamic tasks using so-called tuple artifacts (i.e. finite-state automata which transition guards and actions are SQL-defined, on an evolving database). The demo will illustrates these key features, both from the participant and developer point of view.

Published
2023

48. Modèle explicatif de la sécession des experts dans les communautés de pratiques

Author

Delarre, Sébastien, Eloire, Fabien, Nongaillard, Antoine, Morge, Maxime, Centre Lillois d’Études et de Recherches Sociologiques et Économiques - UMR 8019 (CLERSÉ), Université de Lille-Centre National de la Recherche Scientifique (CNRS), Systèmes Multi-Agents et Comportements (SMAC), Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 (CRIStAL), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Soutien à l’Émergence de Projets InterdisciplinAires – SEPIA 2023. Institut des Sciences Humaines et Sociales du CNRS, and Maxime MORGE

Subjects
Social network analysis, Complex system, Agent-based modeling, Système complexe, [INFO.INFO-MA]Computer Science [cs]/Multiagent Systems [cs.MA], Analyse des réseaux sociaux, Explainability, [INFO.INFO-MO]Computer Science [cs]/Modeling and Simulation, Simulation multi-agents, Explicabilité, [INFO.INFO-AI]Computer Science [cs]/Artificial Intelligence [cs.AI]
Abstract

National audience; Les sites de questions-réponses permettent aux utilisateurs, qui partagent les mêmes intérêts, d'échanger des connaissances dans le cadre d'un processus d'apprentissage continu. En particulier, la plateforme Stack Overflow soutient des communautés de pratique où : (a) la majorité du contenu est produit par un petit nombre de membres très actifs ; (b) les réponses aux questions les plus récurrentes sont rapidement capitalisées. Nous proposons un modèle centré individus d'une communauté de pratique présentant une dynamique sociale conforme à ces faits stylisés et qui explique le phénomène de sécession des experts.

Published
2023

49. Tuning Photoacoustic Generation in Water with Nanotransducers via Laser Pulse Duration

Author

Gandolfi, M., Diego, M., Giordano, Stefano, Vialla, F., Crut, A., Vallée, F., Maioli, P., Fatti, N. Del, Banfi, F., Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Université catholique de Lille (UCL)-Université catholique de Lille (UCL), Acoustique Impulsionnelle & Magnéto-Acoustique Non linéaire - Fluides, Interfaces Liquides & Micro-Systèmes - IEMN (AIMAN-FILMS - IEMN), Université catholique de Lille (UCL)-Université catholique de Lille (UCL)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), and The Electromagnetics Academy (TEMA)

Subjects
[PHYS]Physics [physics], [MATH]Mathematics [math]
Abstract

— The photoacoustic effect in liquids, generated by nanotransducers excited withshort laser pulses, offers high contrast imaging and promising medical treatment techniques.Understanding the role of the thermal boundary resistance (TBR) and the laser pulse durationin the generation mechanism of acoustic waves is essential to implement efficient photoacousticnanotransducers [1–3]. This work theoretically investigates, for the paradigmatic case ofwater-immersed gold nanoplates, gold-nanocylinders [2] and carbon nanotubes [3], the role of theTBR [4] and laser pulse duration in the competition between the launching mechanisms: thethermophone and the mechanophone. In the thermophone, the nanoparticle acts as a nanoheaterand the wave is launched by water thermal expansion. In the mechanophone, the nanoparticledirectly acts as a nanopiston. Specifically, for a laser pulse duration far exceeding the heat transfertime from the nanostructure to the surronunding water, the thermophone prevails. For theopposite case the mechanophone dominates. Activation of the mechanophone effect is sought totrigger few nanometers wavelength sound waves in water, matching the nanotransducer acousticfrequencies. This is at variance with respect to the commonly addressed case of water-immersednanotransducer excited with ns laser pulses, where only the thermophone effect significantly contributes.The present findings might be of impact in fields ranging from nanoscale non-destructivetesting to water dynamics at the meso to nanoscale. Furthermore, the results point to high-TBR,liquid-immersed nanoparticles as potentially efficient photoacoustic nanogenerators [5], with theadvantage of keeping the liquid environment temperature unaltered.REFERENCES1. Prost, A., F. Poisson, and E. Bossy, “Photoacoustic generation by a gold nano-sphere: Fromlinear to nonlinear thermoelastics in the long-pulse illumination regime,” Phys. Rev. B, Vol. 92,115450, 2015.2. Diego, M., M. Gandolfi, S. Giordano, F. Vialla, A. Crut, F. Vall´ee, P. Maioli, N. Del Fatti,and F. Banfi, “Tuning photoacoustics with nanotransducers via thermal boundary resistanceand laser pulse duration,” Appl. Phys. Lett., Vol. 121, 252201, 2022.3. Diego, M., M. Gandolfi, A. Casto, F. M. Bellussi, F. Vialla, A. Crut, S. Roddaro, M. Fasano,F. Vall´ee, N. Del Fatti, P. Maioli, and F. Banfi, “Ultrafast nano generation of acoustic wavesin water via a single carbon nanotube,” Photoacoustics, Vol. 28, 100407, 2022.4. Casto, A., F. M. Bellussi, M. Diego, N. Del Fatti, F. Banfi, P. Maioli, and M. Fasano, “Waterfilling in carbon nanotubes with different wettability and implications on nanotube/water heattransfer via atomistic simulations,” Int. J. Heat Mass Transf., Vol. 205, 123868, 2023.5. Yu, K., Y. Yang, J. Wang, G. V. Hartland, and G. P. Wang, “Nanoparticle-fluid interactionsat ultrahigh acoustic vibration frequencies studied by femtosecond time-resolved microscopy,”ACS Nano, Vol. 15, 1833–1840, 2021.

Published
2023

50. In Vitro and Ex Vivo Models for Assessing Drug Permeation across the Cornea

Author

de Hoon, Inès, Boukherroub, Rabah, de Smedt, Stefaan, Szunerits, Sabine, Sauvage, Félix, Universiteit Gent = Ghent University (UGENT), Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Université catholique de Lille (UCL)-Université catholique de Lille (UCL), NanoBioInterfaces - IEMN (NBI - IEMN), Université catholique de Lille (UCL)-Université catholique de Lille (UCL)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Financial support from the 'Programme Investissement d’Avenir' (I-SITE ULNE/ANR-16-IDEX-0004 ULNE) managed by the 'Agence Nationale de la Recherche' is acknowledged. In addition, this project has received support from the European Union’s Horizon 2020 research and innovation program under the 'Marie Sklodowska-Curie grant' (agreement no. 847568). Financial support from the Centre National de la Recherche Scientifique (CNRS) and the University of Lille are also acknowledged. This work was partly supported by the French Renatech network., Renatech Network, ANR-16-IDEX-0004,ULNE,ULNE(2016), and European Project: 847568,H2020,H2020-MSCA-COFUND-2018,PEARL(2019)

Subjects
[PHYS]Physics [physics], corneal penetration, [SPI]Engineering Sciences [physics], cornea, in vitro model, drug delivery, drug diffusion, ex vivo model
Abstract

International audience; Drug permeation across the cornea remains a major challenge due to its unique and complex anatomy and physiology. Static barriers such as the different layers of the cornea, as well as dynamic aspects such as the constant renewal of the tear film and the presence of the mucin layer together with efflux pumps, all present unique challenges for effective ophthalmic drug delivery. To overcome some of the current ophthalmic drug limitations, the identification and testing of novel drug formulations such as liposomes, nanoemulsions, and nanoparticles began to be considered and widely explored. In the early stages of corneal drug development reliable in vitro and ex vivo alternatives, are required, to be in line with the principles of the 3Rs (Replacement, Reduction, and Refinement), with such methods being in addition faster and more ethical alternatives to in vivo studies. The ocular field remains limited to a handful of predictive models for ophthalmic drug permeation. In vitro cell culture models are increasingly used when it comes to transcorneal permeation studies. Ex vivo models using excised animal tissue such as porcine eyes are the model of choice to study corneal permeation and promising advancements have been reported over the years. Interspecies characteristics must be considered in detail when using such models. This review updates the current knowledge about in vitro and ex vivo corneal permeability models and evaluates their advantages and limitations.

Published
2023

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