101. Pseudoirroratin A, a new cytotoxic ent-kaurene diterpene from Isodon pseudo-irrorata.
- Author
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Zhang H, Fan Z, Tan GT, Chai HB, Pezzuto JM, Sun H, and Fong HH
- Subjects
- Antineoplastic Agents, Phytogenic chemistry, Antineoplastic Agents, Phytogenic pharmacology, Carcinoma, Squamous Cell, Chromatography, High Pressure Liquid, Diterpenes chemistry, Diterpenes pharmacology, Drug Screening Assays, Antitumor, Female, Humans, Inhibitory Concentration 50, KB Cells, Lung Neoplasms, Male, Molecular Conformation, Molecular Structure, Nuclear Magnetic Resonance, Biomolecular, Osteosarcoma, Ovarian Neoplasms, Prostatic Neoplasms, Spectrophotometry, Ultraviolet, Stereoisomerism, Tumor Cells, Cultured drug effects, Antineoplastic Agents, Phytogenic isolation & purification, Diterpenes isolation & purification, Drugs, Chinese Herbal chemistry, Lamiaceae chemistry, Plants, Medicinal chemistry
- Abstract
A new ent-kaurene diterpene, pseudoirroratin A (1), and a known diterpene, pseurata A, were isolated from Isodon pseudo-irrorata. Compound 1 showed significant cytotoxicity against the Lu1, SW626, LNCaP, KB, and HOS cancer cell lines with IC(50) values of 0.26 (0.75), 0.20 (0.57), 0.90 (2.59), 0.90 (2.59), and 0.50 (1.44) microg/mL (microM), respectively. The structure of 1 was elucidated by spectroscopic means including 1D and 2D NMR techniques.
- Published
- 2002
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