Back to Search
Start Over
Cancer chemopreventive activity of resveratrol, a natural product derived from grapes.
- Source :
-
Science (New York, N.Y.) [Science] 1997 Jan 10; Vol. 275 (5297), pp. 218-20. - Publication Year :
- 1997
-
Abstract
- Resveratrol, a phytoalexin found in grapes and other food products, was purified and shown to have cancer chemopreventive activity in assays representing three major stages of carcinogenesis. Resveratrol was found to act as an antioxidant and antimutagen and to induce phase II drug-metabolizing enzymes (anti-initiation activity); it mediated anti-inflammatory effects and inhibited cyclooxygenase and hydroperoxidase functions (antipromotion activity); and it induced human promyelocytic leukemia cell differentiation (antiprogression activity). In addition, it inhibited the development of preneoplastic lesions in carcinogen-treated mouse mammary glands in culture and inhibited tumorigenesis in a mouse skin cancer model. These data suggest that resveratrol, a common constituent of the human diet, merits investigation as a potential cancer chemopreventive agent in humans.
- Subjects :
- Animals
Anti-Inflammatory Agents, Non-Steroidal pharmacology
Anti-Inflammatory Agents, Non-Steroidal therapeutic use
Anticarcinogenic Agents therapeutic use
Antimutagenic Agents pharmacology
Carcinogens
Cell Differentiation drug effects
Cyclooxygenase 1
Cyclooxygenase Inhibitors pharmacology
Cyclooxygenase Inhibitors therapeutic use
Female
Humans
Inflammation drug therapy
Isoenzymes metabolism
Mammary Neoplasms, Experimental chemically induced
Mammary Neoplasms, Experimental prevention & control
Membrane Proteins
Mice
Peroxidases antagonists & inhibitors
Precancerous Conditions prevention & control
Prostaglandin-Endoperoxide Synthases metabolism
Rats
Rats, Wistar
Resveratrol
Skin Neoplasms chemically induced
Skin Neoplasms prevention & control
Stilbenes therapeutic use
Tumor Cells, Cultured
Anticarcinogenic Agents pharmacology
Fruit chemistry
Neoplasms, Experimental prevention & control
Stilbenes pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0036-8075
- Volume :
- 275
- Issue :
- 5297
- Database :
- MEDLINE
- Journal :
- Science (New York, N.Y.)
- Publication Type :
- Academic Journal
- Accession number :
- 8985016
- Full Text :
- https://doi.org/10.1126/science.275.5297.218