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Isolation and characterization of cytotoxic saponin chloromaloside A from Chlorophytum malayense.
- Source :
-
Planta medica [Planta Med] 2000 Aug; Vol. 66 (6), pp. 587-90. - Publication Year :
- 2000
-
Abstract
- A cytotoxic steroidal glycoside was isolated from Chlorophytum malayense Ridley and its structure was characterized as a known compound, neohecogenin 3-O-beta-D-glucopyranosyl(1-->2)-[beta-D-xylopyranosyl(1-->3)]-beta-D- glucopyranosyl(1-->4)-beta-D-galactopyranoside (chloromaloside A). The structural identification was performed using 2D-NMR and LC/MS/MS analysis. The previous, erroneously assigned 1H-NMR spectral data were revised whereas the published 13C-NMR spectral assignments were confirmed. This compound showed in vitro cytotoxicity against several human cancer cell lines.
- Subjects :
- Antineoplastic Agents, Phytogenic chemistry
Antineoplastic Agents, Phytogenic pharmacology
Carbohydrate Conformation
Carbohydrate Sequence
Drug Screening Assays, Antitumor
Humans
Magnetic Resonance Spectroscopy
Molecular Sequence Data
Saponins chemistry
Saponins pharmacology
Tumor Cells, Cultured
Antineoplastic Agents, Phytogenic isolation & purification
Plants chemistry
Saponins isolation & purification
Spirostans
Subjects
Details
- Language :
- English
- ISSN :
- 0032-0943
- Volume :
- 66
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Planta medica
- Publication Type :
- Report
- Accession number :
- 10985095
- Full Text :
- https://doi.org/10.1055/s-2000-8600