Back to Search
Start Over
Cyclooxygenase-inhibitory and antioxidant constituents of the aerial parts of Antirhea acutata.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2001 Jun 18; Vol. 11 (12), pp. 1565-8. - Publication Year :
- 2001
-
Abstract
- Two new compounds, (6S)-hydroxy-29-nor-3,4-seco-cycloart-4(30),24-dien-3-oic acid (1) and 8-[1-(3,4-dihydroxyphenyl)-3-methoxy-3-oxopropyl]epicatechin (3), were isolated by bioassay-guided fractionation from the aerial parts of Antirhea acutata (DC.) Urb. (Rubiaceae). Compound 1 showed moderate inhibitory activities in cyclooxygenase-1 and -2 assays (IC(50) 43.7 and 4.7 microM, respectively), while compound 3 was active in 1,1-diphenyl-2-picrylhydrazyl free-radical and cytochrome c reduction antioxidant assays (IC(50) 29.1 and 16.3 microM, respectively). Additionally, one further new compound was isolated, (3S,24S)-25-trihydroxy-9,19-cycloartane-29-oic acid (2), but this was inactive in the bioassay systems used. Compound 1 is based on the unprecedented 29-nor-3,4-seco-cycloartane skeleton.
- Subjects :
- Animals
Anticarcinogenic Agents isolation & purification
Anticarcinogenic Agents pharmacology
Antioxidants pharmacology
Bepridil metabolism
Biphenyl Compounds
Cyclooxygenase 1
Cyclooxygenase 2
Cyclooxygenase 2 Inhibitors
Cyclooxygenase Inhibitors pharmacology
Cytochrome c Group metabolism
Humans
Inhibitory Concentration 50
Isoenzymes antagonists & inhibitors
Membrane Proteins
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Oxidation-Reduction
Plant Structures chemistry
Prostaglandin-Endoperoxide Synthases
Antioxidants isolation & purification
Bepridil analogs & derivatives
Cyclooxygenase Inhibitors isolation & purification
Picrates
Plants, Medicinal chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 0960-894X
- Volume :
- 11
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 11412982
- Full Text :
- https://doi.org/10.1016/s0960-894x(01)00129-9