Back to Search
Start Over
Antimalarial compounds from Rhaphidophora decursiva.
- Source :
-
Journal of natural products [J Nat Prod] 2001 Jun; Vol. 64 (6), pp. 772-7. - Publication Year :
- 2001
-
Abstract
- Bioassay-directed fractionation led to the isolation of 14 compounds, six of which possess antimalarial activity, from the dried leaves and stems of Rhaphidophora decursiva. Polysyphorin (1) and rhaphidecurperoxin (6) showed strong activities against Plasmodium falciparum. Rhaphidecursinol A (2), rhaphidecursinol B (3), grandisin (4), and epigrandisin (5) were less active against the same organism. Among the isolates, rhaphidecursinol A (2) and rhaphidecursinol B (3) were determined to be new neolignans, and rhaphidecurperoxin (6) is a new benzoperoxide. Known compounds isolated include polysyphorin (1), grandisin (4), epigrandisin (5), (+)-medioresinol, (-)-pinoresinol, (-)-syringaresinol, (+)-glaberide I, (+)-dehydrovomifoliol, (-)-liliolide, (-)-hydroxydihydrobovolide, and N-butylbenzamide, of which compound 1 appears worthy of further evaluation as an antimalarial agent. Structure elucidation and identification were accomplished by spectroscopic means including 1D and 2D NMR analyses.
- Subjects :
- Animals
Antimalarials pharmacology
Antineoplastic Agents, Phytogenic chemistry
Antineoplastic Agents, Phytogenic isolation & purification
Antineoplastic Agents, Phytogenic pharmacology
Magnetic Resonance Spectroscopy
Molecular Conformation
Plant Leaves chemistry
Plant Stems chemistry
Plasmodium falciparum drug effects
Spectrometry, Mass, Fast Atom Bombardment
Spectrophotometry, Infrared
Spectrophotometry, Ultraviolet
Tumor Cells, Cultured
Vietnam
Antimalarials chemistry
Antimalarials isolation & purification
Plants, Medicinal chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 0163-3864
- Volume :
- 64
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of natural products
- Publication Type :
- Academic Journal
- Accession number :
- 11421741
- Full Text :
- https://doi.org/10.1021/np010037c