1. The Oxygen Cascade During Exercise in Health and Disease
- Author
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Timothy W. Secomb, Chad C. Wiggins, Michael J. Joyner, Tuhin K. Roy, Paolo B. Dominelli, and Timothy B. Curry
- Subjects
Adult ,Male ,chemistry.chemical_element ,Disease ,030204 cardiovascular system & hematology ,Oxygen ,Article ,03 medical and health sciences ,Oxygen Consumption ,0302 clinical medicine ,Humans ,Medicine ,Elite athletes ,Exercise physiology ,Exercise ,Aged ,Aged, 80 and over ,Atmospheric oxygen ,business.industry ,Oxygen transport ,Oxygen–haemoglobin dissociation curve ,General Medicine ,Middle Aged ,Healthy Volunteers ,3. Good health ,chemistry ,Athletes ,Cascade ,Physical Endurance ,Female ,business ,Neuroscience ,030217 neurology & neurosurgery - Abstract
The oxygen transport cascade describes the physiological ‘steps’ that bring atmospheric oxygen into the body where it is delivered and consumed by metabolically active tissue. As such, the oxygen cascade is fundamental to our understanding of exercise in health and disease. Our narrative review will highlight each step of the oxygen transport cascade from inspiration of atmospheric oxygen down to mitochondrial consumption in both healthy active males and females along with clinical conditions. We will focus on how different ‘steps’ interact along with principles of homeostasis, physiological redundancies and adaptation. In particular we highlight some of the parallels between elite athletes and clinical conditions in terms of the oxygen cascade.
- Published
- 2021