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Respiratory muscle work influences locomotor convective and diffusive oxygen transport in human heart failure during exercise
- Source :
- Physiological Reports, Vol 8, Iss 12, Pp n/a-n/a (2020), Physiological Reports
- Publication Year :
- 2020
- Publisher :
- Wiley, 2020.
-
Abstract
- Introduction It remains unclear if naturally occurring respiratory muscle (RM) work influences leg diffusive O2 transport during exercise in heart failure patients with reduced ejection fraction (HFrEF). In this retrospective study, we hypothesized that RM unloading during submaximal exercise will lead to increases in locomotor muscle O2 diffusion capacity (DMO2) contributing to the greater leg VO2. Methods Ten HFrEF patients and 10 healthy control matched participants performed two submaximal exercise bouts (i.e., with and without RM unloading). During exercise, leg blood flow was measured via constant infusion thermodilution. Intrathoracic pressure was measured via esophageal balloon. Radial arterial and femoral venous blood gases were measured and used to calculate leg arterial and venous content (CaO2 and CvO2, respectively), VO2, O2 delivery, and DMO2. Results From CTL to RM unloading, leg VO2, O2 delivery, and DMO2 were not different in healthy participants during submaximal exercise (all, p > .15). In HFrEF, leg VO2 (CTL: 0.7 ± 0.3 vs. RM unloading: 1.0 ± 0.4 L/min, p<br />Respiratory muscle work negatively influences convective O2 transport in heart failure patients. The present study investigated the impact of respiratory muscle work on leg O2 diffusive capacity during submaximal exercise. We found the degree of respiratory muscle unloading in heart failure patients is related to the improvement in leg O2 diffusive capacity during submaximal exercise.
- Subjects :
- medicine.medical_specialty
leg blood flow
Physiology
030204 cardiovascular system & hematology
lcsh:Physiology
03 medical and health sciences
Work of breathing
0302 clinical medicine
Oxygen Consumption
Physiology (medical)
Internal medicine
work of breathing
medicine
Respiratory muscle
Humans
Cardiac Output
Lead (electronics)
Exercise
Original Research
Retrospective Studies
Heart Failure
Leg
Ejection fraction
lcsh:QP1-981
business.industry
musculoskeletal, neural, and ocular physiology
Oxygen transport
Hemodynamics
Venous blood
Blood flow
Middle Aged
medicine.disease
Respiratory Muscles
Oxygen
Regional Blood Flow
Heart failure
Case-Control Studies
oxygen transport
Cardiology
Blood Gas Analysis
business
respiratory muscle metaboreflex
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- Volume :
- 8
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- Physiological Reports
- Accession number :
- edsair.doi.dedup.....f8fe9808c39a6ba3e35304ccfab82ebd