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Forearm Vasodilatation to a β(2)-Adrenergic Receptor Agonist in Premenopausal and Postmenopausal Women
- Source :
- Exp Physiol
- Publication Year :
- 2020
-
Abstract
- NEW FINDINGS What is the central question of this study? What is the role of β2 -adrenergic receptor (β2 AR) vasodilatation in older postmenopausal women as compared to premenopausal women and the role of nitric oxide (NO) in β2 AR-mediated vasodilatation in both groups of women? What is the main finding and its importance? β2 AR responsiveness is blunted in postmenopausal women compared to young premenopausal women. Additionally, NO may contribute to β2 AR-mediated vasodilatation in young premenopausal women. ABSTRACT β2 -Adrenergic receptor (β2 AR)-mediated vasodilatation, which is partially dependent on nitric oxide (NO) formation, is blunted in men at risk for developing hypertension. However, the role of β2 AR vasodilatation in hypertension pathophysiology in ageing postmenopausal women is unclear. Therefore, the goals of this study were to determine if forearm vasodilatation to the selective β2 AR agonist terbutaline is blunted in older postmenopausal women (59 ± 4 years) compared to young premenopausal women (27 ± 3 years) and to assess NO contribution to β2 AR-mediated vasodilatation in both groups of women. Forearm blood flow (FBF) and forearm vascular conductance (FVC) were measured using venous occlusion plethysmography at baseline and during intra-arterial infusions of terbutaline at 0.1-2.0 µg (100 ml tissue)-1 min-1 with and without the NO synthase inhibitor l-NG -monomethylarginine (l-NMMA). Mean arterial pressure was significantly greater in postmenopausal women than in young women at baseline (P = 0.01). Baseline FBF and FVC did not differ between young and postmenopausal women (P > 0.05) and rose significantly within each group during terbutaline infusion (P 0.05 for all). These data suggest that β2 AR responsiveness is blunted in postmenopausal women compared to young premenopausal women, and that NO may contribute to β2 AR-mediated vasodilatation in young premenopausal women.
- Subjects :
- Agonist
Adult
medicine.medical_specialty
Mean arterial pressure
Physiology
medicine.drug_class
Terbutaline
Vasodilation
030204 cardiovascular system & hematology
Nitric Oxide
Article
Nitric oxide
03 medical and health sciences
FEV1/FVC ratio
chemistry.chemical_compound
0302 clinical medicine
Forearm
Physiology (medical)
Internal medicine
medicine
Humans
Arterial Pressure
Nutrition and Dietetics
business.industry
General Medicine
Middle Aged
medicine.disease
Adrenergic Agonists
Plethysmography
Postmenopause
medicine.anatomical_structure
Endocrinology
chemistry
Premenopause
Pathophysiology of hypertension
Female
business
030217 neurology & neurosurgery
medicine.drug
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Exp Physiol
- Accession number :
- edsair.doi.dedup.....a6084d52511f02343b7c9af873b5f1e8