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Effects of intravenous low-dose dopamine infusion on glucose regulation during prolonged aerobic exercise
- Source :
- American journal of physiology. Regulatory, integrative and comparative physiology. 314(1)
- Publication Year :
- 2017
-
Abstract
- The carotid body chemoreceptors are activated during hypoglycemia and contribute to glucoregulation during prolonged exercise in dogs. Low-dose intravenous infusions of dopamine have been shown to blunt the activation of the carotid body chemoreceptors during hypoxia. Therefore, we tested the hypotheses that dopamine would blunt glucoregulatory responses and attenuate plasma glucose during prolonged aerobic exercise in healthy participants. Twelve healthy participants completed two randomized exercise sessions at 65% peak oxygen consumption for up to 120 min. Saline was infused during one exercise session, and dopamine (2 μg·kg−1·min−1) was infused during the other session. Arterial plasma glucose, growth hormone, glucagon, cortisol, norepinephrine, and epinephrine were measured every 10 min. Exercise duration during dopamine infusion was 107 ± 6 and 119 ± 0.8 min during saline infusion. Glucose area under the curve during exercise was lower during dopamine (9,821 ± 686 vs. 11,194 ± 395 arbitrary units; P = 0.016). The ratio of circulating growth hormone to glucose and the ratio of glucagon to glucose were greater during dopamine ( P = 0.045 and 0.037, respectively). These results indicate that the infusion of dopamine during aerobic exercise impairs glucoregulation. This suggests that the carotid body chemoreceptors contribute to glucoregulation during prolonged exercise in healthy exercise-trained humans.
- Subjects :
- Adult
Blood Glucose
Male
medicine.medical_specialty
Time Factors
Epinephrine
Hydrocortisone
Physiology
Dopamine
030204 cardiovascular system & hematology
Hypoglycemia
Glucagon
Norepinephrine (medication)
03 medical and health sciences
Carotid chemoreceptor
Norepinephrine
Random Allocation
0302 clinical medicine
Physiology (medical)
Internal medicine
medicine
Aerobic exercise
Humans
Infusions, Intravenous
Exercise
Carotid Body
business.industry
medicine.disease
Endocrinology
Blood sugar regulation
Female
business
030217 neurology & neurosurgery
Biomarkers
medicine.drug
Research Article
Subjects
Details
- ISSN :
- 15221490
- Volume :
- 314
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- American journal of physiology. Regulatory, integrative and comparative physiology
- Accession number :
- edsair.doi.dedup.....b30919e1ccd1d65773754db0d89bed73