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Sustained exercise hyperemia during prolonged adenosine infusion in humans
- Source :
- Physiological Reports
- Publication Year :
- 2019
-
Abstract
- The contribution of Adenosine (ADO) to exercise hyperemia remains controversial and it is unknown whether ADO can evoke the prolonged vasodilation seen during exercise bouts. Therefore, we tested hypotheses in the human forearm during 3 h of intra‐arterial high dose ADO infusion: (1) skeletal muscle blood flow would wane over time; (2) exercise hyperemic responses during ADO administration would be unaffected compared to baseline. Using sodium nitroprusside (SNP), we tested parallel hypotheses regarding nitric oxide (NO) in a separate group of participants. Seventeen young healthy participants (ADO: n = 9; SNP: n = 8) performed multiple rhythmic handgrip exercise bouts (20% of maximum), two during saline and five during 3 h of continuous drug infusion. Five minutes of ADO infusion resulted in a ~5‐fold increase in forearm vascular conductance (FVC; 4.8 ± 0.6 vs. 24.2 ± 3.2 mL/min/100 mmHg, P 0.05]) or SNP (16.6 ± 2 and 14.1 ± 2.4 mL/min/100 mmHg [P > 0.05]) at 5 versus 150 min. Superimposed exercise during ADO or SNP infusions evoked marked and consistent additional dilation over the course of the infusions. Our findings demonstrate that in humans there is no reduction in endothelial or vascular smooth muscle responsiveness to the exogenous vasodilatory metabolites ADO and NO. Additionally, even in the presence of an exogenous vasodilator, superimposed exercise can cause significant hyperemia.
- Subjects :
- Adult
Male
Nitroprusside
Cardiovascular Conditions, Disorders and Treatments
medicine.medical_specialty
Vascular smooth muscle
Adenosine
Skeletal Muscle
Physiology
medicine.medical_treatment
exercise hyperemia
Vasodilation
Hyperemia
030204 cardiovascular system & hematology
Nitric Oxide
Muscle, Smooth, Vascular
Nitric oxide
03 medical and health sciences
FEV1/FVC ratio
chemistry.chemical_compound
0302 clinical medicine
Forearm
Physiology (medical)
Internal medicine
medicine
Humans
Infusions, Intra-Arterial
blood flow
Saline
Original Research
Hand Strength
exercise
business.industry
Endurance and Performance
3. Good health
Circulation
medicine.anatomical_structure
chemistry
Regional Blood Flow
Cardiology
Arm
Female
Sodium nitroprusside
business
030217 neurology & neurosurgery
medicine.drug
Subjects
Details
- ISSN :
- 2051817X
- Volume :
- 7
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Physiological reports
- Accession number :
- edsair.doi.dedup.....95196f2c6d0f09a76614279f33fe463b