33 results on '"Young NA"'
Search Results
2. [Secondary Publication] Standard Operating Procedure for Post-mortem Inspection in a Focus on Coronavirus Disease-19: the Korean Society for Legal Medicine
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Joo Young Na, Minsung Choi, Sang Jae Noh, and Jong Pil Park
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medicine.medical_specialty ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Pneumonia, Viral ,Disease ,medicine.disease_cause ,Postmortem Inspection ,Standard Operating Procedure ,03 medical and health sciences ,Betacoronavirus ,Special Article ,0302 clinical medicine ,Pandemic ,Republic of Korea ,medicine ,Humans ,030212 general & internal medicine ,Medical Waste Disposal ,Pandemics ,Coronavirus ,Communicable disease ,business.industry ,SARS-CoV-2 ,Medical jurisprudence ,Publications ,COVID-19 ,General Medicine ,Forensic Medicine ,Infectious disease (medical specialty) ,Family medicine ,Practice Guidelines as Topic ,Humanities & Forensic Medicine ,Autopsy ,business ,Coronavirus Infections ,Standard operating procedure - Abstract
Coronavirus disease 2019 (COVID-19) is a respiratory syndrome caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and emerged in Wuhan, China, in late 2019. It resulted in a worldwide pandemic, and spread through community transmission in the Republic of Korea (ROK). In the ROK, SARS-CoV-2 is categorized as a first-degree infectious disease of the legal communicable disease present. The Korean Society for Legal Medicine (KSLM) is the sole official academic association of forensic professionals in the ROK. As such, this society has played an important role in forensic medicine and science in the ROK. Therefore, KSLM suggests a standard operating procedure for the postmortem inspection in a focus on COVID-19. This article includes the background of this suggested standard operation procedure, basic principles for postmortem inspections of individuals suggested of having an infectious disease, and specific procedures according to the probability level of SARS-CoV-2 infection., Graphical Abstract
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- 2020
3. Influence of Local Myocardial Infarction on Endothelial Function, Neointimal Progression, and Inflammation in Target and Non-Target Vascular Territories in a Porcine Model of Acute Myocardial Infarction
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Bon Kwon Koo, Hyun Kuk Kim, Joo Myung Lee, Sung Soo Kim, Myung Ho Jeong, Joo Young Na, Joon Hyung Doh, Sun Uk Kim, Jonghanne Park, Doo Sun Sim, In-Ho Bae, Chang-Wook Nam, Young Joon Hong, Han Byul Kim, Joong Sun Kim, Jae Won Shim, Jun-Kyu Park, Dae Sung Park, Kyung Seob Lim, and Min Young Lee
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medicine.medical_specialty ,Endothelium ,Swine ,medicine.medical_treatment ,Cardiovascular Disorders ,Myocardial Infarction ,Revascularization ,Coronary artery disease ,03 medical and health sciences ,Neointimal Formation ,0302 clinical medicine ,Internal medicine ,Neointima ,medicine ,Animals ,030212 general & internal medicine ,Myocardial infarction ,Circumflex ,cardiovascular diseases ,Everolimus ,Endothelial dysfunction ,health care economics and organizations ,Inflammation ,business.industry ,Myocardium ,Drug-Eluting Stents ,General Medicine ,Arteries ,medicine.disease ,Blood Cell Count ,Stenosis ,Disease Models, Animal ,medicine.anatomical_structure ,Treatment Outcome ,Acute Disease ,Cardiology ,cardiovascular system ,Original Article ,business ,Immunosuppressive Agents ,Artery - Abstract
Background Patients with acute myocardial infarction (AMI) have worse clinical outcomes than those with stable coronary artery disease despite revascularization. Non-culprit lesions of AMI also involve more adverse cardiovascular events. This study aimed to investigate the influence of AMI on endothelial function, neointimal progression, and inflammation in target and non-target vessels. Methods In castrated male pigs, AMI was induced by balloon occlusion and reperfusion into the left anterior descending artery (LAD). Everolimus-eluting stents (EES) were implanted in the LAD and left circumflex (LCX) artery 2 days after AMI induction. In the control group, EES were implanted in the LAD and LCX in a similar fashion without AMI induction. Endothelial function was assessed using acetylcholine infusion before enrollment, after the AMI or sham operation, and at 1 month follow-up. A histological examination was conducted 1 month after stenting. Results A total of 10 pigs implanted with 20 EES in the LAD and LCX were included. Significant paradoxical vasoconstriction was assessed after acetylcholine challenge in the AMI group compared with the control group. In the histologic analysis, the AMI group showed a larger neointimal area and larger area of stenosis than the control group after EES implantation. Peri-strut inflammation and fibrin formation were significant in the AMI group without differences in injury score. The non-target vessel of the AMI also showed similar findings to the target vessel compared with the control group. Conclusion In the pig model, AMI events induced endothelial dysfunction, inflammation, and neointimal progression in the target and non-target vessels., Graphical Abstract
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- 2019
4. Evaluation of Point-of-Care Testing for C-Reactive Protein in Forensic Medicine
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Jong Tae Park and Joo Young Na
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Adult ,Male ,medicine.medical_specialty ,Forensic Science ,Adolescent ,Point-of-care testing ,Vena Cava, Inferior ,Autopsy ,Inferior vena cava ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Humans ,030212 general & internal medicine ,Aged ,Aged, 80 and over ,Immunoassay ,biology ,business.industry ,C-reactive protein ,General Medicine ,Postmortem blood ,Forensic Medicine ,Middle Aged ,medicine.disease ,Hemolysis ,Forensic science ,Laboratory test ,C-Reactive Protein ,medicine.vein ,Point-of-Care Testing ,Child, Preschool ,biology.protein ,Original Article ,Humanities & Forensic Medicine ,Female ,Reagent Kits, Diagnostic ,business - Abstract
Background C-reactive protein (CRP) is an acute-phase protein whose level increases in response to tissue injury, infection, or other inflammation. It is used in clinical and forensic settings. Point-of-care (POC) testing has recently become available, and it is considered to be useful during postmortem examinations. However, laboratory testing of postmortem blood samples is difficult due to hemolysis and postmortem clotting. Methods The utility of POC testing for CRP during postmortem examination was evaluated using cardiac blood from the inferior vena cava. The whole blood sample was immediately tested using the POC instrument. Subsequently, the same sample was processed to obtain the serum, which was tested using common laboratory instruments. Results The postmortem POC test had a high positive predictive value and specificity, and the results strongly correlated with the laboratory test results. Conclusion POC CRP testing is valid in postmortem examination and can be used in forensic medicine (postmortem inspection and autopsy)., Graphical Abstract
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- 2019
5. Clinical Usefulness of Unenhanced Computed Tomography in Patients with Acute Pyelonephritis
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Dong-Wan Chae, Ho Jun Chin, Hyo Cheol Kim, Ki Young Na, Sejoong Kim, Sung Il Hwang, and Anna Lee
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Adult ,Male ,medicine.medical_specialty ,Seoul ,030232 urology & nephrology ,Contrast-induced nephropathy ,Computed tomography ,behavioral disciplines and activities ,030218 nuclear medicine & medical imaging ,Adipose capsule of kidney ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Patient age ,mental disorders ,medicine ,Humans ,In patient ,Hydronephrosis ,Aged ,Retrospective Studies ,Aged, 80 and over ,medicine.diagnostic_test ,Pyelonephritis ,business.industry ,Clinical course ,Acute kidney injury ,General Medicine ,Middle Aged ,medicine.disease ,Acute Disease ,Female ,Radiology ,business ,Tomography, X-Ray Computed - Abstract
Background Unenhanced computed tomography (UCT) may be useful for evaluating acute pyelonephritis; however, no study has compared UCT with enhanced computed tomography (ECT) as a diagnostic tool. We evaluated a clinical usefulness of UCT versus ECT in acute pyelonephritis (APN). Methods We reviewed the clinical and radiological data from 183 APN-suspected patients who underwent UCT and ECT simultaneously at emergency room (ER) over a two-year period. Demographic, clinical parameters and computed tomography (CT) parameters of 149 patients were compared. Results The average patient age was 61.2 (± 10) years: 31 patients were men. Ninety-nine (66.4%) patients showed stones (18.7%), perinephric infiltration (56%), swelling (21%), and hydronephrosis (6.7%) on UCT. Seventeen patients (11.4%) had an atypical clinical course, requiring additional tests for accurate diagnosis. In 7 patients UCT and ECT results did not differ; in 10 patients, the diagnosis changed on ECT. On ECT, 112/149 (75.2%) patients had stones (16.7%), perinephric infiltrations (57%), swelling (21%), and hydronephrosis (6.7%); 62.5% showed parenchymal involvement: 34 (22.8%) patients had no abnormal ECT findings. APN CT findings are similar on stone, perinephric infiltration, swelling and hydronephrosis on both CTs. Twelve patients (8.0%) had an abnormal ECT finding, i.e., low-grade (1 and 2) parenchymal involvement. Six (4%) patients developed contrast-induced acute kidney injury within 2 days after ECT. Conclusion We demonstrate that UCT is not inferior to ECT as an initial tool for evaluating APN for screening nephrolithiasis and hydronephrosis without the risk of contrast-induced acute kidney injury (CIAKI). However, patients with an atypical clinical course may still need ECT.
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- 2018
6. Differential Signature of Obesity in the Relationship with Acute Kidney Injury and Mortality after Coronary Artery Bypass Grafting
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Ki Young Na, Kwon Wook Joo, Yon Su Kim, Sejoong Kim, Hongran Moon, Seung Seok Han, Dong Ki Kim, Yeonhee Lee, and Ho Jun Chin
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Male ,medicine.medical_specialty ,Kaplan-Meier Estimate ,030204 cardiovascular system & hematology ,Body Mass Index ,03 medical and health sciences ,Postoperative Complications ,0302 clinical medicine ,Thinness ,Risk Factors ,Internal medicine ,Odds Ratio ,medicine ,Risk of mortality ,Humans ,Obesity ,Underweight ,030212 general & internal medicine ,Coronary Artery Bypass ,Mortality ,Aged ,Proportional Hazards Models ,Retrospective Studies ,Coronary Artery Bypass Grafting ,business.industry ,Hazard ratio ,Acute kidney injury ,General Medicine ,Acute Kidney Injury ,Middle Aged ,medicine.disease ,medicine.anatomical_structure ,Nephrology ,Multivariate Analysis ,Cohort ,Female ,Original Article ,medicine.symptom ,business ,Body mass index ,Artery - Abstract
Background Obesity is related to several comorbidities and mortality, but its relationship with acute kidney injury (AKI) and long-term mortality remain undetermined in patients undergoing coronary artery bypass grafting. Methods Data from 3,018 patients (age ≥ 18 years) who underwent coronary artery bypass graft surgery from two tertiary referral centers were retrospectively reviewed between 2004 and 2015. Obesity was defined using the body mass index, according to the World Health Organization's recommendation. The odds and hazard ratios in post-surgical, AKI, and all-cause mortality were calculated after adjustment for multiple covariates. Patients were followed for 90 ± 40.9 months (maximum: 13 years). Results Among the cohort, 37.4%, 2.4%, 21.1%, 35.1%, and 4.0% of patients were classified as normal weight, underweight, overweight-at-risk, obese I, and obese II, respectively. Post-surgical AKI developed in 799 patients (26.5%). Patients in the obese groups (overweight-at-risk to obese II) had a higher risk of AKI than did those in the normal-weight group. During the follow-up period, 787 patients (26.1%) died. Underweight patients had a higher risk of mortality than did normal-weight patients, whereas overweight-at-risk, obese I, and obese II patients showed better survival rates. Conclusion After coronary artery bypass graft surgery, obese patients encountered a high risk of AKI, and underweight patients exhibited a low chance of survival. Awareness of both obese and underweight statuses should be raised in these patients., Graphical Abstract
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- 2018
7. Is Frailty a Modifiable Risk Factor of Future Adverse Outcomes in Elderly Patients with Incident End-Stage Renal Disease?
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Sun Wook Kim, Ho Jun Chin, Anna Lee, Kwang-Il Kim, Mi Yeon Yu, Ki Young Na, Sung Woo Lee, Cheol Ho Kim, and Dong Wan Chae
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Male ,medicine.medical_specialty ,medicine.medical_treatment ,End-Stage Renal Disease ,030232 urology & nephrology ,Kaplan-Meier Estimate ,Logistic regression ,Disease-Free Survival ,End stage renal disease ,Body Mass Index ,03 medical and health sciences ,0302 clinical medicine ,Sex Factors ,Renal Dialysis ,Risk Factors ,Internal medicine ,Diabetes mellitus ,medicine ,Odds Ratio ,Humans ,Clinical significance ,030212 general & internal medicine ,Risk factor ,Geriatric Assessment ,Dialysis ,Aged ,Proportional Hazards Models ,Frailty ,business.industry ,Proportional hazards model ,Malnutrition ,General Medicine ,medicine.disease ,Logistic Models ,Nephrology ,Physical therapy ,Kidney Failure, Chronic ,Female ,Original Article ,business ,Body mass index ,Follow-Up Studies ,Glomerular Filtration Rate - Abstract
Little is known about the clinical significance of frailty and changes of frailty after dialysis initiation in elderly patients with end-stage renal disease (ESRD). We prospectively enrolled 46 elderly patients with incident ESRD at a dialysis center of a tertiary hospital between May 2013 and March 2015. Frailty was assessed by using a comprehensive geriatric assessment protocol and defined as a multidimensional frailty score of ≥ 10. The main outcome was the composite of all-cause death or cardiovascular hospitalization, as determined in June 2016. The median age of the 46 participants was 71.5 years, and 63.0% of them were men. During the median 17.7 months follow-up, the rate of composite outcome was 17.4%. In multivariate logistic regression analysis, after adjusting for age, sex, diabetes, body mass index (BMI), and time of predialytic nephrologic care, female sex, and increased BMI were associated with increased and decreased odds of frailty, respectively. In multivariate Cox proportional hazards analysis, after adjusting for age, sex, diabetes, BMI, and time of predialytic nephrologic care, frailty was significantly associated with the composite adverse outcome. In repeated frailty assessments, the multidimensional frailty score significantly improved 12 months after the initiation of dialysis, which largely relied on improved nutrition. Therefore, frailty needs to be assessed for risk stratification in elderly patients with incident ESRD., Graphical Abstract
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- 2017
8. Cobalt Chloride Attenuates Oxidative Stress and Inflammation through NF-κB Inhibition in Human Renal Proximal Tubular Epithelial Cells
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Se Won Oh, Sejoong Kim, Ho Jun Chin, Ki Young Na, Yun Mi Lee, and Dong-Wan Chae
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T cell ,Renal Tubular Epithelial Cells ,Inflammation ,Biology ,medicine.disease_cause ,Cell Line ,Kidney Tubules, Proximal ,Interferon-gamma ,medicine ,Nuclear Factor-kappa B ,Humans ,Phosphorylation ,RNA, Small Interfering ,Hemeoxygenase-1 ,Chemokine CCL5 ,Chemokine CCL2 ,Gene knockdown ,Tumor Necrosis Factor-alpha ,Monocyte ,Cobalt Chloride ,NF-kappa B ,Transcription Factor RelA ,NF-kappa B p50 Subunit ,Epithelial Cells ,General Medicine ,Cobalt ,Molecular biology ,IκBα ,Oxidative Stress ,medicine.anatomical_structure ,Cell culture ,Tumor necrosis factor alpha ,Original Article ,RNA Interference ,medicine.symptom ,Oxidative stress ,Heme Oxygenase-1 ,Protein Binding - Abstract
We evaluated the effect of cobalt chloride (CoCl2) on TNF-α and IFN-γ-induced-inflammation and reactive oxygen species (ROS) in renal tubular epithelial cells (HK-2 cells). We treated HK-2 cells with CoCl2 before the administration of TNF-α/IFN-γ. To regulate hemeoxygenase-1 (HO-1) expression, the cells were treated CoCl2 or HO-1 siRNA. CoCl2 reduced the generation of ROS induced by TNF-α/IFN-γ. TNF-α/IFN-γ-treated-cells showed an increase in the nuclear translocation of phosphorylated NF-κBp65 protein, the DNA-binding activity of NF-κBp50 and NF-κB transcriptional activity and a decrease in IκBα protein expression. These changes were restored by CoCl2. We noted an intense increase in monocyte chemoattractant protein-1 (MCP-1) and regulated on activation normal T cell expressed and secreted (RANTES) production in TNF-α/IFN-γ-treated cells. We demonstrated that this effect was mediated through NF-κB signaling because an NF-κB inhibitor significantly reduced MCP-1 and RANTES production. CoCl2 effectively reduced MCP-1 and RANTES production. The expression of HO-1 was increased by CoCl2 and decreased by HO-1 siRNA. However, knockdown of HO-1 by RNA interference did not affect MCP-1 or RANTES production. We suggest that CoCl2 has a protective effect on TNF-α/IFN-γ-induced inflammation through the inhibition of NF-κB and ROS in HK-2 cells. However, CoCl2 appears to act in an HO-1-independent manner. Graphical Abstract
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- 2014
9. Erythropoietin Improves Long-Term Outcomes in Patients with Acute Kidney Injury after Coronary Artery Bypass Grafting
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Ki Young Na, Ho Jun Chin, Se Won Oh, and Dong Wan Chae
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Male ,Kaplan-Meier Estimate ,urologic and male genital diseases ,chemistry.chemical_compound ,Risk Factors ,Prospective Studies ,Coronary Artery Bypass ,Prospective cohort study ,Aged, 80 and over ,Predictive marker ,Acute kidney injury ,General Medicine ,Acute Kidney Injury ,Middle Aged ,female genital diseases and pregnancy complications ,Neutrophil Gelatinase-Associated Lipocalin Protein ,Lipocalins ,Recombinant Proteins ,Treatment Outcome ,Nephrology ,Creatinine ,Original Article ,Female ,medicine.drug ,medicine.medical_specialty ,Urinary system ,Urology ,Placebo ,End stage renal disease ,Double-Blind Method ,Lipocalin-2 ,Proto-Oncogene Proteins ,medicine ,Humans ,Mortality ,Erythropoietin ,Aged ,business.industry ,medicine.disease ,Placebo Effect ,Surgery ,Epoetin Alfa ,chemistry ,ROC Curve ,Hematinics ,business ,Biomarkers ,Acute-Phase Proteins - Abstract
Previous studies reported the beneficial effect of erythropoietin (EPO) in acute injuries. We followed patients with and without acute kidney injury (AKI) after coronary artery bypass grafting (CABG) and evaluated the effect of EPO on long-term outcome. We also assessed the efficacy of urinary neutrophil gelatinase-associated lipocalin (uNGAL) as a predictive marker of AKI. Seventy-one patients scheduled for elective CABG were randomly given either 300 U/kg of EPO or saline before CABG. The primary outcome was AKI, and the secondary outcome was the all-cause-mortality and composite of all-cause-mortality and end stage renal disease (ESRD). Twenty-one patients had AKI, 14 (66.7%) in the placebo group and 7 (33.3%) in the EPO group (P = 0.05). Also, uNGAL was higher in the patients with AKI than in those without AKI at baseline, 2, 4, 24, and 72 hr after CABG (P = 0.011). Among patients with AKI, 2-week creatinine (Cr) was not different from baseline Cr in the EPO group, but 2-week Cr was significantly higher than baseline Cr in the placebo group (P = 0.009). All-cause-mortality (P = 0.022) and the composite of all-cause-mortality and ESRD (P = 0.003) were reduced by EPO. EPO reduces all-cause-mortality and ESRD in patients with AKI, largely due to the beneficial effect of EPO on recovery after AKI.
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- 2012
10. The Heme Oxygenase-1 Genotype is a Risk Factor to Renal Impairment of IgA Nephropathy at Diagnosis, Which is a Strong Predictor of Mortality
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Hyung Jin Yoon, Ki Young Na, Dong-Wan Chae, Young Sun Kang, Dae Ryong Cha, Jong Won Park, Tae Woo Lee, Hyun Jin Cho, Ho Jun Chin, Young-Tai Shin, Ki Ryang Na, Suhnggwon Kim, Kyung-Woo Yoon, Jun-Young Do, Kang Wook Lee, and Un Sil Jeon
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Adult ,Male ,medicine.medical_specialty ,Genotype ,Renal function ,Biology ,Nephropathy ,Gene Frequency ,Risk Factors ,Internal medicine ,medicine ,Odds Ratio ,Humans ,Renal Insufficiency ,Promoter Regions, Genetic ,Allele frequency ,Heme Oxygenase ,Polymorphism, Genetic ,Promoter ,Glomerulonephritis ,Glomerulonephritis, IGA ,General Medicine ,Odds ratio ,Middle Aged ,medicine.disease ,Heme oxygenase ,Endocrinology ,Disease Progression ,Original Article ,Female ,Heme Oxygenase-1 ,Glomerular Filtration Rate - Abstract
The induction of heme oxygenase-1 (HO-1) ameliorates oxidative stress and inflammatory process, which play important roles in IgA nephropathy. We hypothesized length polymorphism in the promoter region of the HO-1 gene, which is related to the level of gene transcription, is associated with disease severity of IgA nephropathy. The subjects comprised 916 patients with IgA nephropathy and gene data. Renal impairment was defined as an estimated glomerular filtration rate less than 60 mL/min/1.73 m2 at diagnosis. The short (S: 28) (GT) repeats in the HO-1 gene was determined. The frequencies of S/S, S/M, M/M, S/L, L/M, and L/L genotypes were 7.2%, 6.9%, 3.1%, 30.8%, 22.7%, and 29.4%, respectively. The baseline characteristics were not different. In the S/S genotypic group, the renal impairment rate was 18.2%, which was lower than 32.2% in the group with M/M, L/M, or L/L genotype. The odds ratio of renal impairment in S/S genotype, compared to that in M/M, L/M, or L/L genotype, was 0.216 (95% confidence interval, 0.060-0.774, p=0.019). The HO-1 gene promoter length polymorphism was related to the renal impairment of IgA nephropathy at diagnosis, which is an important risk factor for mortality in IgA nephropathy patients.
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- 2009
11. The Association between Kidney Function, Coronary Artery Disease, and Clinical Outcome in Patients Undergoing Coronary Angiography
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Dong-Wan Chae, Ki Young Na, Young Rim Song, Chi Weon Kim, and Ho Joon Chin
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Drug-eluting Stents ,Male ,medicine.medical_specialty ,Time Factors ,Renal function ,Coronary Artery Disease ,urologic and male genital diseases ,Coronary Angiography ,Kidney ,Kidney Function Tests ,Coronary artery disease ,chemistry.chemical_compound ,Internal medicine ,medicine ,Humans ,Myocardial infarction ,cardiovascular diseases ,Mortality ,Survival rate ,Aged ,Creatinine ,business.industry ,Incidence (epidemiology) ,General Medicine ,Middle Aged ,medicine.disease ,Treatment Outcome ,chemistry ,Conventional PCI ,Hypertension ,Cardiology ,Kidney Failure, Chronic ,Original Article ,Female ,Kidney Diseases ,Stents ,business ,Kidney disease ,Glomerular Filtration Rate - Abstract
To characterize the association between chronic kidney disease (CKD), mortality, severity of coronary artery disease (CAD), treatment modality of CAD, and type of coronary stents among patients undergoing coronary angiography (CAG), we retrospectively reviewed the electronic medical records of the patients who underwent CAG at Seoul National University Bundang Hospital in Korea between May 2003 and January 2006. CKD was staged using an estimated glomerular filtration rate (eGFR) from the creatinine value prior to CAG. There were 3,637 patients included. The presence of CAD was 48% in CKD stage 1, 61% in stage 2, 73% in stage 3, 87% in stage 4, and 81% in stage 5. Survival rate gradually diminished for patients with decreasing renal function. No significant differences in all-cause and cardiac mortality were observed by medical treatment, PCI or CABG, in CKD patients with an eGFR less than 60 mL/min/1.73 m(2). CKD patients with drug-eluting stents showed significantly lower all-cause mortality (5.4% vs. 13.3%) and incidence of myocardial infarction (1.7% vs. 10%) than those with bare metal stents. In conclusion, an eGFR is a strong independent prognostic marker among patients undergoing CAG and the severity of CAD increases progressively with worsening renal function.
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- 2009
12. Long-term Prognosis of Anti-Neutrophil Cytoplasmic Antibody-Negative Renal Vasculitis: Cohort Study in Korea
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Ki Young Na, Mi Yeon Yu, Sejoong Kim, Sung Woo Lee, Shin Young Ahn, Ho Jun Chin, Seon Ha Baek, and Dong Wan Chae
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Male ,Pathology ,Koreans ,Survival ,Kaplan-Meier Estimate ,030204 cardiovascular system & hematology ,urologic and male genital diseases ,Gastroenterology ,Severity of Illness Index ,Cohort Studies ,0302 clinical medicine ,Interquartile range ,immune system diseases ,Risk Factors ,Medicine ,030212 general & internal medicine ,skin and connective tissue diseases ,Proteinuria ,Hazard ratio ,Age Factors ,General Medicine ,Middle Aged ,Prognosis ,Nephrology ,Female ,Kidney Diseases ,Original Article ,Sex ,medicine.symptom ,Vasculitis ,medicine.medical_specialty ,Enzyme-Linked Immunosorbent Assay ,End stage renal disease ,Antibodies, Antineutrophil Cytoplasmic ,03 medical and health sciences ,Sex Factors ,Internal medicine ,Republic of Korea ,Humans ,cardiovascular diseases ,Mortality ,Survival analysis ,Aged ,Proportional Hazards Models ,Retrospective Studies ,Anti-Neutrophil Cytoplasmic Antibody (ANCA) ,business.industry ,Proportional hazards model ,Retrospective cohort study ,medicine.disease ,respiratory tract diseases ,Microscopy, Fluorescence ,Kidney Failure, Chronic ,business ,Follow-Up Studies - Abstract
Few studies have reported on the long-term prognosis of anti-neutrophil cytoplasmic antibody (ANCA)-negative renal vasculitis. Between April 2003 and December 2013, 48 patients were diagnosed with renal vasculitis. Their ANCA status was tested using indirect immunofluorescence and enzyme-linked immunosorbent assays. During a median (interquartile range) follow-up duration of 933.5 (257.5–2,079.0) days, 41.7% of patients progressed to end stage renal disease (ESRD) and 43.8% died from any cause. Of 48 patients, 6 and 42 were ANCA-negative and positive, respectively. The rate of ESRD within 3 months was higher in ANCA-negative patients than in ANCA-positive patients (P = 0.038). In Kaplan-Meier survival analysis, ANCA-negative patients showed shorter renal survival than did ANCA-positive patients (log-rank P = 0.033). In univariate Cox-proportional hazard regression analysis, ANCA-negative patients showed increased risk of ESRD, with a hazard ratio 3.190 (95% confidence interval, 1.028–9.895, P = 0.045). However, the effect of ANCA status on renal survival was not statistically significant in multivariate analysis. Finally, ANCA status did not significantly affect patient survival. In conclusion, long-term patient and renal survival of ANCA-negative renal vasculitis patients did not differ from those of ANCA-positive renal vasculitis patients. Therefore, different treatment strategy depending on ANCA status might be unnecessary., Graphical Abstract
- Published
- 2015
13. Interleukin-10 Promoter Polymorphism is Associated with the Predisposition to the Development of IgA Nephropathy and Focal Segmental Glomerulosclerosis in Korea
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Ho Jun Chin, Yon Su Kim, Ki Young Na, Dong-Wan Chae, Soo Jin Kim, Suhnggwon Kim, Chun Soo Lim, and Kook-Hwan Oh
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Glomerulosclerosis, Focal ,Biology ,urologic and male genital diseases ,Polymorphism, Single Nucleotide ,Polymerase Chain Reaction ,Nephropathy ,Focal segmental glomerulosclerosis ,Gene Frequency ,Polymorphism (computer science) ,Genotype ,medicine ,Humans ,Promoter Regions, Genetic ,Allele frequency ,Alleles ,Korea ,Polymorphism, Genetic ,Base Sequence ,Glomerulosclerosis, Focal Segmental ,Haplotype ,Glomerulonephritis ,Glomerulonephritis, IGA ,General Medicine ,DNA ,medicine.disease ,Molecular biology ,Interleukin-10 ,Haplotypes ,Case-Control Studies ,Immunology ,Original Article ,Restriction fragment length polymorphism ,Polymorphism, Restriction Fragment Length - Abstract
The roles of interleukin-10 (IL-10) have been emphasized in several models of glomerulonephritis (GN). Three biallelic polymorphisms within the IL-10 promoter region, at positions -1,082, -819, and -592 from the transcription initiation site, were shown to affect the level of IL-10 production. To investigate the effect of IL-10 promoter polymorphisms on the predisposition to development of GN in Korea, IL-10 promoter polymorphisms were assayed by polymerase chain reaction followed by restriction fragment length polymorphism in 108 patients with IgA nephropathy (IgAN), 49 focal segmental glomerulosclerosis (FSGS), and 100 healthy controls. In comparison with the control, the frequency of -1,082*G alleles were lower in IgAN and the frequencies of -592*C and -819*C were lower in FSGS, respectively. As for the haplotype, GCC haplotype was less frequent among IgAN than the control and ATA haplotype was more frequent among FSGS than the control (p
- Published
- 2005
14. Effects of sodium citrate on salt sensitivity and kidney injury in chronic renal failure
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Eun Sook Jung, Jin Young Yang, Jae Wook Lee, Jin Suk Han, Sejoong Kim, Ki Young Na, Jeonghwan Lee, and Nam Ju Heo
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Male ,medicine.medical_specialty ,endocrine system ,Sodium ,medicine.medical_treatment ,chemistry.chemical_element ,Administration, Oral ,Natriuresis ,Sodium Citrate ,Rats, Sprague-Dawley ,chemistry.chemical_compound ,Internal medicine ,Sodium citrate ,medicine ,Animals ,Citrates ,Acidosis ,Kidney ,business.industry ,Metabolic acidosis ,General Medicine ,Salt Tolerance ,Acute Kidney Injury ,medicine.disease ,Nephrectomy ,Rats ,medicine.anatomical_structure ,Endocrinology ,Treatment Outcome ,chemistry ,Nephrology ,Dietary Supplements ,Kidney Failure, Chronic ,Original Article ,medicine.symptom ,business ,hormones, hormone substitutes, and hormone antagonists ,Kidney disease - Abstract
Metabolic acidosis, which is observed in salt-sensitive hypertension, is also associated with kidney injury. Alkali therapy in chronic renal failure (CRF) may ameliorate the progression of kidney disease; however, few studies have examined the effects of alkali therapy on salt sensitivity and kidney injury in CRF. We randomly administered standard diet (SD), sodium chloride with 20% casein diet (NACL), or sodium citrate with 20% casein diet (NACT) to Sprague-Dawley rats after a CRF or a sham operation. Four weeks after 5/6 nephrectomy, serum bicarbonate levels were higher in the NACT-treated group. On the pressure-natriuresis curve, NACT-treated CRF rats were more salt-resistant than NACL-treated CRF rats. Additionally, the NACT-treated CRF group showed less tubulointerstitial damage than the NACL-treated CRF group. The expression and immunoreactivity of NHE3 in the kidney in the NACT-treated CRF group were lower than those in the NACL-treated CRF group. We observed that dietary NACT as alkali therapy in CRF might improve the altered salt-sensitivity and ameliorate the progression of kidney injury compared to the NACL diet, which may be related to reduced renal NHE3 expression. Graphical Abstract
- Published
- 2014
15. Bilirubin activates transcription of HIF-1α in human proximal tubular cells cultured in the physiologic oxygen content
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Ki Young Na, Sejoong Kim, Eun Seong Lee, Shin Young Ahn, Sung Gyun Kim, Dong Wan Chae, and Ho Jun Chin
- Subjects
Transcriptional Activation ,medicine.medical_specialty ,Small interfering RNA ,Bilirubin ,Biology ,Proximal Tubular Cell ,Cell Line ,Kidney Tubules, Proximal ,chemistry.chemical_compound ,Phosphatidylinositol 3-Kinases ,Internal medicine ,medicine ,Humans ,Phosphorylation ,Protein kinase B ,PI3K/AKT/mTOR pathway ,chemistry.chemical_classification ,Mitogen-Activated Protein Kinase 1 ,Gene knockdown ,Reactive oxygen species ,NADPH oxidase ,Mitogen-Activated Protein Kinase 3 ,TOR Serine-Threonine Kinases ,HIF-1 ,NOX4 ,NADPH Oxidases ,Ribosomal Protein S6 Kinases, 70-kDa ,Epithelial Cells ,ROS ,General Medicine ,Hydrogen Peroxide ,Hypoxia-Inducible Factor 1, alpha Subunit ,Molecular biology ,Up-Regulation ,Oxygen ,Endocrinology ,chemistry ,NADPH Oxidase 4 ,biology.protein ,RNA Interference ,Original Article ,Proto-Oncogene Proteins c-akt ,Signal Transduction - Abstract
The expression of hypoxia-inducible factor (HIF) is influenced by reactive oxygen species (ROS). Effect of bilirubin on HIF-1 expression in proximal tubular cells was investigated under physiological oxygen concentration, which is relative hypoxic condition mimicking oxygen content in the medulla of renal tissue. The human kidney (HK2) cells were cultured in 5% oxygen with or without bilirubin. HIF-1α protein expression was increased by bilirubin treatment at 0.01-0.2 mg/dL concentration. The messenger RNA expression of HIF-1α was increased by 1.69±0.05 folds in the cells cultured with 0.1 mg/dL bilirubin, compared to the control cells. The inhibitors of PI3K/mTOR, PI3K/AKT, and ERK 1/2 pathways did not attenuate increased HIF-1α expression by bilirubin. HIF-1α expression decreased by 10 µM exogenous hydrogen peroxide (H2O2); scavenger of ROS with or without bilirubin in the HK2 cells increased HIF-1α concentration more than that in the cells without bilirubin. Exogenous H2O2 decreased the phosphorylation of P70S6 kinase, which was completely reversed by bilirubin treatment. Knockdown of NOX4 gene by small interfering RNA (siRNA) increased HIF-1α mRNA expression. In coonclusion, bilirubin enhances HIF-1α transcription as well as the up-regulation of HIF-1α protein translation through the attenuation of ROS and subunits of NADPH oxidase. Graphical Abstract
- Published
- 2014
16. Does albumin preinfusion potentiate diuretic action of furosemide in patients with nephrotic syndrome?
- Author
-
Curie Ahn, Jung Sang Lee, Suhnggwon Kim, Wooseong Huh, Yon Su Kim, In Jin Jang, Ki Young Na, Jin Suk Han, Un Sil Jeon, Sang-Goo Shin, and Kyun Sup Bae
- Subjects
Adult ,Male ,medicine.medical_specialty ,Nephrotic Syndrome ,Adolescent ,medicine.medical_treatment ,Diuresis ,Pharmacology ,Natriuresis ,Excretion ,Furosemide ,Internal medicine ,Albumins ,medicine ,Humans ,Diuretics ,Serum Albumin ,Aged ,Volume of distribution ,Cross-Over Studies ,business.industry ,Albumin ,Drug Synergism ,General Medicine ,Middle Aged ,Endocrinology ,Female ,Biological half-life ,Diuretic ,business ,medicine.drug ,Research Article - Abstract
The aim of this cross-over study was to investigate whether albumin infusion before furosemide administration could potentiate the diuretic action of furosemide. Seven patients with nephrotic syndrome were given the following infusions in random order on two separate days: 1) a sham solution followed by 160 mg of furosemide, 2) 100 ml of 20% human albumin followed by 160 mg of furosemide. Urine and serum furosemide concentrations were measured by high-performance liquid chromatography. The increment of urine volume was greater in albumin preinfusion than in furosemide alone. However, the increments of sodium and chloride excretions between furosemide alone and albumin preinfusion were not different. No significant differences in the pharmacokinetic parameters between the two treatments were observed: area under the concentration-time curve (AUC: 12.7+/-2.2 vs 15.1+/-4.4 g/ml hr), total plasma clearance (253+/-41 vs 256+/-54 ml/min), volume of distribution (341+/-34 vs 494+/-153 ml/kg), elimination half life (4.0+/-1.1 vs 4.6+/-0.8 hr), and urine furosemide excretion of the administered amount (16.5+/-7.3 vs 7.5+/-1.6%). In conclusion, these data show that albumin preinfusion potentiated diuresis, but not natriuresis, of furosemide without any change in the pharmacokinetics of the agent in patients with nephrotic syndrome.
- Published
- 2001
17. Iron plays a certain role in patterned hair loss
- Author
-
Soyun Cho, Song Youn Park, Se Young Na, Jong Hee Lee, and Jun Hwan Kim
- Subjects
Adult ,Male ,medicine.medical_specialty ,Iron ,Physiology ,Administration, Oral ,Dermatology ,Biology ,Thyroid Function Tests ,Thyroid function tests ,Hemoglobins ,Total iron-binding capacity ,Internal medicine ,Chart review ,medicine ,Humans ,In patient ,Ferrous Compounds ,Serum ferritin ,Retrospective Studies ,Ferritin ,medicine.diagnostic_test ,Alopecia ,General Medicine ,Iron deficiency ,Middle Aged ,medicine.disease ,Hair loss ,Endocrinology ,Premenopause ,Dietary Supplements ,Ferritins ,biology.protein ,Iron Deficiency ,Female ,Original Article - Abstract
Role of iron in hair loss is not clear yet. The purpose of this study was to evaluate the relationship between iron and hair loss. Retrospective chart review was conducted on patients with female pattern hair loss (FPHL) and male pattern hair loss (MPHL). All patients underwent screening including serum ferritin, iron, and total iron binding capacity (TIBC), CBC, ESR and thyroid function test. For normal healthy controls, age-sex matched subjects who had visited the hospital for a check-up with no serious disease were selected. A total 210 patients with FPHL (n = 113) and MPHL (n = 97) with 210 healthy controls were analyzed. Serum ferritin concentration (FC) was lower in patients with FPHL (49.27 ± 55.8 µg/L), compared with normal healthy women (77.89 ± 48.32 µg/L) (P < 0.001). Premenopausal FPHL patients turned out to show much lower serum ferritin than age/sex-matched controls (P < 0.001). Among MPHL patients, 22.7% of them showed serum FC lower than 70 µg/L, while no one had serum FC lower 70 µg/L in healthy age matched males. These results suggest that iron may play a certain role especially in premenopausal FPHL. The initial screening of iron status could be of help for hair loss patients.
- Published
- 2013
18. Predictive Value of Echocardiographic Parameters for Clinical Events in Patients Starting Hemodialysis
- Author
-
Goo Yeong Cho, Sejoong Kim, Dong Wan Chae, Youn Su Park, Ki Young Na, Seon Ha Baek, Seung Seok Han, Shin Young Ahn, and Ho Jun Chin
- Subjects
Male ,medicine.medical_specialty ,medicine.medical_treatment ,Disease ,Ventricular Function, Left ,Renal Dialysis ,Predictive Value of Tests ,Risk Factors ,Internal medicine ,medicine ,Humans ,In patient ,Mortality ,Heart Failure ,Heart Failure, Diastolic ,business.industry ,Clinical events ,Hazard ratio ,General Medicine ,Middle Aged ,Prognosis ,medicine.disease ,Predictive value ,Nephrology ,Echocardiography ,Heart failure ,Predictive value of tests ,Cardiology ,Kidney Failure, Chronic ,Original Article ,Female ,Hemodialysis ,Morbidity ,business - Abstract
Echocardiographic parameters can predict cardiovascular events in several clinical settings. However, which echocardiographic parameter is most predictive of each cardiovascular or non-cardiovascular event in patients starting hemodialysis remains unresolved. Echocardiography was used in 189 patients at the time of starting hemodialysis. We established primary outcomes as follows: cardiovascular events (ischemic heart disease, cerebrovascular disease, peripheral artery disease, and acute heart failure), fatal non-cardiovascular events, all-cause mortality, and all combined events. The most predictable echocardiographic parameter was determined in the Cox hazard ratio model with a backward selection after the adjustment of multiple covariates. Among several echocardiographic parameters, the E/e' ratio and the left ventricular end-diastolic volume (LVEDV) were the strongest predictors of cardiovascular and non-cardiovascular events, respectively. After the adjustment of clinical and biochemical covariates, the predictability of E/e' remained consistent, but LVEDV did not. When clinical events were further analyzed, the significant echocardiographic parameters were as follows: s' for ischemic heart disease and peripheral artery disease, LVEDV and E/e' for acute heart failure, and E/e' for all-cause mortality and all combined events. However, no echocardiographic parameter independently predicted cerebrovascular disease or non-cardiovascular events. In conclusion, E/e', s', and LVEDV have independent predictive values for several cardiovascular and mortality events.
- Published
- 2015
19. Effect of Bilirubin on Triglyceride Synthesis in Streptozotocin-Induced Diabetic Nephropathy
- Author
-
Sejoong Kim, Seon Ha Baek, Eun Seong Lee, Ki Young Na, Jianwei Xu, Ho Jun Chin, Dong-Wan Chae, and Shin Young Ahn
- Subjects
Male ,medicine.medical_specialty ,Bilirubin ,Kidney ,Triglyceride ,Streptozocin ,Diabetes Mellitus, Experimental ,Nephropathy ,Rats, Sprague-Dawley ,Diabetic nephropathy ,Mice ,chemistry.chemical_compound ,Transforming Growth Factor beta ,Cell Line, Tumor ,Internal medicine ,Diabetes mellitus ,medicine ,Animals ,Diabetic Nephropathies ,Triglycerides ,Liver X Receptors ,Creatinine ,NADPH Oxidases ,General Medicine ,Creatine ,Orphan Nuclear Receptors ,Streptozotocin ,medicine.disease ,Fibrosis ,Rats ,Mice, Inbred C57BL ,Disease Models, Animal ,Oxidative Stress ,Diabetes-Related Complications ,Endocrinology ,medicine.anatomical_structure ,Liver ,chemistry ,Original Article ,Lipoproteins, HDL ,Reactive Oxygen Species ,medicine.drug - Abstract
We aimed to elucidate the effect of bilirubin on dyslipidemia and nephropathy in a diabetes mellitus (DM) type I animal model. Sprague-Dawley rats were separated into control, DM, and bilirubin-treated DM (Bil) groups. The Bil group was injected intraperitoneally with 60 mg/kg bilirubin 3 times per week and hepatoma cells were cultured with bilirubin at a concentration of 0.3 mg/dL. The Bil group showed lower serum creatinine levels 5 weeks after diabetes onset. Bilirubin treatment also decreased the amount of mesangial matrix, lowered the expression of renal collagen IV and transforming growth factor (TGF)-β1, and reduced the level of apoptosis in the kidney, compared to the DM group. These changes were accompanied by decreased tissue levels of hydrogen superoxide and NADPH oxidase subunit proteins. Bilirubin decreased serum total cholesterol, high-density lipoprotein cholesterol (HDL-C), free fatty acids, and triglycerides (TGs), as well as the TG content in the liver tissues. Bilirubin suppressed protein expression of LXRα, SREBP-1, SCD-1, and FAS, factors involved in TG synthesis that were elevated in the livers of DM rats and hepatoma cells under high-glucose conditions. In conclusion, bilirubin attenuates renal dysfunction and dyslipidemia in diabetes by suppressing LXRα and SREBP-1 expression and oxidative stress. Graphical Abstract
- Published
- 2014
20. Small Increases in Plasma Sodium Are Associated with Higher Risk of Mortality in a Healthy Population
- Author
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Dong Wan Chae, Sejoong Kim, Se Won Oh, Ki Young Na, Ho Suk Goo, Seon Ha Baek, Suhnggwon Kim, Jung Nam An, and Ho Jun Chin
- Subjects
Adult ,Male ,Risk ,medicine.medical_specialty ,Diastole ,Blood Pressure ,Sex Factors ,Age ,Risk Factors ,Internal medicine ,medicine ,Risk of mortality ,Humans ,Cumulative incidence ,Mortality ,Salt intake ,Plasma Sodium ,Metabolic Syndrome ,Sex Characteristics ,business.industry ,Incidence ,musculoskeletal, neural, and ocular physiology ,Incidence (epidemiology) ,Sodium ,General Medicine ,Middle Aged ,medicine.disease ,Pulse pressure ,Endocrinology ,Blood pressure ,Cardiovascular Diseases ,Nephrology ,Hypertension ,biological sciences ,cardiovascular system ,Female ,Original Article ,Metabolic syndrome ,business ,tissues - Abstract
Elevated blood pressure (BP) is the most common cause of cardiovascular disease. Salt intake has a strong influence on BP, and plasma sodium (pNa) is increased with progressive increases in salt intake. However, the associations with pNa and BP had been reported inconsistently. We evaluated the association between pNa and BP, and estimated the risks of all-cause-mortality according to pNa levels. On the basis of data collected from health checkups during 1995-2009, 97,009 adult subjects were included. Positive correlations between pNa and systolic BP, diastolic BP, and pulse pressure (PP) were noted in participants with pNa ≥138 mM/L (P
- Published
- 2013
21. Prevalence, Clinical Characteristics, and Management of Functional Constipation at Pediatric Gastroenterology Clinics
- Author
-
Sung Kil Kang, Hye Ran Yang, So Young Na, Ji Hyun Uhm, Soo Hee Chang, Ki Soo Kang, Kie Young Park, and Eell Ryoo
- Subjects
Male ,medicine.medical_specialty ,Pediatrics ,Constipation ,Adolescent ,Rectum ,Severity of Illness Index ,Body Mass Index ,Rome III Criteria ,Severity of illness ,Prevalence ,medicine ,Humans ,Prospective Studies ,Child ,Prospective cohort study ,Pediatric gastroenterology ,business.industry ,Infant ,General Medicine ,medicine.disease ,Rome iii ,Hospitals ,medicine.anatomical_structure ,Laxatives ,Child, Preschool ,Functional constipation ,Female ,Original Article ,medicine.symptom ,business ,Body mass index - Abstract
The purpose of this study was to investigate the prevalence, clinical characteristics, and management of functional constipation at pediatric gastroenterology clinics. A prospective survey using the Rome III criteria was distributed to a group of parents of children with a constipation history and its control group in May 2008. The mean prevalence of constipation was 6.4%, which was similar to those in other countries. Statistically significant variables for children without constipation were that more children had a body mass index of below the 10th percentile even though they received more mother's care and ate balanced meals compared to the constipation group. Meanwhile, the constipation group frequently showed a history of constipation in infancy, picky-eating, lack of exercise, and retentive posturing. When analyzed with the Rome III criteria, the children showed greater than 60% rate of hard stools, painful stools, a history of large fecal mass in rectum, and its disappearance of constipation symptoms after passing a large stool. Our study found different approaches amongst pediatric gastroenterologists like rectal examinations, disimpaction, or drug treatment. Several factors addressed in our study can provide better guidelines for clinicians treating constipation and its future research.
- Published
- 2013
22. Effect of RAAS Inhibition on the Incidence of Cancer and Cancer Mortality in Patients with Glomerulonephritis
- Author
-
Suhnggwon Kim, Ki Young Na, Jieun Oh, Dong-Wan Chae, Jong Tae Cho, Ho Suk Goo, Jung Woo Noh, Ho Jun Chin, and Se Won Oh
- Subjects
Adult ,Male ,medicine.medical_specialty ,Angiotensin-Converting Enzyme Inhibitors ,Kidney ,urologic and male genital diseases ,Gastroenterology ,Renin-Angiotensin System ,Glomerulonephritis ,Risk Factors ,Neoplasms ,Internal medicine ,Humans ,Medicine ,cardiovascular diseases ,Aged ,Retrospective Studies ,medicine.diagnostic_test ,business.industry ,Incidence ,Incidence (epidemiology) ,Cancer ,Retrospective cohort study ,General Medicine ,Middle Aged ,medicine.disease ,Angiotensin II ,female genital diseases and pregnancy complications ,Blockade ,Endocrinology ,medicine.anatomical_structure ,Nephrology ,Original Article ,Female ,Renal biopsy ,business ,Angiotensin II Type 1 Receptor Blockers ,hormones, hormone substitutes, and hormone antagonists ,Follow-Up Studies - Abstract
Angiotensin II type 1 receptor blocker (ARB), which is frequently prescribed in patients with glomerulonephritis (GN), is suggested to increase the risk of cancer. We registered 3,288 patients with renal biopsy and analyzed the relationship between the use of renin-angiotensin-aldosterone system (RAAS) blockade and the incidence of cancer or cancer mortality. After renal biopsy, cancer developed in 33 patients with an incidence rate of 1.0% (95% of CI for incidence: 0.7%-1.3%). There was no difference in the cancer incidence among the groups according to the use of angiotensin-converting enzyme inhibitors (ACEI) or ARB: 1.2% in the None (23/1960), 0.7% in the ARB-only (5/748), 0.4% in the ACEI-only (1/247), and 1.2% in the ACEI-ARB (4/333) (P = 0.487) groups. The cancer mortality was 2.1%, 0.4%, 0.0%, and 0.3% in None, ACEI-only, ARB-only, and ACEI-ARB group, respectively (P < 0.001). The risk of cancer mortality in patients with ARB was only 0.124 (0.034-0.445) compared to that of non-users of ARB by Cox's hazard proportional analysis. In conclusion, prescription of ACEI or ARB in patients with GN does not increase cancer incidence and recipients of ARB show rather lower rates of all-cause mortality and cancer mortality.
- Published
- 2011
23. Low Level Light Could Work on Skin Inflammatory Disease: A Case Report on Refractory Acrodermatitis Continua
- Author
-
Mira Choi, Soyun Cho, Jong Hee Lee, and Se Young Na
- Subjects
Adult ,medicine.medical_specialty ,Light ,Inflammatory Skin Disease ,medicine.medical_treatment ,Light treatment ,Case Report ,Acrodermatitis Continua ,Dermatology ,Disease ,Skin Diseases ,Low Level Light ,Calcitriol ,Refractory ,Pregnancy ,Psoriasis ,medicine ,Humans ,Inflammation ,business.industry ,Inflammatory skin disease ,Acrodermatitis ,General Medicine ,Phototherapy ,medicine.disease ,Low level light ,Pregnancy Complications ,Female ,business ,Topical steroid - Abstract
Low level laser or light treatment on the various clinical condition is getting considerable attention now. However, there has been no report about the clinical effect of low level polarized polychromatic noncoherent light (LPPL) on the inflammatory skin disease. We experienced a case of acrodermatitis continua in a pregnant woman refractory to any conventional treatment including the most potent topical steroid. She was successfully treated with LPPL. LPPL could be a possible treatment modality producing substantial clinical result in inflammatory skin condition without any side-effect.
- Published
- 2011
24. High Dose Vitamin D3Attenuates the Hypocalciuric Effect of Thiazide in Hypercalciuric Rats
- Author
-
Ki Young Na, Hye Ryoun Jang, Ji Yong Jung, Jin Suk Han, Yun Kyu Oh, Kwon Wook Joo, Nam Ju Heo, Hyosang Kim, Jay Wook Lee, Jeonghwan Lee, and Sejoong Kim
- Subjects
medicine.medical_specialty ,Sodium-Hydrogen Exchangers ,Sodium-Potassium-Chloride Symporters ,Sodium Chloride Symporter Inhibitors ,Hypercalciuria ,TRPV Cation Channels ,chemistry.chemical_element ,Calcium ,Rats, Sprague-Dawley ,Thiazides ,Excretion ,chemistry.chemical_compound ,Sodium-Glucose Transporter 1 ,Hydrochlorothiazide ,Internal medicine ,medicine ,Vitamin D and neurology ,Animals ,Thiazide ,Cholecalciferol ,Solute Carrier Family 12, Member 1 ,Sodium-Hydrogen Exchanger 3 ,Chemistry ,General Medicine ,medicine.disease ,Urinary calcium ,Rats ,Sodium Transporters ,Endocrinology ,Nephrology ,Original Article ,Calcium Channels ,TRPV5 ,medicine.drug - Abstract
Thiazide is known to decrease urinary calcium excretion. We hypothesized that thiazide shows different hypocalciuric effects depending on the stimuli causing hypercalciuria. The hypocalciuric effect of hydrochlorothiazide (HCTZ) and the expression of transient receptor potential vanilloid 5 (TRPV5), calbindin-D(28K), and several sodium transporters were assessed in hypercalciuric rats induced by high calcium diet and vitamin D(3). Urine calcium excretion and the expression of transporters were measured from 4 groups of Sprague-Dawley rats; control, HCTZ, high calcium-vitamin D, and high calcium-vitamin D with HCTZ groups. HCTZ decreased urinary calcium excretion by 51.4% in the HCTZ group and only 15% in the high calcium-vitamin D with HCTZ group. TRPV5 protein abundance was not changed by HCTZ in the high calcium-vitamin D with HCTZ group compared to the high calcium-vitamin D group. Protein abundance of NHE3, SGLT1, and NKCC2 decreased in the hypercalciuric rats, and only SGLT1 protein abundance was increased by HCTZ in the hypercalciuric rats. The hypocalciuric effect of HCTZ is attenuated in high calcium and vitamin D-induced hypercalciuric rats. This attenuation seems to have resulted from the lack of HCTZ's effect on protein abundance of TRPV5 in severe hypercalciuric condition induced by high calcium and vitamin D.
- Published
- 2010
25. Effects of Thiazide on the Expression of TRPV5, Calbindin-D28K, and Sodium Transporters in Hypercalciuric Rats
- Author
-
Nam Ju Heo, Jin Suk Han, Hyosang Kim, Hye Ryoun Jang, Yun Kyu Oh, Sejoong Kim, Jeonghwan Lee, Kwon Wook Joo, Ki Young Na, Un Sil Jeon, and Søren Nielsen
- Subjects
Male ,Calbindins ,medicine.medical_specialty ,Sodium-Hydrogen Exchangers ,Sodium-Potassium-Chloride Symporters ,Sodium ,Hypercalciuria ,TRPV Cation Channels ,chemistry.chemical_element ,Calcium ,S100 Calcium Binding Protein G ,Models, Biological ,Thiazides ,Rats, Sprague-Dawley ,Excretion ,Hydrochlorothiazide ,Internal medicine ,medicine ,Animals ,Thiazide ,Solute Carrier Family 12, Member 1 ,Sodium-Hydrogen Exchanger 3 ,Chemistry ,Biological Transport ,General Medicine ,medicine.disease ,Urinary calcium ,Rats ,Transporters ,Endocrinology ,Calbindin 1 ,Original Article ,Calcium Channels ,medicine.drug - Abstract
TRPV5 is believed to play an important role in the regulation of urinary calcium excretion. We assessed the effects of hydrochlorothiazide (HCTZ) on the expression of TRPV5, calbindin-D(28K), and several sodium transporters in hypercalciuric rats. Sprague-Dawley rats were divided into 4 groups; control, HCTZ, high salt, and high salt with HCTZ group in experiment 1; control, HCTZ, high calcium (Ca), and high Ca with HCTZ group in experiment 2. To quantitate the expression of TRPV5, calbindin-D(28K), and sodium transporters, western blotting was performed. In both experiments, HCTZ significantly decreased urinary calcium excretion. TRPV5 protein abundance decreased in all hypercalciuric rats, and restored by HCTZ in both high salt with HCTZ and high Ca with HCTZ group. Calbindin-D(28K) protein abundance increased in the high salt and high salt with HCTZ groups, but did not differ among groups in experiment 2. Protein abundance of NHE3 and NKCC2 decreased in all hypercalciuric rats, and were restored by HCTZ in only high Ca-induced hypercalciuric rats. In summary, protein abundance of TRPV5, NHE3, and NKCC2 decreased in all hypercalciuric rats. The hypocalciuric effect of HCTZ is associated with increased protein abundance of TRPV5 in high salt or calcium diet-induced hypercalciuric rats.
- Published
- 2009
26. The Bilirubin Level is Negatively Correlated with the Incidence of Hypertension in Normotensive Korean Population
- Author
-
Yon-Su Kim, Dong Wan Chae, Ki Young Na, Hyung Jin Yoon, Young Rim Song, Minseon Park, Hyosang Kim, Ho Jun Chin, and Suhnggwon Kim
- Subjects
Adult ,Male ,Risk ,medicine.medical_specialty ,Bilirubin ,Blood Pressure ,Heme ,Lower risk ,chemistry.chemical_compound ,Surveys and Questionnaires ,Internal medicine ,medicine ,Humans ,Risk factor ,Hyperbilirubinemia ,Proportional Hazards Models ,Korea ,business.industry ,Risk Factor ,Incidence (epidemiology) ,Smoking ,General Medicine ,Middle Aged ,Confidence interval ,Heme oxygenase ,Endocrinology ,chemistry ,Relative risk ,Hypertension ,Heme Oxygenase (Decyclizing) ,Original Article ,Female ,Liver function ,business - Abstract
Reactive oxygen species have been known to be an important factor in the patho- genesis of hypertension. Bilirubin, one of the metabolites of heme degraded by heme oxygenase, is a potent anti-oxidant. We verified the effect of serum bilirubin level on the incidence of hypertension in normotensive subjects. We grouped 1,208 normoten- sive subjects by the criterion of the highest quintile value of serum bilirubin, 1.1 mg/dL. The incidence of hypertension was higher in group 1 with bilirubin less than 1.1 mg/ dL than in group 2 with bilirubin 1.1 mg/dL or more (186/908 vs. 43/300, p=0.018). The relative risk for hypertension was 0.71 (95% confidence interval, 0.51-0.99), p=0.048 in group 2 compared to group 1 by Cox's proportional hazard model. Among the groups stratified by gender, smoking, and liver function status, the group 2 showed a lower risk of hypertension in females and in non-smokers. In conclusion, a mild increase within the physiological range of serum bilirubin con- centration was negatively correlated with the incidence of hypertension. The effect of bilirubin on the development of hypertension was more evident in females and in non-smokers.
- Published
- 2009
27. The Mildly Elevated Serum Bilirubin Level is Negatively Associated with the Incidence of End Stage Renal Disease in Patients with IgA Nephropathy
- Author
-
Won Yong Cho, Young Rim Song, Suhnggwon Kim, Chun Soo Lim, Hyung Jin Yoon, Yong-Lim Kim, Dong Chan Jin, Seong Gyun Kim, Jung Eun Lee, Jin Suk Han, Sang Koo Lee, Kook Hwan Oh, Ho Jun Chin, Curie Ahn, En Sil Jeon, Hyun Jin Cho, Yon-Su Kim, Sang-Kyung Jo, Dong-Wan Chae, Tae Woo Lee, Ki Young Na, Sun-Hee Park, Chan-Duck Kim, Hyoung Kyu Kim, Yoon Kyu Oh, Kwon Wook Joo, and Yoon Goo Kim
- Subjects
Adult ,Male ,Risk ,medicine.medical_specialty ,Bilirubin ,Renal function ,urologic and male genital diseases ,Gastroenterology ,Nephropathy ,End stage renal disease ,chemistry.chemical_compound ,Risk Factors ,Internal medicine ,medicine ,Humans ,Proteinuria ,business.industry ,Incidence ,Incidence (epidemiology) ,Glomerulonephritis, IGA ,Glomerulonephritis ,General Medicine ,Middle Aged ,medicine.disease ,Treatment Outcome ,Endocrinology ,chemistry ,Relative risk ,Hypertension ,Disease Progression ,Kidney Failure, Chronic ,Original Article ,Female ,medicine.symptom ,business ,Glomerular Filtration Rate - Abstract
Oxidative stress plays various roles in the development and progression of IgA nephropathy, while bilirubin is known as a potent antioxidant. We therefore hypothesized that serum bilirubin would be associated with renal prognosis in IgA nephropathy. The study subjects comprised 1,458 adult patients with primary IgA nephropathy in Korea. We grouped patients according to the following quartile levels of bilirubin: 0.8 mg/dL (Q4). The outcome data were obtained from the Korean Registry of end-stage renal disease (ESRD). Eighty patients (5.5%) contracted ESRD during a mean follow-up period of 44.9 months. The ESRD incidences were 10.7% in Q1, 8.2% in Q2, 2.8% in Q3, and 2.8% in Q4 (p
- Published
- 2009
28. Short- and Long-Term Results of Triple Valve Surgery: A Single Center Experience
- Author
-
Chan Young Na, Sung Ho Shinn, Man Jong Baek, Chang-Ha Lee, Sam Sae Oh, Jae Hyun Kim, Hong Gook Lim, Dong Seop Song, and Kil Soo Yie
- Subjects
Adult ,Male ,Reoperation ,Aortic valve ,medicine.medical_specialty ,Triple valve surgery ,Heart Valve Diseases ,Hemorrhage ,Regurgitation (circulation) ,Single Center ,Severity of Illness Index ,Postoperative Complications ,Risk Factors ,Thromboembolism ,Internal medicine ,Mitral valve ,Severity of illness ,medicine ,Humans ,Renal Failure ,Renal Insufficiency ,Intraoperative Complications ,Stroke ,Survival analysis ,Aged ,Heart Valve Prosthesis Implantation ,Tricuspid valve ,business.industry ,Anticoagulants ,General Medicine ,Middle Aged ,medicine.disease ,Survival Analysis ,Surgery ,medicine.anatomical_structure ,Aortic Valve ,Cardiology ,Mitral Valve ,Female ,Original Article ,Tricuspid Valve ,business - Abstract
Triple valve surgery is usually complex and carries a reported operative mortality of 13% and 10-yr survival of 61%. We examined surgical results based on our hospital's experience. A total of 160 consecutive patients underwent triple valve surgery from 1990 to 2006. The most common aortic and mitral valve disease was rheumatic disease (82%). The most common tricuspid valve disease was functional regurgitation (80%). Seventy-four percent of the patients were in New York Heart Association (NYHA) class III and IV. Univariate and multivariable analyses were performed to identify predictors of early and late survival. Operative mortality was 6.9% (n=11). Univariate factors associated with mortality included old age, preoperative renal failure, postoperative renal failure, pulmonary complications, and stroke. Of them, postoperative renal failure and stroke were associated with mortality on multivariable analysis. Otherwise, neither tricuspid valve replacement nor reoperation were statistically associated with late mortality. Survival at 5 and 10 yr was 87% and 84%, respectively. Ninety-two percent of the patients were in NYHA class I and II at their most recent follow-up. Ten-year freedom from prosthetic valve endocarditis was 97%; from anticoagulation-related hemorrhage, 82%; from thromboembolism, 89%; and from reoperation, 84%. Postoperative renal failure and stroke were significantly related with operative mortality. Triple valve surgery, regardless of reoperation and tricuspid valve replacement, results in acceptable long-term survival.
- Published
- 2009
29. Association of Angiotensin II Type 2 Receptor Gene A1818T Polymorphism with Progression of Immunoglobulin A Nephropathy in Korean Patients
- Author
-
Suhnggwon Kim, Tae-Woo Lee, Hye-Young Kim, Jaeseok Yang, Sejoong Kim, Hyun Hee Lee, Woo Kyung Chung, Un Sil Jeon, Hyung Jin Yoon, Hyun Chul Kim, Ho Jun Chin, Sung Bae Park, Young Joo Kwon, Ki Young Na, and Dong-Wan Chae
- Subjects
Nephrology ,medicine.medical_specialty ,Time Factors ,Genotype ,Biology ,urologic and male genital diseases ,Polymorphism, Single Nucleotide ,Receptor, Angiotensin, Type 2 ,Gastroenterology ,chemistry.chemical_compound ,Internal medicine ,medicine ,Humans ,Allele ,Alleles ,Survival analysis ,Creatinine ,Korea ,Models, Statistical ,Polymorphism, Genetic ,Proteinuria ,Models, Genetic ,Proportional hazards model ,Hazard ratio ,Glomerulonephritis, IGA ,General Medicine ,Treatment Outcome ,chemistry ,Immunology ,Disease Progression ,Original Article ,medicine.symptom ,Polymorphism, Restriction Fragment Length - Abstract
We determined the relationship between the progression of immunoglobulin A nephropathy (IgAN) and the A1818T polymorphism in intron 2 of Angiotensin II type 2 receptor (AT2R) gene, which might play protective roles in the pathogenesis of IgAN. Patients with biopsy-proven IgAN were recruited from the registry of the Progressive REnal disease and Medical Informatics and gEnomics Research (PREMIER) which was sponsored by the Korean Society of Nephrology. A1818T polymorphism of AT2R gene was analyzed with PCR-RFLP method and the association with the progression of IgAN, which was defined as over 50% increase in baseline serum creatinine level, was analyzed with survival analysis. Among the 480 patients followed for more than 10 months, the group without T allele had significantly higher rates of progression of IgAN than the group with T allele (11.4% vs. 3.9%, p=0.024), although there were no significant differences in the baseline variables such as initial serum creatinine level, the degree of proteinuria, and blood pressure. In the Cox's proportional hazard model, the hazard ratio of disease progression in the patients with T allele was 0.221 (95% confidence interval for Exp(B): 0.052-0.940, p=0.041) compared to that of without T allele. In conclusion, A1818T polymorphism of AT2R gene was associated with the progression of IgAN.
- Published
- 2009
30. Investigation of the Bovine Leukemia Virus Proviral DNA in Human Leukemias and Lung cancers in Korea
- Author
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Lee, Jehoon, primary, Kim, Yonggoo, additional, Kang, Chang Suk, additional, Cho, Dae Hyun, additional, Shin, Dong Hwan, additional, Yum, Young Na, additional, Oh, Jae Ho, additional, Kim, Sheen Hee, additional, Hwang, Myung Sil, additional, Lim, Chul Joo, additional, Yang, Ki Hwa, additional, and Han, Kyungja, additional
- Published
- 2005
- Full Text
- View/download PDF
31. Altered Renal Sodium Transporter Expression in an Animal Model of Type 2 Diabetes Mellitus
- Author
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Kwon Wook Joo, Yun Kyu Oh, Ki Young Na, Jin Suk Han, Jay Wook Lee, Chun Soo Lim, Un Sil Jeon, and Mark A. Knepper
- Subjects
Blood Glucose ,Male ,Epithelial sodium channel ,medicine.medical_specialty ,Sodium-Hydrogen Exchangers ,Sodium-Potassium-Chloride Symporters ,Rats, Inbred OLETF ,Sodium ,Immunoblotting ,chemistry.chemical_element ,Type 2 diabetes ,Kidney ,Diabetic nephropathy ,chemistry.chemical_compound ,Diabetes mellitus ,Internal medicine ,medicine ,Animals ,Diabetic Nephropathies ,Thiazide Sensitive Nacl Cotransporter ,Epithelial Sodium Channels ,Solute Carrier Family 12, Member 1 ,Creatinine ,Sodium-Hydrogen Exchanger 3 ,urogenital system ,business.industry ,Kidney metabolism ,General Medicine ,Bumetanide Sensitive NaK2Cl Cotransporter ,medicine.disease ,Epithelial Sodium Channel ,Immunohistochemistry ,Rats ,Disease Models, Animal ,Endocrinology ,medicine.anatomical_structure ,Diabetes Mellitus, Type 2 ,chemistry ,Hypertension ,Original Article ,business - Abstract
Hemodynamic factors play an important role in the development and/or progression of diabetic nephropathy. We hypothesized that renal sodium transporter dysregulation might contribute to the hemodynamic alterations in diabetic nephropathy. Otsuka Long Evans Tokushima Fatty (OLETF) rats were used as an animal model for type 2 diabetes. Long Evans Tokushima (LETO) rats were used as controls. Renal sodium transporter regulation was investigated by semiquantitative immunoblotting and immunohistochemistry of the kidneys of 40-week-old animals. The mean serum glucose level in OLETF rats was increased to 235+/-25 mg/dL at 25 weeks, and the hyperglycemia continued up to the end of 40 weeks. Urine protein/ creatinine ratios were 10 times higher in OLETF rats than in LETO rats. At 40th week, the abundance of the epithelial sodium channel (ENaC) beta-subunit was increased in OLETF rats, but the abundance of the ENaC gamma-subunit was decreased. No significant differences were observed in the ENaC alpha-subunit or other major sodium transporters. Immunohistochemistry for the ENaC beta-subunit showed increased immunoreactivity in OLETF rats, whereas the ENaC gamma-subunit showed reduced immunoreactivity in these rats. In OLETF rats, ENaC beta-subunit upregulation and ENaC gamma-subunit downregulation after the development of diabetic nephropathy may reflect an abnormal sodium balance.
- Published
- 2007
32. Investigation of the Bovine Leukemia Virus Proviral DNA in Human Leukemias and Lung cancers in Korea
- Author
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Young Na Yum, Chang Suk Kang, Myung Sil Hwang, Chul Joo Lim, Jae Ho Oh, Dong Hwan Shin, Yonggoo Kim, Sheen Hee Kim, Jehoon Lee, Kyungja Han, Ki Hwa Yang, and Dae Hyun Cho
- Subjects
Lung Neoplasms ,animal diseases ,viruses ,Adenocarcinoma ,Polymerase Chain Reaction ,Cell Line ,Leucosis ,Myelogenous ,Proviruses ,immune system diseases ,Leukemia, Myelogenous, Chronic, BCR-ABL Positive ,hemic and lymphatic diseases ,Leukemia Virus, Bovine ,medicine ,Humans ,Lung cancer ,Leukemia ,Korea ,Bovine leukemia virus ,biology ,Human Infection ,business.industry ,virus diseases ,Myeloid leukemia ,General Medicine ,Precursor Cell Lymphoblastic Leukemia-Lymphoma ,medicine.disease ,biology.organism_classification ,Virology ,Leukemia, Myeloid ,Acute Disease ,DNA, Viral ,Original Article ,business ,Chronic myelogenous leukemia - Abstract
The bovine leukemia virus (BLV) is the causative agent of enzootic bovine leucosis. This study investigated the presence of the BLV in leukemia (179 acute lymphoblastic leukemia, 292 acute myeloid leukemia and 46 chronic myelogenous leukemia cases) and 162 lung cancer patients (139 adenocarcinoma, 23 squamous cell carcinoma) to determine if the BLV is a causative organism of leukemia and lung cancer in Koreans. A BLV infection was confirmed in human cells by PCR using a BLV-8 primer combination. All 517 cases of human leukemia and 162 lung cancer were negative for a PCR of the BLV proviral DNA. In conclusion, although meat has been imported from BLV endemic areas, the BLV infection does not appear to be the cause of human leukemia or lung cancer in Koreans. These results can be used as a control for further studies on the BLV in Koreans.
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- 2005
33. Genistein Supplementation Inhibits Atherosclerosis with Stabilization of the Lesions in Hypercholesterolemic Rabbits
- Author
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Junghee Lee, Sun-Young Na, Seung-Pyung Lim, Su-Jin Kwon, and Choong-Sik Lee
- Subjects
Male ,medicine.medical_specialty ,Normal diet ,Arteriosclerosis ,Blotting, Western ,Hypercholesterolemia ,Genistein ,Biology ,Muscle, Smooth, Vascular ,Lesion ,Lipid peroxidation ,chemistry.chemical_compound ,Internal medicine ,Hyperlipidemia ,medicine ,Animals ,Endothelial dysfunction ,Aorta ,Aortic atherosclerosis ,Macrophages ,General Medicine ,medicine.disease ,Metalloproteinases ,Growth Inhibitors ,Endocrinology ,chemistry ,Diet, Atherogenic ,Matrix Metalloproteinase 3 ,Original Article ,Rabbits ,medicine.symptom - Abstract
The effect of genistein on aortic atherosclerosis was studied by immunohistochemistry with RAM-11 and HHF-35 antibodies and western blotting for matrix metalloproteinase-3 (MMP-3) in New Zealand White rabbits. After provocation of atherosclerosis with hyperlipidemic diet, the rabbits were divided as hyperlipidemic diet group (HD), normal diet group (ND) and hyperlipidemic plus genistein diet group (HD+genistein) for 4 and half months. The average cross sectional area of atherosclerotic lesion was 0.269 mm2 after provocation. The lesion was progressed by continuous hyperlipidemic diet (10.06 mm2) but was increased mildly by genistein (0.997 mm2), and decreased by normal diet (0.228 mm2). The ratio of macrophages to smooth muscle cells in the lesion was not changed by genistein supplementmentation. The western blotting showed reduction of MMP-3 expression in HD+genistein and ND groups than HD group. The inhibition of atherogenesis by genistein was might be due to improve the endothelial dysfunction rather than direct action on macrophages and/or smooth muscle cells in the lesion, since endothelial dysfunction by lipid peroxidation was the main atherogenic factor in the hypercholesterolemicrabbits. The genistein supplementmentation also suggests that it helps the stabilization of the atherosclerotic lesion by inhibition of MMP-3 expression.
- Published
- 2004
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