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The Heme Oxygenase-1 Genotype is a Risk Factor to Renal Impairment of IgA Nephropathy at Diagnosis, Which is a Strong Predictor of Mortality
- Source :
- Journal of Korean Medical Science
- Publication Year :
- 2009
- Publisher :
- The Korean Academy of Medical Sciences, 2009.
-
Abstract
- The induction of heme oxygenase-1 (HO-1) ameliorates oxidative stress and inflammatory process, which play important roles in IgA nephropathy. We hypothesized length polymorphism in the promoter region of the HO-1 gene, which is related to the level of gene transcription, is associated with disease severity of IgA nephropathy. The subjects comprised 916 patients with IgA nephropathy and gene data. Renal impairment was defined as an estimated glomerular filtration rate less than 60 mL/min/1.73 m2 at diagnosis. The short (S: 28) (GT) repeats in the HO-1 gene was determined. The frequencies of S/S, S/M, M/M, S/L, L/M, and L/L genotypes were 7.2%, 6.9%, 3.1%, 30.8%, 22.7%, and 29.4%, respectively. The baseline characteristics were not different. In the S/S genotypic group, the renal impairment rate was 18.2%, which was lower than 32.2% in the group with M/M, L/M, or L/L genotype. The odds ratio of renal impairment in S/S genotype, compared to that in M/M, L/M, or L/L genotype, was 0.216 (95% confidence interval, 0.060-0.774, p=0.019). The HO-1 gene promoter length polymorphism was related to the renal impairment of IgA nephropathy at diagnosis, which is an important risk factor for mortality in IgA nephropathy patients.
- Subjects :
- Adult
Male
medicine.medical_specialty
Genotype
Renal function
Biology
Nephropathy
Gene Frequency
Risk Factors
Internal medicine
medicine
Odds Ratio
Humans
Renal Insufficiency
Promoter Regions, Genetic
Allele frequency
Heme Oxygenase
Polymorphism, Genetic
Promoter
Glomerulonephritis
Glomerulonephritis, IGA
General Medicine
Odds ratio
Middle Aged
medicine.disease
Heme oxygenase
Endocrinology
Disease Progression
Original Article
Female
Heme Oxygenase-1
Glomerular Filtration Rate
Subjects
Details
- Language :
- English
- ISSN :
- 15986357 and 10118934
- Volume :
- 24
- Issue :
- Suppl 1
- Database :
- OpenAIRE
- Journal :
- Journal of Korean Medical Science
- Accession number :
- edsair.doi.dedup.....cf953a746989955314a54ace265482bb