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Interleukin-10 Promoter Polymorphism is Associated with the Predisposition to the Development of IgA Nephropathy and Focal Segmental Glomerulosclerosis in Korea
- Source :
- Journal of Korean Medical Science
- Publication Year :
- 2005
- Publisher :
- The Korean Academy of Medical Sciences, 2005.
-
Abstract
- The roles of interleukin-10 (IL-10) have been emphasized in several models of glomerulonephritis (GN). Three biallelic polymorphisms within the IL-10 promoter region, at positions -1,082, -819, and -592 from the transcription initiation site, were shown to affect the level of IL-10 production. To investigate the effect of IL-10 promoter polymorphisms on the predisposition to development of GN in Korea, IL-10 promoter polymorphisms were assayed by polymerase chain reaction followed by restriction fragment length polymorphism in 108 patients with IgA nephropathy (IgAN), 49 focal segmental glomerulosclerosis (FSGS), and 100 healthy controls. In comparison with the control, the frequency of -1,082*G alleles were lower in IgAN and the frequencies of -592*C and -819*C were lower in FSGS, respectively. As for the haplotype, GCC haplotype was less frequent among IgAN than the control and ATA haplotype was more frequent among FSGS than the control (p
- Subjects :
- Glomerulosclerosis, Focal
Biology
urologic and male genital diseases
Polymorphism, Single Nucleotide
Polymerase Chain Reaction
Nephropathy
Focal segmental glomerulosclerosis
Gene Frequency
Polymorphism (computer science)
Genotype
medicine
Humans
Promoter Regions, Genetic
Allele frequency
Alleles
Korea
Polymorphism, Genetic
Base Sequence
Glomerulosclerosis, Focal Segmental
Haplotype
Glomerulonephritis
Glomerulonephritis, IGA
General Medicine
DNA
medicine.disease
Molecular biology
Interleukin-10
Haplotypes
Case-Control Studies
Immunology
Original Article
Restriction fragment length polymorphism
Polymorphism, Restriction Fragment Length
Subjects
Details
- Language :
- English
- ISSN :
- 15986357 and 10118934
- Volume :
- 20
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Journal of Korean Medical Science
- Accession number :
- edsair.doi.dedup.....6a235334552e37b05008c861011bf914