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The Mildly Elevated Serum Bilirubin Level is Negatively Associated with the Incidence of End Stage Renal Disease in Patients with IgA Nephropathy
- Source :
- Journal of Korean Medical Science
- Publication Year :
- 2009
- Publisher :
- Korean Academy of Medical Sciences, 2009.
-
Abstract
- Oxidative stress plays various roles in the development and progression of IgA nephropathy, while bilirubin is known as a potent antioxidant. We therefore hypothesized that serum bilirubin would be associated with renal prognosis in IgA nephropathy. The study subjects comprised 1,458 adult patients with primary IgA nephropathy in Korea. We grouped patients according to the following quartile levels of bilirubin: 0.8 mg/dL (Q4). The outcome data were obtained from the Korean Registry of end-stage renal disease (ESRD). Eighty patients (5.5%) contracted ESRD during a mean follow-up period of 44.9 months. The ESRD incidences were 10.7% in Q1, 8.2% in Q2, 2.8% in Q3, and 2.8% in Q4 (p
- Subjects :
- Adult
Male
Risk
medicine.medical_specialty
Bilirubin
Renal function
urologic and male genital diseases
Gastroenterology
Nephropathy
End stage renal disease
chemistry.chemical_compound
Risk Factors
Internal medicine
medicine
Humans
Proteinuria
business.industry
Incidence
Incidence (epidemiology)
Glomerulonephritis, IGA
Glomerulonephritis
General Medicine
Middle Aged
medicine.disease
Treatment Outcome
Endocrinology
chemistry
Relative risk
Hypertension
Disease Progression
Kidney Failure, Chronic
Original Article
Female
medicine.symptom
business
Glomerular Filtration Rate
Subjects
Details
- ISSN :
- 10118934
- Volume :
- 24
- Database :
- OpenAIRE
- Journal :
- Journal of Korean Medical Science
- Accession number :
- edsair.doi.dedup.....6f3f23670fadb6ffcc66d9562c5935c9